检索结果-南通市图书馆

Rare loss-of-function variants in FLNB cause non-syndromic orofacial clefts

Journal of Genetics and Genomics 2024年第2期51卷 222-229页

作者： Wenbin Huang Shiying Zhang Jiuxiang Lin Yi Ding Nan Jiang Jieni Zhang Huaxiang Zhao Feng Chen department of Orthodontics Peking University School and Hospital of StomatologyBeijing100081China Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi’an Jiaotong UniversityXi’anShaanxi710004China Guangdong Provincial High-level clinical Key Specialty Guangdong Province Engineering Research Center of Oral Disease Diagnosis and TreatmentDepartment of OrthodonticsStomatological CenterPeking University Shenzhen HospitalShenzhen Peking University-The Hong Kong University of Science and Technology Medical CenterShenzhenGuangdong 518036China department of physiology and Pathophysiology School of Basic Medical SciencesXi'an Jiaotong UniversityXi'anShaanxi710049China National Center for Stomatology National Clinical Research Center for Oral DiseasesNational Engineering Laboratory for Digital and Material Technology of StomatologyBeijing Key Laboratory for Digital StomatologyResearch Center of Engineering and Technology for Computerized Dentistry Ministry of HealthNMPA Key Laboratory for Dental MaterialsBeijing100101China Central Laboratory Peking University School and Hospital of StomatologyBeijing100081China

Orofacial clefts (OFCs) are the most common congenital craniofacial disorders, of which the etiology is closely related to rare coding variants. Filamin B (FLNB) is an actin-binding protein implicated in bone formation. FLNB mutations have been identified in several types of syndromic OFCs and previous studies suggest a role of FLNB in the onset of non-syndromic OFCs (NSOFCs). Here, we report two rare heterozygous variants (p.P441T and p.G565R) in FLNB in two unrelated hereditary families with NSOFCs. Bioinformatics analysis suggests that both variants may disrupt the function of FLNB. In mammalian cells, p.P441T and p.G565R variants are less potent to induce cell stretches than wild type FLNB, suggesting that they are loss-of-function mutations. Immunohistochemistry analysis demonstrates that FLNB is abundantly expressed during palatal development. Importantly, Flnb^(−/−) embryos display cleft palates and previously defined skeletal defects. Taken together, our findings reveal that FLNB is required for development of palates in mice and FLNB is a bona fide causal gene for NSOFCs in humans.

关键词： Or ofacial clefts FLNB Loss-of-function mutati on Cleft palate Filamin B Actin flannent Knockout mouse

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Melatonin improves synapse development by PI3K/Akt signaling in a mouse model of autism spectrum disorder

引用

Neural Regeneration Research 2024年第7期19卷 1618-1624页

作者： Luyi Wang Man Xu Yan Wang Feifei Wang Jing Deng Xiaoya Wang Yu Zhao Ailing Liao Feng Yang Shali Wang Yingbo Li Institute of Neuroscience Department of PhysiologySchool of Basic Medical ScienceChongqing Medical UniversityChongqingChina department of Pediatric Chongqing University Fuling HospitalChongqingChina department of Neurosurgery Xinqiao HospitalArmy Medical UniversityChongqingChina department of Pathology Affiliated Hospital of North Sichuan Medical CollegeNanchongSichuan ProvinceChina NHC Key Laboratory of Birth Defects and Reproductive Health Chongqing Population and Family Planning Science and Technology Research InstituteChongqingChina China National clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijingChina

Autism spectrum disorders are a group of neurodevelopmental disorders involving more than 1100 genes,including Ctnnd2 as a candidate ***2knockout mice,serving as an animal model of autis m,have been demonstrated to exhibit decreased density of dendritic *** role of melatonin,as a neuro hormone capable of effectively alleviating social interaction deficits and regulating the development of dendritic spines,in Ctnnd2 deletion-induced nerve injury remains unclea *** the present study,we discove red that the deletion of exon 2 of the Ctnnd2 gene was linked to social interaction deficits,spine loss,impaired inhibitory neurons,and suppressed phosphatidylinositol-3-kinase(PI3K)/protein kinase B(Akt) signal pathway in the prefrontal *** findings demonstrated that the long-term oral administration of melatonin for 28 days effectively alleviated the aforementioned abnormalities in Ctnnd2 gene-knockout ***,the administration of melatonin in the prefro ntal cortex was found to improve synaptic function and activate the PI3K/Akt signal pathway in this *** pharmacological blockade of the PI3K/Akt signal pathway with a PI3K/Akt inhibitor,wo rtmannin,and melatonin receptor antagonists,luzindole and 4-phenyl-2-propionamidotetralin,prevented the melatonin-induced enhancement of GABAergic synaptic *** findings suggest that melatonin treatment can ameliorate GABAe rgic synaptic function by activating the PI3K/Akt signal pathway,which may contribute to the improvement of dendritic spine abnormalities in autism spectrum disorders.

关键词： autism Ctnnd2 deletion GABAergic neurons melatonin PI3K/Akt signal pathway prefrontal cortex social behavior spine density synaptic-associated proteins

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Osteogenic and antibacterial ability of micro-nano structures coated with ZnO on Ti-6Al-4V implant fabricated by two-step laser processing

引用

Journal of Materials Science & Technology 2022年第36期131卷 240-252页

作者： Yi Wan Zihe Zhao Mingzhi Yu Zhenbing Ji Teng Wang Yukui Cai Chao Liu Zhanqiang Liu Key Laboratory of High Efficiency and Clean Manufacturing School of Mechanical EngineeringShandong UniversityJinan 250061China department of oral and Maxilofacial Surgery Qilu Hospital of Shandong UniversityJinan 250012China Centre of Micro/Nano Manufacturing Technology(MNMT-Dublin) School of Mechanical and Materials EngineeringUniversity College DublinDublin D04 KW52Ireland School of Engineering Sciences in Chemistry Biotechnology and HealthKTH RoyalInstitute of TechnologyStockholmStockholm S-10044Sweden department of oral Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghai 200011China

The biological performance of Ti-6Al-4V implant is primarily determined by their surface ***,traditional surface modification methods,such as acid etching,hardly make improvement in their osseointegration ability and antibacterial *** this study,we prepared a multi-scale composite structure coated with zinc oxide(ZnO)on Ti-6Al-4V implant by an innovative technology of two-step laser processing combined with *** with the acid etching method,the physicochemical properties of surface significantly *** in vitro results showed that the particular dimension of micro-nano structure and the multifaceted nature of ZnO synergistically affected MC3T3-E1 osteogenesis and bacterial activities:(1)The surface morphology showed a‘contact guidance'effect on cell arrangement,which was conducive to the adhesion of filopodia and cell spreading,and the osteogenesis level of MC3T3-E1 was enhanced due to the release of zinc ions(Zn^(2+));(2)the characterization of bacterial response revealed that periodic nanostructures and Zn^(2+)released could cause damage to the cell wall of *** and reduce the adhesion and aggregation of *** conclusion,the modified surface showed a synergistic effect of physical topography and chemical composition,making this a promising method and providing new insight into bone defect repairment.

关键词： Ti-6Al-4V implant Laser processing Micro-nano structure Zinc oxide Osseointegration ability Antibacterial capacity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evolution and host-specific adaptation of Pseudomonas aeruginosa

引用

四川生理科学杂志 2024年第7期46卷 1579-1579页

作者： Aaron Weimann Victor Phillip Dahdaleh Heart & Lung Research Institute University of Cambridge Cambridge UK. University of Cambridge Molecular Immunity Unit MRC Laboratory of Molecular Biology Cambridge UK. Cambridge Centre for AI in Medicine University of Cambridge Cambridge UK. department of Veterinary Medicine University of Cambridge Cambridge UK. Laboratory of Pathogens and Host Immunity (LPHI) UMR5235 CNRS/Université de Montpellier Montpellier France. Cambridge Centre for Lung Infection Royal Papworth Hospital Cambridge UK. department of physiology Bioscience Institute University College Cork Cork Ireland. department of Biochemistry University of Cambridge Cambridge UK. department of Medicine University of Cambridge Cambridge UK. Wellcome Sanger Institute Hinxton UK. Cambridge University Hospitals Trust Cambridge UK. Institut de Biologie Intégrative et des Systèmes (IBIS) Université Laval Québec City Québec Canada. department of Science University Roma Tre Rome Italy. IRCCS Fondazione Santa Lucia Rome Italy. London School of Hygiene and Tropical Medicine London UK. department of clinical Infection Microbiology and Immunology University of Liverpool Liverpool UK.

The major human bacterial pathogen Pseudomonas aeruginosa causes multidrug-resistant infections in people with underlying immunodeficiencies or structural lung diseases such as cystic fibrosis(CF).We show that a few environmental isolates,driven by horizontal gene acquisition,have become dominant epidemic clones that have sequentially emerged and spread through global transmission networks over the past 200 years.

关键词： lung diseases sequentially

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cyclin-dependent kinase inhibitors in brain cancer:current state and future directions

引用

Cancer Drug Resistance 2020年第1期3卷 48-62页

作者： Viktorija Juric Brona Murphy department of physiology and Medical Physics Royal College of Surgeons in IrelandDublin D02Ireland

Cyclin-dependent kinases(CDKs)are important regulatory enzymes in the normal physiological processes that drive cell-cycle transitions and regulate *** all cancers harbour genomic alterations that lead to the constitutive activation of CDKs,resulting in the proliferation of cancer *** inhibitors(CKIs)are currently in clinical use for the treatment of breast cancer,combined with endocrine *** this review,we describe the potential of CKIs for the treatment of cancer with specific focus on glioblastoma(GBM),the most common and aggressive primary brain tumour in *** intense effort to combat GBM with surgery,radiation and temozolomide chemotherapy,the median survival for patients is 15 months and the majority of patients experience disease recurrence within 6-8 months of treatment *** therapeutic approaches are urgently needed for both newly diagnosed and recurrent GBM *** this review,we summarise the current preclinical and clinical findings emphasising that CKIs could represent an exciting novel approach for GBM treatment.

关键词： Cyclin-dependent kinases cyclin-dependent kinase inhibitors gliomas glioblastoma clinical trials resistance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mucosal delivery of nanovaccine strategy against COVID-19 and its variants

引用

药学学报:英文版 2023年第7期13卷 2897-2925页

作者： Junwoo Lee Dongwoo Khang college of Medicine Gachon UniversityIncheon 21999South Korea Lee Gil Ya Cancer and Diabetes Institute Gachon UniversityIncheon 21999South Korea Gachon Advanced Institute for Health Science&Technology Gachon UniversityIncheon 21999South Korea department of physiology College of MedicineGachon UniversityIncheon 21999South Korea

Despite the global administration of approved COVID-19 vaccines(e.g.,ChAdOx1 nCoV-19?,mRNA-1273?,BNT162b2?),the number of infections and fatalities continue to rise at an alarming rate because of the new variants such as Omicron and its *** COVID-19 vaccines that are licensed for human use,most of the vaccines that are currently in clinical trials are administered via parenteral ***,it has been proven that the parenteral vaccines do not induce localized immunity in the upper respiratory mucosal surface,and administration of the currently approved vaccines does not necessarily lead to sterilizing *** further supports the necessity of a mucosal vaccine that blocks the main entrance route of COVID-19:nasal and oral mucosal *** the mechanism of immune regulation of M cells and dendritic cells and targeting them can be another promising approach for the successful stimulation of the mucosal immune *** paper reviews the basic mechanisms of the mucosal immunity elicited by mucosal vaccines and summarizes the practical aspects and challenges of nanotechnology-based vaccine platform development,as well as ligand hybrid nanoparticles as potentially effective target delivery agents for mucosal vaccines.

关键词： COVID-19 Vaccine platforms Mucosal vaccine Mucosa-associated lymphoid tissue(MALT) Microfold cell(M cell) Dendritic cell(DC) Polymeric nanoparticleLiposome

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of Granule Dendrobii on chronic atrophic gastritis induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats

引用

World Journal of Gastroenterology 2022年第32期28卷 4668-4679页

作者： Yue Wu Yu Li Xiao-Ming Jin Guan-Hai Dai Xuan Chen Ye-Ling Tong Ze-Ming Ren Yu Chen Xiao-MinXue Ren-Zhao Wu First college of clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310052Zhejiang ProvinceChina Institute of Basic Medicine Zhejiang Academy of Traditional Chinese MedicineHangzhou 310007Zhejiang ProvinceChina college of Basic Medicine Zhejiang Chinese Medical UniversityHangzhou 310052Zhejiang ProvinceChina Stark Neuroscience Research Institute&department of Anatomy Cell Biology and PhysiologyIndiana University School of MedicineIndianapolisIN 46202United States department of Experimental Animals Zhejiang Academy of Traditional Chinese MedicineHangzhou 310007Zhejiang ProvinceChina

BACKGROUND Dendrobium officinale is an herb of Traditional Chinese Medicine(TCM)commonly used for treating stomach *** formula of Granule Dendrobii(GD)consists of Dendrobium officinale and American Ginseng(Radix Panacis quinquefolii),and is a potent TCM product in *** treatment with GD can promote gastric acid secretion and alleviate gastric gland atrophy in chronic atrophic gastritis(CAG)requires *** To determine the effect of GD treatment on CAG and its potential cellular *** A CAG model was induced by feeding rats N-methyl-N'-nitro-N-nitrosoguanidine(MNNG)for 12 *** oral administration of low,moderate,and high doses of GD in CAG rats for 8 wk,its effects on body weight,gastric mucosa histology,mucosal atrophy,intestinal metaplasia,immunohistochemical staining of proliferating cell nuclear antigen(PCNA)and B-cell lymphoma-2,and hemoglobin and red blood cells were *** The body weights of MNNG-induced CAG model rats before treatment(143.5±14.26 g)were significantly lower than that of healthy rats(220.2±31.20 g,P<0.01).At the 8th week of treatment,the body weights of rats in the low-,moderate-,and high-dose groups of GD(220.1±36.62 g)were significantly higher than those in the untreated group(173.3±28.09 g,all P<0.01).The level of inflammation in gastric tissue of the high-dose group(1.68±0.54)was significantly reduced(P<0.01)compared with that of the untreated group(3.00±0.00,P<0.05).The number and thickness of gastric glands in the high-dose group(31.50±6.07/mm,306.4±49.32μm)were significantly higher than those in the untreated group(26.86±6.41/mm,244.3±51.82μm,respectively,P<0.01 and P<0.05),indicating improved atrophy of gastric *** areas of intestinal metaplasia were significantly lower in the high-dose group(1.74%±1.13%),medium-dose group(1.81%±0.66%)and low-dose group(2.36%±1.08%)than in the untreated group(3.91%±0.96%,all P<0.01).The expression of PCNA in high-dose group was significantly

关键词： Chronic atrophic gastritis Granule Dendrobii N-methyl-N'-nitro-N-nitrosoguanidine Intestinal metaplasia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Gene therapy and erectile dysfunction： the current status

引用

Asian Journal of Andrology 2007年第1期9卷 8-15页

作者： David H. W. Lau Sashi S. Kommu Emad J. Siddiqui Cecil S. Thompson Robert J. Morgan Dimitri P. Mikhailidis Faiz H. Mumtaz department of Urology Royal Free Hospital and University College Medical School University College London Royal Free Campus Rowland Hill Street London NW3 2QG UK department of clinical Biochemistry Royal Free Hospital and University College Medical School University College London Royal Free Campus Rowland Hill Street London NW3 2QG UK department of Surgery Royal Free Hospital and University College Medical School University College London Royal Free Campus Rowland Hill Street London NW3 2QG UK department of Urology Chase Farm Hospital The Ridgeway Enfield EN2 8JL UK Institute of Cancer Research and The royal Marsden Hospitals NHS Foundation Trust Surrey SM2 5PT UK

Current available treatment options for erectile dysfunction （ED） are effective but not without failure and/or side effects. Although the development of phosphodiesterase type 5 （PDE5） inhibitors （i.e. sildenafil, tadalafil and vardenafil） has revolutionized the treatment of ED, these oral medications require on-demand access and are not as effective in treating ED related to diabetic, post-prostatectomy and severe veno-occlusive disease states. Improvement in the treatment of ED is dependent on understanding the regulation of human corporal smooth muscle tone and on the identification of relevant molecular targets. Future ED therapies might consider the application of molecular technologies such as gene therapy. As a potential therapeutic tool, gene therapy might provide an effective and specific means for altering intracavernous pressure ＂on demand＂ without affecting resting penile function. However, the safety of gene therapy remains a major hurdle to overcome before being accepted as a mainstream treatment for ED. Gene therapy aims to cure the underlying conditions in ED, including fibrosis. Furthermore, gene therapy might help prolong the efficacy of the PDE5 inhibitors by improving penile nitric oxide bioactivity. It is feasible to apply gene therapy to the penis because of its location and accessibility, low penile circulatory flow in the flaccid state and the presence of endothelial lined （lacunar） spaces. This review provides a brief insight of the current role of gene therapy in the management of ED.

关键词： gene therapy nitric oxide synthase erectile dysfunction calcium-sensitive potassium channel vascular endothelial growth factor calcitonin gene-related peptide

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Zingiber officinale(Ginger)Methanol Extract Abates Kidney Dysfunction in Mice Co-exposed to Sub-chronic Alcohol Intoxication and Post-traumatic Stress Disorder

引用

clinical Complementary Medicine and Pharmacology 2023年第4期3卷 79-90页

作者： Olusegun G.Adebayo Benneth Ben-Azu Egwonor Akpofure Modo U.Emmanuel Iheanyichukwu Wopara Wadioni Aduema Lawrence Dayo Adedayo Jude Ijuo Abeje Neurosciences and oral physiology Unit Department of PhysiologyFaculty of Basic Medical SciencesCollege of MedicineUniversity of IbadanIbadan 200005Nigeria department of Pharmacology Faculty of Basic Medical SciencesCollege of Health SciencesDelta State UniversityAbrakaDelta StateNigeria department of Medicine Evercare HospitalLekkiLagos State 105102Nigeria department of Biochemistry Faculty of Basic Medical SciencesPAMO University of Medical SciencesPort-HarcourtRiver State 500272Nigeria department of Biochemistry Faculty of SciencesRiver State UniversityPort HarcourtRiver State 500004Nigeria department of physiology Faculty of Basic Medical SciencesBayelsa Medical UniversityYenagoaBayelsa State 178Nigeria Neurophysiology Division Physiology ProgrammeCollege of Health ScienceBowen UniversityIwo 232101Nigeria

Background:Increasing number of people globally gives in to indiscriminate consumption of excess alcohol as a coping mechanism to relieve any form of physical or psychological ***,ethnomedicinal use of Zingiber officinale Roscoe(Ginger)have been shown to exhibit broad range of pharmacological benefits but no data has reported the phytotherapeutic treatment of Zingiber officinale methanol extract(MEZO)on alcohol-use disorder(AUD)and post-traumatic stress disorder(PTSD)-induced oxidative and inflammatory stress relevant to disruption of kidney functions in animal ***:To investigate the protective effect of MEZO on kidney-oxidative and inflammatory biomarkers in sub-chronic alcohol exacerbation of PTSD symptoms in ***:Male Swiss mice were administered 30%ethanol for two weeks and thereafter introduced to single pro-longed stress to induce AUD and PTSD respectively prior to post-treatment with MEZO and vitamin *** of oxidative stress,inflammatory cytokines,kidney functions,HPA-axis signaling molecules,vasodilator substance,and histopathology of the kidney were ***:Sub-chronic alcohol intoxication heightened PTSD-induced oxido-inflammatory stress,altered the kidney function indices and HPA-axis,and reduced nitric oxide production,which were ameliorated by the phytother-apeutic treatment with ***,severe degeneration and atrophy of renal tubules were ***,MEZO interventions strongly abated all these ***:Herein,the study shows that phytotherapeutic treatment with MEZO prevents the damaging effects of co-exposure to sub-chronic alcohol intoxication and PTSD.

关键词： Zingiber officinale Kidney Alcohol Single prolonged stress Oxidative stress

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nutritional status and prognostic factors for mortality in patients admitted to emergency department observation units:a national multi-center study in China

引用

世界急诊医学杂志(英文) 2023年第1期14卷 17-24页

作者： Hai-jiang Zhou Dong-jing Zuo Da Zhang Xin-hua He Shu-bin Guo Nutrition School of Education college of Chinese Emergency Medicine Beijing Key Laboratory of Cardio-pulmonary Cerebral ResuscitationEmergency Medicine Clinical Research CenterBeijing Chao-yang HospitalCapital Medical UniversityBeijing 100020China

BACKGROUND:Nutritional risk is common among patients admitted to the emergency department and is associated with adverse clinical *** its large population,few comprehensive studies have been conducted in China concerning the nutritional status of patients admitted to emergency department observation units(EDOUs).METHODS:Patients admitted to EDOUs of 90 tertiary hospitals in China between June 2020 and December 2020 were *** information,laboratory parameters,nutritional support therapies,and 28-day mortality were *** factors for mortality were examined using multi-variateadjusted logistic regression *** operating characteristic(ROC)curves for each predictor of mortality were plotted,and the area under the ROC(AUROC)curves was ***:A total of 2,005 eligible patients were finally *** the 28-day follow-up,1,911 patients survived,and 94 *** group with a Nutritional Risk Screening 2002(NRS 2002)score of 3-4 points was the largest(52.01%).The number of patients receiving oral nutritional supplements,enteral nutrition(EN),parenteral nutrition(PN),and the combination of EN and PN was 425,314,853,and 413,*** the total,77.55%of patients had nutritional risk(NRS 2002≥3).The proportion of patients with high nutritional risk(NRS2002≥5)in the age group>80 years was significantly higher than that in the age group 66-80 years(29.00%vs.23.93%,P=0.032),but not significantly higher than that in the age group 18-65 years(29.00%vs.26.54%,P=0.449).Logistic regression analysis revealed that heart failure(odds ratio[OR]1.856,95%confidence interval[CI]1.087-3.167,P=0.023),consciousness(OR 2.967,95%CI 1.894-4.648,Pphysiology and Chronic Health Evaluation II(APACHE II)score(OR 1.037,95%CI 1.017-1.058,P<0.001),NRS 2002 score(OR 1.286,95%CI 1.115-1.483,P=0.001),and Mini Nutritional Assessment-Short Form score(OR 0.946,95%CI 0.898-0.997,P=0.039)were all independent risk factors for 28-day m

关键词： Nutritional risk Malnutrition Nutritional Risk Screening 2002 Mini Nutritional Assessment-Short Form

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：