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Triple rule-out computed tomography angiography:Evaluation of acute chest pain in COVID-19 patients in the emergency department

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World Journal of Radiology 2022年第8期14卷 311-318页

作者： Suzan Bahadir Sonay Aydın Mecit Kantarci Edhem Unver Erdal Karavas Düzgün CanŞenbil department of Radiology Baskent UniversityAntalya 07000Turkey department of Radiology Erzincan Binali Yıldırım UniversityErzincan 24100Turkey department of Radiology Ataturk UniversityErzurum 25100Turkey department of chest Disease Erzincan Binali Yildirim UniversityErzincan 24100Turkey

BACKGROUND The aim of this study was to define clinical evidence supporting that triple ruleout computed tomography angiography(TRO CTA)is a comprehensive and feasible diagnostic tool in patients with novel coronavirus disease 2019(COVID-19)who were admitted to the emergency department(ED)for acute chest *** diagnostic imaging strategies in COVID-19 related thromboembolic events,will help for rapid and noninvasive diagnoses and results will be effective for patients and healthcare systems in all *** To define clinical evidence supporting that TRO CTA is a comprehensive and feasible diagnostic tool in COVID-19 patients who were admitted to the ED for acute chest pain,and to assess outcomes of optimizing diagnostic imaging strategies,particularly TRO CTA use,in COVID-19 related thromboembolic *** TRO CTA images were evaluated for the presence of coronary artery disease,pulmonary thromboembolism(PTE),or acute aortic *** analyses were used for evaluation of significant association between the variables.A two tailed P-value<0.05 was considered statistically *** Fifty-three patients were included into the *** 31 patients(65.9%),there was not any pathology,while PTE was diagnosed in 11 *** was no significant relationship between the rates of pathology on CTA and history of *** the other hand,the diabetes mellitus rate was much higher in the acute coronary syndrome group,particularly in the PTE group(8/31=25.8%vs 6/16=37.5%,P=0.001).The rate of dyslipidemia was significantly higher in the group with pathology on CTA while compared to those without pathology apart from imaging findings of the pneumonia group(62.5%vs 38.7%,P<0.001).Smoking history rates were similar in the ***,D-dimer,fibrinogen,C-reactive protein,and erythrocyte sedimentation rate values were higher in COVID-19 cases with additional *** TRO CTA is an effective imaging method in evaluat

关键词： COVID-19 Pulmonary thromboembolism Coronary artery disease Acute aortic syndromes Triple rule-out computed tomography angiography

A pilot study on Paxlovid therapy for hemodialysis patients with severe acute respiratory syndrome coronavirus 2 infections

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Frontiers of Medicine 2024年第1期18卷 169-179页

作者： Xu Hao Zhiyao Bao Ranran Dai Xiaojing Wu Xin Li Muyin Zhang Hao Li Lili Xu Panpan Qiao Xuefei Liu Weiting Hu Ze Zhang Jie Fang Min Zhou Weiming Wang Jieming Qu department of Nephrology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China department of Pulmonary and Critical Care Medicine Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Institute of Respiratory Diseases Shanghai Jiao Tong University School of MedicineShanghai200025China department of Pharmacy Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China

We aimed to investigate the safety and efficacy of nirmatrelvir/ritonavir(Paxlovid)therapy for hemodialysis-dependent patients with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** hemodialysis patients infected with the Omicron variant of SARS-CoV-2 from April 3 to May 30,2022,were *** parameters and chest CT(computed tomography)imaging were *** treatment group included six patients who received 150 mg/100 mg of Paxlovid orally once daily for 5 days,whereas the control group included seven patients who received basic *** serious adverse reactions or safety events were *** control patients progressed to moderate disease,and none in the treatment group showed progression of chest CT findings(P<0.05).Paxlovid therapy tended toward early viral clearance and low viral load on Day ***,83.3%of the patients in the treatment group and 57.1%of the patients in the control group turned negative within 22 *** the Paxlovid treatment group,we found significantly increased levels of lymphocytes(P=0.03)and eosinophils(P=0.02)and decreased levels of D-dimer on Day 8 compared with those on Day *** therapy showed a potential therapeutic effect with good tolerance in hemodialysis *** optimal dose and effectiveness evaluation must be further investigated in a largeer cohort.

关键词： Paxlovid hemodialysis SARS-CoV-2 viral load chest CT scan

Multiple aortico-cameral tunnels associated with bicuspid aortic valve in aged： a case report

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Chinese Medical Journal 2009年第18期122卷 2184-2185页

作者： QIU Xing-biao SHI Hong-yu LIU Lan CHEN Hui WU Wei-hua QIU Zhao-kun ZHANG Wei FANG Wei-yi department of Cardiology Shanghai Chest Hospital Jiao Tong University Shanghai 200030 China department of Cardiac surgery Shanghai Chest Hospital Jiao Tong University Shanghai 200030 China department of Echocardiology Shanghai Chest Hospital Jiao Tong University Shanghai 200030 China

Aortico-cameral tunnel is a rare congenital cardiac .anomaly, which arises from the right coronary sinus and enters the left ventricle, occasionally the right ventricle and right atrium. However, more than one tunnel are seldom seen simultaneously in one patient. Here we present a case of multiple aortico-cameral tunnels associated with the bicuspid aortic valve in a 63-year-old man.

关键词： aortico-cameral tunnels," aged bicuspid aortic vavle

Deferred revascularization in diabetic patient according to combined invasive functional and intravascular imaging data:A case report

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World Journal of Clinical Cases 2024年第13期12卷 2269-2274页

作者： Arif Al Nooryani Wael Aboushokka Branko Beleslin Biljana Nedeljkovic-Beleslin department of Cardiology Al Qassimi HospitalSharjah 1234United Arab Emirates department of Cardiology Medical FacultyUniversity of BelgradeBelgrade 11000Serbia Institute of Endocrinology Diabetes and Metabolic DisordersUniveristy Clinical Center of SerbiaBelgrade 11000Serbia department of Internal Medicine/Endocrinology Medical facultyUniversity of BelgradeBelgrade 11000Serbia

BACKGROUND Invasive functional evaluation by fractional flow reserve(FFR)is considered as a gold standard for the evaluation of intermediate coronary ***,in patients with diabetes due to accelerated progression of atherosclerosis the outcome may be worse even in the presence of negative functional *** SUMMARY We present a case of 55-year-old male diabetic patient who was admitted for chest *** coronary angiography disclosed 2 intermediate stenoses of the obtuse marginal branch with no evidence of restenosis on previously implanted *** undergone invasive functional testing of intermediate lesion with preserved FFR(0.88),low coronary flow reserve(1.2)and very high index of microvascular resistance(84).Due to discrepancy in invasive functional parameters,intravascular imaging with optical coherence tomography showed fibrotic stenoses without signs of thin-sup *** of the preserved FFR and no signs of vulnerable plaque,the interventional procedure was deferred and the patient continued with optimal *** Combined functional and anatomic imaging of intermediate coronary stenosis in diabetic patients represent comprehensive contemporary decision pathway in the management of the patients.

关键词： Fractional flow reserve Coronary flow reserve Index of microvascular resistance Optical coherence tomography Intermediate coronary stenosis Case report

Landscape of global urban environmental resistome and its association with local socioeconomic and medical status

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Science China(Life Sciences) 2024年第6期67卷 1292-1301页

作者： Jun Wu Yige Hu Michael H Perlin David Danko Jun Lu Manuela Oliveira Johannes Werner Maria M Zambrano Maria A Sierra Olayinka O Osuolale Paweł Łabaj Nicolás Rascovan Nur Hazlin Hazrin-Chong Soojin Jang Haruo Suzuki Marina Nieto-Caballero Bharath Prithiviraj Patrick K H Lee Agnieszka Chmielarczyk Anna Różańska Yongxiang Zhao Lan Wang Christopher E Mason Tieliu Shi Center for Bioinformatics and Computational Biology and the Institute of Biomedical SciencesSchool of Life SciencesEast China Normal UniversityShanghai 200241China department of Biology Program on Disease EvolutionUniversity of LouisvilleLouisville 40292USA Weill Cornell Medicine New York 10065USA The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine New York 10065USA department of Pulmonary Medicine Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200025China i3S-Instituto de Investiga玢o e Inova玢o em Saúde Universidade do PortoPorto 4050-290Portugal Ipatimup-Instituto de Patologia e Imunologia Molecular da Universidade do Porto Porto 4200-465Portugal Departamento de Biologia Faculdade de CiênciasUniversidade do PortoPorto 4050-290Portugal High Performance and Cloud Computing Group Zentrum für Datenverarbeitung(ZDV)Eberhard Karls University of TübingenW鋍hterstra遝7672074TübingenGermany Corporación Corpogen Research Center Bogotá110311Colombia Applied Environmental Metagenomics and Infectious Diseases Research(AEMIDR) Department of Biological SciencesElizade UniversityIlara-Mokin 340271Nigeria Maopolska Centre of Biotechnology Jagiellonian UniversityKraków 30-005Poland Aix-Marseille Université Mediterranean Institute of OceanologyUniversitéde ToulonCNRSIRDUM 110Marseille 83041France department of Biological Sciences and Biotechnology Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 UKM BangiSelangor Institut Pasteur Korea Seoul 13488Republic of Korea Faculty of Environment and Information Studies Keio UniversityFujisawaKanagawa 252-0882Japan University of Colorado at Boulder CivilEnvironmental and Architectural DepartmentBoulder 80303USA Brooklyn College of the City University of New York Brooklyn 11210USA School of Energy and Environment City University of Hong KongHong Kong 999077China department of Microbiology Faculty of MedicineJagiellonian UniversityKraków 30-005Poland Biological Targeting Diagnosis and The

Antimicrobial resistance(AMR)poses a critical threat to global health and development,with environmental factors—particularly in urban areas—contributing significantly to the spread of antibiotic resistance genes(ARGs).However,most research to date has been conducted at a local level,leaving significant gaps in our understanding of the global status of antibiotic resistance in urban *** address this issue,we thoroughly analyzed a total of 86,213 ARGs detected within 4,728 metagenome samples,which were collected by the Meta SUB International Consortium involving diverse urban environments in 60 cities of 27 countries,utilizing a deep-learning based *** findings demonstrated the strong geographical specificity of urban environmental resistome,and their correlation with various local socioeconomic and medical *** also identified distinctive evolutionary patterns of ARG-related biosynthetic gene clusters(BGCs)across different countries,and discovered that the urban environment represents a rich source of novel *** study provides a comprehensive overview of the global urban environmental resistome,and fills a significant gap in our knowledge of large-scale urban antibiotic resistome analysis.

关键词： urban environment metagenome antibiotic resistance resistance diversity biosynthetic gene clusters

High Serum CEA and CYFRA21-1 Levels after a Two-Cycle Adjuvant Chemotherapy for NSCLC:Possible Poor Prognostic Factors

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Clinical oncology and cancer resexreh 2012年第4期9卷 270-273页

作者： Xue-feng Lin Xiao-dong Wang Da-qiang Sun Zhi Li Yue Bai Tianjin Medical College department of Thoracic surgery Tianjin Chest Hospital

Objective The aim of this study was to test whether carcinoembryonic antigen(CEA) and cytokeratin 19 fragments(CYFRA21-1) can be used as a prognostic factor for non-small-cell lung cancer(NSCLC) after two cycles of adjuvant chemotherapy in NSCLC patients. Methods A total of 169 patients underwent at least two cycles of adjuvant *** serum levels of CEA and CYFRA21-1 were recorded after the second cycle of chemotherapy,and the patient follow-up was *** survival(OS) and diseasefree survival(DFS) were used as the primary endpoint and the secondary endpoint,respectively. Results The high levels of CEA and CYFRA21-1 after two cycles of adjuvant chemotherapy were poor prognostic factors for OS,with risk ratios(RR) of 2.003 and 1.702,respectively.A high CEA level was a poor prognostic factor(RR 1.152) for *** median survival time(MST) of the high CEA level group was 26 months,whereas that of the normal group was 61 months(P<0.0001).The median DFS time of the high CEA group and the normal group was 34 and 53 months,respectively(P<0.0001).The MST of the high CYFRA21-1 group and the normal group was 43 and 56 months,respectively(PO.0001). Conclusions The high serum levels of CEA or CYFRA21-1 after two cycles of adjuvant chemotherapy are poor prognostic factors for NSCLC patients.

关键词：非小细胞肺癌 CEA 化疗周期预后血清高水生存时间

Pleural empyema with endobronchial mass due to Rhodococcus equi infection after renal transplantation: A case report and review of literature

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World Journal of Clinical Cases 2024年第1期12卷 224-231页

作者： Guo-Fu Liang Sheng Chao Zhou Sun Ke-Jing Zhu Qian Chen Lei Jia Yu-Lin Niu department of Organ Transplantation School of Clinical MedicineGuizhou Medical UniversityGuiyang 550025Guizhou ProvinceChina department of Organ Transplantation The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550000Guizhou ProvinceChina

BACKGROUND Kidney transplantation is the best option for patients with end-stage renal ***,the need for lifelong immunosuppression results in renal transplant recipients being susceptible to various *** equi(***)is a rare opportunistic pathogen in humans,and there are limited reports of infection with *** in post-renal transplant recipients and no uniform standard of *** article reports on the diagnosis and treatment of a renal transplant recipient infected with *** 21 mo postoperatively and summarizes the charac-teristics of infection with *** after renal transplantation,along with a detailed review of the ***,we present the case of a 25-year-old man who was infected with *** 21 mo after renal *** the clinical features at the time of presentation were not specific,chest computed tomography(CT)showed a large volume of pus in the right thoracic cavity and right middle lung atelectasis,and fiberoptic bronchoscopy showed an endobronchial mass in the right middle and lower lobe *** culture and metagenomic next-generation sequen-cing sequencing of the pus were suggestive of *** *** immunosup-pressive drugs were immediately suspended and intravenous vancomycin and azithromycin were administered,along with adequate drainage of the *** endobronchial mass was then *** the patient’s clinical symptoms and chest CT presentation resolved,he was switched to intravenous ciprofloxacin and azithromycin,followed by oral ciprofloxacin and *** patient was re-hospitalized 2 wk after discharge for recurrence of *** *** recovered after another round of adequate abscess drainage and intravenous ciprofloxacin and *** Infection with *** in renal transplant recipients is rare and complex,and the clinical presentation lacks *** antibiotic therapy is required,and adequate abscess drainage and s

关键词： Kidney transplantation Rhodococcus equi Pleural empyema Pulmonary atelectasis Immunosuppression Case report

Effect and molecular mechanism of mir-146a on proliferation of lung cancer cells by targeting and regulating MIF gene

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Asian Pacific Journal of Tropical Medicine 2016年第8期9卷 783-788页

作者： Wu-Ming Wang Ji-Chun Liu Medical College of Nanchang University department of Thoracic surgery Jiangxi Chest Hospital department of Thoracic & Cardiovascular surgery the First Affiliated Hospital of Nanchang University

Objective: To discuss the effect and molecular mechanism of mi R-146 a on the proliferation of lung cancer cells by targeting and regulating the macrophage migration inhibitory factor(MIF) gene. Methods: RT-PCR was employed to detect expression of mi R-146a; immunohistochemistry was used to detect the expression of MIF. The luciferase reporter gene technique was adopted to verify that MIF was the specific reverse target gene of mi R-146 a and the liposome LipofectamineTM2000 was employed to transfer the modeled mi R-146 a mimics, and mi R-146 a negative control(NC) in NSCLC cells to detect the expression of MIF m RNA and protein. MTT assay was used to detect cell viability, cloning technique to detect cell proliferation ability, Annexin V-PI to detect cell apoptosis, UV spectrophotometry to detect viability of cysteinyl aspartate specific proteinase 3(Caspase 3), and western blot to detect expression of nuclear factor-κB(NF-κB) in cells. Results: The expression of mi R-146 a in NSCLC lung tissues was lower than that in the normal lung tissues besides the lung cancer; while the expression of mi R-146 a in NSCLC cells was lower than that in normal human embryonic lung tissues. It was chosen as the subsequent cell line for its appropriate expression in A549. The expression of MIF protein in NSCLC lung tissues was higher than that in the normal lung tissues besides the lung cancer. The luciferase reporter gene proved that MIF was the reverse target gene of mi R-146 a. The mi R-146 a mimics were transfected into A549 cells through the liposome. Compared with NC group, the expression of MIF protein and m RNA was significantly decreased(P<0.01), with the decrease in the cell viability(P<0.01), the decrease in the number of clones(P<0.01), cell apoptosis(P<0.01), the increase in the activity of Caspase 3(P<0.01), and decrease in the phosphorylation of NF-κB p65(P<0.01). Conclusions: mi R-146 a has low expression in NSCLC tissues and cell lines, while MIF has the over expres

关键词： MicroRNA-146a Macrophage migration inhibition factor Non-small cell lung cancer Proliferation

Lactobacillus levels and prognosis of patients with acute myocardial infarction

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Journal of Geriatric Cardiology 2022年第2期19卷 101-114页

作者： Jing-Jing CAI Yin LIU Jie WANG Jing-Xian WANG Yuan WANG Shi-Bo XU Zhuang CUI Jing GAO Graduate School Tianjin Medical UniversityTianjinChina department of Cardiology Xing’anmeng People’s HospitalInner MongoliaChina Clinical School of Thoracic Tianjin Medical UniversityTianjinChina department of Cardiology Tianjin Chest HospitalTianjinChina School of Public Health Tianjin Medical UniversityTianjinChina Cardiovascular Institute Tianjin Chest HospitalTianjinChina

OBJECTIVE To explore the relationship between Lactobacillus and prognosis of acute myocardial infarction(AMI)patients treated by percutaneous coronary intervention(PCI)and its correlation with clinical *** Consecutive patients with AMI in the coronary care unit of Tianjin chest Hospital in China who received emergency PCI between July 2017 and December 2018 were ***’fecal 16 S r DNA gene sequencing data were analyzed and subjects were categorized into low,medium and high level groups according to stool Lactobacillus *** primary endpoints were major adverse cardiac *** regression analysis was used to analyze the relationship between Lactobacillus and *** correlation analysis and trend tests were used to assess the relationship between Lactobacillus and the clinical *** The data of 254 patients were included in the *** age was 65.90±11.56 years,and 152 patients(59.84%)were ***-up time was 652(548.25-753.00)*** Cox regression analysis showed a significantly lower risk of major adverse cardiac events in patients with Lactobacillus>7.1 copies/g[adjusted hazard ratio(HR)=0.216,95%CI:0.094-0.493,P<0.001]compared to patients with Lactobacillus≤3.6 copies/*** significant differences were shown in ST-segment elevation myocardial infarction(STEMI)(HR=0.217,95%CI:0.085-0.551,P=0.001).Lactobacillus was a protective factor for male smokers aged over 60 years whose brain natriuretic peptide was over 1,000 pg/m *** correlation analysis showed that Lactobacillus correlated negatively with white blood cells,neutrophils,high-sensitivity C-reactive protein,Troponin T,creatine kinase,creatine kinase-MB and brain natriuretic peptide(downward trend),and correlated positively with left ventricular ejection fraction(upward trend).CONCLUSIONS This study is the first to reveal the correlation between Lactobacillus and inflammation and myocardial damage after STEMI.

关键词： patients infarction prognosis