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diagnostic significance of complete blood cell count and hemogramderived markers for neonatal sepsis at Southwest Public Hospitals,Ethiopia

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World Journal of Clinical Pediatrics 2024年第2期13卷 114-126页

作者： Dereje Abebe Regassa Rahel Shumi Nagaash Bisirat Fikadu Habtu Woyesa Beyene Haile department of Medical Laboratory Sciences Wolkite UniversityWolkite 11330Ethiopia department of Medical Laboratory Sciences Dire Dawa UniversityDire Dawa 3000Ethiopia

BACKGROUND Neonatal sepsis is defined as an infection-related condition characterized by signs and symptoms of bacteremia within the first month of *** is the leading cause of mortality and morbidity among *** several studies have been conducted in other parts of world to assess the usefulness of complete blood count parameters and hemogram-derived markers as early screening tools for neonatal sepsis,the associations between sepsis and its complications with these blood parameters are still being investigated in our setting and are not yet part of routine *** To evaluate the diagnostic significance of complete blood cell count hemogramderived novel markers for neonatal sepsis among neonates attending public hospitals in the southwest region of Oromia,Ethiopia,through a case control *** A case control study was conducted from October 2021 to October 2023 Sociodemographic,clinical history,and laboratory test results data were collected using structured *** collected data were entered into Epi-data 3.1 version and exported to SPSS-25 for ***-square,independent sample ttest,and receiver operator characteristics curve of curve were used for analysis.A P-value of less than 0.05 was considered statistically *** In this study,significant increases were observed in the following values in the case group compared to the control group:In white blood cell(WBC)count,neutrophils,monocyte,mean platelet volume(MPV),neutrophils to lymphocyte ratio,monocyte to lymphocyte ratio(MLR),red blood cell width to platelet count ratio(RPR),red blood width coefficient variation,MPV to RPR,and platelet to lymphocyte *** MLR,a cut-off value of≥0.26 was found,with a sensitivity of 68%,a specificity of 95%,a positive predictive value(PPV)of 93.2%,and a negative predictive value(NPV)of 74.8%.The area under the curve(AUC)was 0.828(P<0.001).For WBC,a cutoff value of≥11.42 was identified,with a sensitivity of 55%,a s

关键词： Complete blood count Hemogram-derived marker Neonate Sepsis Ethiopia

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Integrative bioinformatics and in vitro exploration of EVI2A expression:unraveling its immunological and prognostic implications in kidney renal clear cell carcinoma

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Oncology Research 2024年第11期32卷 1733-1746页

作者： RONG LIU SHENG LI SITU XIONG FUCUN ZHENG XIANGPENG ZHAN JIN ZENG BIN FU SONGHUI XU SHAOXING ZHU RU CHEN department of Urology Fujian Medical University Union HospitalFuzhou350000China department of Urology The First Affiliated Hospital of Nanchang UniversityNanchang350000China

EVI2A has emerged as a significant biomarker in various diseases;however,its biological role and mechanism in kidney renal clear cell carcinoma(KIRC)remains *** used TCGA and GEO databases to analyze EVI2A gene expression comprehensively and performed pan-cancer *** relevance was evaluated through Kaplan-Meier analysis and ROC *** gene’s immune relevance was explored through analyses of the tumor microenvironment(TME),Tumor Immune Single-cell Hub(TISCH),immune checkpoints,and immunotherapy *** results indicate that EVI2A expression is upregulated in KIRC,showing correlations with tumor grade and T/N/M ***2A demonstrates high diagnostic accuracy(AUC=0.906)and predicts poor overall and progression-free survival in KIRC ***,EVI2A expression exhibits significant associations with immunity,including TME scores and specific immune cell types such as Tfh cells,CD4 memory T cells,and CD8+T *** EVI2A expression suggests increased sensitivity to PD-1/CTLA-4 and tyrosine kinase *** vitro assays confirmed the impact of EVI2A on KIRC behavior,with its knockdown resulting in reduced cell proliferation and *** conclusion,our comprehensive analysis identifies EVI2A as a promising biomarker and a novel therapeutic target for intervening in *** findings hold significant implications for further research and potential clinical applications.

关键词： EVI2A Kidney Renal Clear Cell Carcinoma(KIRC) Prognosis Immunological analysis

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The generation and use of animal models of osteosarcoma in cancer research

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Genes & Diseases 2024年第2期11卷 664-674页

作者： Feifei Pu Haoyu Guo Deyao Shi Fengxia Chen Yizhong Peng Xin Huang Jianxiang Liu Zhicai Zhang Zengwu Shao department of Orthopedics Wuhan Hospital of Traditional Chinese and Western Medicine (Wuhan No.1 Hospital)Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China department of Radiation and Medical Oncology Zhongnan HospitalWuhan UniversityWuhanHubei 430071China Hubei Cancer Clinical Study Center Zhongnan HospitalWuhan UniversityWuhanHubei 430071China

Osteosarcoma is the most common malignant bone tumor affecting children and ***,the most common treatment is surgery combined with neoadjuvant *** the survival rate of patients with osteosarcoma has improved in recent years,it remains poor when the tumor(s)progress and distant metastases ***,better animal models that more accurately replicate the natural progression of the disease are needed to develop improved prognostic and diagnostic markers,as well as targeted therapies for both primary and metastatic *** present review described animal models currently being used in research investigating osteosarcoma,and their characteristics,advantages,and *** models may help elucidate the pathogenic mechanism(s)of osteosarcoma and provide evidence to support and develop clinical treatment strategies.

关键词： Animal model Cancer Osteosarcoma Pathogenic mechanism Translational research

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Morphometry and Significance of Collodiaphyseal Angle among Bini Tribe in Southern Nigeria

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Journal of Forensic Science and Medicine 2024年第1期10卷 20-23页

作者： Dayo Rotimi Omotoso Uche Christiana Okwuonu Emmanuel Olusola Yawson Paul Olugbemiga Awoniran department of Human Anatomy Redeemer’s UniversityEdeOsun StateNigeria department of Anatomy Igbinedion UniversityOkadaEdo StateNigeria

Introduction:The collodiaphyseal angle(CDA)is an angle formed between the femoral neck and femoral shaft *** is a vital determinant of femoral neck fracture as narrower angle is often used as a predictor of stress *** is also important in orthopedic treatment planning,especially hip replacement ***:This study was carried out to evaluate the CDA values among the Bini tribe and elucidate its ***:This study employed 200 anterior-posterior pelvic radiographs of the Bini tribe(100 males and 100 females)aged between 25 and 55 years obtained from selected radiological diagnostic centers in Benin City,Nigeria,after obtaining the Institutional Ethical *** were used to evaluate the right and left CDA as an angle formed by intersection of the femoral neck and shaft axes and measured using the *** were statistically analyzed using IBM-SPSS(version 20)with the mean,standard deviation,and range evaluated,and side and gender comparisons were done using t-test,and P0.05).Conclusion:The CDA can be employed as a morphometric indicator of sexual differences and for other clinical applications.

关键词： Bini tribe collodiaphyseal angle human morphometry Nigeria

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Computed tomography radiogenomics:A potential tool for prediction of molecular subtypes in gastric stromal tumor

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1296-1308页

作者： Xiao-Nan Yin Zi-Hao Wang Li Zou Cai-Wei Yang Chao-Yong Shen Bai-Ke Liu Yuan Yin Xi-Jiao Liu Bo Zhang Gastric Cancer Research Center West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina department of Paediatric Surgery West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina department of Radiology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina department of Gastrointestinal Surgery Sichuan University West China HospitalChengdu 610041Sichuan ProvinceChina

BACKGROUND Preoperative knowledge of mutational status of gastrointestinal stromal tumors(GISTs)is essential to guide the individualized precision *** To develop a combined model that integrates clinical and contrast-enhanced computed tomography(CE-CT)features to predict gastric GISTs with specific genetic mutations,namely KIT exon 11 mutations or KIT exon 11 codons 557-558 *** A total of 231 GIST patients with definitive genetic phenotypes were divided into a training dataset and a validation dataset in a 7:3 *** models were constructed using selected clinical features,conventional CT features,and radiomics features extracted from abdominal CE-CT *** models were developed:ModelCT sign,modelCT sign+rad,and model CTsign+rad+*** diagnostic performance of these models was evaluated using receiver operating characteristic(ROC)curve analysis and the Delong *** The ROC analyses revealed that in the training cohort,the area under the curve(AUC)values for model_(CT sign),model_(CT sign+rad),and modelCT_(sign+rad+clinic)for predicting KIT exon 11 mutation were 0.743,0.818,and 0.915,*** the validation cohort,the AUC values for the same models were 0.670,0.781,and 0.811,*** predicting KIT exon 11 codons 557-558 deletions,the AUC values in the training cohort were 0.667,0.842,and 0.720 for model_(CT sign),model_(CT sign+rad),and modelCT_(sign+rad+clinic),*** the validation cohort,the AUC values for the same models were 0.610,0.782,and 0.795,*** on the decision curve analysis,it was determined that the model_(CT sign+rad+clinic)had clinical significance and *** Our findings demonstrate that the combined modelCT_(sign+rad+clinic)effectively distinguishes GISTs with KIT exon 11 mutation and KIT exon 11 codons 557-558 *** combined model has the potential to be valuable in assessing the genotype of GISTs.

关键词： Gastrointestinal stromal tumor Radiomics Gene mutation Computed tomography Model

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Uncertainty-Aware Deep Learning: A Promising Tool for Trustworthy Fault Diagnosis

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1317-1330页

作者： Jiaxin Ren Jingcheng Wen Zhibin Zhao Ruqiang Yan Xuefeng Chen Asoke K.Nandi School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710049China department of Electronic and Electrical Engineering Brunel University LondonKingston LaneUxbridgeUB83PHUK IEEE

Recently,intelligent fault diagnosis based on deep learning has been extensively investigated,exhibiting state-of-the-art ***,the deep learning model is often not truly trusted by users due to the lack of interpretability of“black box”,which limits its deployment in safety-critical applications.A trusted fault diagnosis system requires that the faults can be accurately diagnosed in most cases,and the human in the deci-sion-making loop can be found to deal with the abnormal situa-tion when the models *** this paper,we explore a simplified method for quantifying both aleatoric and epistemic uncertainty in deterministic networks,called *** SAEU,Multivariate Gaussian distribution is employed in the deep architecture to compensate for the shortcomings of complexity and applicability of Bayesian neural *** on the SAEU,we propose a unified uncertainty-aware deep learning framework(UU-DLF)to realize the grand vision of trustworthy fault ***,our UU-DLF effectively embodies the idea of“humans in the loop”,which not only allows for manual intervention in abnor-mal situations of diagnostic models,but also makes correspond-ing improvements on existing models based on traceability ***,two experiments conducted on the gearbox and aero-engine bevel gears are used to demonstrate the effectiveness of UU-DLF and explore the effective reasons behind.

关键词： Out-of-distribution detection traceability analysis trustworthy fault diagnosis uncertainty quantification.

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Linear endoscopic ultrasound:Current uses and future perspectives in mediastinal examination

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World Journal of Gastroenterology 2024年第33期30卷 3803-3809页

作者： Eyad Gadour Sarah Al Ghamdi Bogdan Miutescu Hossam E Shaaban Zeinab Hassan Aymen Almuhaidb Hussein H Okasha department of Gastroenterology and Hepatology King Abdulaziz National Guard HospitalAhsa 36428Saudi Arabia department of Internal Medicine Zamzam University CollegeSchool of MedicineKhartoum 11113Sudan department of Medicine Division of GastroenterologyKing Abdulaziz UniversityJeddah 3646Saudi Arabia department of Gastroenterology and Hepatology Victor Babes University of Medicine and PharmacyTimisoara 300041Romania Advanced Regional Research Center in Gastroenterology and Hepatology Victor Babes University of Medicine and PharmacyTimisoara 300041Romania department of Internal Medicine and Gastroenterology NhtmriCairo 11796Egypt department of Internal Medicine Stockport Hospitals NHS Foundation TrustManchester SK27JEUnited Kingdom department of Gastroenterology King Faisal Specialist Hospital and Research CenterRiyadh 11211Saudi Arabia department of Internal Medicine Division of Gastroenterology and HepatologyKasr Al-Aini School of MedicineCairo UniversityCairo 11562Egypt

This editorial elaborates on the current and future applications of linear endoscopic ultrasound(EUS),a substantial diagnostic and therapeutic modality for various anatomical *** scope of endosonographic assessment is broad and,among other factors,allows for the evaluation of the mediastinal anatomy and related pathologies,such as mediastinal lymphadenopathy and the staging of central malignant lung ***,EUS assessment has proven more accurate in detecting small lesions missed by standard imaging examinations,such as computed tomography or magnetic resonance *** focus on its current uses in the mediastinum,including lung and esophageal cancer staging,as well as evaluating mediastinal lymphadenopathy and submucosal *** editorial also explores future perspectives of EUS in mediastinal examination,including ultrasound-guided therapies,artificial intelligence integration,advancements in mediastinal modalities,and improved diagnostic approaches for various mediastinal lesions.

关键词： Linear endoscopic ultrasound Mediastinal examination Lung cancer Computed tomography Magnetic resonance imaging

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diagnostic Value of GDF10 for the Tumorigenesis and Immune Infiltration in Lung Squamous Cell Carcinoma

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Current Medical Science 2024年第2期44卷 309-327页

作者： Xiao-jun WANG Jia-ping CHEN Xin-wei QIAO Wang-yang MENG Yang-wei WANG Yun-chong MENG Rong ZHAO Wei LIN Yong-de LIAO Han XIAO Pei-yuan MEI department of Thoracic Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China department of Thoracic Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021China

Objective:Lung squamous cell carcinoma(LUSC)is associated with a low survival *** suggests that bone morphogenetic proteins(BMPs)and their receptors(BMPRs)play crucial roles in tumorigenesis and ***,a comprehensive analysis of their role in LUSC is *** study aimed to explore the relationship between BMPs/BMPRs expression levels and the tumorigenesis and prognosis of ***:The“R/Limma”package was utilized to analyze the differential expression characteristics of BMPs/BMPRs in LUSC,using data from TCGA,GTEx,and GEO ***,the“survminer”packages were employed to investigate their prognostic value and correlation with clinical features in *** core gene associated with LUSC progression was further explored through weighted gene correlation network analysis(WGCNA).LASSO analysis was conducted to construct a prognostic risk model for *** specimens were examined by immunohistochemical analysis to confirm the diagnostic value in ***,based on the tumor immune estimation resource database and tumor-immune system interaction database,the role of the core gene in the tumor microenvironment of LUSC was ***:GDF10 had a significant correlation only with the pathological T stage of LUSC,and the protein expression level of GDF10 decreased with the tumorigenesis of LUSC.A prognostic risk model was constructed with GDF10 as the core gene and 5 hub genes(HRASLS,HIST1H2BH,FLRT3,CHEK2,and ALPL)for ***10 showed a significant positive correlation with immune cell infiltration and immune checkpoint ***:GDF10 might serve as a diagnostic biomarker reflecting the tumorigenesis of LUSC and regulating the tumor immune microenvironment to guide more effective treatment for LUSC.

关键词： lung squamous cell carcinoma tumorigenesis bone morphogenetic protein GDF10 tumor immune microenvironment

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pH-Responsive Theranostic Colloidosome Drug Carriers Enable Real-Time Imaging of Targeted Thrombolytic Process with Near-Infrared-II for Deep Venous Thrombosis

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Research 2024年第3期2024卷 17-33页

作者： Yaxin Ye Zhechang Chen Shengzhang Zhang Paul Slezak Fei Lu Ruiqi Xie Dongwon Lee Guangqian Lan Enling Hu State Key Laboratory of Resource Insects College of SericultureTextile and Biomass SciencesSouthwest UniversityChongqing 400715China department of Cardiovascular Medicine Yueqing People's Hospital.Wenzhou 325699China Ludwig Boltzmann Institute for Traumatology AUVA Research Center1200 ViennaAustria department of Bionanotechnology and Bioconvergence Engineering and department of Polymer-Nano Science and Technology Jeonbuk National UniversityJeonjuChonbuk 54896Republic of Korea School of Fashion and Textiles The Hong Kong Polytechnic UniversityHong KongChina

Thrombosis can cause life-threatening disorders. Unfortunately, current therapeutic methods for thrombosis using injecting thrombolytic medicines systemically resulted in unexpected bleeding complications. Moreover, the absence of practical imaging tools for thrombi raised dangers of undertreatment and overtreatment. This study develops a theranostic drug carrier, Pkr(IR-Ca/Pda-uPA)-cRGD, that enables real-time monitoring of the targeted thrombolytic process of deep vein thrombosis (DVT). Pkr(IR-Ca/Pda-uPA)-cRGD, which is prepared from a Pickering-emulsion-like system, encapsulates both near-infrared-II (NIR-II) contrast agent (IR-1048 dye, loading capacity: 28%) and urokinase plasminogen activators (uPAs, encapsulation efficiency: 89%), pioneering the loading of multiple drugs with contrasting hydrophilicity into one single-drug carrier. Upon intravenous injection, Pkr(IR-Ca/Pda-uPA)-cRGD considerably targets to thrombi selectively (targeting rate: 91%) and disintegrates in response to acidic thrombi to release IR-1048 dye and uPA for imaging and thrombolysis, respectively. Investigations indicate that Pkr(IR-Ca/Pda-uPA)-cRGD enabled real-time visualization of targeted thrombolysis using NIR-II imaging in DVT models, in which thrombi were eliminated (120 min after drug injection) without bleeding complications. This may be the first study using convenient NIR-II imaging for real-time visualization of targeted thrombolysis. It represents the precision medicine that enables rapid response to acquire instantaneous medical images and make necessary real-time adjustments to diagnostic and therapeutic protocols during treatment.

关键词： Infrared enable eliminated

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Influence of transcatheter arterial embolization on symptom distress and fatigue in liver cancer patients

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 810-818页

作者： Xu-Min Yang Xu-Yan Yang Xin-Yu Wang Yue-Xia Gu department of Nursing The First Affiliated Hospital of Naval Medical University(Changhai Hospital)Shanghai 200433China department of Thyroid Breast and Vascular SurgeryShanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China department of Nursing Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China

BACKGROUND Hepatocellular carcinoma(HCC)is a prevalent malignancy,and transcatheter arterial embolization(TAE)has emerged as a pivotal therapeutic ***-ever,TAE may induce symptom distress and fatigue,adversely affecting the quality of life of *** To investigate symptom distress,fatigue,and associated factors in HCC patients undergoing *** We used a cross-sectional design and purposive sampling to enroll HCC patients who underwent TAE at our institution from January to December ***-naires were utilized to collect data on symptom distress and fatigue scores from the first to the third day after *** Our study revealed a significant reduction in fatigue and symptom distress among patients after ***,fatigue,insomnia,fever and abdominal dis-tension were the most common symptoms troubling patients during the first 3 d *** status,presence of family support,physical functional status,age,and symptom distress were identified as predictors of fatigue in *** Healthcare professionals should educate HCC patients on symptom distress and INTRODUCTION Hepatocellular carcinoma(HCC)ranks as the fifth most prevalent cancer and the third leading cause of cancer-related mortality *** intervention remains the cornerstone of HCC treatment;however,due to the challenges associated with early diagnosis and the lack of specific diagnostic markers,a considerable proportion of patients are diagnosed at advanced stages,rendering them ineligible for surgical *** arterial embolization(TAE)is an interventional therapeutic approach involving the insertion of a fine catheter via the femoral artery to reach the vasculature near the tumor *** aims to obstruct the arterial supply to the tumor by deploying embolic agents,thereby inducing necrosis in cancer *** procedure is suitable for patients with good liver function and overall health,particularly those with large HCCs that ha

关键词： Transcatheter arterial embolization Fatigue Symptom distress Hepatocellular carcinoma Influencing factors

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