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Clinical efficacy of femtosecond laser-assisted phacoemulsification in diabetic cataract patients

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World Journal of Clinical Cases 2024年第10期12卷 1733-1741页

作者： Yi-Fei Tang Zhi-Hui Duan department of glaucoma and cataracts Han Yang Eyegood Ophthalmic HospitalWuhan 430056Hubei ProvinceChina

BACKGROUND Diabetic patients with cataracts encounter specific difficulties during cataract surgery due to alterations in microcirculation,blood supply,metabolism,and the *** phacoemulsification may not fully tackle these issues,especially in instances with substantial preoperative *** utilization of femtosecond laser-assisted phacoemulsification,in conjunction with Toric intraocular lens(IOL)implantation,offers a potentially more efficient *** research seeks to evaluate the efficacy and possible complications of this approach in diabetic cataract *** To investigate the clinical efficacy and complications of femtosecond laser-assisted phacoemulsification combined with Toric IOL implantation in diabetic cataract patients,comparing it with traditional phacoemulsification *** This retrospective study enrolled 120 patients with diabetes cataract from May 2019 to May *** patients were divided into two groups:the control group underwent traditional phacoemulsification and Toric IOL implantation,while the treatment group received Len Sx femtosecond laser-assisted *** measures included naked eye vision,astigmatism,high-level ocular phase difference detection,clinical efficacy,and *** There were no significant preoperative differences in astigmatism or naked eyesight between the two ***,postoperative improvements were observed in both groups,with the treatment group showing greater enhancements in naked eye vision and astigmatism six months after the ***-level corneal phase difference tests also indicated significant differences in favor of the treatment *** This study suggests that femtosecond laser-assisted phacoemulsification combined with Toric IOL implantation appears to be more effective in enhancing postoperative vision in diabetic cataract patients compared to traditional methods offering valuable insights for clinical practice.

关键词： Diabetic cataract Femtosecond laser-assisted phacoemulsification Toric intraocular lens implantation Naked vision

Practice patterns among ophthalmic surgeons in treating concomitant oculoplastic conditions in preoperative period:A questionnaire-based study

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World Journal of Clinical Cases 2025年第1期13卷 29-37页

作者： Bijnya Birajita Panda Chitaranjan Mishra Bhagabat Nayak Avik Kumar Roy Logesh Balakrishnan Priyadarshini Mishra department of Ophthalmology All India Institute of Medical SciencesBhubaneswar 751019OdishaIndia department of Vitreo-Retina Trilochan NetralayaSambalpur 768004India department of glaucoma Services LV Prasad Eye InstituteBhubaneswar 751013India department of Statistics Apollo HospitalsChennai 823104India

BACKGROUND Addressing oculoplastic conditions in the preoperative period ensures both the safety and functional success of any ophthalmic *** oculoplastic conditions,like nasolacrimal duct obstruction,have been extensively studied,whereas others,like eyelid malposition and thyroid eye disease,have received minimal or no *** To investigate the current practice patterns among ophthalmologists while treating concomitant oculoplastic conditions before any subspecialty ophthalmic *** A cross-sectional survey was disseminated among ophthalmologists all over *** survey included questions related to pre-operative evaluation,anaesthetic and surgical techniques preferred,post-operative care,the use of adjunctive therapies,and patient follow-up *** A total of 180 ophthalmologists responded to the *** practitioners(89%)felt that the ROPLAS test was sufficient during pre-operative evaluation before any subspecialty surgery was *** most common surgical techniques employed were lacrimal drainage procedures(Dacryocystorhinostomy)(63.3%),eyelid malposition repair(36.9%),and ptosis repair(58.7%).Post-operatively,47.7%of respondents emphasized that at least a 4-week gap should be maintained after lacrimal drainage procedures and eyelid ***-seven percent of ophthalmologists felt that topical anaesthetic procedures should be preferred while performing ocular surgeries in thyroid eye disease *** Approximately 50%of ophthalmologists handle prevalent oculoplastic issues themselves,seeking the expertise of an oculoplastic surgeon under particular *** ophthalmologists still favor using ROPLAS as a preliminary screening method before proceeding with cataract *** conditions and thyroid eye disease are not as commonly addressed before subspecialty procedures compared to issues like nasolacrimal duct obstruction and periocular infections.

关键词： Oculoplasty Ophthalmic plastic surgery Nasolacrimal duct obstruction Practice patterns Survey

Efficacy and safety of XEN 45 gel stent alone or in combination with phacoemulsification in advanced open angle glaucoma patients: 1-year retrospective study

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International Journal of Ophthalmology(English edition) 2020年第8期13卷 1250-1256页

作者： Teresa Laborda-Guirao Juan M Cubero-Parra Antonio Hidalgo-Torres department of glaucoma Hospital La ArruzafaCordoba 14012Spain

AIM:To assess the effectiveness of the XEN 45 gel stent,either alone or combined with cataract surgery,in advanced stage open angle glaucoma(OAG)***:Retrospective and single-center study conducted on consecutive OAG patients who underwent a XEN 45 gel stent implantation surgery,between July 2017 and September *** primary efficacy end-point was the mean intraocular pressure(IOP)reduction at the end of the follow-up *** was defined as an IOP reduction of at least 20%and an IOP value≤18 mm Hg without(complete)or with(qualified)hypotensive ***:Seventy-four patients(80 eyes)were included in the *** the overall study sample,XEN implant significantly reduced IOP from 21.0(19.8 to 22.1)mm Hg at baseline to 9.3(8.2 to 10.4),10.7(9.6 to 11.9),13.4(12.2 to 14.7),14.5(13.6 to 15.4),14.7(13.8 to 15.6),and 14.7(13.9 to 15.4)mm Hg at 1 d,1 wk,1,3,6,and 12 mo of follow-up,respectively(P<0.0001 each).In the overall study population,at the end of the study the mean IOP reduction was 27.4%(23.3%to 31.5%).Adjusted IOP reduction was similar in XEN and XEN+phacoemulsification groups[30.0(23.4 to 36.4)mm Hg vs 24.8(18.4 to 31.2)mm Hg,respectively,P=0.2939].At the last follow-up visit,52(65.0%)eyes were considered success,29(36.3%)eyes as complete success and 23(28.7%)as qualified *** number of hypotensive medications was significantly reduced from 2.8(2.7 to 3.0)at baseline to 1.1(0.8 to 1.3),P<***-Meier survival analysis did not find any difference in the success rate between XEN and XEN+PHACO,mean hazard ratio 0.56,95%CI 0.26 to 1.23;P=*** was performed in 7(8.8%)eyes at months 1(n=3);3(n=2);4(n=1)and 11(n=1).Eleven(13.8%)eyes presented adverse ***:XEN implant,either alone or in combination with phacoemulsification,significantly reduced the IOP and the number of hypotensive medications in patients with OAG in advanced stage.

关键词： open angle glaucoma advanced stage XEN implant intraocular pressure minimally-invasive glaucoma surgery

Hammered silver appearance of the corneal endothelium in Fuchs uveitis syndrome:A case report

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World Journal of Clinical Cases 2022年第35期10卷 13081-13087页

作者： Yan-Yan Cheng Cong-Ying Wang Yan-Fang Zheng Ming-Yu Ren department of glaucoma Hebei Eye HospitalXingtai 054000Hebei ProvinceChina department of glaucoma Hebei Provincial Key Laboratory of OphthalmologyXingtai 054000Hebei ProvinceChina department of glaucoma Hebei Provincial Clinical Research Center for Eye DiseasesXingtai 054000Hebei ProvinceChina

BACKGROUND Hammered silver appearance of the corneal endothelium is considered a characteristic change in iridocorneal-endothelial *** we report an interesting case of hammered silver appearance of the corneal endothelium in Fuchs uveitis syndrome(FUS).CASE SUMMARY A 49-year-old man with progressive vision loss in the right eye for one year was admitted to our *** clinical manifestations of the patient’s right eye were mild conjunctival hyperemia,scattered stellate keratic precipitates on the corneal endothelium,normal depth anterior chamber,2+cellular reaction in the aqueous humor,diffuse iris depigmentation,absence of synechia,Koeppe nodules,opalescent lens,and vitreous *** and a complicated cataract were diagnosed based on the typical clinical *** corneal endothelial changes were recorded in detail by slit-lamp examination,specular microscopy,and in vivo confocal microscopy before cataract extraction,revealing a hammered silver appearance of the corneal endothelium in the affected eye,a wide-band dark area,as well as irregular corneal endothelial protuberances and dark bodies of various ***,the patient underwent phacoemulsification combined with intraocular lens implantation,and his postoperative visual acuity recovered to *** Hammered silver appearance of the corneal endothelium in FUS,which is considered a more serious manifestation of endothelial damage,is rare and may be caused by many irregular protrusions in the corneal endothelium.

关键词： Fuchs uveitis syndrome Corneal endothelium Hammered silver Case report

Potential role of nuclear receptor ligand all-trans retinoic acids in the treatment of fungal keratitis

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International Journal of Ophthalmology(English edition) 2015年第4期8卷 826-832页

作者： Hong-Yan Zhou Wei Zhong Hong Zhang Miao-Miao Bi Shuang Wang Wen-Song Zhang department of Ophthalmology China-Japan Union HospitalJilin University department of glaucoma the Second Hospital of Jilin University

·Fungal keratitis(FK) is a worldwide visual impairment disease. This infectious fungus initiates the primary innate immune response and, later the adaptive immune response. The inflammatory process is related to a variety of immune cells, including macrophages, helper T cells, neutrophils, dendritic cells, and Treg cells, and is associated with proinflammatory, chemotactic and regulatory cytokines. All-trans retinoic acids(ATRA)have diverse immunomodulatory actions in a number of inflammatory and autoimmune conditions. These retinoids regulate the transcriptional levels of target genes through the activation of nuclear *** acid receptor α(RAR α), retinoic acid receptor γ(RAR γ), and retinoid X receptor α(RXR α) are expressed in the cornea and immune cells. This paper summarizes new findings regarding ATRA in immune and inflammatory diseases and analyzes the perspective application of ATRA in FK.

关键词： nuclear receptor all-trans retinoic acid fungal keratitis cornea

Understanding practice patterns of glaucoma sub-specialists in India

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International Journal of Ophthalmology(English edition) 2017年第10期10卷 1580-1585页

作者： Nikhil S.Choudhari Vanita Pathak-Ray Sushmita Kaushik Prateep Vyas Ronnie George V S T glaucoma Centre Dr.Kallam Anji Reddy CampusL V Prasad Eye Institute Advanced Eye Centre Postgraduate Institute of Medical Education and Research Centre for Sight Glaucoma Society of India department of glaucoma Medical Research Foundation

AIM：To obtain information on the prevailing practice patterns of glaucoma specialists in ***：glaucoma specialists attending the Annual Conference of the glaucoma Society of India（GSI）were *** survey,conducted in 2013,was based on an interactive audience response ***：The information was obtained from 146 glaucoma *** half（n=83;57%）had≥10y of experience in managing glaucoma and were in institutional practice（n=74,51%）.Goldmann applanation tonometry was preferred by 103（72%）specialists whilst n=25（17.4%）used non-contact *** gonioscopy was favoured by two-thirds（n=90,66%）whereas stereoscopic optic disc examination and visual fields using Humphrey perimeter was performed by a majority of the specialists surveyed（n=115,86%and n=114;83%respectively）.Nearly three quarter specialists（n=96;72%）preferred optical coherence tomography for *** primary choice for treatment of angle closure disease and primary open angle glaucoma was laser（iridotomy,n=117;93%）and medical management（prostaglandin analogue,n=104;78%）,*** only a third of the specialists surveyed（n=37;28%）were performing both trabeculectomy and implantation of a glaucoma drainage device and about half（n=64;47%）were not operating on congenital glaucoma at ***：This survey has found conformance with preferred practice patterns in several areas of diagnosisand management of glaucoma,but there was diversity in a few *** information is a significant step towards improvement of glaucoma care in India,including planning for future strategies.

关键词： glaucoma practice patterns glaucoma specialists glaucomatologist audience response system survey

Full-thickness scleral incisions technique for the treatment of a cyclodialysis cleft following ab interno trabeculotomy

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International Journal of Ophthalmology(English edition) 2019年第10期12卷 1662-1665页

作者： Daniela Alvarez-Ascencio Jesus Jimenez-Roman Rafael Castaneda-Diez Gabriel Lazcano-Gomez glaucoma department Asociacion Para Evitar la Ceguera en Mexico

Dear Editor, I am *** Alvarez-Ascenciofromtheglaucoma department at Asociacion Para Evitar la Ceguera (APEC)in Mexico City, Mexico. I write to present a successful case of cyclodyalisis repair in a direct visualizatio... 详细信息

关键词： CC OS UBM Full-thickness scleral incisions technique for the treatment of a yclodialysis cleft following ab interno trabeculotomy

A-kinase anchoring protein-mediated compartmentalization of pro-survival signaling in the retina

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Neural Regeneration Research 2025年第2期20卷 479-480页

作者： Joanna Mackiewicz Tomasz Boczek department of Molecular Neurochemistry Medical University of LodzLodzPoland

The retina plays a fundamental role in the process of vision,serving as the primary interface between external visual stimuli and the central nervous *** the retina is exposed to a variety of environmental stresses and deleterious insults,it is susceptible to a spectrum of pathological conditions that can detrimentally affect *** often leads to irreversible vision loss due to the injury of specific cell *** instance,inherited retinal degeneration and age-related macular degeneration can lead to the death of photoreceptors,while conditions like glaucoma and optic nerve injury can result in the loss of ganglion *** precise pathological mechanisms driving retinal degeneration remain largely elusive,although research utilizing mouse models suggests that disruptions in intracellular signal transduction pathways may play a pivotal *** pathways within the retina orchestrate various aspects of retinal physiology,including phototransduction,synaptic transmission,and neuronal survival.

关键词： degeneration utilizing irreversible

Comparison of encirclage and cryotherapy with argon laser in the management of traumatic cyclodialysis cleft

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International Journal of Ophthalmology(English edition) 2019年第1期12卷 165-168页

作者： Gitanjli Sood Vinata Rajendran Ronnie George Tarun Sharma Rajiv Raman Shri Bhagawan Mahavir Vitreo Retinal Services Sankara Nethralaya department of glaucoma Medical Research FoundationSankara NethralayaChennai

The study compared anatomical and functional outcome of a novel technique of encirclage and cryotherapy with the conventional argon laser in the management of traumatic cyclodialysis cleft in 19 patients(10: encirclage and 9: argon laser). The postoperative anatomical success was taken as rise in intraocular pressure(IOP) more than 6 mm Hg or the closure of cleft on gonioscopy or ultrasound biomicroscopy(UBM). Visual outcome was measured as change in logMAR visual acuity. Traumatic cataract and hypotony were present in majority. IOP>6 mm Hg was noted in 90% of encirclage group and in 77.70% of argon laser group. Two cases had non-closure of cleft. Encirclage is comparable to argon laser in terms of anatomical and functional success with possible advantage of single procedure and use in cases with failed laser.

关键词： traumatic cyclodialysis encirclage cryotherapy laser hypotony