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Acquired Syphilis in a Chinese Family among Three Generations

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Chinese Medical Journal 2018年第14期131卷 1761-1762页

作者： Fu-Quan Long Li-Shi Zhao Jia Chen department of Sexually Transmitted Diseases Shanghai Dermatology Hospital Shanghai 200443 China department of dermatopathology Shanghai Dermatology Hospital Shanghai 200443 China

To the Editor： Syphilis is primarily a sexually transmitted disease caused by Treponema pallidum, which can be present in various body fluids such as blood, saliva, sperm, cerebrospinal fluid, and also in active skin lesions,i^i Acquired syphilis contracted by Children is highly attributed to sexual abuse; however, infection can also occur by nonsexual contact： for example, prechewing feeding, kissing, fondling, or by contaminated utensils, particularly when family members or caregivers have active syphilis.

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Inhibitory Effects of Berberine on the Activation and Cell Cycle Progression of Human Peripheral Lymphocytes

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Cellular & Molecular Immunology 2005年第4期2卷 295-300页

作者： Lihui Xu Yi Liu Xianhui He Key Laboratory of Ministry of Education for Tissue Transplantation and Immunology College of Life Science and Technology Jinan University Guangzhou 510632 China Institute of Bioengineering Jinan University Guangzhou 510632 China department of dermatopathology Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing 210042 China

The immunosuppressive property of berberine, an isoquinoline alkaloid, has been well documented, but the mechanism of its action on lymphocytes has not been completely elucidated. The present study is to investigate the effect of berberine on the activation and proliferation of lymphocytes, in particular T lymphocytes. Whole peripheral blood from healthy donors was stimulated with phytohemagglutinin （PHA） alone or phorbol dibutyrate （PDB） plus ionomycin, and the expression of CD69 and CD25 on T lymphocytes was evaluated with flow cytometry. The distribution of cell cycles and cell viability were analyzed by staining with propidium iodide （PI） and 7-aminoactinomycin D （7-AAD）, respectively. The results showed that 100 μmol/L and 50 μmol/L of berberine significantly inhibited CD69 expression on T cells stimulated with PDB plus ionomycin or PHA, whereas the effect of 25 μmol/L berberine was not significant. As the incubation time increased, the extent of inhibition decreased. Similarly, the expression of CD25 was also reduced by berberine in a dose-dependent manner over the concentration range of 25-100 μmol/L. Besides, this alkaloid could block lymphocyte cell cycle progression from G0/G1 phase to S and G2/M phase without phase specificity. Moreover, analysis following 7-AAD staining revealed that berberine had no significant cytotoxicity on lymphocytes. Taken together, berberine significantly inhibits the expression of activation antigens on T lymphocytes and also blocks the progression of cell cycles of lymphocytes, suggesting that berberine may exert immunosuppressive effect through inhibiting the activation and proliferation of T cells.

关键词： berberine lymphocyte activation antigen cell cycle

Somatic genetic alterations in melanoma:Implications for diagnosis,classification,and therapy stratification

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Somatic genetic alterations in melanoma:Implications for dia...

Cutaneous perivascular epithelioid cell tumors:A review on an infrequent neoplasm

中华医学会第十八次全国皮肤性病学术年会

作者： Boris C.Bastian department of Dermatology Dermatopathology Section.UCSF Cardiovascular Research Institute

Melanomas show distinct patterns of clinical and genetic features,suggesting the existence of biologically distinct subtypes that differ in their requirements for clinical *** mutations in BRAF occur predominantly in melanomas on the intermittently sun-exposed skin such as the trunk and proximal extremities,BRAF mutations are infrequent in melanomas that arise on skin with chronic sun-induced

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来源： cnki会议评论

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World Journal of Methodology 2016年第1期6卷 87-92页

作者： Mar Llamas-Velasco Luis Requena Thomas Mentzel department of Dermatology Hospital Universitario de La Princesa department of Dermatology Fundación Jiménez Díaz department of dermatopathology Dermatohis- topathologisches Gemeinschaftslabor

"Perivascular epithelioid cutaneous" cell tumors(PEComa) are a family of mesenchymal tumors with shared microscopic and immunohistochemical properties: They exhibit both smooth muscle cell and melanocytic differentiation. Non-neoplastic counterpart of PEComa's cells are unknown, as well as the relationship between extracutaneous PEComa and primary cutaneous ones. We will review the clinical setting, histopathologic features, chromosomal abnormalities, differential diagnosis and treatment options for cutaneous PEComa.

关键词： Perivascular epithelioid cell tumor Skin Cutaneous perivascular epithelioid cell tumors Clear cell myomelanocytic tumor

Expression and Purification of Soluble Human Programmed Death-1 in Escherichia coli

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Cellular & Molecular Immunology 2006年第2期3卷 139-143页

作者： Lihui Xu Yi Liu Xianhui He Institute of Bioengineering College ot Life Science and lecnnology Jinan University Guangzhou 510632 China Institute of Tissue Transplantation and Immunology College of Life Science and Technology Jinan University Guangzhou 510632 China department of dermatopathology Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing 210042 China

Programmed death-1 （PD-1）, a member of CD28 family, is able to negatively regulate the TCR complex-initiated signaling by interacting with its cognate ligands （PD-L1 and/or PD-L2）. PD-1/PD-L1 pathway plays an important role in down-regulating the effective phase of adaptive immune responses and the blockade of this pathway has been proved to enhance antiviral and antitumoral immunity, suggesting that it might be a potential target for the development of therapies to improve T cell responses in patients with virus infections or malignancies. In present study, the extracellular domain of human PD-1 with a carboxyl terminal His-tag （designated as sPD-1） was expressed as inclusion bodies in Escherichia coll. The product was on-column refolded, purified by immobilized metal affinity chromatography, and characterized by Western blotting. Furthermore, the soluble PD-1 with high purity possessed specific binding activity with its cognate ligand PD-L1, and the dissociation constant was 0.43 nmol/L as determined by Scatchard plot analysis. These results suggest that refolded sPD-1 from prokaryotic cells may be of therapeutic interest in enhancing antivirus and antitumoral immune responses.

关键词： PD-1 extracellular domain prokaryotic expression inclusion body binding activity

Cutaneous Metastases Arising from Synovial Sarcoma： A Case Report

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Chinese Medical Journal 2017年第24期130卷 3019-3020页

作者： Xue Zeng Li Li Wa-Li Liu department of Dermatology Guang'anmen Hospital China Academy of Chinese Medical Sciences Beijing 100053 China department of dermatopathology Guang'anmen Hospital China Academy of Chinese Medical Sciences Beijing 100053 China

To the Editor：Synovial sarcoma （SS） is a relatively rare type of soft tissue sarcoma that constitutes approximately 8% of all soft tissue *** frequently occurs in the para-articular structures of the limbs and is predominantly found in the lower *** other involved locations of invasion are lung,lymph nodes,and ***,the skin is rarely involved.[1-3] Here,we reported an extremely rare case ofbiphasic SS presenting with disseminated cutaneous metastases.

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Treatment of Wrinkles and Acne Scars Using the TriFractional, a Novel Fractional Radiofrequency Technology—Clinical and Histological Results

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Journal of Cosmetics, Dermatological Sciences and Applications 2012年第3期2卷 117-125页

作者： Alex Levenberg Andrea Gat Marie Christine Branchet Sylvie Boisnic dermatopathology Unit Sourasky Medical Center Tel Aviv Israel GREDECO Research Group Paris France Physicians Center Plastic Surgery Department Tel Aviv Israel

Introduction: The need for cosmetic facial enhancement procedures with minimal down time and low risk has led to the development of methods for non-surgical skin rejuvenation. Various ablative lasers were developed, which remove the full skin surface in a controlled manner. However, the prolonged recovery and the significant risks prompted the development of fractional lasers which ablate the skin in a fractional manner, leaving untreated areas to improve healing process. In the past few years, fractional radiofrequency (RF) systems have been introduced that enable controlled skin resurfacing accompanied with dermal collagen remodeling. The new TriFractional technology from Pollogen? is designed to enable skin resurfacing and treatment of wrinkles using RF energy. The objective of the current research was to evaluate the safety and effectiveness of the novel TriFractional technology using the TriFractional applicator (A3F) for micro-ablative skin resurfacing and the treatment of wrinkles and acne scars. Methods: Healthy volunteers consented to undergo TriFractional treatments for various aesthetic indications. In addition, in-vivo and ex-vivo histologycal results showing immediate and long term effects of the TriFractional technology were obtained. A portion of the subjects underwent the complete TriLipo MedTM Procedure which includes 2 TriFractional treatments spaced one month apart, with 2 TriLipo RF + Dynamic Muscle Activation (DMA) face treatments two weeks after each TriFractional treatment. Results: Subjects experienced an improvement of wrinkles, skin texture and acne scars along with facial contouring. No significant adverse effects were detected post-treatment. Histology findings demonstrated immediate and long term TriFractional effects on both epidermal and dermal skin layers. Conclusions: TriFractional is a promising technology for skin resurfacing, treatment of wrinkles and improvement of additional aesthetic indications such as acne scars. The TriLipo

关键词： Radiofrequency Trifractional Wrinkles Acne Scars Collagen

Chromoblastomycosis:a tropical-subtropical fungal disease with pathognomonic features not to be neglected in a global health scenario

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Clinical Research Communications 2023年第1期6卷 1-4页

作者： Larissa de Andrade Defendi Giuliano Ferreira Morgantetti Guilherme Alencar de Medeiros Marcelo Balancin department of Radiology Escola Paulista de MedicinaSão Paulo/SP 04024-002Brazil department of dermatopathology NORDD PathologyFortaleza/CE 60140-110Brazil department of Pathology FOSPOncocentro FoundationSão Paulo/SP 04024-002Brazil

Chromoblastomycosis(CBM)is a fungal disease,distributed in tropical and subtropical regions,affecting mainly rural *** is characterized by chronic skin lesions that may vary from nodular,tumorous,verrucous or plaque *** constitutional symptoms are rarely *** histological presentation may yield a pathognomonic feature,the Medlar(sclerotic)bodies,in which a typical brown to black pigment is depicted,explaining“copper pennies”as its *** this article,the case of a 56-year-old woman in the countryside of Brazil is reported,whose main complaint was a chronic leg ulcer for the past 8 *** left leg had a large,partially ulcerated plaque lesion was *** cultures were positive for the *** analysis demonstrated pseudoepitheliomatous hyperplasia,lymphohistiocytic infiltrate and sclerotic bodies(“copper pennies”).CBM’s epidemiological panorama,once established uniquely by geographical distribution,is transitioning to a global health issue,influenced by immunosuppressive conditions,global warming and *** scenario demands CBM to be widely considered as a differential diagnosis and may represent a clinical challenge in regions whose professionals have little expertise in infectious tropical diseases.

关键词： chromoblastomycosis fungal infection histopathology global health

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脂膜炎的病理诊断线索分析

中华皮肤科杂志 2021年第10期54卷 931-933页

作者：王艳青郭莹山西医科大学第二医院皮肤科太原030001 Ackerman Academy of dermatopathology New York 10016

脂膜炎是累及皮下脂肪组织的一组皮肤病,包括原发性脂膜炎以及继发性(炎症和肿瘤)脂膜炎。作者根据其炎症反应模式和脂肪坏死类型,结合在美国Ackerman皮肤病理学院学习体会,对各种原发性脂膜炎的病理变化进行梳理,提出脂膜炎的诊断线索... 详细信息

脂膜炎是累及皮下脂肪组织的一组皮肤病,包括原发性脂膜炎以及继发性(炎症和肿瘤)脂膜炎。作者根据其炎症反应模式和脂肪坏死类型,结合在美国Ackerman皮肤病理学院学习体会,对各种原发性脂膜炎的病理变化进行梳理,提出脂膜炎的诊断线索,希望能为脂膜炎的病理诊断提供思路。

关键词：脂膜炎脂肪坏死中性白细胞巨细胞血管炎