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Associations of soybean products intake with blood pressure changes and hypertension incidence: the China-PAR project

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Journal of Geriatric Cardiology 2020年第7期17卷 384-392页

作者： Jia-Liu WEI Xin-Yan WANG Fang-Chao LIU Ji-Chun CHEN Jie CAO Jian-Xin LI Dong-Sheng HU Chong SHEN Fang-Hong LU Ying-Xin ZHAO Jian-Feng HUANG Xiang-Feng LU Key Laboratory of Cardiovascular epidemiology Chinese Academy of Medical SciencesBeijingChina department of epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina department of Prevention Medicine Shenzhen University School of MedicineShenzhenChina department of epidemiology and Health statistics College of Public HealthZhengzhou UniversityZhengzhouChina department of epidemiology and Biostatistics School of Public HealthNanjing Medical UniversityNanjingChina Cardio-Cerebrovascular Control and Research Center Institute of Basic MedicineShandong First Medical UniversityJinanShandongChina

Background The relationships between dietary intake of soybean products and incident hypertension were still *** study aimed to illustrate the associations between intake of soybean products with risks of incident hypertension and longitudinal changes of blood pressure in a prospective cohort *** We included 67,499 general Chinese adults from the Project of Prediction for Atherosclerosis Cardiovascular Disease Risk in China(China-PAR).Information about soybean products consumption was collected by standardized questionnaires,and study participants were categorized into the ideal(≥125 g/day)or non-ideal(<125 g/day)*** ratios(HRs)and corresponding 95%confidence intervals(95%CIs)for incident hypertension were calculated using Cox proportional hazard *** participants with repeated measures of blood pressure,generalized linear models were used to examine the relationships between soybean products consumption and blood pressure *** During a median follow-up of 7.4 years,compared with participants who consumed<125 g of soybean products per day,multivariable adjusted HR for those in the ideal group was 0.73(0.67-0.80).This inverse association remained robust across most subgroups while significant interactions were tested between soybean products intake and age,sex,urbanization and geographic region(P values for interaction<0.05).The mean systolic and diastolic blood pressure levels were 1.05(0.71-1.39)mmHg and 0.44(0.22-0.66)mmHg lower among participants in the ideal group than those in the non-ideal *** Our study showed that intake of soybean products might reduce the long-term blood pressure levels and hypertension incidence among Chinese population,which has important public health implications for primary prevention of hypertension.

关键词： Blood pressure changes Chinese population Cohort study Hypertension Soybean products

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Effect of nicotinamide on newly diagnosed type 1 diabetic children

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Acta Pharmacologica Sinica 2006年第6期27卷 724-727页

作者： Madeeha KAMAL Abdul-JabbarAlABBASY AhoodAlMUSLEMANI Abdulbari BENER department of Pediatrics Salmaniya Medical ComplexManamaBahrain School of Health Department of PediatricsHamad Medical CorporationDohaQatar department of Pediatrics.Salmaniya Medical Complex ManamaBahrain department of Medical statistics and epidemiology Hamad General HospitalHamad Medical CorporationDohaQatar department of Evidence for Population Health Unit School of Epidemiology and Health SciencesUniversity of ManchesterManchester.UK

Aim:To determine whether a low dose of nicotinamide(NA)therapy for pediatricpatients with type 1 diabetes,initiated within the first 24 h of diagnosis,prolongsthe"honeymoon"period and lowers their insulin ***:Allchildren(n=66)with newly diagnosed type 1 diabetes admitted to Salmaniya MedicalComplex between 1998 and 2000,received NA 1-2 mg/kg per day,in addition tosc insulin *** patients were followed for 24 months(NA group).Findings inthis group were compared with records from a similarly diagnosed control group(n=37),who were admitted to the same hospital between 1995 and 1997 and did notreceive NA *** insulin dose per kg bodyweight required at baselineand at 3-monthly intervals up to 2 years after diagnosis was ***:At baseline,the two groups did not differ with respect to age,ethnic background,weight,insulin dose per kg bodyweight or glucose levels on ***,NA group had lower insulin requirements than control group at each 3-monthinterval up to 2 years after ***:Our study results suggest thateven low doses of oral NA given to children with newly diagnosed type 1 diabetesmay reduce insulin requirements and prolong the"honeymoon"period.

关键词： type 1 diabetes nicotinamide insulin therapy insulin dose glycated hemoglobin A

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Mortality associated with hepatitis C and hepatitis B virus infection: A nationwide study on multiple causes of death data

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World Journal of Gastroenterology 2017年第10期23卷 1866-1871页

作者： Ugo Fedeli Enrico Grande Francesco Grippo Luisa Frova Epidemiological department Italian National Institute of statistics

To analyze mortality associated with hepatitis C virus (HCV) and hepatitis B virus (HBV) infection in *** certificates mentioning either HBV or HCV infection were retrieved from the Italian National Cause of Death Register for the years 2011-2013. Mortality rates and proportional mortality (percentage of deaths with mention of HCV/HBV among all registered deaths) were computed by gender and age class. The geographical variability in HCV-related mortality rates was investigated by directly age-standardized rates (European standard population). Proportional mortality for HCV and HBV among subjects aged 20-59 years was assessed in the native population and in different immigrant *** infection was mentioned in 1.6% (n = 27730) and HBV infection in 0.2% (n = 3838) of all deaths among subjects aged ≥ 20 years. Mortality rates associated with HCV infection increased exponentially with age in both genders, with a male to female ratio close to unity among the elderly; a further peak was observed in the 50-54 year age group especially among male subjects. HCV-related mortality rates were higher in Southern Italy among elderly people (45/100000 in subjects aged 60-79 and 125/100000 in subjects aged ≥ 80 years), and in North-Western Italy among middle-aged subjects (9/100000 in the 40-59 year age group). Proportional mortality was higher among Italian citizens and North African immigrants for HCV, and among Sub-Saharan African and Asian immigrants for *** ageing, immigration, and new therapeutic approaches are shaping the epidemiology of virus-related chronic liver disease. In spite of limits due to the incomplete reporting and misclassification of the etiology of liver disease, mortality data represent an additional source of information for surveillance.

关键词： Hepatitis C virus Hepatitis B virus Mortality epidemiology Immigrants

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Treatment of hepatitis C virus genotype 4 with peginterferon alfa-2a: Impact of bilharziasis and fibrosis stage

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World Journal of Gastroenterology 2006年第35期12卷 5692-5698页

作者： MF Derbala SR Al Kaabi NZ El Dweik F Pasic MT Butt R Yakoob A Al-Marri AM Amer N Morad A Bener department of Gastroenterology and Hepatology Hamad Medical Corporation Doha Qatar department of Immunology Hamad Medical Corporation Doha Qatar department of Haematology Hamad Medical Corporation Doha Qatar department of Histopathology Hamad Medical Corporation Doha Qatar department of Medical statistics and epidemiology Hamad Medical Corporation Doha Qatar

AIM： To evaluate pegylated interferon alpha2a （PegIFN-α2a） in Egyptian patients with HCV genotype 4, and the impact of pretreatment viral load, co-existent bilharziasis and histological liver changes on response rate. METHODS： A total of 73 nafve patients （61 with history of bilharziasis） with compensated chronic HCV genotype 4 were enrolled into： group A （38 patients） who received 180 mg PegIFN-alpha2a subcutaneously once weekly for a year and group B （35 patients） received IFN alpha-2a 3 MU 3 times weekly. Ribavirin was added to each regimen at a dose of 1200 mg. Patients were followed for 72 wk and sustained response was assessed. RESULTS： Significant improvement in both end of treatment response （ETR）（P 〈 0.002） and sustained response （SR）（P 〈 0.05） was noted with pegylated interferon, where ETR was achieved in 29 （76.3%） and 14 patients （40%） in both groups respectively, and 25 patients in group A （65.8%） and 9 （25.7%） in group B could retain negative viraemia by the end of follow up period. Sustained virological response （SVR） showed a significant negative correlation with age and positive correlation with pretreatment inflammation in patients receiving PegIFN. Viral clearance after 3 mo of therapy was associated with high incidence of ETR and SR （P 〈 0.001）, but without significant difference between both forms of interferon. Significant improvement in response was achieved in patients with high grade fibrosis （grade 3 and 4） with PegIFN-α2a, where SR was seen in 5 out of 13 patients in group A, but none in group B. There was no significant difference in response between bilharzial and non-bilharzial patients in both groups. In terms of safety and tolerability, neutropenia was the predominant side effect, both drugs were comparable. CONCLUSION： PegIFN-~2a combined with ribavirin results in improvement in sustained response in HCV genotype 4, irrespective of history of bilharzial infestation.

关键词： Hepatitis C virus Genotype 4 Pegasys Bilharziasis

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Compliance with Malaria Rapid Diagnostic Test Results and Correlates among Clinicians in Uyo, Akwa Ibom State, Nigeria: 2018

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Open Journal of epidemiology 2019年第4期9卷 259-288页

作者： Goodwill B. Effah Bernadine Ekpenyong Gbadebo Babatunde Ikeoluwapo O. Ajayi David Dairo epidemiology and Medical statistics Unit Department of Public Health University of Calabar Calabar Nigeria department of epidemiology and Medical statistics University of Ibadan Ibadan Nigeria

Introduction: In sub-Saharan Africa, 80% to 85% of RDT negative febrile patients, seen in outpatient clinics, were given anti-malarial medicines. Previous studies recommended investigating determinants of “compliance with RDT’ results” in specific cadre and setting, as intervention is most effective when context specific. Compliance with malaria RDT results and correlates among clinicians in Uyo was determined. Methods: A cross-sectional study of clinicians selected using stratified sampling. Data were collected using self-administered, semi-structured questionnaire on socio-demographics, facility audit of RDT supplies, knowledge, perception and practice of clinicians. Outcome variable of interest was whether or not clinicians self-reported compliance with RDT results. Exposure variables of interest were whether or not clinicians received RDT training;received supportive supervision for malaria RDT;had positive perception of RDT usefulness;had good knowledge of RDT use (scores of ≥75% in questions testing for knowledge);had readily available treatment guidelines;had diagnostic capacity for other common febrile illness;experienced patient overload;experienced stock-out of supplies;work in the private/public sector. Descriptive, bivariate and multivariate analyses were conducted. Results: Mean age of the clinicians was 33.0 years ± (6.0 SD). Of the total clinicians, 31.1% were female;66.0% received RDT training;36.4% had supportive supervision;43.3% exhibited good knowledge of RDT use;45.3% had positive perception of RDT usefulness and 41.7% relied on presumptive diagnosis. Compliances with RDT negative and positive results were 66.4% and 83.4% respectively. Compliance with RDT negative result was more in clinicians with good knowledge of RDT use (aOR = 25.0;95% CI = 2.92 - 213.52). Compliance with RDT positive result was more in clinicians with good knowledge of RDT use (aOR = 10.0;95% CI =2.70 - 18.72), positive perception of RDT usefulness (aOR = 10.2;95%CI =3.50 -

关键词： Compliance Knowledge Perception Practice Malaria RDT Results

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Injury Morbidity between 2013 and 2018 in Hunan Province,China

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Biomedical and Environmental Sciences 2022年第3期35卷 263-269页

作者： WANG Wan Hui GAO De Yue HUA Jun Jie NING Pei Shan SCHWEBEL David C HU Guo Qing department of epidemiology and Health statistics Hunan Provincial Key Laboratory of Clinical EpidemiologyXiangya School of Public HealthCentral South UniversityChangsha 410083HunanChina Shanxi Bethune Hospital Taiyuan 030032ShanxiChina department of Psychology University of Alabama at BirminghamBirminghamAlabama35294United States of America

Accurate and timely injury statistics are critical to assess the severity of public health *** statistics allow researchers,practitioners,and policymakers to determine morbidity and mortality rate disparities across s... 详细信息

关键词： Hunan problems. policy

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CO_(2) combining power and outcomes in patients with acute ischaemic stroke or transient ischaemic attack

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Stroke & Vascular Neurology 2021年第2期6卷 252-259页

作者： Anxin Wang Xue Tian Hongqiu Gu Yingting Zuo Xia Meng Wei Lv Hao Li Yongjun Wang China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina department of epidemiology and Health statistics School of Public HealthCapital Medical UniversityBeijingChina Beijing Municipal Key Laboratory of Clinical epidemiology BeijingChina

Background and purpose The clinical significance of carbon dioxide combining power(CO_(2) CP)in ischaemic cerebrovascular disease is not well established,and the role of CO_(2) CP in the prognosis of acute ischaemic stroke(AIS)or transient ischaemic attack(TIA)has not been *** objective of the study was to investigate the associations between CO2CP and clinical outcomes in patients with AIS or *** Data were derived from the China National Stroke Registry *** were classified into five groups by quintiles of CO_(2) CP levels and three groups according to the normal range of CO_(2)CP(23-29 mmol/L).Multivariable Cox and logistic regressions were adopted to explore the associations of CO_(2) CP levels with all-cause death and poor functional outcomes(modified Rankin Scale(mRS)3-6/2-6)at 3 months and 1 *** Among 9531 patients included in the study,the median(IQR)CO_(2) CP was 24.9(23.0-27.0)mmol/*** adjustment for potential confounders,patients in the first CO_(2) CP quintile(21.1-23.3 mmol/L)had higher risk of all-cause death and poor functional outcomes(mRS score of 3-6/2-6)(HR or OR with 95% CI 2.37(1.32 to 4.25),1.49(1.20 to 1.83)and 1.21(1.03 to 1.42),respectively)compared with those in the fourth *** results were found for outcomes at 1 ***,all associations were also significant when CO_(2) CP was<23 mmol/L compared with CO_(2) CP of 23-29 mmol/*** Decreased CO_(2) CP was associated with high risk of all-cause death and poor functional outcomes in patients with AIS or TIA.

关键词： patients ischaemic acute

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Biliary spontaneous dislodgement spiral stent for patients who underwent mechanical lithotripsy

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World Journal of Gastroenterology 2020年第7期26卷 740-748页

作者： Lian-Song Ye Xiang-Lei Yuan Chun-Cheng Wu Wei Liu Jiang Du Ming-Hong Yao Qing-Hua Tan Bing Hu department of Gastroenterology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina department of epidemiology and Health statistics West China School of Public HealthSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND The incidence of post-endoscopic retrograde cholangiopancreatography(ERCP)cholangitis(PEC)in patients who underwent mechanical lithotripsy(ML)for large stone removal is high(up to 13.3%).One of the main causes is remaining small fragments or sludge that can impair normal biliary *** placement of a nasobiliary tube or a conventional plastic biliary stent has been commonly used under such conditions,but the patient may suffer from significant discomfort after the placement of a nasobiliary tube,while additional endoscopy is required for stent *** developed a biliary spontaneous dislodgement spiral stent(BSDSS)to overcome those *** To evaluate the feasibility,safety,and effectiveness of inserting a BSDSS for patients who underwent ML for large stone *** We conducted a single-center,retrospective,cohort study at West China Hospital,Sichuan University.A total of 91 consecutive patients with large biliary stones(≥10 mm)in the common bile duct who underwent ML between November 2017 and July 2018 were *** 49 eligible patients were divided into the BSDSS group and the nasobiliary tube *** success,post-ERCP adverse events(including PEC,post-ERCP pancreatitis,stone recurrence,BSDSS retention,self-extraction and dislocation of the nasobiliary tube),drainage time,and postoperative stay were measured and *** Twenty-one patients in the BSDSS group and 28 patients in the nasobiliary tube group were included in the *** baseline characteristics and clinical information were similar in the two *** of BSDSS and nasobiliary tube were technically successful in all 49 *** was no significant difference in the incidence of overall post-ERCP adverse events between the two groups(4.8%in the BSDSS group vs 17.9%in the nasobiliary tube group,P=0.219).The median duration of drainage time(3 d in the BSDSS group vs 4 d in the nasobiliary tube group)and length of postoperat

关键词： Cholangitis Choledocholithiasis Drainage Endoscopic nasobiliary drainage Mechanical lithotripsy Pancreatitis Spiral Stents

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Altered expression of MUC2 and MUC5AC in progression of colorectal carcinoma

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World Journal of Gastroenterology 2010年第32期16卷 4089-4094页

作者： Xiao-Dong Bu Nan Li Xiao-Qiang Tian Pei-Lin Huang Li Li Jin-Song Wang Xiao-Jin Yu department of Pathology School of Medicine Southeast University Nanjing 210009 Jiangsu Province China Nanjing First Hospital of Nanjing Medical University Nanjing 210006 department of epidemiology and statistics School of Public Health Southeast UniversityNanjing 210009 Jiangsu ProvinceChina

AIM:To study the expression profiles of MUC2 and MUC5AC in tumorigenesis of colorectal carcinoma and in its different pathologic ***:Formalin-fixed,paraffin-embedded human colorectal tissue specimens were immunostained with antibodies against MUC2 and *** samples of normal mucosa(NM),12 samples of hyperplastic polyp(HP),15 samples of tubular adenoma with low-grade dysplasia(LGD),14 samples of tubular adenoma with high-grade dysplasia(HGD),26 samples of conventional colorectal adenocarcinoma(CCA),15 samples of mucinous carcinoma(MC),and 8 samples of signetring cell carcinoma(SRCC) were ***:MUC2 was the most widely expressed protein in each study group,although the number of MUC2positive cases was less in CCA group than in other groups(P < 0.05).The staining score for MUC2 was significantly decreased in the HP-LGD-HGD-CCA sequence(r =-0.73436,P < 0.0001).Among the neoplasms,MC and SRCC were more frequently associated with the high expression of MUC2(P < 0.05) than with that of ***5AC expression was detected in all groups but not in NM ***,the staining score for MUC5AC was higher in HP,LGD,HGD,MC and SRCC groups than in NM and CCA groups(P < 0.05).The frequency of simultaneous expression of MUC proteins was significantly higher in MC and SRCC groups than in CCA group(P < 0.05).CONCLUSION:Alterations in MUC expression occur during colorectal *** transformation process in MC and SRCC may be different from that in the traditional adenoma-carcinoma sequence.

关键词： Colorectum Tumorigenesis MUC2 MUC5AC Immunohistochemistry

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Functional data analysis: An application to COVID-19 data in the United States in 2020

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Quantitative Biology 2022年第2期10卷 172-187页

作者： Chen Tang Tiandong Wang Panpan Zhang Research School of Finance Actuarial Studies&StatisticsThe Australian National UniversityCanberraACT 2601Australia department of statistics Texas A&M UniversityCollege StationTX 77843USA department of Biostatistics Epidemiology and InformaticsUniversity of PennsylvaniaPhiladelphiaPA 19104USA

Background: In this paper, we conduct an analysis of the COVID-19 data in the United States in 2020 via functional data analysis methods. Through this research, we investigate the effectiveness of the practice of public health measures, and assess the correlation between infections and deaths caused by the COVID-19. Additionally, we look into the relationship between COVID-19 spread and geographical locations, and propose a forecasting method to predict the total number of confirmed cases ***: The functional data analysis methods include functional principal analysis methods, functional canonical correlation analysis methods, an expectation-maximization (EM) based clustering algorithm and a functional time series model used for ***: It is evident that the practice of public health measures helps to reduce the growth rate of the epidemic outbreak over the nation. We have observed a high canonical correlation between confirmed and death cases. States that are geographically close to the hot spots are likely to be clustered together, and population density appears to be a critical factor affecting the cluster structure. The proposed functional time series model gives more reliable and accurate predictions of the total number of confirmed cases than standard time series ***: The results obtained by applying the functional data analysis methods provide new insights into the COVID-19 data in the United States. With our results and recommendations, the health professionals can make better decisions to reduce the spread of the epidemic, and mitigate its negative effects to the national public health.

关键词： COVID-19 canonical correlation cluster analysis functional time series forecasting principal component analysis

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