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Validity and reliability of the Thai version of the Utrecht Gender Dysphoria Scale-Gender Spectrum(UGDS-GS)in Thai youths and young adults with gender dysphoria

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General psychiatry 2023年第4期36卷 284-293页

作者： Tanawis Jamneankal Komsan Kiatrungrit Jiraporn Arunakul Sira Korpaisarn Suthra Auapisithwong department of psychiatry Faculty of MedicineSrinakharinwirot UniversityNakhon NayokThailand department of psychiatry Faculty of Medicine Ramathibodi HospitalMahidol UniversityBangkokThailand department of Pediatrics Faculty of Medicine Ramathibodi HospitalMahidol UniversityBangkokThailand department of Internal Medicine Faculty of Medicine Ramathibodi HospitalMahidol UniversityBangkokThailand department of Mental Health Ministry of Public HealthChild and Adolescent Mental Health Rajanagarindra Institute(CAMRI)BangkokThailand

Background Many people who are gender variant have undiagnosed gender dysphoria,resulting in delayed receipt of gender-affirming support and prolonged distress in living with their gender-non-conforming *** Utrecht Gender Dysphoria Scale-Gender Spectrum(UGDS-GS)is a newly developed tool that measures dissatisfaction with gender identity and ***,there is no translated version of this tool in ***,the sensitivity,specificity and cut-off point of the UGDS-GS to detect gender dysphoria in people who are transgender remain *** This study translated the UGDS-GS into Thai and then examined the validity and reliability of the Thai *** 185 participants with and without gender dysphoria were selected from the Gender Variation Clinic in Ramathibodi Hospital and from social media *** UGDS-GS was translated into Thai according to the World Health Organization(WHO)guidelines on *** medical records of patients with gender dysphoria and semi-structured interviews were used to confirm the diagnosis of gender ***,the validity and reliability of the instrument were *** The mean age of participants was 30.43(7.98)years among the 51 assigned males(27.6%)and 134 assigned females(72.4%)at *** Thai UGDS-GS average score was 77.82(9.71)for those with gender dysphoria(n=95)and 46.03(10.71)for those without gender dysphoria(n=90).Cronbach’s alpha coefficient was 0.962,showing excellent internal *** addition,exploratory factor analysis showed compatibility with the original version’s *** value of the area under the curve was 0.976(95%confidence interval:0.954 to 0.998),indicating outstanding *** the cut-off point of‘60’,sensitivity and specificity were good(96.84%and 91.11%,respectively).Conclusions The Thai UGDS-GS is an excellent,psychometrically reliable and valid tool for screening gender dysphoria in clinical and community settings in *** cut-

关键词： specificity instrument assigned

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Phenomenology of obsessive-compulsive disorder in children and adolescents: Sample from a tertiary care center in Istanbul, Turkey

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World Journal of Methodology 2022年第1期12卷 54-63页

作者： Anil Cifter Ayse Burcu Erdogdu School of Medicine Marmara UniversityIstanbul 34899Turkey department of child and adolescent psychiatry School of MedicineMarmara UniversityIstanbul 34899Turkey

BACKGROUND Obsessive-compulsive disorder(OCD)is a heterogeneous disease in many respects and exhibits this diversity in terms of *** also displays several different characteristics in children compared to *** To describe the socio-demographic and phenomenological features of children with OCD and to investigate the impact of these features on response to *** This retrospective study was carried out with 150 children and adolescents who had been diagnosed with OCD between 2014 and *** was collected by examining the files of the patients with diagnosis of OCD and similar disorders from the hospital ***-Brown Obsessive-Compulsive Scale for children was used for the assessment of obsession-compulsion *** clinical Global Impression(CGI)scale was used to evaluate the severity of the disease(CGI-S)and global improvement(CGI-I).The predictors of treatment response were evaluated using linear regression *** level of significance for all statistic tests was set as Padolescent(56%)age *** most prevalent obsessions were contamination and aggression obsessions,and the most frequent compulsions were washing and *** contamination was observed more commonly in the prepubertal age group,the religious obsession was seen more frequently in *** with aggression obsession presented a higher frequency of comorbid anxiety(P=0.022)and mood subgroups(P>0.05).A lower CGI-I score was linked to a lower CGI-S score(95%confidence interval 0.21-0.39,Pchildren and adolescents.

关键词： Obsessive-compulsive disorder Phenomenology Comorbidity Treatment response Serotonin reuptake inhibitors

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Tardive sensory syndrome related to lurasidone:A case report

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World Journal of psychiatry 2023年第3期13卷 126-130页

作者： Mei-Chun Lin Yung-Yee Chang Yu Lee Liang-Jen Wang department of psychiatry Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine KaohsiungKaohsiung 83301Taiwanchina department of Neurology Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine KaohsiungKaohsiung 83301Taiwanchina department of child and adolescent psychiatry Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of MedicineKaohsiung 83301Taiwanchina

BACKGROUND Tardive sensory syndrome(TSS)is a subtype of tardive syndrome(TS),and its etiology is still *** is an atypical antipsychotic that has high affinity for dopamine D2-and serotonergic 5HT2A-and *** SUMMARY A 52-year-old woman,previously diagnosed with schizophrenia,and with no history of movement disorders and no sensory paresthesia,had taken lurasidone,initiate dose 40 mg daily then up titration to 120 mg daily,since March 2021,and developed mandibular sensory(pain)paresthesia after 3 mo of *** switching from lurasidone to quetiapine,she reported obvious improvement in her mandibular *** It is noteworthy that TSS is a rare subtype of TS,and lurasidone,an atypical antipsychotic,usually has a lower risk of causing *** light of the temporal relationship,it is therefore concluded that use of lurasidone might have caused TSS in this *** reported this rare case as a reminder that clinicians should adopt a cautious approach when prescribing atypical antipsychotics,so as to prevent TS.

关键词： Antipsychotic Tardive syndrome Tardive sensory syndrome Lurasidone Case report

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Effects of age and sex on clinical high-risk for psychosis in the community

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World Journal of psychiatry 2020年第5期10卷 101-124页

作者： Frauke Schultze-Lutter Benno G Schimmelmann Rahel Fluckiger Chantal Michel department of psychiatry and Psychotherapy Medical FacultyHeinrich-Heine UniversityDüsseldorf 40692Germany University Hospital of child and adolescent psychiatry and Psychotherapy University of BernBern 3000Switzerland University Hospital of child and adolescent psychiatry University Hospital Hamburg-EppendorfHamburg 20246Germany

BACKGROUND Recent reports of both heightened prevalence rates and limited clinical relevance of clinical high-risk(CHR)criteria and their relevant symptoms in children and adolescents indicate an important role of neurodevelopment in the early detection of ***,sex effects in CHR symptoms have been reported,though studies were *** sex also impacts on neurodevelopment,we expected that sex might have an additional contribution to age in the prevalence and clinical relevance of CHR symptoms and *** To investigate age and sex effects on CHR criteria and symptoms and their association with psychosocial impairment and mental *** In this cross-sectional cohort study,n=29168-to 40-year-olds,randomly drawn from the population register of the Swiss canton Bern,were assessed in semistructured interviews by phone or face-to-face for CHR symptoms and criteria using the Structured Interview for Psychosis-Risk Syndromes and the Schizophrenia Proneness Instrument in its child and youth,and adult version,***,social and occupational functioning and DSM-IV axis I disorders were *** and interaction effects of age and sex on CHR symptoms and criteria,and interaction effects of age,sex,and CHR symptoms and criteria on presentation of functional impairment and of non-psychotic disorder were investigated using logistic regression *** Altogether,542(18.6%)participants reported any CHR symptom;of these,261(9.0%)participants reported any one of the 11 criteria relevant cognitive and perceptual basic symptoms,and 381(13.1%)any one of the five attenuated or transient psychotic symptoms(attenuated psychotic symptoms/brief intermittent psychotic symptoms).Fewer participants met any one of the CHR criteria(n=82,2.8%)or any one of the three recently recommended CHR criteria(n=38,1.3%).Both age and sex were significantly(P<0.05)associated with CHR symptoms and criteria,mostly by younger age and female se

关键词： Psychosis clinical high-risk Attenuated psychotic symptoms Basic symptoms Community Age Sex Interview assessment Prevalence

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Classification,prevalence and integrated care for neurodevelopmental and child mental health disorders:A brief overview for paediatricians

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World Journal of clinical Pediatrics 2022年第2期11卷 120-135页

作者： Michael O Ogundele Michael Morton department of Community Paediatrics Bridgewater Community Healthcare NHS Foundation TrustRuncorn WA71TWHaltonUnited Kingdom Institute of Health&Wellbeing University of GlasgowChild and Adolescent PsychiatryYorkhill HospitalGlasgow G38SJUnited Kingdom

‘Neurodevelopmental disorders’comprise a group of congenital or acquired longterm conditions that are attributed to disturbance of the brain and or neuromuscular system and create functional limitations,including autism spectrum disorder,attention deficit/hyperactivity disorder,tic disorder/Tourette’s syndrome,developmental language disorders and intellectual *** palsy and epilepsy are often associated with these conditions within the broader framework of paediatric ***-occurrence with each other and with other mental health disorders including anxiety and mood disorders and behavioural disturbance is often the *** these are referred to as neurodevelopmental,emotional,behavioural,and intellectual disorders(NDEBIDs)in this *** prevalence rates for NDEBID have been reported in developed countries,up to 15%,based on varying methodologies and *** are commonly managed by either child health paediatricians or child/adolescent mental health(CAMH)professionals,working within multidisciplinary teams alongside social care,education,allied healthcare practitioners and voluntary *** services are common problems for children and young people with multi-morbidity,and often complicated by subthreshold *** repeated reviews,limited consensus among clinicians about classification of the various NDEBIDs may hamper service improvement based upon *** recently developed“Mental,Behavioural and Neurodevelopmental disorder”chapter of the International Classification of Diseases-11 offers a way *** this narrative review we search the extant literature and discussed a brief overview of the aetiology and prevalence of NDEBID,enumerate common problems associated with current classification systems and provide recommendations for a more integrated approach to the nosology and clinical care of these related conditions.

关键词： Neurodevelopmental disorders Mental health disorders adolescents child health Mental health services Emotional problems Behavioural problem Sub-threshold diagnosis Sleep disorders Integrated care

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Relationship between quality of life and adolescent glycolipid metabolism disorder:A cohort study

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World Journal of Diabetes 2022年第7期13卷 566-580页

作者： Xiao-Hua Liang Yang-Ling Ren Xiao-Yue Liang Jing-Yu Chen Ping Qu Xian Tang department of clinical Epidemiology and Biostatistics Children’s Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChongqing Key Laboratory of Child Health and NutritionChongqing 400016China Ultrasound department of children’s Hospital of Chongqing Medical University Children’s Hospital of Chongqing Medical UniversityChongqing 400014China

BACKGROUND The prevalence of glucolipid metabolic disorders(GLMDs)in children and adolescents has a recognized association with cardiovascular diseases and type 2 diabetes mellitus in ***,it is important to enhance our understanding of the risk factors for GLMD in childhood and *** To explore the relationship between quality of life(QoL)and adolescent *** This study included 1956 samples in 2019 from a cohort study established in *** QoL scale and glycolipid indexes were collected during follow-up;other covariates of perinatal factors,physical measures,and socioeconomic indicators were collected and adjusted.A generalized linear regression model and logistic regression model were used to analyse the correlation between QoL and *** Higher scores of QoL activity opportunity,learning ability and attitude,attitude towards doing homework,and living convenience domains correlated negatively with insulin and homeostasis model assessment insulin resistance(IR)*** factors,QoL satisfaction factors,and total QoL scores had significant protective effects on insulin and IR *** opportunity,learning ability and attitude,attitude towards doing homework domains of QoL,psychosocial factor,and total score of QoL correlated positively with high density *** addition,the attitude towards doing homework domain was a protective factor for dyslipidaemia,IR>3,and increased fasting blood glucose;four factors,QoL and total QoL score correlated significantly negatively with IR>*** subgroup analyses of sex,more domains of QoL correlated with insulin and triglyceride levels,dyslipidaemia,and IR>3 in *** QoL was associated with an increased prevalence of GLMD,and the effect was more pronounced in males than in *** to improve the QoL of adolescents are essential to reduce rates of *** Our study revealed that QoL scores mainly correlate negatively with the prevalence of GLMD i

关键词： Quality of life Insulin resistance Lipids Metabolic abnormality

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Very early family-based intervention for anxiety:two case studies with toddlers

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General psychiatry 2019年第6期32卷 349-355页

作者： Dina R Hirshfeld-Becker Aude Henin Stephanie J Rapoport Timothy E Wilens Alice S Carter child CBT Program Department of PsychiatryMassachusetts General HospitalBostonMassachusettsUSA department of psychiatry Harvard Medical SchoolBostonMassachusettsUSA Division of child and adolescent psychiatry Department of PsychiatryMassachusetts General HospitalBostonMassachusettsUSA department of Psychology University of Massachusetts BostonBostonMassachusettsUSA

Anxiety disorders represent the most common categor of psychiatric disorder in children and adolescents and contribute to distress,impairment and *** Anxiety disorders or their temperamental precursors are often evident in early childhood,and anxiety can impair functioning,even during preschool age and in toddlerh A growing number of investigators have shown that anxiety in preschoolers can be treated efficaciously using cognitive-behavioural therapy(CBT)administere either by training the parents to apply CBT strategies with their children or through direct intervention with parents and *** date,most investigators have drawn the line at offering direct CBT to children under the age of ***,since toddlers can also present with impairing symptoms,and since behaviour strategi can be applied in older preschoolers with poor languag ability successfully,it ought to be possible to apply CBT anxiety to younger children as *** therefore prese two cases of very young children with impairing anxiet(ages 26 and 35 months)and illustrate the combinatio parent-only and parent-child CBT sessions that compri their *** treatment was well tolerated by parents and children and showed promise for reducing anxiety symptoms and improving coping skills.

关键词： distress behaviour apply

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Relationship between left-behind status and cognitive function in older Chinese adults: a prospective 3-year cohort study

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General psychiatry 2023年第3期36卷 148-157页

作者： Hong-Guang Zhang Fang Fan Bao-Liang Zhong Helen Fung-Kum Chiu department of psychiatry Affiliated Wuhan Mental Health CenterTongji Medical College of Huazhong Universityof Science&TechnologyWuhanHubeiChina department of psychiatry Wuhan Mental Health CenterWuhanHubeiChina department of clinical Psychology Wuhan Hospital for PsychotherapyWuhanHubeiChina department of psychiatry The Chinese University of Hong KongHong KongChina

Background Due to the inaccuracy of the traditional geographical distance-based definition of left-behind status,data on the negative effect of left-behind status on cognitive function among older adults are *** This study examined the cross-sectional and longitudinal associations of left-behind status with cognitive function in older Chinese *** left-behind status definition was based on the frequency of face-to-face parent-child *** Data from a nationally representative sample of 8682 older adults(60+years)in 2015(5658 left behind and 3024 non-left behind),of which 6933 completed the follow-up in 2018,were obtained from the China Health and Retirement Longitudinal ***-behind older adults werebroadlydefined as those aged 60+years who had living adult children and saw their children less than once per *** cognitive function was assessed with a composite cognitive test with higher total scores indicating better cognitive *** Left-behind older adults had significantly lower cognitive test scores than non-left-behind older adults in both 2015(11.1(6.0)vs 13.2(5.9),t=15.863,pchildren to visit their parents more regularly,are warranted to maintain or delay the progression of cognitive decline.

关键词： function cognitive maintain

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Aberrant Hippocampal Development in Early‑onset Mental Disorders and Promising Interventions:Evidence from a Translational Study

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Neuroscience Bulletin 2024年第6期40卷 683-694页

作者： Jingyu Yang Huiling Guo Aoling Cai Junjie Zheng Juan Liu Yao Xiao Sihua Ren Dandan Sun Jia Duan Tongtong Zhao Jingwei Tang Xizhe Zhang Rongxin Zhu Jie Wang Fei Wang Early Intervention Unit Department of PsychiatryAffiliated Nanjing Brain HospitalNanjing Medical UniversityNanjing 210029China School of Biomedical Engineering and Informatics NanjingMedical UniversityNanjing 211166China The Affiliated Changzhou Second People’s Hospital of Nanjing Medical University Changzhou Second People’s HospitalChangzhou Medical CenterNanjing Medical UniversityChangzhou 213004China department of Radiology First Hospital of China Medical UniversityShenyang 110002China department of Cardiac Function The People’s Hospital of China Medical University and the People’s Hospital of Liaoning ProvinceShenyang 110067China Key Laboratory of Magnetic Resonance in Biological Systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsNational Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences-Wuhan National Laboratory for OptoelectronicsWuhan 430064China Institute of Neuroscience and Brain Diseases Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyang 441021China Functional Brain Imaging Institute of Nanjing Medical University Nanjing 210029China

Early-onset mental disorders are associated with disrupted neurodevelopmental processes during *** methylazoxymethanol acetate(MAM)animal model,in which disruption in neurodevelopmental processes is induced,mimics the abnormal neurodevelopment associated with early-onset mental disorders from an etiological *** conducted longitudinal structural magnetic resonance imaging(MRI)scans during childhood,adolescence,and adulthood in MAM rats to identify specific brain regions and critical windows for ***,the effect of repetitive transcranial magnetic stimulation(rTMS)intervention on the target brain region during the critical window was *** addition,the efficacy of this intervention paradigm was tested in a group of adolescent patients with early-onset mental disorders(diagnosed with major depressive disorder or bipolar disorder)to evaluate its clinical translational *** results demonstrated that,compared to the control group,the MAM rats exhibited significantly lower striatal volume from childhood to adulthood(all Pchildhood(P>0.05)but was significantly lower than the control group from adolescence to adulthood(both P0.05).In the clinical trial,adolescents with early-onset mental disorders showed a significant increase in hippocampal volume after rTMS treatment compared to baseline(P<0.01),and these volumetric changes were associated with improvement in depressive symptoms(r=−0.524,P=0.018).These findings highlight the potential of targeting aberrant hippocampal development during adolescence as a viable intervent

关键词： Early-onset Mental disorder Neurodevelopment Animal model Hippocampus Repetitive transcranial magnetic stimulation

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Thinking about worry:A systematic review and meta-analysis on the assessment of metacognitions in children and adolescents

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World Journal of psychiatry 2021年第9期11卷 635-658页

作者： Laura M Kocher Kai Schneider Hanna Christiansen department of Psychology University of MarburgMarburg 35037Germany department of clinical child and adolescent Psychology University of LandauLandau 76829Germany

BACKGROUND The metacognitive model of generalized anxiety disorder identifies three forms of metacognition:Positive metacognitive beliefs about worry(POS),negative metacognitive beliefs about worry(NEG),and *** this model was originally developed relying on adult samples,it has since been applied to children and youth in different studies,and results mostly support its validity for this *** the roles of POS,meta-worry,and age-effects do not appear to be fully clarified for children and adolescents yet,an integration of studies on children and adolescents and the metacognitive model is both timely and *** To summarize the current research on relationships,age-effects,and measurements for POS,NEG,and meta-worry in childhood and *** We carried out a literature search in the electronic databases PsycINFO,PubMed,PSYNDEX,and ERIC in 2017 and updated in *** research in German or English language on metacognition was included with child and adolescent samples diagnosed with anxiety disorders or healthy controls if POS,NEG,or meta-worry were *** were included for meta-analysis if they reported correlations between these metacognitions and anxiety or *** rating for eligibility was done for 20.89% of full-texts with 90.32% *** of bias was assessed with the appraisal tool for cross-sectional studies and consensus rating of appraisal tool for cross-sectional studies for 20.83% of included studies attaining agreement of intraclass correlation=***,correlations between metacognitions,anxiety and worry were calculated with RevMan 5.4.1,assuming random-effects ***-regressions with mean age as the covariate were performed via the online tool MetaMar ***-ID:*** Overall,k=763 records and k=78 additional records were *** those,k=48 studies with 12839 participants were included and of those,k=24 studies were included for *** studie

关键词： Metacognition Anxiety child adolescent Measures Meta-analysis

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