Lipid metabolism of hepatocellular carcinoma impacts targeted therapy and immunotherapy
作者机构：The Third Department of Hepatic SurgeryEastern Hepatobiliary Surgery HospitalShanghai 200082China
出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)
年 卷 期：2023年第15卷第4期
页 面：617-631页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by National Natural Science Foundation of China,No.81970453,and No.82270634 Shanghai Science and Technology Innovation Action Plan Project,No.20XD1405100
主 题：Hepatocellular carcinoma Lipid metabolism Targeted therapy Immunotherapy Drug resistance Therapeutic efficacy
摘 要：Hepatocellular carcinoma(HCC)is a common malignant tumor that affecting many people s lives *** common risk factors for HCC include being overweight and *** liver is the center of lipid metabolism,synthesizing most cholesterol and fatty *** lipid metabolism is a significant feature of metabolic reprogramming in HCC and affects the prognosis of HCC patients by regulating inflammatory responses and changing the immune *** therapy and immunotherapy are being explored as the primary treatment strategies for HCC patients with unresectable ***,we detail the specific changes of lipid metabolism in HCC and its impact on both these therapies for *** treatment strategies aimed at targeting lipid metabolism and how to integrate them with targeted therapy or immunotherapy rationally are also presented.
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