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Polychlorinated biphenyls and omega-3 fatty acid exposure from fish consumption,and thyroid cancer among New York anglers

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Journal of Environmental Sciences 2016年第3期28卷 270-277页

作者： Alyson Haslam Sara Wagner Robb Matthew R.Bonner William Lindblad Joey Allegra Ye Shen John E.Vena department of Epidemiology and Biostatistics College of Public HealthUniversity of Georgia department of Epidemiology and Environmental health School of Public Health and Health ProfessionsUniversity of Buffalo department of Public health Sciences School of MedicineMedical University of South Carolina

Fish from the Great Lakes contain polychlorinated biphenyls（PCBs）which have been shown to disrupt endocrine function and mimic thyroid hormones,but they also contain beneficial omega-3 fatty acids that may offer protection against endocrine *** purpose of this study was to examine the effects of Lake Ontario fish consumption and the estimated consumption of PCBs and omega-3 fatty acids on the risk of thyroid cancer in a group of sport *** from the New York State Angler Cohort Study were followed for cancer incidence from 1991–***-seven cases of incident thyroid cancer and 108 controls were included in the *** estimated fish consumption,estimated omega-3 fatty acid consumption,and estimated PCB consumption from Lake Ontario fish were examined for an association with the incidence of thyroid cancer,while matching on sex,and controlling for age and smoking *** from logistic regression indicate no significant associations between fish consumption,short-term estimated omega-3 fatty acids,or estimated PCB consumption from Great Lakes fish and the development of thyroid cancer,but it was suggested that long-term omega-3 fatty acid from Great Lakes fish may be protective of the development of thyroid *** conclusion,fish consumption,with the possible concomitant PCBs,from the Great Lakes does not appear to increase the risk of thyroid cancer in New York *** research is needed in order to separate the individual health effects of PCBs from omega-3 fatty acids contained within the fish.

关键词： Polychlorinated biphenyls Omega-3 fatty acids Thyroid cancer Lake Ontario Fish consumption

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Biogeographical characteristics of Schistosoma mansoni endemic areas in Ethiopia: a systematic review and meta analysis

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Infectious Diseases of Poverty 2021年第3期10卷 96-97页

作者： Keerati Ponpetch Berhanu Erko leshome Bekana Lindsay Richards Song Liang department of Environmental and Global health College of Public Health and Health ProfessionsUniversity of FloridaGainesvilleFL 32610USA 不详

Background:In Ethiopia,schistosomiasis is caused by Schistosoma mansoni and *** with the former being widespread and more than 4 million people are estimated to be infected by *** annually with 35 million at risk of *** many school-and community-based epidemiological surveys were conducted over the past decades,the national distribution of schistosomiasis endemic areas and associated socio-environinental determinants remain less well *** this paper,we review *** prevalence of infections and describe key biogeographical characteristics in the endemic areas in Ethiopia.

关键词： Schistosoma mansoni Biogeographical characteristic Systematic review Ethiopia

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Multidrug resistance associated proteins in multidrug resistance

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Chinese Journal of Cancer 2012年第2期31卷 58-72页

作者： Kamlesh Sodani Atish Patel Rishil J.Kathawala department of Pharmaceutical Sciences College of Pharmacy and Allied Health ProfessionsSt.John's UniversityQueensNY 11439USA

Multidrug resistance proteins(MRPs) are members of the C family of a group of proteins named ATP-binding cassette(ABC) *** ABC transporters together form the largest branch of proteins within the human *** MRP family comprises of 13 members,of which MRP1 to MRP9 are the major transporters indicated to cause multidrug resistance in tumor cells by extruding anticancer drugs out of the *** are mainly lipophilic anionic transporters and are reported to transport free or conjugates of glutathione(GSH),glucuronate,or *** addition,MRP1 to MRP3 can transport neutral organic drugs in free form in the presence of free ***,MRPs can transport drugs that differ structurally and mechanistically,including natural anticancer drugs,nucleoside analogs,antimetabolites,and tyrosine kinase *** of these MRPs transport physiologically important anions such as leukotriene C4,bilirubin glucuronide,and cyclic *** review focuses mainly on the physiological functions,cellular resistance characteristics,and probable in vivo role of MRP1 to MRP9.

关键词：多药耐药相关蛋白酪氨酸激酶抑制剂葡萄糖醛酸 MRPs 离子转运抗癌药物肿瘤细胞

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Optimizing air purification for household particulate matters using sensor-based and time-based intervention strategies

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Particuology 2023年第8期79卷 78-84页

作者： Meng Wang Tianjun Lu Yang Li department of Epidemiology and Environmental health School of Public and Health ProfessionsUniversity at BuffaloBuffalo14214USA department of Earth Science and Geography California State UniversityDominguez HillsCarson90747USA department of Environmental Science Baylor UniversityWaco76798USA

Filtration efficiency of portable air cleaner(PAC)is affected by resident perceptions and adherences to when and how to operate the *** PAC with smart control and sensor technology holds the promise to effectively reduce indoor air *** study aims to evaluate the efficiency of a PAC at removing indoor fine particulate matters(PM_(2.5))exposure under two automated operation settings:(1)a time-based mode in which the operation time is determined based on perceived time periods of indoor pollution by residents;(2)a sensor-based mode in which an air sensor monitor is used to determine the PAC based on the actual PM_(2.5) level against the indoor air quality *** study was conducted in a residential room for 55 days with a rolling setting on PAC(no filtration,sensor-based,time-based fil-trations)and a continuous measurement of PM_(2.5).We found that the PAC operated with sensor-based mode removed PM_(2.5) concentrations by 47%and prolonged clean air(<35 μg/m^(3))period by 23%compared to the purifications with time-based mode which reduced PM_(2.5) by 29%and increased clean air period by 13%.The sensor-based filtration identified indoor pollution episodes that are hardly detected by personal *** study findings support an automated sensor-based approach to optimize the use of PAC for effectively reducing indoor PM_(2.5) exposure.

关键词： Aircleaner Particulate matter Sensor-based filtration Time-based filtration Indoor pollution

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Acute effects of partial-body vibration in sitting position

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World Journal of Orthopedics 2018年第9期9卷 156-164页

作者： Yannik Faes Nora Banz Nathalie Buscher Angela Blasimann Lorenz Radlinger Patric Eichelberger Achim Elfering department of Work and Organizational Psychology University of Bern department of health professions Bern University of Applied Sciences

AIM To investigate the acute effects of sinusoidal and stochastic resonance partial-body vibration in sitting position, including muscle activity, heart rate variability, balance and *** Fifty healthy participants were assigned randomly to two training conditions: A sinusoidal partial-body vibration(SIN, 8 Hz) or a stochastic resonance partial-body vibration(STOCH, 8 ± 2 Hz). For baseline assessment participants sat on the vibration platform without vibration. Both training conditions consisted of five series of a one-minute vibration training and a one-minutebreak between them. In this experimental study surface electromyography(EMG) of the erector spinae(ES), one of the back muscles, and heart rate variability(HRV) was measured at baseline and during training. Balance and flexibility were assessed at baseline and immediately after training. Balance was measured with the modified star excursion balance test(mS EBT) and flexibility was assessed through the modified fingertip-to-floor method(mF TF).RESULTS Paired sample t-test showed a significant increase in balance that was restricted to STOCH(t =-2.22, P = 0.018; SIN: t =-0.09, P = 0.466). An increase in flexibility was also restricted to STOCH(t = 2.65, P = 0.007; SIN: t = 1.41, P = 0.086). There was no significant change of muscle activity in the ES-EMG in STOCH or SIN conditions. In both training conditions, HRV decreased significantly, but remained in a low-load range(STOCH: t = 2.89, P = 0.004; SIN: t = 2.55, P = 0.009).CONCLUSION In sitting position, stochastic resonance partial-body vibration can improve balance and flexibility while cardiovascular load is low. STOCH can be a valuable training option to people who are unable to stand(e.g., people, who are temporarily wheelchair-bound).

关键词： Partial-body vibration Balance Flexibility Sinusoidal Stochastic resonance

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Progression of motor symptoms in Parkinson’s disease

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Neuroscience Bulletin 2012年第1期28卷 39-48页

作者： Ruiping Xia Zhi-Hong Mao department of Physical Therapy School of Pharmacy and Health Professions Creighton University Omaha NebraskaUSA department of Electrical and Computer Engineering and department of Bioengineering University of Pittsburgh Pittsburgh Pennsylvania USA

Parkinson＇s disease （PD） is a chronic progressive neurodegenerative disease that is clinically manifested by a triad of cardinal motor symptoms - rigidity, bradykinesia and tremor - due to loss of dopaminergic neurons. The motor symptoms of PD become progressively worse as the disease advances. PD is also a heterogeneous disease since rigidity and bradykinesia are the major complaints in some patients whereas tremor is predominant in others. In recent years, many studies have investigated the progression of the hallmark symptoms over time, and the cardinal motor symptoms have dif- ferent rates of progression, with the disease usually progressing faster in patients with rigidity and bradykinesia than in those with predominant tremor. The current treatment regime of dopamine-replacement therapy improves motor symptoms and alleviates disability. Increasing the dosage of dopaminergic medication is commonly used to combat the worsening symptoms. However, the drug-induced involuntary body movements and motor complications can significantly contribute to overall disability. Further, none of the currently-available therapies can slow or halt the disease progression. Significant research efforts have been directed towards developing neuroprotective or disease-modifying agents that are intended to slow the progression. In this article, the most recent clinical studies investigating disease progression and current progress on the development of disease-modifying drug trials are reviewed.

关键词： Parkinson's disease progression motor symptoms disease modification treatment

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Are claudin-5 tight-junction proteins in the blood-brain barrier porous?

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Neural Regeneration Research 2020年第10期15卷 1838-1839页

作者： David Fisher Shireen Mentor department of Medical Biosciences University of the Western CapeBellvilleCape TownSouth Africa School of health professions University of MissouriColumbiaMOUSA

The capillaries of the brain are particularly special,as they are not simply conduits for blood,but are primarily responsible to ensure that the neurons function in a strictly regulated homeostatic *** endothelial cells(BECs)express a plethora of ion channels on its luminal and abluminal surfaces,namely:potassium(K^+)channels(i.e.,Kir2 and Kv1),chloride(Cl^)/bicarbonate(HCO3^–)channels,as well as a number of ion-solute exchangers(Redzic et al.,2011).

关键词： porous potassium solute

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Patellar tendon stress between two variations of the forward step lunge

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Journal of Sport and health Science 2019年第3期8卷 235-241页

作者： Matthew Zellmer Thomas W.Kernozek Naghmeh Gheidi Jordan Hove Michael Torry La Crosse Institute for Movement Science Physical Therapy Program Department of Health Professions University of Wisconsin-La Crosse department of Kinesiology and Recreation Illinois State University

Background: Patellar tendinopathy(PT) or "jumper's knee" is generally found in active populations that perform jumping activities. Graded exposure of patellar tendon, stress through functional exercise has been demonstrated to be effective for the treatment of PT. However, no studies have compared how anterior knee displacement variations during the commonly performed forward step lunge(FSL) affect patellar tendon ***:Twenty-five subjects(age: 22.69 ± 0.74 years; height: 169.39 ± 6.44 cm; mass: 61.55 ± 9.74 kg) performed 2 variations of an FSL with the anterior knee motion going in front of the toes(FSL-FT) and the knee remaining behind the toes(FSL-BT). Kinematic and kinetic data were used with an inverse-dynamics based static optimization technique to estimate individual muscle forces to determine patellar tendon stress during both lunge techniques. A repeated measures multivariate analysis was used to analyze these ***: The peak patellar tendon stress, stress impulse, quadriceps force, knee moment, knee flexion, and ankle dorsiflexion angle were significantly greater(p< 0.001) during the FSL-FT as compared to the FSL-BT. The peak patellar tendon stress rate did not differ between the FSL-FT and ***: The use of an FSL-FT as compared to an FSL-BT increased the load and stress on the patellar tendon. Because a graded exposure of patellar tendon loading with other closed kinetic chain exercises has proven to be effective in treating PT, consideration for the prescription of variations of the FSL and further clinical evaluation of this exercise is warranted in individuals with PT.

关键词： Biomechanics Kinematics Kinetics Knee Modeling Rehabilitation

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Pulmonary diseases induced by ambient ultrafine and engineered nanoparticles in twenty-first century

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National Science Review 2016年第4期3卷 416-429页

作者： Tian Xia Yifang Zhu Lina Mu Zuo-Feng Zhang Sijin Liu State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of Sciences Division of Nano Medicine Department of MedicineUniversity of California Los Angeles department of Environmental health Sciences Fielding School of Public HealthUniversity of California Los Angeles department of Epidemiology and Environmental health School of Public Health and Health ProfessionsUniversity at Buffalo department of Epidemiology Fielding School of Public HealthUniversity of California Los Angeles

Air pollution is a severe threat to public health globally,afecting everyone in developed and developing countries *** diferent air pollutants,particulate mater(PM),particularly combustion-produced ine PM(PM2.5) has been shown to play a major role in inducing various adverse health *** associations have been demonstrated by epidemiological and toxicological studies between increases in PM2.5 concentrations and premature mortality,cardiopulmonary diseases,asthma and allergic sensitization,and lung *** mechanisms of PM-induced toxicological efects are related to their size,chemical composition,lung clearance and retention,cellular oxidative stress responses and pro-inlammatory efects locally and *** in the ultraine range(health *** these add to the complexity of PM-induced health efects that largely remains to be determined,and mechanistic understanding on the toxicological efects of ambient ultraine particles and nanomaterials will be the focus of studies in the near future.

关键词： air pollution particulate mater pulmonary disease ultraine particle nanoparticle

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Recent advances on the role of long non-coding RNAs in Alzheimer’s disease

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Neural Regeneration Research 2020年第12期15卷 2253-2254页

作者： Kyle Doxtater Manish K.Tripathi Mohammad Moshahid Khan department of Pharmaceutical Sciences University of Tennessee Health Science CenterMemphisTNUSA department of immunology and Microbiology University of Texas Rio Grande ValleyMcAllenTXUSA department of Neurology College of MedicineDivision of Rehabilitation Sciences and Department of Physical TherapyCollege of Health ProfessionsUniversity of Tennessee Health Science CenterMemphisTNUSA

Dementia is a progressive cognitive impairment that affects the activities of daily ***’s disease (AD) is the most common form of the dementia worldwide accounting for 60-80%of all dementia *** an estimated cost exceeding$290 billion in the USA,understanding and development of future therapeutic strategies is *** this perspective,we will be examining the current thinking of AD research and therapeutic strategies,while proposing a possible new direction for diagnosis,understanding,and treatment targets.

关键词： Alzheimer diagnosis exceeding

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