Differentiation of endogenous neural stem cells in adult versus neonatal rats after brachial plexus root avulsion injury

作     者：Bingqi Wang Lei Chen Bin Liu Zhigang Liu Zhixin Zhang Yuehai Pan Liangsong Song Laijin Lu 

作者机构：Department of Hand and Foot SurgeryFirst Hospital of Jilin UniversityChangchun 130031Jilin ProvinceChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2012年第7卷第23期

页      面：1786-1790页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 08[工学] 09[农学] 071006[理学-神经生物学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种] 

基　　金：supported by the Young Scientist Fund of Jilin Provincial Science and Technology Department No.20090183 

主　　题：neural stem cells neurotrophic factors brain-derived neurotrophic factor neuroregeneration brachial plexus nerve root avulsion injury neural regeneration 

摘      要：An experimental model of brachial plexus root avulsion injury of cervical dorsal C5-6 was established in adult and neonatal ***-time PCR showed that the levels of brain-derived neurotrophic factor,nerve growth factor and neurotrophin-3 in adult rats increased rapidly 1 day after brachial plexus root avulsion injury,and then gradually decreased to normal levels by 21 *** neonatal rats,levels of the three neurotrophic factors were decreased on the first day after injury,and then gradually increased from the seventh day and remained at high levels for an extended period of *** observed that greater neural plasticity contributed to better functional recovery in neonatal rats after brachial plexus root avulsion injury compared with adult ***, immunohistochemical staining showed that the number of bromodeoxyuridine/nestin-positive cells increased significantly in the spinal cords of the adult rats compared with neonatal rats after brachial plexus root avulsion *** addition,the number of bromodeoxyuridine/glial fibrillary acidic protein-positive cells in adult rats was significantly higher than in neonatal rats 14 and 35 days after brachial plexus ***/β-tubulin-positive cells were not found in either adult or neonatal *** results indicate that neural stem cells differentiate mainly into astrocytes after brachial plexus root avulsion ***,the degree of neural stem cell differentiation in neonatal rats was lower than in adult rats.