Multidrug resistance associated proteins in multidrug resistance

作     者：Kamlesh Sodani Atish Patel Rishil J.Kathawala 

作者机构：Department of Pharmaceutical SciencesCollege of Pharmacy and Allied Health ProfessionsSt.John's UniversityQueensNY 11439USA 

出 版 物：《Chinese Journal of Cancer》 (Chin. J. Cancer)

年 卷 期：2012年第31卷第2期

页      面：58-72页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported in part by grants from NIH R15No.1R15CA143701(to Z.S.Chen) St.John's University Seed Grant No.579-1110-7002(Z.S.Chen) 

主　　题：多药耐药 相关蛋白 酪氨酸激酶抑制剂 葡萄糖醛酸 MRPs 离子转运 抗癌药物 肿瘤细胞 

摘      要：Multidrug resistance proteins(MRPs) are members of the C family of a group of proteins named ATP-binding cassette(ABC) *** ABC transporters together form the largest branch of proteins within the human *** MRP family comprises of 13 members,of which MRP1 to MRP9 are the major transporters indicated to cause multidrug resistance in tumor cells by extruding anticancer drugs out of the *** are mainly lipophilic anionic transporters and are reported to transport free or conjugates of glutathione(GSH),glucuronate,or *** addition,MRP1 to MRP3 can transport neutral organic drugs in free form in the presence of free ***,MRPs can transport drugs that differ structurally and mechanistically,including natural anticancer drugs,nucleoside analogs,antimetabolites,and tyrosine kinase *** of these MRPs transport physiologically important anions such as leukotriene C4,bilirubin glucuronide,and cyclic *** review focuses mainly on the physiological functions,cellular resistance characteristics,and probable in vivo role of MRP1 to MRP9.