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Is metaphyseal ulnar shortening osteotomy superior to diaphyseal ulnar shortening osteotomy in the treatment of ulnar impaction syndrome?A meta-analysis

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World Journal of Clinical Cases 2023年第12期11卷 2753-2765页

作者： Hai-Lin Deng Ming-Ling Lu Zhe-Ming Tang Qing-Long Mao Jin-Min Zhao Guangxi Medical University Nanning 530021Guangxi Zhuang Autonomous RegionChina Ministry of Public Health Department of Public Health UnitLiuzhou Liunan District Center for Disease ControlLiuzhou 545005Guangxi Zhuang Autonomous RegionChina department of Hand Foot and Ankle SurgeryLiuzhou Workers'HospitalThe Fourth Affiliated Hospital of Guangxi Medical UniversityLiuzhou 545005Guangxi Zhuang Autonomous RegionChina

BACKGROUND Although metaphyseal ulnar shortening osteotomy(MUSO)is safer for the treatment of ulnar impaction syndrome(UIS)than diaphyseal ulnar shortening osteotomy(DUSO),DUSO is widely used for UIS *** To evaluate the effectiveness of DUSO and MUSO for UIS treatment and determine the factors that should be considered when choosing surgical treatment for *** Articles comparing the effectiveness of DUSO and MUSO for UIS treatment were systematically retrieved from MEDLINE(Ovid),PubMed,EMBASE,and Cochrane *** demography,incidence of complications,secondary operation rate,postoperative DASH score,wrist pain on the visual analogue scale,and grip strength improvement were also *** addition,the correlation between the improvement of grip strength and the shortening of osteotomy length of ulna was *** outcome of the patient was discontinuous,and the odds ratio,risk ratio(RR),and 95%CI were calculated and analyzed via RevMan5.3 *** Six studies,including 83 patients receiving MUSO(experimental group)and 112 patients receiving DUSO(control group),were included in the *** second operation rate was significantly higher after DUSO than after *** DASH scores were slightly lower in the MUSO group than in the DUSO *** patients receiving MUSO had slightly better pain relief effect than patients receiving ***,the incidence of complications and improvement of grip strength were not significantly different between the two *** Although DUSO and MUSO provide similar effects for UIS,MUSO is associated with a lower secondary operation rate,slightly lower postoperative DASH scores and slightly better pain relief effect than DUSO,indicating that MUSO can effectively be used for UIS treatment.

关键词： Metaphyseal Diaphyseal Ulnar shortening osteotomy Ulnar impaction syndrome Metaanalysis

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Salvianolic acid B protects the myelin sheath around injured spinal cord axons

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Neural Regeneration Research 2016年第3期11卷 487-492页

作者： Zhe Zhu Lu Ding Wen-feng Qiu Hong-fu Wu Rui Li Hand & foot surgery and Reparative & Reconstruction surgery Center the Second Hospital of Jilin University department of Physiology Guangdong Medical University

Salvianolic acid B,an active pharmaceutical compound present in Salvia miltiorrhiza,exerts a neuroprotective effect in animal models of brain and spinal cord *** acid B can promote recovery of neurological function;however,its protective effect on the myelin sheath after spinal cord injury remains poorly ***,in this study,in vitro tests showed that salvianolic acid B contributed to oligodendrocyte precursor cell differentiation,and the most effective dose was 20 μg/m *** in vivo investigation,rats with spinal cord injury were intraperitoneally injected with 20 mg/kg salvianolic acid B for 8 *** amount of myelin sheath and the number of regenerating axons increased,neurological function recovered,and caspase-3 expression was decreased in the spinal cord of salvianolic acid B-treated animals compared with untreated control *** results indicate that salvianolic acid B can protect axons and the myelin sheath,and can promote the recovery of neurological *** mechanism of action is likely to be associated with inhibiting apoptosis and promoting the differentiation and maturation of oligodendrocyte precursor cells.

关键词： nerve regeneration spinal cord injury salvianolic acid B oligodendrocytes myelin sheath neural regeneration

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Lower limb suspension induces threshold-specific alterations of motor units properties that are reversed by active recovery

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Journal of Sport and Health Science 2024年第2期13卷 264-276页

作者： Giacomo Valli Fabio Sarto Andrea Casolo Alessandro Del Vecchio Martino V.Franchi Marco V.Narici Giuseppe De Vito department of Biomedical Sciences University of PadovaPadova 35131Italy department Artificial Intelligence in Biomedical Engineering Friedrich-Alexander UniversityErlangen-Nurnberg 91052Germany

Purpose:This study aimed to non-invasively test the hypothesis that(a) short-term lower limb unloading would induce changes in the neural control of force production(based on motor units(MUs) properties) in the vastus lateralis muscle and(b) possible changes are reversed by active recovery(AR).Methods:Ten young males underwent 10 days of unilateral lower limb suspension(ULLS) followed by 21 days of *** ULLS,participants walked exclusively on crutches with the dominant leg suspended in a slightly flexed position(15°-20°) and with the contralateral foot raised by an elevated *** AR was based on resistance exercise(leg press and leg extension) and executed at 70% of each participant’s 1repetition maximum,3 times/*** voluntary isometric contraction(MVC) of knee extensors and MUs properties of the vastus lateralis muscle were measured at baseline,after ULLS,and after *** were identified using high-density electromyography during trapezoidal isometric contractions at 10%,25%,and 50% of the current MVC,and individual MUs were tracked across the 3 data collection ***:We identified 1428 unique MUs,and 270 of them(18.9%) were accurately *** ULLS,MVC decreased by 29.77%,MUs absolute recruitment/derecruitment thresholds were reduced at all contraction intensities(with changes between the 2 variables strongly correlated),while discharge rate was reduced at 10% and 25% but not at 50% *** MVC and MUs properties fully recovered to baseline levels after *** changes were observed in the pool of total as well as tracked ***:Our novel results demonstrate,non-invasively,that 10 days of ULLS affected neural control predominantly by altering the discharge rate of lower-threshold but not of higher-threshold MUs,suggesting a preferential impact of disuse on motoneurons with a lower depolarization ***,after 21 days of AR,the impaired MUs properties were fully restored to baseline levels,highlighting the plas

关键词： Disuse High-density EMG Muscle disuse Neural impairment Neuromuscular degeneration

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Müller-Weiss disease:Four case reports

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World Journal of Orthopedics 2020年第11期11卷 507-515页

作者： Antonio Volpe Luca Monestier Teresa Malara Giacomo Riva Giuseppe La Barbera Michele FrancescoSurace foot and ankle Clinic Policlinico Abano TermeAbano Terme 35031Italy Orthopedic and Trauma Unit ASST Sette LaghiVarese 21100Italy department of Biomedical Science and Functional Images Universitàdi MessinaMessina 98122Italy Interdisciplinary Research Centre for Pathology and surgery of the Musculoskeletal System Department of Biotechnology and Life Sciences(DBSV)University of InsubriaVarese 21020Italy

BACKGROUND Müller-Weiss disease(MWD)is an idiopathic foot condition characterized by spontaneous tarsal“scaphoiditis”in *** bilateral and affecting females during the 4th-6th decades of life,the pathogenesis of MWD remains unclear:It has been traditionally considered a spontaneous osteonecrosis of the *** typical presentation of MWD is a long period of subtle discomfort followed by prolonged standing,atraumatic,disabling ***,there is no gold standard for the treatment of patients with *** support initial conservative *** treatment should be considered for failure of conservative therapies longer than 6 *** indication for surgery is severity of symptoms rather than severity of *** treatment options include core decompression,internal fixation of the tarsal navicular,open or arthroscopic triple fusion,talo-navicular or talo-navicular-cuneiform arthrodesis,and navicular excision with reconstruction of the medial *** SUMMARY In this study,we report four patients affected by *** and radiographic assessment,follow-up and treatment are *** As it is frequently misdiagnosed,MWD is challenging for orthopedic *** diagnosis and effective treatment are mandatory to avoid sequelae.

关键词： Müller-Weiss Etiopathogenesis Review Treatment Case report

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Transfer of the extensor indicis proprius branch of posterior interosseous nerve to reconstruct ulnar nerve and median nerve injured proximally:an anatomical study

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Neural Regeneration Research 2017年第1期12卷 143-148页

作者： Pei-ji Wang Yong Zhang Jia-ju Zhao Ju-pu Zhou Zhi-cheng Zuo Bing-bing Wu department of Hand and foot surgery Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina

Proximal or middle lesions of the ulnar or median nerves are responsible for extensive loss of hand motor *** occurs even when the most meticulous microsurgical techniques or nerve grafts are *** studies had proposed that nerve transfer was more effective than nerve grafting for nerve *** hypothesis is that transfer of the posterior interosseous nerve,which contains mainly motor fibers,to the ulnar or median nerve can innervate the intrinsic muscles of *** present study sought to investigate the feasibility of reconstruction of the deep branch of the ulnar nerve and the thenar branch of median nerve by transferring the extensor indicis proprius branch of the posterior interosseous nerve obtained from adult *** results suggested that the extensor indicis proprius branch of the posterior interosseous nerve had approximately similar diameters and number of fascicles and myelinated nerve fibers to those of the deep branch of ulnar nerve and the thenar branch of the median *** confirm the feasibility of extensor indicis proprius branch of posterior interosseous nerve transfer for reconstruction of the deep branch of the ulnar nerve and the thenar branch of median *** procedure could be a novel and effective method for the functional recovery of the intrinsic muscles of hands after ulnar nerve or median nerve injury.

关键词： nerve regeneration posterior interosseous nerve ulnar nerve median nerve extensor indicis proprius thenar branch nerve transfer neural regeneration

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The longitudinal epineural incision and complete nerve transection method for modeling sciatic nerve injury

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Neural Regeneration Research 2015年第10期10卷 1663-1668页

作者： Xing-long Cheng Pei Wang Bo Sun Shi-bo Liu Yun-feng Gao Xin-ze He Chang-yu Yu department of Hand and foot surgery Affiliated Hospital of Chengde Medical University Graduate School of Chengde Medical University

Injury severity, operative technique and nerve regeneration are important factors to consider when constructing a model of peripheral nerve injury. Here, we present a novel peripheral nerve injury model and compare it with the complete sciatic nerve transection method. In the experimental group, under a microscope, a 3-mm longitudinal incision was made in the epineurium of the sciatic nerve to reveal the nerve fibers, which were then transected. The small, longitudinal incision in the epineurium was then sutured closed, requiring no stump anastomosis. In the control group, the sciatic nerve was completely transected, and the epineurium was repaired by anastomosis. At 2 and 4 weeks after surgery, Wallerian degeneration was observed in both groups. In the experimental group, at 8 and 12 weeks after surgery, distinct medullary nerve fibers and axons were observed in the injured sciatic nerve. Regular, dense myelin sheaths were visible, as well as some scarring. By 12 weeks, the myelin sheaths were normal and intact, and a tight lamellar structure was observed. Functionally, limb movement and nerve conduction recovered in the injured region between 4 and 12 weeks. The present results demonstrate that longitudinal epineural incision with nerve transection can stably replicate a model of Sunderland grade IV peripheral nerve injury. Compared with the complete sciatic nerve transection model, our method reduced the difficulties of micromanipulation and surgery time, and resulted in good stump restoration, nerve regeneration, and functional recovery.

关键词： nerve regeneration peripheral nerve sciatic nerve injury animal models longitudinal epineural incision Sunderland IV nerve regeneration and repair rats neural regeneration

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Expression and clinical significance of pattern recognition receptor-associated genes in hand, foot and mouth disease

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Asian Pacific Journal of Tropical Medicine 2024年第4期17卷 173-183,I0001-I0003页

作者： Muqi Wang Huiling Deng Yuan Chen Yikai Wang Yufeng Zhang Chenrui Liu Meng Zhang Ting Li Shuangsuo Dang Yaping Li department of Infectious Diseases The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004China department of Pediatrics Xi'an Central HospitalXi'an 710004China department of Infectious Diseases Xi'an Children's HospitalXi'an 710003China

Objective:To explore which pattern recognition receptors(PRRs)play a key role in the development of hand,foot,and mouth disease(HFMD)by analyzing PRR-associated ***:We conducted a comparative analysis of PRR-associated gene expression in human peripheral blood mononuclear cells(PBMCs)infected with enterovirus 71(EV-A71)which were derived from patients with HFMD of different severities and at different stages.A total of 30 PRR-associated genes were identified as significantly upregulated both over time and across different EV-A71 ***,ELISA was employed to quantify the expression of the six most prominent genes among these 30 identified genes,specifically,BST2,IRF7,IFI16,TRIM21,MX1,and ***:Compared with those at the recovery stage,the expression levels of BST2(P=0.027),IFI16(P=0.016),MX1(P=0.046)and DDX58(P=0.008)in the acute stage of infection were significantly upregulated,while no significant difference in the expression levels of IRF7(P=0.495)and TRIM21(P=0.071)was found between different stages of the *** expression levels of BST2,IRF7,IFI16 and MX1 were significantly higher in children infected with single pathogen than those infected with mixed pathogens,and BST2,IRF7,IFI16 and MX1 expression levels were significantly lower in coxsackie B virus(COXB)positive patients than the negative *** levels of one or more of BST2,IRF7,IFI16,TRIM21,MX1 and DDX58 genes were correlated with PCT levels,various white blood cell counts,and serum antibody levels that reflect disease course of *** aminotransferase was correlated with BST2,MX1 and DDX58 expression ***:PRR-associated genes likely initiate the immune response in patients at the acute stage of HFMD.

关键词： Pattern recognition receptors(PRRs) Hand,foot,and mouth disease(HFMD) Immune Enterovirus 71(EV-A71)

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Small gap anastomosis to repair peripheral nerve rupture using a nerve regeneration chamber constructed by scissoring and sleeve jointing autologous epineurium

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Neural Regeneration Research 2011年第8期6卷 623-628页

作者： Peiji Wang Zhongliang Zhou Qirong Dong department of Hand and foot surgery Second Affiliated Hospital of Soochow University Suzhou 215004 Jiangsu Province China

A number of studies have shown how to eliminate the misorientated docking of the peripheral nerve bundle in the traditional epineurium or perineurium anastomosis, thus avoiding neuroma formation and axonal outgrowth from the coaptation sites, and seriously hindering neural function recovery. Based on the ＂peripheral nerve seJective regeneration theory＂, this experiment was designed to investigate the feasibility and benefits of a new small gap anastomosis repairing peripheral nerve rupture, by scissoring and sleeve jointing an autologous epineufium, in the proximal stump of the nerve, a 1 mm-long epineurium was annularly separated and removed, while a 3 mm-long epineurium was longitudinally incised in the distal stump after the epineurium was dissociated from proximal to distal. The epineuria of the two stumps and the longitudinal incision were sutured, leaving a 2 mm gap between the two nerve stumps. Results show that the experimental rats quickly recovered autonomic activities, and there were minimal adhesions at the outer surface of the epineudal tube to the surrounding tissue. The morphologJc changes to the sciatic nerve showed that connective tissue hyperplasia of the small gaps was significantly reduced, and nerve fibers were arranged orderly. No such changes were observed in the neurorrhaphy in situ group. Thus, the experiment confirmed that the new small gap anastomosis to repair peripheral nerve rupture by scissoring and sleeve jointing autologous epineurium is feasible, and that it is superior to epineurium neurorrhaphy in situ.

关键词： sciatic nerve epineurium neurorrhaphy peripheral nerve injury neural regeneration

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Differentiation of endogenous neural stem cells in adult versus neonatal rats after brachial plexus root avulsion injury

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Neural Regeneration Research 2012年第23期7卷 1786-1790页

作者： Bingqi Wang Lei Chen Bin Liu Zhigang Liu Zhixin Zhang Yuehai Pan Liangsong Song Laijin Lu department of Hand and foot surgery First Hospital of Jilin UniversityChangchun 130031Jilin ProvinceChina

An experimental model of brachial plexus root avulsion injury of cervical dorsal C5-6 was established in adult and neonatal ***-time PCR showed that the levels of brain-derived neurotrophic factor,nerve growth factor and neurotrophin-3 in adult rats increased rapidly 1 day after brachial plexus root avulsion injury,and then gradually decreased to normal levels by 21 *** neonatal rats,levels of the three neurotrophic factors were decreased on the first day after injury,and then gradually increased from the seventh day and remained at high levels for an extended period of *** observed that greater neural plasticity contributed to better functional recovery in neonatal rats after brachial plexus root avulsion injury compared with adult ***, immunohistochemical staining showed that the number of bromodeoxyuridine/nestin-positive cells increased significantly in the spinal cords of the adult rats compared with neonatal rats after brachial plexus root avulsion *** addition,the number of bromodeoxyuridine/glial fibrillary acidic protein-positive cells in adult rats was significantly higher than in neonatal rats 14 and 35 days after brachial plexus ***/β-tubulin-positive cells were not found in either adult or neonatal *** results indicate that neural stem cells differentiate mainly into astrocytes after brachial plexus root avulsion ***,the degree of neural stem cell differentiation in neonatal rats was lower than in adult rats.

关键词： neural stem cells neurotrophic factors brain-derived neurotrophic factor neuroregeneration brachial plexus nerve root avulsion injury neural regeneration

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Orchestrated cellular,biochemical,and biomechanical optimizations endow platelet-rich plasma-based engineered cartilage with structural and biomechanical recovery

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Bioactive Materials 2021年第11期6卷 3824-3838页

作者： Ketao Wang Ji Li Yuxing Wang Yaqiang Wang Yuanyuan Qin Fei Yang Mingzhu Zhang Heng Zhu Zhongli Li department of Orthopedics Chinese PLA General HospitalHaidianBeijing100853China Beijing Institute of Radiation Medicine/Beijing Institute of Basic Medical Sciences HaidianBeijing100850China department of foot and ankle Beijing Tongren HospitalCapital Medical UniversityBeijing100730China Beijing National Laboratory for Molecular Sciences Institute of ChemistryChinese Academy of SciencesBeijing100190China department of Orthopedic surgery Zhongshan HospitalFudan UniversityShanghai200032China department of Blood Transfusion Chinese PLA General HospitalHaidianBeijing100853China

Recently,biomaterials for cartilage regeneration has been intensively ***,the development of scaffolds that capture regenerated cartilage with biomechanical and structural recovery has rarely been *** address this challenge,platelet-rich plasma(PRP)-based cartilage constructs with a well-orchestrated symphony of cellular,biochemical and biomechanical elements were prepared by simultaneously employing chondrogenic progenitor cells(CPCs)as a cell source,optimizing platelet concentration,and adding an enzyme-ion *** was shown that this triple-optimized PRP+CPC construct possessed increased biomechanical properties and suitable biochemical *** following in vitro study demonstrated that the triple-optimized PRP+CPC constructs generated cartilage-like tissue with higher expression levels of chondrogenic-specific markers,more deposition of cartilage-specific extracellular matrix(ECM),and greater biomechanical values than those of the other *** weeks after the construct was implanted in a cartilage defect in vivo,histological analysis,qPCR,and biomechanical tests collectively showed that the triple-optimized constructs yielded a more chondrocyte-like cell phenotype with a higher synthesis of Col-Ⅱand *** importantly,the triple-optimized constructs facilitated cartilage regeneration with better biomechanical recovery than that of the other *** results demonstrate the efficacy of the triple-optimization strategy and highlight the simplicity and potency of this PRP+CPC construct for cartilage regeneration.

关键词： Platelet-rich plasma Cartilage regeneration Structural recovery Biomechanical recovery

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