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A facile phototheranostic nanoplatform integrating NIR-Ⅱ fluorescence/PA bimodal imaging and image-guided surgery/PTT combinational therapy for improved antitumor efcacy

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Journal of Materials Science & Technology 2022年第35期130卷 208-218页

作者： Xiuping Han Wenyou Fang Tianqi Zhang Xuan Zhong Kun Qian Zhitao Jiang Rongfeng Hu Guoqiang Shao Lei Zhang Qing Zhang department of Pharmaceutics and Key Laboratory of Cardiovascular&Cerebrovascular Medicine School of PharmacyNanjing Medical UniversityNanjing 211166China State Key Laboratory of Organic electronics and Information Displays&Institute of Advanced Materials(IAM) Nanjing University of Posts&TelecommunicationsNanjing 210023China department of Nuclear Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 211166China Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application Anhui Province Engineering Technology Research Center of Modern Pharmaceutical PreparationAnhui University of Chinese MedicineHefei 230012China department of Nuclear Medicine Taizhou People’s HospitalNanjing University of Chinese MedicineTaizhou 225300China Center for Molecular Imaging Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China

Phototheranostic with highly integrated functions is an attractive platform for cancer management. It remains challenging to develop a facile phototheranostic platform with complementary bimodal imaging and combinational therapy capacity. Herein, the small-molecule cyanine IR780 loaded liposomes have been harnessed as a nanoplatform to simultaneously realize photoacoustic(PA)/the second near-infrared window(NIR-Ⅱ) fluorescence imaging and image-guided surgery/adjuvant photothermal therapy(PTT).This nanoplatform exhibits attractive properties like uniform controllable size, stable dispersibility, NIR-Ⅱ fluorescence emission, photothermal conversion, and biocompatibility. Benefiting from the complementary PA/NIR-Ⅱ fluorescence bimodal imaging, this nanoplatform was successfully applied in precise vasculature delineation and tumor diagnosis. Interestingly, the tumor was clearly detected by NIR-Ⅱ fluorescence imaging with the highest tumor-to-normal-tissue ratio up to 12.69, while signal interference from the liver was significantly reduced, due to the difference in the elimination rate of the nanoplatform in the liver and tumor. Under the precise guidance of the image, the tumor was accurately resected, and the simulated residual lesion after surgery was completely ablated by adjuvant PTT. This combined therapy showed improved antitumor efcacy over the individual surgery or PTT. This work develops a facile phototheranostic nanoplatform with great significance in accurately diagnosing and effectively treating tumors using simple NIR light irradiation.

关键词： NIR-Ⅱfluorescence imaging Photoacoustic imaging Image-guided surgery Adjuvant photothermal therapy Phototheranostics

Saliency Preserved Image Fusion Using Nonsubsampled Contourlet Transform

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Saliency Preserved Image Fusion Using Nonsubsampled Contourl...

Fiber Laser Based Hydrophone Systems

2013年中国智能自动化学术会议

作者： Liang Xu Junping Du Qingping Li JangMyung Lee Beijing Key Laboratory of Intelligent Telecommunication Software and Multimedia School of Computer ScienceBeijing University of Posts and Telecommunications department of electronics engineering Pusan National University

The visual attention model inspired by the early primate visual system is a very important tool in image *** on the visual attention model, the paper proposes a novel saliency preserved image fusion algorithm with a nonsubsampled contourlet transform(NSCT).The basic idea is that the visual saliency map is first built on the coefficients of the NSCT using the visual attention model,and then is combined with the coefficients of the NSCT to form the activity level which is employed to select the final fused *** algorithm can transform successfully the visual sensitive information from source images into the fused image which contains abundant detailed contents and preserves effectively the saliency structure while enhances the image *** demonstrate that the proposed algorithm yields the encouraging results.

关键词： Saliency map Nonsubsampled contourlet transform Image fusion

来源： cnki会议评论

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Photonic Sensors 2011年第3期1卷 210-221页

作者： Asrul Izam AZMI Ian LEUNG Xiaobao CHEN Shaoling ZHOU Qing ZHU Kan GAO Paul CHILDS Gangding PENG School of Electrical engineering and telecommunications The University of New South Wales NSW 2052 Australia 23rd Research Institute China Electronic Technology Group Corporation ShanghaL 200437 China department of electronics Tsinghua University Beijing 100084 China

We report our recent work on distributed feedback fiber laser based hydrophones. Some issues related to sensitivity, such as fiber laser phase condition, demodulation, and packaging, are also discussed. With the development of appropriate digital signal processing （DSP） techniques and packaging designs, an interferometric-type distributed feedback （DFB） fiber laser hydrophone system with acoustic sensitivity of 58.0 dB·re·uPa-Hz-0.5 at 1 kHz or a minimum detectable acoustic pressure below 800 uPa during field test is attained. We have also investigated an intensity-type DFB fiber laser hydrophone system and its performance.

关键词： Fiber laser hydrophone interferometric acoustic sensitivity

Design and Implementation of Double Base Integer Encoder of Term Metrical to Direct Binary

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Journal of Signal and Information Processing 2013年第4期4卷 370-374页

作者： Takialddin A. Al Smadi department of Communications and electronics engineering College of Engineering Jerash University Jerash Jordan.

The digital processing signal is one of the subdivisions of the analog digital converter interface;data transfer rate in modern telecommunications is a critical parameter. The greatest feature of parallel conversion rate (4-bit parallel Flash 5/s converter) is designed and modeled in 0.18 micron CMOS technology. Low speed swing operation as analog and digital circuits leads to high speed of low power operation power with 70 mVt 1.8 V A/D converter from the power dissipated during operation in the 5 GHz range. Average offset is used to minimize the effect of the bias of a comparator. This paper contains the 8-bit encoder of the metrical term code to direct binary code decreasing power consumption, which is shown by results and comparison with other designs using computer simulation. The results of the flash ADC time-interleaved are a more significant improvement in terms of power and areas than those previously reported.

关键词： ADC CMOS VLSI High Speed Data Converters Code

Design of an 8 bit differential paired eFuse OTP memory IP reducing sensing resistance

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Journal of Central South university 2012年第1期19卷 168-173页

作者： JANG Ji-Hye 金丽妍 JEON Hwang-Gon KIM Kwang-Il HA Pan-Bong KIM Young-Hee department of Electronic engineering Changwon National University9 Sarim-DongChangwon 641-773Korea

For the conventional single-ended eFuse cell, sensing failures can occur due to a variation of a post-program eFuse resistance during the data retention time and a relatively high program resistance of several kilo ohms. A differential paired eFuse cell is designed which is about half the size smaller in sensing resistance of a programmed eFuse link than the conventional single-ended eFuse cell. Also, a sensing circuit of sense amplifier is proposed, based on D flip-flop structure to implement a simple sensing circuit. Furthermore, a sensing margin test circuit is proposed with variable pull-up loads out of consideration for resistance variation of a programmed eFuse. When an 8 bit eFuse OTP IP is designed with 0.18 ~tm standard CMOS logic of TSMC, the layout dimensions are 229.04 μm ×100.15μm. All the chips function successfully when 20 test chips are tested with a program voltage of 4.2 V.

关键词： eFuse differential paired efuse cell one time programmable memory sensing resistance D flip-flop based sense amplifier

调控分子间的电子耦合效应实现多彩超长有机室温磷光

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Science China Materials 2023年第12期66卷 4749-4755页

作者：佘鹏飞段嘉宇李飞阳周宇翔秦妍妍魏娟刘淑娟马云赵强 State Key Laboratory of Organic electronics and Information Displays&Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)&Institute of Flexible Electronics(Future Technology)Nanjing University of Posts and Telecommunications(NUPT)Nanjing 210023China department of Applied Biologyand Chemical Technology and Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHung HomHong Kong(China)and the Hong Kong Polytechnic University Shenzhen Research InstituteShenzhen 518057China School of Environmental and Chemical engineering Jiangsu University of Science and TechnologyZhenjiang 212100China College of Electronic and Optical engineering&College of Flexible electronics(Future Technology) Jiangsu Province Engineering Research Center for Fabrication and Application of Special Optical Fiber Materials and DevicesNanjing University of Posts and Telecommunications(NUPT)Nanjing 210023China

有机超长室温磷光聚合物因其优异的可加工性、灵活性和可重复性等特点,在各种光电应用中表现出巨大的应用潜力.然而,实现全彩的室温磷光仍然是一个挑战.在本文中,我们通过在聚乙烯醇中掺杂不同浓度的三苯基膦盐,成功制备了一系列余晖颜... 详细信息

有机超长室温磷光聚合物因其优异的可加工性、灵活性和可重复性等特点,在各种光电应用中表现出巨大的应用潜力.然而,实现全彩的室温磷光仍然是一个挑战.在本文中,我们通过在聚乙烯醇中掺杂不同浓度的三苯基膦盐,成功制备了一系列余晖颜色可调的有机室温磷光聚合物(从蓝色到红色).实验和理论计算证明:室温磷光聚合物颜色的宽范围调控归因于掺杂体膦盐分子间的电子耦合作用大小.此外,这些多彩的磷光聚合物可应用于柔性3D显示和防伪.

关键词： electronic coupling room-temperature phosphorescence polymer continuous RTP band tuning full-color RTP secure information printing

Image enhancement with intensity transformation on embedding space

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CAAI Transactions on Intelligence Technology 2024年第1期9卷 101-115页

作者： Hanul Kim Yeji Jeon Yeong Jun Koh department of Applied Artificial Intelligence Seoul National University of Science and TechnologySeoulSouth Korea department of Computer Science and engineering Chungnam National UniversityDaejeonSouth Korea

In recent times,an image enhancement approach,which learns the global transformation function using deep neural networks,has gained ***,many existing methods based on this approach have a limitation:their transformation functions are too simple to imitate complex colour transformations between low-quality images and manually retouched high-quality *** order to address this limitation,a simple yet effective approach for image enhancement is *** proposed algorithm based on the channel-wise intensity transformation is ***,this transformation is applied to the learnt embedding space instead of specific colour spaces and then return enhanced features to *** this end,the authors define the continuous intensity transformation(CIT)to describe the mapping between input and output intensities on the embedding ***,the enhancement network is developed,which produces multi-scale feature maps from input images,derives the set of transformation functions,and performs the CIT to obtain enhanced *** experiments on the MIT-Adobe 5K dataset demonstrate that the authors’approach improves the performance of conventional intensity transforms on colour space ***,the authors achieved a 3.8%improvement in peak signal-to-noise ratio,a 1.8%improvement in structual similarity index measure,and a 27.5%improvement in learned perceptual image patch ***,the authors’algorithm outperforms state-of-the-art alternatives on three image enhancement datasets:MIT-Adobe 5K,Low-Light,and Google HDRþ.

关键词： computer vision deep learning image enhancement image processing

Efficient Object Localization Scheme Based on Vanishing Line in Road Image for Autonomous Vehicles

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Journal of Computer and Communications 2021年第9期9卷 85-97页

作者： Bongkyo Moon Jiwon Choi Juehyun Lee Minyoung Lee department of Computer Science and engineering Dongguk University Seoul South Korea Graduate School of Information Security KAIST Daejeon South Korea electronics and telecommunications Research Institute (ERTI) Daejeon South Korea

This paper proposes an efficient object localization method based on a vanishing line. The proposed method can be much improved in time efficiency since it requires scanning only vanishing line area. It requires the time complexity of O(n) while the existing sliding window method requires the time complexity O(n2) for detecting all objects in the entire image. In addition, the range of detection area can be also remarkably reduced when compared with the sliding window method. As a result, the total range and times for searching in the proposed method can be significantly reduced by considering together the distance and position of the object. The experiment on the proposed method is performed with the virtual road data set known as SYNTHIA, and the competitive results are obtained.

关键词： Object Localization Image Preprocessing Sliding Window Vanishing Line Autonomous Vehicle

Mitochondria-targeted Janus mesoporous nanoplatform for tumor photodynamic therapy

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Chinese Chemical Letters 2024年第2期35卷 544-547页

作者： Min Dong Rui Tang Jing Li Jiajia Zhao Yu Wang Lin Ouyang Wei Lu Jun Tao Meng Dang Yuxia Tang Zhaogang Teng Key Laboratory for Organic electronics & Information Displays and Jiangsu Key Laboratory for Biosensors Institute of Advanced MaterialsJiangsu National Synergetic Innovation Centre for Advanced MaterialsNanjing University of Post and TelecommunicationsNanjing 210023China Laboratory of Molecular Imaging Department of RadiologyThe First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China department of Radiology The 909th HospitalSoutheast HospitalSchool of MedicineXiamen UniversityZhangzhou 363000China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringInstitute of Functional MaterialsDonghua UniversityShanghai 201620China

Photodynamic therapy(PDT)is an effective treatment method for *** the specifically accumulated of photosensitizer was very difficult in the tumor site,which greatly limited the efficacy of ***,mitochondria-targeted Janus mesoporous nanoplatform(JPMO-Pt-CTPP-ZnPc)for PDT was prepared,the nanoplatform has uniform size(275 nm)and good dispersion and *** confocal laser scanning microscopy(CLSM)revealed the signal of ZnPc of JPMO-Pt-CTPP-ZnPc were higher than JPMO-Pt-ZnPc in tumor cells,and flow cytometry results showed the cell uptake efficiency of JPMO-Pt-CTPP-ZnPc was 2.5-fold higher than that of *** revealed the modification of CTPP significantly improves the targeting ability of the *** vitro anti-tumor experiment showed the JPMO-Pt-CTPP-ZnPc significantly inhibited the growth of tumor cells upon the irradiation of low-power laser,and the survival rate of cells incubated with 60μg/mL JPMO-Pt-CTPP-ZnPc was only 3%.Simultaneously,compared with JPMO-Pt-ZnPc(not modified with mitochondria targeting molecules CTPP),the PDT efficacy of JPMO-Pt-CTPP-ZnPc was significantly better,as it has targeted mitochondria in cells.

关键词： Mesoporous materials Janus particle Photodynamic therapy Mitochondria targeting Tumor treatment