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Differences of Plasma Levels of Tryptophan, Serotonin, 5-Hydroxyindole Acetic Acid, and Kynurenine between Healthy People and Patients of Major Monopolar Depression at Various Age and Gender

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food and Nutrition Sciences 2020年第6期11卷 431-441页

作者： Hiroi Tomioka Junichi Masuda Akikazu Takada Akira Iwanami department of Psychiatry School of Medicine Showa University Tokyo Japan department of Psychiatry Showa University Northern Yokohama Hospital Yokohama Japan Global Application development Center Shimadzu Corporation Tokyo Japan International Projects on food and Health (NPO) Tokyo Japan

Background: It is not well analyzed whether there are differences in plasma levels of tryptophan (TRP) metabolites between healthy control people (HC) and patients of major monopolar depression (MMD). Methods: Ultra high-speed liquid chromatography/mass spectrometry has been used for the simultaneous determination of plasma levels of tryptophan metabolites in depressive patients. Results: There are no significant differences between plasma levels of TRP between HC and MMD. Plasma levels of TRP of HC are higher in young men, young women, old men, and old women in this order. Serotonin (5-HT) levels are higher in MMD than HC. Plasma levels of 5-HIAA of HC are also higher than those of patients of MMD. Plasma levels of kynurenine (KYN) of healthy old men and old women are higher than those of young men and old women. Plasma levels of KYN are higher in old women and young men of MMD than those of HC. Conclusion: Plasma levels of 5-HT are higher in patients of MMD than those of HC, which may suggest that use of drugs inhibiting the 5-HT transportation may increase plasma levels of 5-HT in MMD.

关键词： Depression Monopolar Depression Bipolar Depression Tryptophan Serotonin 5-Hydroxyindole Acetic Acid Kynurenine 3-Hydroxykynurenine Kynurenic Acid Anthranilic Acid Xanthurenic Acid Indole-3-Acetic Acid SSRI (Selective Serotonin Reuptake Inhibitor) SNRI (Serotonin Norepinephrine Reuptake Inhibitor)

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development and quality Evaluation of Choco Quinoa Nutri Bar during Storage

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food and Nutrition Sciences 2018年第7期9卷 899-914页

作者： Ananthan Padmashree Neha Negi Soorya Haridas Thimma Govindaraj Kandanganth Raghavan Anila Kumar Anil Dutt Semwal Gopal Kumar Sharma Defence food Research Laboratory Siddartha Nagar Mysuru India

Choco quinoa nutri bar was developed using quinoa as one of the ingredients to explore its nutritional benefits. Bars were packed in polypropylene (PP, 75 μ) and metallised polyester (12 μ) low density—high density (MP, 100 μ) (with/without vacuum) films, stored under ambient and 37°C temperature conditions for shelf life evaluation. Bar contained 14.43% protein, 14.93% fat with a calorific value of 426.75 k cal/100g. Chemical changes were observed significantly (p < 0.05) more in the samples stored at 37°C than the ones stored at ambient conditions (15°C - 34°C). Bars showed maximum stability at 0.33 aw with less chemical changes. Oleic acid (36.06%) was found to be the major fatty acids in the bar followed by palmitic (29.35%), stearic (17.12%) and linoleic (12.05%) acids. Hardness of the bar enhanced significantly during storage, and was observed significantly (p < 0.05) higher in the samples packed in MP films (with/without vacuum) as compared to bars packed in PP films thus restricting the shelf life of the bar to 6 months in MP films (with/without vacuum) and 9 months in PP films at both the temperature conditions.

关键词： Choco Quinoa Nutri Bar Quinoa Packaging Material Chemical Changes Hardness Shelf Life

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DNA Barcoding and Mini-DNA Barcoding Reveal Mislabeling of Salmonids in Different Distribution Channels in the Qingdao Area

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Journal of Ocean University of China 2021年第6期20卷 1537-1544页

作者： HAN Cui DONG Shuanglin LI Li GAO Qinfeng ZHOU Yangen Key Laboratory of Mariculture Ministry of EducationOcean University of ChinaQingdao 266003China Function Laboratory for Marine Fisheries Science and food Production Processes Qingdao National Laboratory for Marine Science and TechnologyQingdao 266235China

There is an increasing demand for salmonid authentication due to the globalization of the salmonid *** barcoding and mini-DNA barcoding are widely used for identifying fish species based on a fragment of the mitochondrial cytochrome c oxidase subunit I(COI)*** this study,rainbow trout(Oncorhynchus mykiss),steelhead trout(***),and Atlantic salmon(Salmo salar)collected from two salmonid aquaculture bases in China were authenticated by DNA barcoding(about 650 bp)and mini-DNA barcoding(127 bp)to evaluate the accuracy of the two methods in the identification of different salmonid *** results revealed that both methods could effectively distinguish *** and *** with 100%***,the two methods failed to separate rainbow trout(***)and steelhead trout(***),which are the same species but cultured in different water ***,salmonid samples from three main distribution channels in the Qingdao area(traditional supermarkets,online supermarkets,and sushi bars)were identified by the two *** of *** with *** was discovered,and the 27.78%overall substitution rate of salmonids in the Qingdao area was higher than those in other regions reported in previous *** addition,the mislabeling rates of salmonids from traditional supermarkets,online supermarkets,and sushi bars were compared in this *** mislabeling rate was significantly greater in sushi bars(50%)than in the other two channels(16.67%),suggesting that stronger monitoring and enforcement measures are necessary for the aquatic food catering industry.

关键词： salmonid DNA barcoding mini-DNA barcoding species authentication mislabeling rate

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Aqueous Components of Tomato Accelerate Alcohol Metabolism by Increasing Pyruvate Level

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food and Nutrition Sciences 2014年第10期5卷 870-879页

作者： Yusuke Ushida Shunji Oshima Koichi Aizawa Hiroyuki Suganuma Akihiro Nemoto Hiroko Ishikiriyama Yasushi Kitagawa Research & development Division Kagome Co. Ltd. Tochigi Japan Research Laboratories for Fundamental Technology of food Asahi Group Holdings Ltd. Ibaraki Japan

Consumption of food while drinking alcohol has been suggested to play important roles in alleviating the physiological and pharmacological influences of alcohol. Vegetables are believed to provide health benefits, but there is little evidence for their influence on the effects of alcohol consumption. The present study aimed to investigate the effect of a common vegetable, tomato, on alcohol metabolism. In a randomized, controlled, crossover study with12 Japanese healthy men aged between 24 and 56 years, drinking tomato juice containing 5% (v/v) alcohol (TJAlc) significantly attenuated the elevation of blood ethanol level and subsequently increased the level of acetate compared with a water-based alcoholic beverage with an equal dose of alcohol (0.4 g/kg body weight). Significantly higher levels of blood pyruvate and lactate were also observed in subjects who had consumed TJAlc compared with those consuming the water-based beverage. Additionally, a biphasic alcohol effects scale method showed that subjective feelings for alcohol-induced stimulant effects were significantly enhanced by drinking TJAlc. Animal experiments using male Sprague Dawleyrats suggested that the effect on blood biomarkers was attributable to the serum fraction of tomato (TS), which largely consisted of aqueous compounds, but not lipophilic compounds such as the carotenoid lycopene. Furthermore, it was suggested the TS possibly included potent compound(s) in addition to alanine, glutamine, and citric acid, all of which have previously been reported to affect alcohol metabolism. Administration of TS clearly increased the activity of NAD (H)-dependent enzymes such as lactate-(LDH), alcohol-, and aldehyde-dehydrogenase in rat liver cytosols. These findings suggest that aqueous compound(s) in tomato promote alcohol metabolism, probably through increasing pyruvate level, enhancing LDH activity, and improving the ratio of NAD to NADH.

关键词： Tomato Blood Ethanol Level Pyruvate Lactate Dehydrogenase Alcohol Metabolism

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SUMOylation-modified Pelota-Hbs1 RNA surveillance complex restricts the infection of potyvirids in plants

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Molecular Plant 2023年第3期16卷 632-642页

作者： Linhao Ge Buwei Cao Rui Qiao Hongguang Cui Shaofang Li Hongying Shan Pan Gong Mingzhen Zhang Hao Li Aiming Wang Xueping Zhou Fangfang Li State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBejingChina Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests Ministry of Education and College of Plant ProtectionHainan UniversityHaikouHainanChina London Research and development Centre Agriculture and Agri-Food CanadaLondonONCanada department of Biology Western UniversityLondonONCanada state Key Laboratory of Rice Biology Institute of BiotechnologyZhejiang UniversityHangzhouZhejiangChina

RNA quality control nonsense-mediated decay is involved in viral restriction in both plants and ***,it is not known whether two other RNA quality control pathways,nonstop decay and no-go decay,are capable of restricting viruses in ***,we show that the evolutionarily conserved Pelota–Hbs1 complex negatively regulates infection of plant viruses in the family Potyviridae(termed potyvirids),the largest group of plant RNA viruses that accounts for more than half of the viral crop damage *** enables the recognition of the functional G1-2A6-7 motif in the P3 cistron,which is conserved in almost all *** allows Pelota to target the virus and act as a viral restriction ***,Pelota interacts with the SUMO E2-conjugating enzyme SCE1 and is SUMOylated in *** Pelota SUMOylation disrupts the ability to recruit Hbs1 and inhibits viral RNA *** findings reveal the functional importance of Pelota SUMOylation during the infection of potyvirids in plants.

关键词： SUMOylation Pelota-Hbs1 G1-2A6-7 motif Potyviruses

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A review of whole-medical systems and holistic care approach for type 2 diabetes and associated metabolic syndrome

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Journal of Integrative Medicine 2024年第3期22卷 199-209页

作者： Loveness Makoni Idah T.Manduna Alaisa L.Mbiriri department of Health Sciences Faculty of Health and Environmental Health SciencesCentral University of TechnologyFree State20 President Brand StreetPrivate bag X20539Bloemfontein 9300South Africa Centre for Applied food Sustainability and Biotechnology(CAFSaB) Faculty of Health and Environmental Health SciencesCentral University of TechnologyFree State20 President Brand StreetPrivate bag X20539Bloemfontein 9300South Africa Adventist development and Relief Agency(ADRA) 5 Cecil RoadGreendaleHarare 0000Zimbabwe

Whole-person care and holistic care approach has been proposed for complementary and integrative health care for type 2 diabetes ***,some doubts still exist on the feasibility of replicating processes followed in clinical trials and observational studies in real-world *** narrative literature review summarized and assessed existing clinical evidence(clinical trials,observational studies,and case reports)describing holistic and integrated care approach in adult and adolescent individuals with type 2 diabetes mellitus in clinical *** goal was to highlight existing evidence for implementation and outcomes of whole-medical systems and holistic integrated care approach for type 2 diabetes mellitus.A nonsystematic literature search was performed on Google Scholar,PubMed,Web of Science,ProQuest and ScienceDirect to identify clinical evidence from different parts of the world,evaluating the use of whole-medical systems and/or holistic care interventions in clinical practice for management of type 2 diabetes *** keywords were used in the *** were analyzed using content analysis and simple descriptive statistics(percentages).Most of the studies(64%)were mainly conducted in Eastern countries(India,China and Israel)while 36%of the studies were conducted in the Western countries(USA,Netherlands,Canada and Mexico).Lifestyle medicine and integrated naturopathy were shown to be the commonly used whole-medical systems for type 2 diabetes mellitus *** improvements in type 2 diabetes parameters,medication use,other symptoms,and overall feeling of wellness were observed in all *** review study revealed limited utilization and/or documentation of whole-medical systems or holistic care treatments for type 2 diabetes mellitus in regions of the world other than eastern *** medicine,naturopathy,yoga,Ayurveda and traditional Chinese medicine were shown to be effective for type 2 diabetes mellitu

关键词： Complementary and alternative medicine Holistic care Integrative medicine Type 2 diabetes mellitus Team-based intervention

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Pediatric non-alcoholic fatty liver disease: Recent solutions, unresolved issues, and future research directions

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World Journal of Gastroenterology 2016年第36期22卷 8078-8093页

作者： Maria Grazia Clemente Claudia Mandato Marco Poeta Pietro Vajro Pediatric Clinic Department of SurgicalMicrosurgical and Medical SciencesUniversity of Sassari07100 SassariItaly Pediatrics of AORN Santobono-Pausilipon 80123 NaplesItaly Pediatrics Department of MedicineSurgery and Dentistry'Scuola Medica Salernitana'University of Salerno84081 BaronissiItaly ELFID European Laboratory for the Investigation of food Induced Disease 80138 NaplesItaly

Non-alcoholic fatty liver disease(NAFLD) in children is becoming a major health concern. A "multiple-hit" pathogenetic model has been suggested to explain the progressive liver damage that occurs among children with NAFLD. In addition to the accumulation of fat in the liver, insulin resistance(IR) and oxidative stress due to genetic/epigenetic background, unfavorable lifestyles, gut microbiota and gut-liver axis dysfunction, and perturbations of trace element homeostasis have been shown to be critical for disease progression and the development of more severe inflammatory and fibrotic stages [non-alcoholic steatohepatitis(NASH)]. Simple clinical and laboratory parameters, such as age, history, anthropometrical data(BMI and waist circumference percentiles), blood pressure, surrogate clinical markers of IR(acanthosis nigricans), abdominal ultrasounds, and serum transaminases, lipids and glucose/insulin profiles, allow a clinician to identify children with obesity and obesity-related conditions, including NAFLD and cardiovascular and metabolic risks. A liver biopsy(the "imperfect" gold standard) is required for a definitive NAFLD/NASH diagnosis, particularly to exclude other treatable conditions or when advanced liver disease is expected on clinical and laboratory grounds and preferably prior to any controlled trial of pharmacological/surgical treatments. However, a biopsy clearly cannot represent a screening procedure. Advancements in diagnostic serum and imaging tools, especially for the non-invasive differentiation between NAFLD and NASH, have shown promising results, e.g., magnetic resonance elastography. Weight loss and physical activity should be the first option of *** pharmacological treatments are still under development; however, drugs targeting IR, oxidative stress, proinflammatory pathways, dyslipidemia, gut microbiota and gut liver axis dysfunction are an option for patients who are unable to comply with the recommended lifestyle changes

关键词： Non-alcoholic fatty liver disease Childhood obesity Non-alcoholic steatohepatitis Hepatic metabolic syndrome Non-alcoholic fatty liver disease diagnosis

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Semi-volatile organic compounds in a museum in China:A non-targeted screening approach

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Science China(Technological Sciences) 2024年第9期67卷 2693-2705页

作者： SONG ZiDong NIAN LuYing SHI Meng REN XiaoPeng TANG Ming SHI AnMei HAN Ying LIU Min WANG LuYang ZHANG YinPing XU Ying FENG XiaoMeng department of Building Science Tsinghua UniversityBeijing 100084China Beijing Key Laboratory of Indoor Air quality Evaluation and Control Beijing 100084China National Museum of China Beijing 100006China department of Endocrinology Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China

Non-targeted analysis(NTA)was conducted to identify semi-volatile organic compounds(SVOCs)in a museum in China using the gas chromatography(GC)-Orbitrap-mass spectrometer(MS).Approximately 160 SVOCs were detected,of which 93 had not been reported in previous studies of museum *** of the detected SVOCs were found to be associated with the chemical agents applied in conservation treatment and the materials used in *** results of hierarchical cluster analysis(HCA)indicated a spatial variation of SVOCs in the indoor air in the museum,but there were no obvious temporal differences of SVOCs observed in indoor ***'s correlation analysis showed that several classes of SVOCs were well correlated,suggesting their common *** and plasticizers were found to be the primary sources of SVOC pollution detected in the *** with compounds in outdoor air,indoor SVOCs had a lower level of unsaturation and more portions of chemically reduced *** study is the first of its kind to comprehensively characterize SVOCs in a museum using an automated NTA approach with *** SVOCs identified in the current study are likely to be present in other similar museums;therefore,further examination of their potential impacts on cultural heritage artifacts,museum personnel,and visitors may be warranted.

关键词： non-target analysis high-resolution mass spectrometry semi-volatile organic compounds museum environment air pollutants

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Effects of intelligent feedingmethod on the growth,immunity and stress of juvenile Micropterus salmoides

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Artificial Intelligence in Agriculture 2021年第1期5卷 118-124页

作者： Dan Wei Fengdeng Zhang Zhangying Ye Songming Zhu Daxiong Ji Jian Zhao Fan Zhou Xueyan Ding College of Biosystems Engineering and food Science Zhejiang UniversityHangzhou 310000China Ocean Academy Zhejiang UniversityZhoushan 316000China Zhejiang Fisheries Technical Extension Center Hangzhou 310023China

The feeding method is of great significance for aquaculture production and *** recent years,research on intelligent feeding,a method based on fish appetite,has been ***,however,have focused on fish welfare issues that can result from intelligent *** this study,an adaptive feeder based on a practical intelligent feeding method was designed to evaluate whether this intelligent feeding method would impair fish welfare compared to traditional automatic *** results indicated that the amount of residual feed and size inhomogeneity in the traditional group was significantly higher than that in the intelligent *** results of the growth indicator showed that theweight gain rate(WGR)in the intelligent feeding groupwas significantly higher(30.17%)than in the traditional feeding *** no significant differences were observed in the survival rate(SR),the condition factor(CF)and the hepatosomatic index(HSI),the specific growth rate(SGR)in the intelligent feeding group was significantly increased by 8.33%while the feed conversion rate(FCR)was reduced by a remarkable 17.07%compared to the traditional feeding ***,intelligent feeding significantly improved the pepsin activity of the *** terms of immunity and antioxidant capacity,however,the fish in the intelligent feeding group had a significantly lower lysozyme(LZM)level than those fed with the traditional *** superoxide dismutase(SOD),the intelligent group also displayed a lower activity value,although it was not *** intelligent feeding group had 0.14 nmol/mg protein higher malondialdehyde(MDA)activity than the traditional *** stress,although no statistical significance was observed,the cortisol level in the intelligent group was 1.9 ng/ml higher than in the traditional ***,these data suggested that the intelligent feeding method can significantly improve fish growth but may also result in stress and suppress innate immunity.

关键词： Intelligent feeding method Fish welfare Growth Immunity Stress

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Characterization of Imipenem Unsusceptible Pseudomonas Aeruginosa Isolates from Inpatients without Carbapenem Treatment

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国际感染病学（电子版） 2013年第1期2卷 1-5页

作者： Yi-hai Gu Xiao Zhu Jing-yun Li Jun Zhang Qing-yuan Zhou Yue Ma Chang-qin Hu Shao-hong Jin Sheng-hui Cui department of Microbiology 3201 Hospital The National Center for Surveillance of Antimicrobial Resistance the State Food and Drug Administration

Objective To identify the risk factors for imipenem resistance development and transmission of clinical Pseudomonas aeruginosa *** Thirty-seven imipenem unsusceptible Pseudomonas aeruginosa isolates collected from patients in absence of carbapenem treatment were characterized by antimicrobial susceptibility test,pulsed field gel electrophoresis(PFGE)and carbapenem resistant mechanism *** Before the collection of imipenem unsusceptible Pseudomonas aeruginosa isolates,the average time of patients treated with more than one antimicrobial(20.0±9.5 days,n=16)was significantly longer than those treated with only one antimicrobial(12.6±4.4 days,n=21;t-test,Welch,t=-2.9004,P<0.01).And 32 isolates showed resistance to more than 3 classes of *** PFGE clusters were identified and 26 isolates were grouped into one dominant cluster(C2).An ISpa1328 sequence insertion in oprD was detected in 33 isolates and the function of efflux was observed in all 37 isolates in the presence of a wide spectrum efflux *** Our data demonstrated that exposure to non-carbapenem drug classes,especially fluoroquinolones andβ-lactams,may be important risk factors for the spread of carbapenem resistant Pseudomonas aeruginosa.

关键词： Pseudomonas aeruginosa Imipenem resistance Carbapenem

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