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中国解剖学会2019年年会

作者： Sun Lijuan Wang Tingting Lv Ying Yang Rui Yu Li department of Histology and embryology Weifang Medical University

To investigate the mechanism of cerebral cortex neuroinflammation in mice offspring after gestational exposure to PM

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Observation on In Situ Hybridization and Immunocytochemistry of Matrix Metalloproteinases in Rat Pancreas

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2003年第4期23卷 332-334页

作者：唐立华刘胜洪王芳刘子龙许耘王小丽李肇春 department of Histology and embryology department of Reproductive Medicine

In situ hybridization and immunocytochemical techniques were employed to examine the expression of matrix metalloproteinases 1 (MMP 1) and to identify the pattern of its distribution in rat pancreas. The results indicated that the signal of MMP 1 mRNA and MMP 1 positive immunoreaction were detected in some fiberoblasts around interlobular ducts and exocrine cell in margin acinus of some lobules, but the signal of MMP 1 mRNA and MMP 1 positive immunoreaction could not be detected in most of other acinus and islets of pancreas. It is concluded that the expression of MMP 1 in above cells of rat might play an important role in acinar proliferation and differentiation of rat pancreatic tissues.

关键词： matrix metalloproteinases 1 in situ hybridization pancreas rat

Induction of Sirt1-AMPK mediated autophagy improves the maturation and quality of the oocytes from aged mouse via reduction of ROS

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Induction of Sirt1-AMPK mediated autophagy improves the matu...

中国解剖学会2019年年会

作者： Liu Zhao-Jun Liu Er-Zhen Shen Xing-Hui Lei Lei department of Histology and embryology Harbin Medical University

＜正＞Maternal aging can cause reduced fertility, the main reasons for age-related changes is an reduce in oocyte quality due to an increase in reactive oxygen species （ROS）.Sirt1 belongs to the lysine deacetylase family.Several studies indicate that sirt1 can protect mouse oocytes against external oxidative stress,but there is still insufficient data for

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Mesoporous polydopamine nanoparticles carrying peptide RL-QN15 show potential for skin wound therapy

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Mesoporous polydopamine nanoparticles carrying peptide RL-QN...

中国解剖学会2021年年会

作者： Yang Xinwang Qin Pan department of Anatomy and Histology and embryology Kunming Medical University

Skin wound healing remains a considerable clinical challenge,thus stressing the urgent need for the development of new interventions to promote repair.Recent researches indicate that both peptides and nanoparticles ma...

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Interleukin 4-induced neuroprotection and regulation of microglia activation as a therapeutic approach in the MPTP model of Parkinson's disease

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Neural Regeneration Research 2017年第9期12卷 1433-1434页

作者： Bjorn Spittau Institute for Anatomy and Cell Biology Department of Molecular Embryology Faculty of Medicine University of Freiburg Institute of Anatomy University of Rostock

Parkinson＇s disease （PD） has been described as one of the most common neurodegenerative diseases affecting up to 2% of the worldwide population over 60 years of age. The hallmarks of PD are progressive loss of midbrain dopaminergic （mDA） neurons and a decrease in striatal dopamine levels, which result in typ- ical clinical motor symptoms such as akinesia, resting tremor, rigidity, and gait impairments. Although the causes for PD are only partially understood and seem to be very heterogeneous, one of the common phenomenons observed in toxin-based an- imal models of PD as well as PD patients is a microglia-driven neuroinflammatory response,

关键词：小胶质细胞动物模型白细胞介素4 帕金森病 MPTP 细胞活化神经保护诱导

Expression of vasa Gene in Development Process of Germ Cells in Male Rat

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Animal Husbandry and Feed Science 2016年第3期8卷 167-170,181页

作者： He Zhiquan Gao Yingdong Chen Wei Lu Xiang department of Histology and embryology Zunyi Medical College

In order to explore the role of vasa gene in the development of germ cells after gonad differentiation in male rats,the expression of vasa mRNA and vasa protein in 17.5-day-old fetal rats and neonatal rats was detected by real-time fluorescent quantitative PCR and immunohistochemistry method.The results showed that the expression of vasa mRNA was detected in the testis tissue of 17.5-day-old fetal rats and neonatal rats,and the expression of vasa mRNA in testis of neonatal rats was high than that in fetal rats.The expression of vasa protein was detected in neonatal rats,but it was not found in fetal rats.In conclusion,vasa gene plays an important role in the development of germ cells.However,as a marker,it can only be used to label all kinds of germ cells after formation of prespermatogonia.

关键词： vasa gene SD rat Prespermatogonia Germ cell

Epigallocatechin-3-gallate treatment to promote neuroprotection and functional recovery after nervous system injury

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Neural Regeneration Research 2015年第9期10卷 1390-1392页

作者： Pere Boadas-Vaello Enrique Verdú Research Group of Clinical Anatomy Embryology and Neuroscience (NEOMA) Universitat de Girona Faculty of Medicine Department of Medical Sciences

Traumatic spinal cord injury （SCI） causes motor paralysis, sensory anesthesia and autonomic dysfunction below the le- sion site and additionally some SCI patients refer neuropathic pain together with these signs and symptoms. Clinical and experimental studies have revealed the main pathological changes of injured spinal cord implicated in all these signs and symptoms, including neuropathic pain. After few hours of traumatic SCI, it is usual to observe broken blood brain barrier with plasma and blood cells extravasation, cell necrosis, disruption of ascending and descending spinal cord pathways and increased potassium and glutamate. Glutamate contributes to excitotoxicity of neurons whereas potassium facilitates ectopic depolarization of survival neurons and activation of resident microglia.

关键词： EGCG JAK STAT NF Epigallocatechin-3-gallate treatment to promote neuroprotection and functional recovery after nervous system injury SCI

Histological and ultrastructural changes induced by selenium in early experimental gastric carcinogenesis

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World Journal of Gastroenterology 2005年第29期11卷 4457-4460页

作者： Yan-Ping Su Jun-Min Tang Yan Tang Hui-Ying Gao department of Histology and embryology Taishan Medical College Taian 271000 Shandong Province China department of Histology and embryology Peking University Health Science Center Beijing 100083 China

AIM: To investigate the effect and significance of selenium in early experimental gastric carcinogenesis.METHODS: Weaning male Wistar rats were divided randomly into normal control group, experiment control group, low selenium (2 mg/L) group and high selenium (4 mg/L) group. Wistar rat gastric carcinogenesis was induced by N-methyl-N-nitro-N-nitroso guanidine (MNNG) (20 mg/kg) gavage daily for 10 d. Na2SeO3 was given by piped drinking 1 wk prior to MNNG gavage. The rats were killed at the 43rd wk. The surface characteristics of gastric mucosa were observed with naked eyes. Histopathologic changes of rat gastric mucosa were observed by HE staining and AB-PAS methods. The changes of cellular ultrastructure were observed under transmission electron microscope. Statistical analysis was carried out by SPSS.RESULTS: The incidence rate of gastric mucosa erosion,hemorrhage and intestinal metaplasia was 0, 45.5%,66.7%, and 92.9%, respectively (92.9% vs45.5%, P＜0.05)in the normal control group, experiment control group,low selenium group, and high selenium group. Leiomyoma formed in the process of inducement of rat gastric carcinoma. Dietary Na2SeO3 (2 and 4 mg/L) slightly increased the incidence rate of leiomyoma (0, 23%, 46.6%, and 46.6%). gastric mucosa did not change in the course of rat gastric carcinogenesis. Dietary Na2SeO3 by pipe drinking could expand the intracellular secretory canaliculus of parietal cells and increase the number of endocrine cells and lysosomes.CONCLUSION: Dietary Na2SeO3 by pipe drinking aggravates gastric erosion, hemorrhage and promotes intestinal metaplasia of gastric mucosa. The mechanism may be related with the function of parietal cells.

关键词：组织学硒元素胃癌实验研究

Astrocytic connexin 43 deletion promotes central nervous system remyelination by inhibiting local inflammation

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Astrocytic connexin 43 deletion promotes central nervous sys...

中国解剖学会2019年年会

作者： Tao Li Jianqin Niu Shouyu Wang Xing Gao Lan Xiao department of Histology and embryology Third Military Medical University

As the most abundant gap junction protein in the central nervous system(CNS),astrocytic connexin43 (Cx43) maintains astrocyte network homeostasis,affects oligodendroglial development and participates in CNS pathologies and injury progression,but its role in remyelination is not yet fully understood.To address this issue,we used the

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Ankfy1 is dispensable for neural stem/precursor cell development

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Neural Regeneration Research 2016年第11期11卷 1804-1809页

作者： Chao Weng Man Ding Lian-sheng Chang Ming-xin Ren Hong-feng Zhang Zu-neng Lu Hui Fu department of Neurology Renmin Hospital of Wuhan University department of Anatomy and embryology School of Basic Medical SciencesWuhan University department of Pathology Central Hospital of Wuhan Hubei-MOST KLOS & KLOBME

There are few studies on the membrane protein Ankfyl. We have found Ankfyl is specifically expressed in neural stem/precursor cells during early development in mice （murine）. To further explore Ankfyl function in neural development, we developed a gene knockout mouse with a mixed Balb/C and C57/BL6 genetic background. Using immunofluorescence and in situ hybridization, neural defects were absent in mixed genetic Ankfyl null mice during development and in adults up to 2 months old. However, Ankfyl gene knockout mice with a pure genetic background were found to be lethal in the C57/BL6 inbred mice embryos, even after seven generations of backcrossing. Polymerase chain reaction confirmed homozygotes were unattainable as early as embryonic day 11.5. We conclude that Ankfyl protein is dispensable in neural stem/precursor ceils, but could be critical for early embryonic murine development, depending on the genetic background.

关键词： nerve regeneration Ankfyl neural development genetic background protein function gene knockout neural stem/precursor cells embryo neural regeneration