检索结果-南通市图书馆

Piceatannol enhances Beclin-1 activity to suppress tumor progression and its combination therapy strategy with everolimus in gastric cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2023年第2期66卷 298-312页

作者： Longtao Huangfu Xiaoyang Wang Shanshan Tian Junbing Chen Xueying Wang Biao Fan Qian Yao Gangjian Wang Cong Chen Jing Han Xiaofang Xing Jiafu Ji Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Division of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital&InstituteBeijing 100142China department of Pharmacy Peking University Cancer Hospital&InstituteBeijing 100142China National Institute on Drug dependence Peking UniversityBeijing 100191China Gastrointestinal Cancer Center Peking University Cancer Hospital&InstituteBeijing 100142China department of Pathology Peking University Cancer Hospital&InstituteBeijing 100142China

The effects and regulation of Beclin-1-an autophagy-related protein-have not been fully defined, however, a negative correlation has been reported between Beclin-1 expression and carcinogenesis. Meanwhile, no compound has been shown to directly inhibit its activity. Here, we evaluate piceatannol, a naturally occurring polyphenolic compound, as a potential targeting agonist of Beclin-1, to assess its efficacy as an antitumor agent against gastric cancer. More specifically, we determine the effects of piceatannol treatment on cell viability using a monitoring system and colony forming assay. Piceatannol was found to efficiently inhibit the proliferation of several human gastric cancer cell lines. Autophagic flux is increased by piceatannol treatment, and correlates with inhibition of cell proliferation and colony formation. Additionally, microscale thermophoresis and surface plasmon resonance results show a direct interaction between piceatannol and Beclin-1, which reduces the phosphorylation activity of Beclin-1 at the Ser-295 site. Notably, piceatannol impairs the binding of Beclin-1 to Bcl-2 and enhances the recruitment of binding of UV radiation resistance-associated gene protein, which further triggers Beclin-1-dependent autophagy signaling. An increase in autophagic activity via treatment with the mTOR inhibitor, everolimus, effectively sensitizes piceatannol-induced antitumor effects. Xenograft models confirmed that piceatannol inhibits tumor development and elicits a potent synergistic effect with everolimus in vivo. Taken together, the findings of this study strongly support the application of combinatorial piceatannol and everolimus therapy in future clinical trials for gastric cancer patients.

关键词： piceatannol Beclin-1 autophagy everolimus gastric cancer drug synergy

Notification Rate of Tuberculosis among Migrants in China 2005-2014： A Systematic Review and Meta-analysis

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2016年第15期129卷 1856-1860页

作者： Yi-Xuan Sun Lei Zhu Zu-Hong Lu Zhong-Wei Jia department of Drug Epidemiology National Institute of Drug Dependence Health Science Center Peking University Beijing 100191 China department of Epidemiology and Biostatistics School of Public Health Health Science Center Peking University Beijing 100191 China department of Biomedical Engineering College of Engineering Peking University Beijing 100871 China

Background： Migrations have been reported to be associated with the high risk of tuberculosis （TB）, but there is no systematic analysis of the available data for TB among migrant in China. The aim of this study was to examine the notification rate of active and sputum smear-positive TB by a systematic review and meta-analysis. Methods： A systematic review and meta-analysis were performed to examine the notification rate of active and sputum smear-positive TB among migrants in China. Two reviewers searched the cross-sectional studies published in PubMed, EMBASE, SciFinder, and Web of Science in English and in CNKI and Wanfang databases in Chinese. Pooled estimates of notification rate of TB among migrants were calculated using a random effects model. Meta-regression analysis and subgroup analysis stratified by year, region were also performed. Results： Seventy eligible studies met the inclusion criteria for the final analysis. The overall notification rate of active TB and sputum smear-positive cases among migrants were 53.12 （95% confidence interval [CI]： 47.32 59.63） and 24.53 （95% Cl： 22.01-27.34） per 100,000 populations, respectively. The notification rate of active TB significantly increased from 50.95 （95% CI： 41.11 -63.14） per 100,000 populations in 2005 to 84.62 （95% CI： 78.00-91.80） per 100,000 populations in 2014 while that of smear-positive TB was constant during the study time （P = 0.79）. The geographic difference was identified both for active and sputum smear-positive TB, with the higher notification rates mainly distributing along the eastern coastal areas. Conclusions： The pooled estimate of active TB and sputum smear-positive TB among migrants was lower than the national notification rate among general population, but the gap between our data and national notification rate among general population is narrowed down during 2005-2014.

关键词： Meta-analysis Migrants Notification Rate Systematic Review Tuberculosis

Psychological impact of the COVID-19 pandemic on healthcare workers:a cross-sectional study in China

在线全文

学校读者我要写书评

暂无评论

General Psychiatry 2020年第3期33卷 156-167页

作者： Jianyu Que Le Shi Jiahui Deng Jiajia Liu Li Zhang Suying Wu Yimiao Gong Weizhen Huang Kai Yuan Wei Yan Yankun Sun Maosheng Ran Yanping Bao Lin Lu Peking University Sixth Hospital Peking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)BeijingChina National Institute on Drug dependence and Beijing Key Laboratory on Drug dependence Research Peking UniversityBeijingChina Mental Health Institute of Inner Mongolia Autonomous Region HohhotInner MongoliaChina Xiamen City Xianyue Hospital XiamenFujianChina Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research BejjingChina department of Social Work and Social Administration University of Hong KongHong KongChina

Background Healthcare workers fighting against the coronavirus disease 2019(COVID-19)pandemic are under tremendous pressure,which puts them at an increased risk of developing psychological *** This study aimed to investigate the prevalence of psychological problems in different healthcare workers(ie,physicians,medical residents,nurses,technicians and public health professionals)during the COVID-19 pandemic in China and explore factors that are associated with the onset of psychological problems in this population during this public health *** A cross-sectional,web-based survey was conducted in February 2020 among healthcare workers during the COVID-19 *** problems were assessed using the Generalized Anxiety Disorder Scale,Patient Health Questionnaire and Insomnia Severity *** regression analyses were used to explore the factors that were associated with psychological *** The prevalence of symptoms of anxiety,depression,insomnia and the overall psychological problems in healthcare workers during the COVID-19 pandemic in China was 46.04%,44.37%,28.75%and 56.59%,*** prevalence of the overall psychological problems in physicians,medical residents,nurses,technicians and public health professionals was 60.35%,50.82%,62.02%,57.54%and 62.40%,*** with healthcare workers who did not participate in front-line work,front-line healthcare workers had a higher risk of anxiety,insomnia and overall psychological *** addition,attention to negative or neutral information about the pandemic,receiving negative feedback from families and friends who joined front-line work,and unwillingness to join front-line work if given a free choice were three major factors for these psychological *** Psychological problems are pervasive among healthcare workers during the COVID-19 *** negative information and participating in front-line work appear to *** ris

关键词： nurse workers sectional

Clinical profile and outcomes of hepatocellular carcinoma in primary Budd-Chiari syndrome

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第3期16卷 699-715页

作者： Ankit Agarwal Sagnik Biswas Shekhar Swaroop Arnav Aggarwal Ayush Agarwal Gautam Jain Anshuman Elhence Arun Vaidya Amit Gupte Ravi Mohanka Ramesh Kumar Ashwani Kumar Mishra Shivanand Gamanagatti Shashi Bala Paul Subrat Kumar Acharya Akash Shukla Shalimar department of Gastroenterology and Human Nutrition All India Institute of Medical SciencesNew Delhi 110029DelhiIndia department of Gastroenterology Seth Gordhandas Sunderdas Medical College and KEM HospitalMumbai 400012MaharashtraIndia department of Gastroenterology Sir HN Reliance Foundation HospitalMumbai 400004India department of Liver Transplant and HPB Sir HN Reliance Foundation HospitalMumbai 400004India department of Gastroenterology All India Institute of Medical SciencesPatna 801507India Professor of Biostatistics National Drug Dependence Treatment Centre(NDDTC)All India Institute of Medical SciencesNew Delhi 110029India department of Radiodiagnosis All India Institute of Medical SciencesNew Delhi 110029DelhiIndia

BACKGROUND There is scant literature on hepatocellular carcinoma(HCC)in patients with Budd-Chiari syndrome(BCS).AIM To assess the magnitude,clinical characteristics,feasibility,and outcomes of treatment in *** A total of 904 BCS patients from New Delhi,India and 1140 from Mumbai,India were *** prevalence and incidence of HCC were determined,and among patients with BCS-HCC,the viability and outcomes of interventional therapy were *** In the New Delhi cohort of 35 BCS-HCC patients,18 had HCC at index presentation(prevalence 1.99%),and 17 developed HCC over a follow-up of 4601 person-years,[incidence 0.36(0.22-0.57)per 100 person-years].BCS-HCC patients were older when compared to patients with BCS alone(P=0.001)and had a higher proportion of inferior vena cava block,cirrhosis,and long-segment vascular *** median alpha-fetoprotein level was higher in patients with BCS-HCC at first presentation than those who developed HCC at follow-up(13029 ng/mL vs 500 ng/mL,P=0.01).Of the 35 BCS-HCC,26(74.3%)underwent radiological interventions for BCS,and 22(62.8%)patients underwent treatment for HCC[transarterial chemoembolization in 18(81.8%),oral tyrosine kinase inhibitor in 3(13.6%),and transarterial radioembolization in 1(4.5%)].The median survival among patients who underwent interventions for HCC compared with those who did not was 3.5 years vs 3.1 mo(P=0.0001).In contrast to the New Delhi cohort,the Mumbai cohort of BCS-HCC patients were predominantly males,presented with a more advanced HCC[Barcelona Clinic Liver Cancer C and D],and 2 patients underwent liver *** HCC is not uncommon in patients with *** interventions and liver transplantation are feasible in select primary BCS-HCC patients and may improve outcomes.

关键词： Budd chiari syndrome Cancer Cirrhosis Thrombosis Liver Varices Transarterial chemoembolization Hepatic venous outflow tract obstruction

Prevalence of substance use among moroccan adolescents and association with academic achievement

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2015年第4期5卷 425-431页

作者： Fatima El Omari Stacy Salomonsen-Sautel Analice Hoffenberg Tyler Anderson Christian Hopfer Jallal Toufiq Arrazi University Psychiatric Hospital of Salé CHU Ibn Sina Rabat-Salé University Mohammed V~(th) of Rabat Medical School Division of Substance dependence Department of Psychiatry University of Colorado Denver School of Medicine

AIM: To investigate rates of drug and alcohol use and their association with academic performance in Moroccan youth. METHODS: An adapted version of the European School Project on Alcohol and Other Drugs survey was administered to 2139 10^(th)-12^(th) graders in 36 Moroccan public high schools. Two multiple logistic regressions were completed, one for male and one for female subjects. Grade average was used as a two-part outcome variable, and drug use was used as a four-level categorical independent variable. Parents' education levels and socioeconomic status were included as covariates. RESULTS: Of the subjects, 181 girls(16%) and 390 boys(40%) reported ever having used alcohol, hashish, or psychotropic drugs. Girls who had used any of those substances in the past 30 d demonstrated an adjusted odds ratio(AOR) of 2.62(95%CI: 1.31-5.22) of having average or below-average grades, and those with any lifetime use showed an AOR of 1.72(95%CI: 1.07-2.77). Among the boys, use in the past 30 d was associated with an AOR of 2.08(95%CI: 1.33-3.24) of average or below average grades, and use in the last 12 mo with an AOR of 1.74(95%CI: 1.00-3.05). Any lifetime use among male and previous 12 mo use among female subjects were not significantly associated with academic ***: Among Moroccan adolescents, drug use is substantially different between boys and girls. In both genders, lower academic achievement was associated with alcohol, hashish, or psychotropic drug use in the last 30 d.

关键词： Morocco Academic performance Drug and alcohol use Adolescence

Complement Factor H Displays Opposite Expression Patterns Under Two Situations of Methamphetamine Administration:Acute Exposure and Chronic dependence

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2020年第12期36卷 1558-1562页

作者： Ming Lin Jiamin Xu Zhimin Liu Liang Qin Xiaodong Wang Xiaoping Pu National Key Research Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing 100191China department of Molecular and Cellular Pharmacology School of Pharmaceutical SciencesPeking UniversityBeijing 100191China National Institute on Drug dependence Peking UniversityBeijing 100191China Centre for Imaging and Systems Biology Minzu University of ChinaBeijing 100081China College of Life and Environmental Sciences Minzu University of ChinaBeijing 100081China

Dear Editor,Methamphetamine(METH)is a highly addictive central nervous system stimulant that has severe physical and psychological side-effects,including loss of appetite,hyperactivity,dysphoria,and depression[1].Due to its illegal production,distribution,sale,and possession it has become a worldwide *** is directly toxic to dopaminergic and serotoninergic neurons,resulting in excitotoxicity,oxidative stress,and other processes[2].Research on biomolecules associated with these processes will be useful for identifying potential markers,exploring the mechanism of METH dependence,and even developing prevention and treatment strategies.

关键词： prevention identifying burden

Abnormal function of the posterior cingulate cortex in heroin addicted users during resting-state and drug-cue stimulation task

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2013年第4期126卷 734-739页

作者： LI Qiang YANG Wei-chuan WANG Ya-rong HUANG Yu-fang LI Wei ZHU Jia ZHANG Yi ZHAO Li-yan QIN Wei YUAN Kai Karen M. von Deneen WANG Wei TIAN Jie department of Radiology Tangdu Hospital the Fourth Military Medical University Xi'an Shaanxi 710038 China Life Sciences Research Center School of Life Sciences and Technology Xidian University Xi'an Shaanxi 710071 China National Institute on Drug dependence Peking University Beijing100191 China

Background Previous animal and neuroimaging studies have demonstrated that brain function in heroin addicted users is impaired. However, the posterior cingulate cortex （PCC） has not received much attention. The purpose of this study was to investigate whether chronic heroin use is associated with craving-related changes in the functional connectivity of the PCC of heroin addicted users. Methods Fourteen male adult chronic heroin users and fifteen age and gender-matched healthy subjects participated in the present study. The participants underwent a resting-state functional magnetic resonance imaging （fMRI） scan and a cue-induced craving task fMRI scan. The activated PCC was identified in the cue-induced craving task by means of a group contrast test. Functional connectivity was analyzed based on resting-state fMRI data in order to determine the correlation between brain regions. The relationship between the connectivity of specific regions and heroin dependence was investigated. Results The activation of PCC, bilateral anterior cingulate cortex, caudate, putamen, precuneus, and thalamus was significant in the heroin group compared to the healthy group in the cue-induced craving task. The detectable functional connectivity of the heroin users was stronger between the PCC and bilateral insula, bilateral dorsal striatum, right inferior parietal Iobule （IPL） and right supramarginal gyrus （P 〈0.001） compared to that of the healthy subjects in the resting-state data analysis. The strength of the functional connectivity, both for the PCC-insula （r=0.60, P 〈0.05） and for PCC-striatum （t=0.58, P 〈0.05）, was positively correlated with the duration of heroin use. Conclusion The altered functional connectivity patterns in the PCC-insula and PCC-striatum areas may be regarded as biomarkers of brain damage severity in chronic heroin users.

关键词： heroin craving resting-state posterior cingulate cortex functional magnetic resonance imaging

A NOTE ON OLEVSKI'S FORMULA FOR SELF-ADJOINT HYPERBOLIC EQUATIONS OF THE SECOND ORDER

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 1981年第10期26卷 869-873页

作者：杜心华 department of Mathematics Sichuan Teachers Collegeome dependence among the Riemann functions for self-adjoint hyperbolic equations of the second order had long been studied. M. N. Olevskit considered the equation

Some dependence among the Riemann functions for self-adjoint hyperbolic equations of the second order had long been studied. M. N. Olevskit considered the

关键词： Riemann hyperbolic adjoint satis operators 心勿二业 string arbitrary identical

Causal relationships between chronotype and risk of multiple cancers by using longitudinal data and Mendelian randomization analysis

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2023年第10期66卷 2433-2436页

作者： Shanshan Tian Longtao Huangfu Sizhi Ai Junwei Zheng Le Shi Wei Yan Ximei Zhu Qianwen Wang Jiahui Deng Yanping Bao Suhua Chang Lin Lu Peking University Sixth Hospital Peking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)Beijing 100191China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Division of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital&InstituteBeijing 100142China department of Cardiology Heart CenterThe First Affiliated Hospital of Xinxiang Medical UniversityXinxiang 453100China National Institute on Drug dependence and Beijing Key Laboratory of Drug dependence Peking UniversityBeijing 100191China Chinese Academy of Medical Sciences Research Unit(No.2018RU006) Peking UniversityBeijing 100191China Peking-Tsinghua Center for Life Sciences PKU-IDG/McGovern Institute for Brain ResearchBeijing 100871China

Dear Editor,Cancer is the second leading cause of death worldwide,and the cancer situation is becoming more complicated(Zhou et al.,2022).The International Agency for Research on Cancer(IARC)Monographs Working Group c... 详细信息

关键词： Cancer death