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Identification of loop-vessel countercurrent arrangements in the early development of mouse kidney based on digital tracing and immunohistochemistry

Identification of loop-vessel countercurrent arrangements in...

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中国解剖学会2021年年会

作者： Deng Siqi Ma Yunsheng Chang Shijie Zhai Xiaoyue department of Histology and embryology China Medical University

The proper establishment of loop-vessel countercurrent arrangement in medulla provides the basis for formation of the concentrated urine.To date,the morphogenesis of it has not been fully discovered.The present study investigated the spatial arrangement of nephron loop and vessel of developing kidneys using 3D visualization technique and immunohistochemistry for AQP-1 and NKCC2.Five-mm-thick serial paraffin sections were obtained from E14.5 and P5 kidneys and stained with hematoxylin,while 2.5-mm-thick serial epoxy sections were obtained from E17.5 and P56 kidneys and stained with toluidine blue.

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Morphometric studies of the capillary loop stage glomerulus in developing mice

Morphometric studies of the capillary loop stage glomerulus ...

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中国解剖学会2021年年会

作者： Song Kexin Zhang Jie Zhai Xiaoyue department of Histology and embryology China Medical University

The effective filtration area is determined by the length of capillaries in the glomerulus,however,a quantitative morphological data describing it is not available.Present study aims at quantitatively describing the development of the capillary loop stage glomerulus (capG) with respect to the volume density of the glomerular capillary endothelial cells based on the kidney morphogenesis.

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Proteomics of spermatogenesis： from protein lists to understanding the regulation of male fertility and infertility

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Asian Journal of Andrology 2011年第1期13卷 18-23页

作者： Xiaoyan Huang Jiahao Sha Lab of Reproductive Medicine Department of Histology and Embryology Nanjing Medical University Nanjing 210029 China

Proteomic technologies have undergone significant development in recent years, which has led to extensive advances in protein research. Currently, proteomic approaches have been applied to many scientific areas, including basic research, various disease and malignant tumour diagnostics, biomarker discovery and other therapeutic applications. In addition, proteomics-driven research articles examining reproductive biology and medicine are becoming increasingly common. The key challenge for this field is to move from lists of identified proteins to obtaining biological information regarding protein function. The present article reviews the available scientific literature related to spermatogenesis. In addition, this study uses two-dimensional electrophoresis mass spectrometry （2DE-MS） and liquid chromatography （LC）-MS to construct a series of proteome profiles describing spermatogenesis. This large-scale identification of proteins provides a rich resource for elucidating the mechanisms underlying male fertility and infertility.

关键词： infertility male fertility proteomics spermatogenesis

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The role of SALL2 and its interaction with p21 in motor neuron degeneration of ALS

The role of SALL2 and its interaction with p21 in motor neur...

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中国解剖学会2021年年会

作者： Wang Xuemei Wangqing Chen Yanchun Guan yingjun Gao Xueshuai department of Histology and embryology Weifang Medical University

Amyotrophic lateral sclerosis is a neurodegenerative disease characterized by the progressive loss of motor neurons.SALL2 is novel interacting protein of neurotrophin receptors.Sall2 suppresses tumorigenesis by the activation of P21 promoter.To explore the relationship between the expression of SALL2 and P21 and the pathogenesis of ALS, ALS transgenic mice and wild-type mice at different stages were selected,and the spinal cords were isolated.

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Principle of relative positioning of structures in the human body

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Neural Regeneration Research 2013年第9期8卷 853-856页

作者： Buliang Meng Ailan Pang Ming Li department of Human Anatomy Histology and embryology Kunming Medical University department of Neurology First Affiliated Hospital of Kunming Medical University

The arrangement of various biological structures should generally ensure the safety of crucial structures and increase their working efficiency; however, other principles governing the relative positions of structures in humans have not been reported. The present study therefore investigated other principles using nerves and their companion vessels in the human body as an example. Nerves and blood vessels usually travel together and in the most direct way towards their targets. Human embryology, histology, and gross anatomy suggest that there are many possible positions for these structures during development. However, for mechanical reasons, tougher or stronger structures should take priority. Nerves are tougher than most other structures, followed by arteries, veins, and lymphatic vessels. Nerves should therefore follow the most direct route, and be followed by the arteries, veins, and lymphatic vessels. This general principle should be applicable to all living things.

关键词： neural regeneration reviews principle position anatomy human embryology histology neuroregeneration

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Leishmania donovani:Immune response and immune evasion with emphasis on PD-1/PDL-1 pathway and role of autophagy

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Asian Pacific Journal of Tropical Medicine 2021年第5期14卷 195-208页

作者： Samar Habib Manar Azab Khaled Elmasry Aya Handoussa department of Medical Parasitology Faculty of MedicineMansoura UniversityMansouraEgypt department of Human Anatomy and embryology Faculty of MedicineMansoura UniversityMansouraEgypt

Leishmania donovani is one of the causative agents of visceral leishmaniasis.The immune response against Leishmania depends on CD4^(+)T helper type 1 cells.The immune system is unable to combat Leishmania because the parasite can exert several immune suppressive mechanisms that facilitate escaping the immune responses.One of these mechanisms is the up-regulation of programmed death-1/programmed death ligand-1 pathway which causes T cells to undergo exhaustion.Autophagy is strongly linked to the immune response,with some research indicating that activating autophagy reduces the immune response to some intracellular pathogens,while others indicate that activating autophagy limits the growth of intracellular pathogens.Leishmania was found to subvert the host defense mechanisms for its own persistence,such as Leishmania-induced autophagy modulation.Leishmania was reported to activate autophagy in different studies,thus getting a dual benefit by evading the immune system and simultaneously utilizing the autophagy byproducts as nutrients.In this review,we introduced different immune evasion/suppressive mechanisms used by Leishmania,and different immunotherapies which were developed accordingly.We focused on the programmed death-1/programmed death ligand-1 pathway as well as autophagy with the potential interplay of both mechanisms.

关键词： Leishmania donovani PD-1/PDL-1 Autophagy Immune response Immunity

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The mechanism of ethanol exposure on osteogenesis and blood vessel development in chick embryo

The mechanism of ethanol exposure on osteogenesis and blood ...

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中国解剖学会2019年年会

作者： Guang Wang Ping Zhang Jia-hui Nie Yu Yan Xin Cheng Xuesong Yang department of Histology and embryology Jinan University

＜正＞It is now known that excess alcohol consumption during pregnancy can cause fetal alcohol syndrome and abortion.We firstly used the chick embryo model to investigate the effects of ethanol on endochondral and intramembranous ossification in long and flat bones.Histological examination revealed that ethanol exposure reduced the width of the proliferation and

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MiR-590-5p suppresses renal fibrosis via targeting YAP

MiR-590-5p suppresses renal fibrosis via targeting YAP

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中国解剖学会2021年年会

作者： Wang Kaiyue Wan Pengzhi Zou Yu Li Xue Xing Jia Deng Siqi Zhai Xiaoyue department of Histology and embryology China Medical University

Persistent activation of Yes-associated protein (YAP) is profoundly implicated in facilitating transformation of myofibroblasts.However,its roles in the pathogenesis of renal fibrosis remain largely unexplored.In the present study,an upregulation of YAP was detected by qRTPCR,Western blotting,and immunohistochemistry both in the kidney tissues of folic acid (FA)-induced chronic kidney disease (CKD) mice,and in SV40MES 13 cells stimulated with TGF-β1.

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Roxadustat(FG-4592) pretreatment attenuates folic acid induced kidney injury via mitophagy

Roxadustat(FG-4592) pretreatment attenuates folic acid induc...

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中国解剖学会2021年年会

作者： Zou Yu Li Xue Wang Kaiyue Xing Jia Wan Pengzhi Cong Jing Fu Yuanyuan Song Kexin Deng Siqi Zhai Xiaoyue department of Histology and embryology China Medical University

Hypoxia precondition plays a protective role in tissues injured by oxidative stress.Whether or not mitophagy is involved needs to be explored.In the present study,the acute kidney injury model was established by folic acid(FA) administration.Roxadustat (FG-4592),a stabilizer of hypoxia-inducible factor (HIF) was used 2 days before FA insult to mimic hypoxia precondition.

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Gestational vitamin B supplementation alleviates neurodevelopmental abnormalities induced by PM2.5 in mice offspring

Gestational vitamin B supplementation alleviates neurodevelo...

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中国解剖学会2021年年会

作者： Wang Tingting Sun Lijuan Liu Chong Lyu Ying Zhang Tianliang Yu Li department of Histology and embryology Weifang Medical University

Gestational exposure to PM leads to neurodevelopmental impairment in offsprings.However,no effective means has been found to alleviate the neurodevelopmental impairment of embryos induced by PM.To clarify the effects of vitamin B on anti-inflammatory,antioxidant,synaptic remodeling and neuroprotection, we used it in a mouse model simulating gestational exposure to PM.

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