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Multifaceted superoxide dismutase 1 expression in amyotrophic lateral sclerosis patients:a rare occurrence?

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Neural Regeneration Research 2025年第1期20卷 130-138页

作者： Ilaria Martinelli Jessica Mandrioli Andrea Ghezzi Elisabetta Zucchi Giulia Gianferrari Cecilia Simonini Francesco Cavallieri Franco Valzania department of Neurosciences Azienda Ospedaliero Universitaria di ModenaModenaItaly Clinical and experimental Medicine Ph.D.Program University of Modena and Reggio EmiliaModenaItaly department of Biomedical Metabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModenaItaly Neurology Unit Neuromotor&Rehabilitation DepartmentAzienda USL-IRCCS di Reggio EmiliaReggio EmiliaItaly

Amyotrophic lateral sclerosis(ALS)is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex,brainstem,and spinal *** the typical clinical phenotype of ALS involves both upper and lower motor neurons,human and animal studies over the years have highlighted the potential spread to other motor and non-motor regions,expanding the phenotype of *** superoxide dismutase 1(SOD1)mutations represent a minority of ALS cases,the SOD1 gene remains a milestone in ALS research as it represents the first genetic target for personalized *** numerous single case reports or case series exhibiting extramotor symptoms in patients with ALS mutations in SOD1(SOD1-ALS),no studies have comprehensively explored the full spectrum of extramotor neurological manifestations in this *** this narrative review,we analyze and discuss the available literature on extrapyramidal and non-motor features during *** multifaceted expression of SOD1 could deepen our understanding of the pathogenic mechanisms,pointing towards a multidisciplinary approach for affected patients in light of new therapeutic strategies for SOD1-ALS.

关键词： amyotrophic lateral sclerosis(ALS) autonomic extramotor genotype-phenotype multisystem involvement Parkinson’s disease sensory SOD1 superoxide dismutase 1 urinary vocal cord palsy

How dopamine tunes parvalbumin interneurons in the hippocampus:new experimental observations in Alzheimer's disease

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Neural Regeneration Research 2025年第5期20卷 1405-1406页

作者： Livia La Barbera Paraskevi Krashia Annalisa Nobili department of Medicine and Surgery UniversitàCampus Bio-Medico di RomaViaÁlvaro del PortilloRomeItaly department of experimental Neurosciences IRCCS Santa Lucia FoundationVia del Fosso di FioranoRomeItaly department of Science and Technology for Sustainable Development and One Health UniversitàCampus Bio-Medico di RomaViaÁlvaro del PortilloRomeItaly

Despite decades of dedicated resea rch,Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disorder for which the mechanisms of onset are sti unc *** is cha racterized by featured histological alterations including amyloid-beta (AB) plaque deposition,accumulation of neurofibrillary to ngles of hyperphosphorylated-tau,and neuronal loss,accompanied by progressive cognitive decline and behavioral changes.

关键词： Alzheimer alterations dopamine

Coriander(Coriandrum sativum L.) essential oil: chemistry and biological activity

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Asian Pacific Journal of Tropical Biomedicine 2015年第6期5卷 421-428页

作者： Shyamapada Mandal Manisha Mandal Laboratory of Microbiology and experimental Medicine Department of ZoologyUniversity of Gour Banga department of Physiology MGM Medical College and LSK Hospital

Coriandrum sativum L.(C. sativum) is one of the most useful essential oil bearing spices as well as medicinal plants, belonging to the family Umbelliferae/Apiaceae. The leaves and seeds of the plant are widely used in folk medicine in addition to its use as a seasoning in food preparation. The C. sativum essential oil and extracts possess promising antibacterial, antifungal and anti-oxidative activities as various chemical components in dif erent parts of the plant, which thus play a great role in maintaining the shelf-life of foods by preventing their spoilage. This edible plant is non-toxic to humans, and the C. sativum essential oil is thus used in dif erent ways, viz., in foods(like l avoring and preservatives) and in pharmaceutical products(therapeutic action) as well as in perfumes(fragancias and lotions). The current updates on the usefulness of the plant C. sativum are due to scientii c research published in dif erent web-based journals.

关键词： Coriandrum sativum essential oil Coriander chemistry Antibacterial activity Antifungal activity Antioxidant activity Food spoila

Simultaneous occurrence of autoimmune pancreatitis and pancreatic cancer in patients resected for focal pancreatic mass

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World Journal of Gastroenterology 2017年第12期23卷 2185-2193页

作者： Peter Macinga Adela Pulkertova Lukas Bajer Jana Maluskova Martin Oliverius Martin Smejkal Maria Heczkova Julius Spicak Tomas Hucl department of Gastroenterology and Hepatology Institute for Clinical and Experimental Medicine department of Pathology Institute for Clinical and Experimental Medicine department of Transplant Surgery Institute for Clinical and Experimental Medicine department of Radiodiagnostics and Interventional Radiology Institute for Clinical and Experimental Medicine Center for experimental Medicine Institute for Clinical and Experimental Medicine

AIM To assess the occurrence of autoimmune pancreatitis(AIP) in pancreatic resections performed for focal pancreatic *** We performed a retrospective analysis of medical records of all patients who underwent pancreatic resection for a focal pancreatic enlargement at our tertiary center from January 2000 to July 2013. The indication for surgery was suspicion of a tumor based on clinical presentation, imaging findings and laboratory evaluations. The diagnosis of AIP was based on histology findings. An experienced pathologist specialized in pancreatic disease reviewed all the cases and confirmed the diagnosis in pancreatic resection specimens suggestive of AIP. The histological diagnosis of AIP was set according to the international consensus diagnostic *** Two hundred ninety-five pancreatic resections were performed in 201 men and 94 women. AIP was diagnosed in 15 patients(5.1%, 12 men and 3 women) based on histology of the resected specimen. Six of them had AIP type 1, nine were diagnosed with AIP type 2. Pancreatic adenocarcinoma(PC) was also present in six patients with AIP(40%), all six were men. Patients with AIP + PC were significantly older(60.5 vs 49 years of age, P = 0.045), more likely to have been recently diagnosed with diabetes(67% vs 11%, P = 0.09), and had experienced greater weight loss(15.5 kg vs 8.5 kg, P = 0.03) than AIP patients without PC. AIP was not diagnosed in any patients prior to surgery; however, the diagnostic algorithm was not fully completed in every case. CONCLUSION The possible co-occurrence of PC and AIP suggests that preoperative diagnosis of AIP does not rule out simultaneous presence of PC.

关键词： Chronic pancreatitis Pancreatic cancer Ig G4related disease Autoimmune pancreatitis Malignancy

Local Phase Portraits through the Newton Diagram of a Vector Field

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Acta Mathematica Sinica,English Series 2015年第6期31卷 1015-1034页

作者： Antonio ALGABA Isabel CHECA Cristóbal GARCIA Manuel REYES department of Mathematics Faculty of Experimental Sciences

The Newton diagram and, in particular, the lowest-degree quasi-homogeneous terms of an analytic planar vector field allow us to determine the existence of characteristic orbits and separatrices of an isolated singular point. We give an easy algorithm for obtaining the local phase portrait near the origin of a bi-dimensional differential system and we provide several examples.

关键词： Monodromy separatrices phase portraits quasi-homogeneous vector field

Radiation Hydrodynamic Simulations in the Planar Scheme for the Fundamental Studies of Shock Ignition

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Plasma Science and Technology 2016年第4期18卷 376-381页

作者：董云松杨家敏宋天明朱托黄成武 department of experimental Physics Laser Fusion Research Center

As a fundamental and crucial research topic in the direct-driven inertial confinement fusion（ICF）,especially for shock ignition（SI）,investigation on the laser coupling with planar lowZ targets is beneficial for deep physical comprehension at the primary phase of *** production of the intense shock and the shock coalescence in the multi-layer targets,driven by the 3ω intense laser（351 nm the wavelength）,were studied in detail with the 1D and 2D radiation hydrodynamic *** was inferred that the 1D simulation would overrate the shock velocity and the ablation pressure of the spike;the coalescence time and the velocity of the coalescence shock depended evidently on the pulse shape and the start time of the *** present study can also provide a semi-quantitative reference for the design of the SI decomposition experiments on the Shenguang-III prototype laser facility.

关键词： shock ignition planar scheme radiation hydrodynamic simulation

Histochemical pattern of gastrocnemius muscle in fluoride toxicity syndrome

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Asian Pacific Journal of Tropical Medicine 2010年第2期3卷 136-140页

作者： Shashi A Bhushan B Bhardwaj M department of zoology Punjabi University

Objective:To evaluate the effect of sodium fluoride(NaF) on cytochemical distribution of proteins,DNA,and RNA in the gastrocnemius muscle of rat in experimental ***: Young Sprague Dawley albino rats were administered with NaF at 30,45,and 75 mg/kg bw/ day subcutaneously for 15 and 30 days,*** control animals were given the vehicle(1cc deionized double distilled water/kg bw/day).Results:In the first phase of 15 days experimentation,the gastrocnemius muscle of rats intoxicated with NaF at 30,45,and 75 mg /kg bw/ day showed decline in proteins including a amino acids as compared to control. In the second phase of 30 days experimentation,the muscle fibers of rat showed elevation in sarcolemmal and sarcoplasmic proteins in 30 mg NaF dose group,and angulated fibers exhibited increase in sarcolemmal proteins in 45 mg NaF *** marginal regions of angular and rim fibers showed deeply stained rings of sarcoplasmic proteins whereas the split fibers were faindy stained in rats treated with NaF at 75 mg/kg bw/day for 30 *** rats treated with NaF at 30 mg/kg bw/day for 15 days,the hypertrophied peripheral muscle fibers contained more DNA,however the atrophied fibers had more *** 45 mg NaF group,RNA was located in sarcolemmal regions,while DNA content decreased as compared to *** 75 mg NaF group,the muscle fibers had dark and light staining regions of DNA and *** the 30 days of experimentation,the DNA level decreased whereas RNA content increased in the gastrocnemius muscle fibers of the rat treated with NaF at 30 mg/kg bw/*** treatment group with NaF at 45 mg/kg bw/day,the RNA content slighdy declined in comparison to control,in all treatments for 15 days as well as in treatment group with NaF at 30 mg/kg bw/day for 30 days whereas the amount of DNA slightly increased as compared to treatment group with NaF at 75 mg/kg bw/day for 15 *** highest dose group revealed elevated amount of RNA whereas DNA content remained stable.C

关键词： Albino rats DNA Gastrocnemius muscle Proteins RNA Sodium fluoride

Pathological evaluation of pancreatic exocrine glands in experimental fluorosis

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Asian Pacific Journal of Tropical Medicine 2010年第1期3卷 36-40页

作者： Shashi Aggarwal Sharma N Bhardwaj M department of zoology Punjabi University

Objective:To monitor the pathological alterations in pancreas of rat during experimental fluorosis. Methods:Sixty Sprague Dawley albino rats of both sexes were divided into 12 experimental groups and one control *** rats of control group were administered subcutaneously double distilled water 1 mL/kg bw *** experimental groups were injected with 30,45,and 75 mg NaF/kg bw/*** experimental period was divided into 4 phases at interval of 15,22,30,and 36 *** were sacrificed from each group at the end of 16,23,31,and 37 ***: The following changes were observed in this study:(1) Pathological examination of pancreas after 15 days of fluoride treatment revealed:hypertrophy of acini,leucocytes infilteration and pycnouc nuclei due to necrosis of acini in group 1;uremic alterations,invulsion and infoldings of reticular layer of islets of Langerhans in group 2;and a decrease in number of acini and interlobular connective tissues resulted in an increase in intercellular spaces in pancreas of rats in group 3.(2)Hyalinization and hypertrophy in the lobules of acini and hyperplasia and hypertrophy in intercalated duct with mucinous secretion in pancreas of rat of group 4;squamous metaplasia of pancreatic duct,adenoma of pancreas,hemorrhagic necrosis in group 5;and hyperplasia of acini and reduction in number of pancreatic islets in group 6.(3) Disorganization and atrophy of pancreatic lobules and presence of vacuoles in a group of six were visible in pancreas of rats in group 7;acute pancreatic and lamellated inflammatory cells in test rats of group 8;and islet adenoma and decrease in number of islets cells,and exudation in acini were noticed in experimental rats of group 9.(4) In the last phase of experimentation,atrophic alterations in pancreatic acini,invulsions,and necrosis was prominent in group 10,deep inflammation and proliferation of connective tissue of pancreas in experimental group 11,and periodical fibrosis, hyperplasia of acini,degener

关键词： Acini Albino rat Exocrine gland experimental fluorosis Pancreas Sodium fluoride

OPIOID PEPTIDES IN AMPHIOXUS DURING BREEDING SEASON

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Chinese Science Bulletin 1991年第17期36卷 1481-1484页

作者：沈卫斌殷红王红张崇理 Laboratory of experimental Marine Biology Institute of Oceanography Qingdao 266071 department of Endocrinology Institute of Zoology Academia Sinica Beijing 100080 PRC

Ⅰ. INTRODUCTIONThe small fish-like lancelet is phylogenetically a unique and important living species of chordate and it has long been suggested to be the likely kinsman of the ancestral type of vertebrates. The stud... 详细信息

关键词： opioid peptide breeding.