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Combined hepatectomy and radiofrequency ablation versus TACE in improving survival of patients with unresectable BCLC stage B HCC

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Hepatobiliary & Pancreatic Diseases International 2016年第4期15卷 378-385页

作者： Yi-Fu Hou Yong-Gang Wei Jia-Yin Yang Tian-Fu Wen Ming-Qing Xu Lu-Nan Yan Bo Li department of hepatic Surgery West China HospitalSichuan University

BACKGROUND： Combined hepatectomy and radiofrequency ablation（RFA） provides an additional treatment for patients with Barcelona Clinic Liver Cancer（BCLC） stage B hepatocellular carcinoma（HCC） who are conventionally deemed unresectable. This study aimed to analyze the outcome of this combination therapy by comparing it with transarterial chemoembolization（TACE）. METHODS： We retrospectively reviewed 51 patients with unresectable BCLC stage B HCC who had received the combination therapy. We compared the survival of these patients with that of 102 patients in the TACE group（control）. Prognostic factors associated with worse survival in the combination group were ***： No differences in tumor status and liver function were observed between the TACE group and combination group. The median survival time for the combination group and TACE group was 38（6-54） and 17（3-48） months, respectively（P〈0.001）. The combination group required longer hospitalization than the TACE group [8（5-14） days vs 4（2-9） days,P〈0.001]. More than two ablations decreased the survival rate in the combination group. CONCLUSIONS： Combined hepatectomy and RFA yielded a better long-term outcome than TACE in patients with unresectable BCLC stage B HCC. Patients with a limited ablated size（≤2 cm）, a limited number of ablations（≤2）, and adequate surgical margin should be considered candidates for combination therapy.

关键词： hepatocellular carcinoma hepatectomy radiofrequency ablation transarterial chemoembolization Barcelona Clinic Liver Cancer system

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Combined vascular resection and analysis of prognostic factors for hilar cholangiocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2015年第6期14卷 626-632页

作者： Shu-Tong Wang Shun-Li Shen Bao-Gang Peng Yun-Peng Hua Bin Chen Ming Kuang Shao-Qiang Li Qiang He Li-Jian Liang department of hepatic Surgery First Affiliated HospitalSun Yat-Sen University

BACKGROUND： Hilar cholangiocarcinoma （HCCA） is a devastating malignancy arising from the bifurcation of the hepatic duct, whether combined vascular resection benefits HCCA patients is controversial. This study was undertaken to assess the effect of combined vascular resection in HCCA patients and to analyze the prognostic factors.

关键词： hilar cholangiocarcinoma hepatic artery resection portal vein resection prognostic factors

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Reducing the measurement errors in nonadiabatic holonomic quantum computers

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 64-70页

作者： Guo-Fu Xu department of Physics Shandong University

Nonadiabatic holonomic quantum computers serve as the physical platform for nonadiabatic holonomic quantum *** quantum computation has entered the noisy intermediate-scale era, building accurate intermediate-scale nonadiabatic holonomic quantum computers is clearly necessary. Given that measurements are the sole means of extracting information, they play an indispensable role in nonadiabatic holonomic quantum computers. Accordingly, developing methods to reduce measurement errors in nonadiabatic holonomic quantum computers is of great importance. However, while much attention has been given to the research on nonadiabatic holonomic gates, the research on reducing measurement errors in nonadiabatic holonomic quantum computers is severely lacking. In this study, we propose a measurement error reduction method tailored for intermediate-scale nonadiabatic holonomic quantum computers. The reason we say this is because our method can not only reduce the measurement errors in the computer but also be useful in mitigating errors originating from nonadiabatic holonomic gates. Given these features,our method significantly advances the construction of accurate intermediate-scale nonadiabatic holonomic quantum computers.

关键词： quantum holonomy quantum computation measurement errors

Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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Journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua Jo Jonggeol Na J.Jay Liu Young-Ju Kim Wangyun Won department of Chemical and Biological Engineering Korea University department of Chemical Engineering (Integrated process) Kyung Hee University department of Chemical Engineering and Materials Science Ewha Womans University department of Chemical Engineering Pukyong National University Resources Engineering Plant Research department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Carbon capture and utilization

Hepatitis B virus-related liver cirrhosis complicated with dermatomyositis: A case report

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World Journal of Clinical Cases 2019年第10期7卷 1206-1212页

作者： Juan Zhang Xiao-Yu Wen Run-Ping Gao department of hepatic-Biliary-Pancreatic Medicine the First Hospital of Jilin University

BACKGROUND Twenty percent of patients infected with hepatitis B virus(HBV)develop extrahepatic manifestations with HBV detected in the lymph nodes,spleen,bone marrow,kidneys,and *** infection has been associated with some autoimmune ***(DM)is an idiopathic inflammatory myopathy,which involves a viral infection,and DM has been identified in patients infected with HBV,but there is no direct histological evidence for an association between HBV and *** SUMMARY We describe a familial HBV-infected patient admitted with liver function abnormality,rashes,a movement disorder,and an elevated level of creatine kinase(CK).A computed tomography scan of the lung showed pulmonary fibrosis,and a liver biopsy identified nodular *** electromyogram revealed myogenic damage,and a muscle biopsy showed nuclear migration in local sarcolemma and infiltration of chronic inflammatory *** staining showed negative results for HBsAg and *** in situ hybridization showed a negative result for HBV *** patient was diagnosed with HBV-related liver cirrhosis complicated with DM and was treated with methylprednisolone,mycophenolate mofetil,and *** months later,the patient was readmitted for anorexia and *** blood examination showed elevated levels of aminotransferases and HBV DNA,however,the CK level was within the normal *** patient developed a virological breakthrough and lamivudine was replaced with *** DM in chronic HBV-infected patients does not always associate with *** and immunosuppressive drugs should be taken into consideration.

关键词： Chronic hepatitis B Dermatomyositis Extrahepatic manifestations Case report

Status and prospects for symmetric organic redox flow batteries

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Journal of Energy Chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan C.Adam Dyker department of Chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

Surgery for hepatocellular carcinoma with tumor thrombosis in inferior vena cava: A case report

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World Journal of Clinical Cases 2021年第36期9卷 11495-11503页

作者： Zun-Yi Zhang Er-Lei Zhang Bi-Xiang Zhang Wei Zhang Research Laboratory and hepatic Surgery Center Department of Hepatic SurgeryTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430000Hubei ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)accompanied by a tumor thrombus is very ***,the treatment strategy is controversial and varies by the location of the *** SUMMARY We report herein a case of HCC with a tumor thrombus in the suprahepatic inferior vena cava(IVC),which was successfully treated by hepatectomy combined with thrombectomy following sorafenib chemotherapy.A 47-year-old woman with chronic hepatitis was diagnosed with *** tomography and magnetic resonance imaging showed that the tumor lesion was located in the right half of the liver,and a tumor thrombus was detected in the suprahepatic IVC near the right *** multi-departmental discussion and patient informed consent,right major hepatectomy and total removal of the tumor thrombus were successfully performed under cardiopulmonary *** were no serious complications after *** sorafenib treatment,no recurrence has been detected so far(11 mo later).CONCLUSION Surgical treatment followed by adjuvant sorafenib therapy might be an acceptable choice for HCC patients with tumor thrombosis in the IVC.

关键词： Hepatocellular carcinoma Tumor thrombosis Inferior vena cava Hepatectomy Thrombectomy Sorafenib Cardiopulmonary bypass Case report

Lipid metabolism of hepatocellular carcinoma impacts targeted therapy and immunotherapy

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World Journal of Gastrointestinal Oncology 2023年第4期15卷 617-631页

作者： Xiao-Chen Feng Fu-Chen Liu Wu-Yu Chen Jin Du Hui Liu The Third department of hepatic Surgery Eastern Hepatobiliary Surgery HospitalShanghai 200082China

Hepatocellular carcinoma(HCC)is a common malignant tumor that affecting many people's lives *** common risk factors for HCC include being overweight and *** liver is the center of lipid metabolism,synthesizing most cholesterol and fatty *** lipid metabolism is a significant feature of metabolic reprogramming in HCC and affects the prognosis of HCC patients by regulating inflammatory responses and changing the immune *** therapy and immunotherapy are being explored as the primary treatment strategies for HCC patients with unresectable ***,we detail the specific changes of lipid metabolism in HCC and its impact on both these therapies for *** treatment strategies aimed at targeting lipid metabolism and how to integrate them with targeted therapy or immunotherapy rationally are also presented.

关键词： Hepatocellular carcinoma Lipid metabolism Targeted therapy Immunotherapy Drug resistance Therapeutic efficacy

Risk factors and surgical outcomes for spontaneous rupture of BCLC stages A and B hepatocellular carcinoma: A case-control study

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World Journal of Gastroenterology 2014年第27期20卷 9121-9127页

作者： Jing Li Liang Huang Cai-Feng Liu Jie Cao Jian-Jun Yan Feng Xu Meng-Chao Wu Yi-Qun Yan department of hepatic Surgery Ⅰ Eastern Hepatobiliary Surgery Hospital Second Military Medical University

AIM: To investigate the risk factors and surgical outcomes for spontaneous rupture of Barcelona Clinic Liver Cancer (BCLC) stages A and B hepatocellular carcinoma (HCC).

关键词： Hepatocellular carcinoma Rupture Risk factor Tumor location Surgical outcome