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AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

Science China(Life Sciences) 2025年第1期68卷 204-218页

作者： Chen Xiong Hong Ling Yingdan Huang Hanzhi Dong Bangxiang Xie Qian Hao Xiang Zhou fudan university shanghai Cancer Center and Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China department of Breast Surgery Fudan University Shanghai Cancer CenterFudan UniversityShanghai 200032China department of Oncology First Affiliated Hospital of Nanchang UniversityNanchang 330006China Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Beijing 100069China Key Laboratory of Breast Cancer in shanghai Fudan University Shanghai Cancer CenterFudan UniversityShanghai 200032China shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology)Institutes of Biomedical SciencesFudan UniversityShanghai 200032China

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies,including WEE1 *** that p53 activation can also lead to multiple types of cell death,the role of this tumor suppressor in WEE1 inhibitor-based therapies remains *** this study,we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer *** findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake,an action similar to that of ***,inhibition of WEE1 by the WEE1 inhibitors or siRNAs induced compensatory upregulation of SLC7A11,which conferred resistance to ***,AZD1775 prevented the enrichment of H3K9me3,a histone marker of transcriptional repression,on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1,thereby enhancing NRF2-mediated SLC7A11 *** finding was also validated using the H3K9me3 inhibitor ***,we found that the nucleolar stress-inducing agent Actinomycin D(Act.D)inhibited SLC7A11 expression by activating p53,thus augmenting AZD1775-induced ***,the combination of AZD1775 and Act.D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in ***,our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription,and inhibition of SLC7A11 by Act.D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

关键词： p53 NRF2 SLC7A11 WEE1 AZD1775 ferroptosis nucleolar stress

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Enhancing weather predictions: Initial condition sensitivity and error dynamics in data assimilation

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Science China Earth Sciences 2025年第2期68卷 649-652页

作者： Weiwei FU department of Atmospheric and Oceanic Sciences Fudan UniversityShanghai 200438China Key Laboratory of Polar Atmosphere-ocean-ice System for Weather and Climate Ministry of EducationFudan UniversityShanghai 200438China IRDR International Center of Excellence on Risk Interconnectivity and Governance on Weather Fudan UniversityShanghai 200438China

Data Assimilation(DA) plays a crucial role in modern numerical forecasting(Kalnay, 2002). It has been demonstrated that incorporating real-time observational data into forecast models significantly enhances the accuracy of both shortterm weather forecasts(Bauer et al., 2015;Bannister, 2017)and long-term climate predictions(Karspeck et al., 2013;Mochizuki et al., 2016).

关键词： weather assimilation forecasting

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A low redox potential and long life organic anode material for sodium-ion batteries

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Journal of Energy chemistry 2025年第1期100卷 557-564页

作者： Zhi Li Yang Wei Kang Zhou Xin Huang Xing Zhou Jie Xu Taoyi Kong Junwei Lucas Bao Xiaoli Dong Yonggang Wang department of chemistry and shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New EnergyCollaborative Innovation Center of Chemistry for Energy Materials(iChEM)Fudan UniversityShanghai 200433China department of chemistry Boston CollegeChestnut HillMA 02467USA School of Materials Science and Engineering Anhui University of TechnologyMa’anshan 243002AnhuiChina

Sodium-ion batteries (SIBs) with organic electrodes are an emerging research direction due to the sustainability of organic materials based on elements like C,H,O,and sodium ***,organic electrode materials for SIBs are mainly used as cathodes because of their relatively high redox potentials(>1 V).Organic electrodes with low redox potential that can be used as anode are ***,a novel organic anode material (tetrasodium 1,4,5,8-naphthalenetetracarboxylate,Na_(4)TDC) has been developed with low redox potential (<0.7 V) and excellent cyclic *** three-sodium storage mechanism was demonstrated with various in-situ/ex-situ spectroscopy and theoretical calculations,showing a high capacity of 208 mAh/g and an average decay rate of merely 0.022%per ***,the Na_(4)TDC-hard carbon composite can further acquire improved capacity and cycling stability for 1200 cycles even with a high mass loading of up to 20 mg cm^(-2).By pairing with a thick Na_(3)V_(2)(PO_(4))_(3)cathode (20.6 mg cm^(-2)),the as-fabricated full cell exhibited high operating voltage (2.8 V),excellent rate performance and cycling stability with a high capacity retention of 88.7% after 200 cycles,well highlighting the Na_(4)TDC anode material for SIBs.

关键词： Organic anode material Low redox potential Composite anode Sodium-ion batteries

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Thermoelectric Modulation of Neat Ti_(3)C_(2)T_(x) MXenes by Finely Regulating the Stacking of Nanosheets

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Nano-Micro Letters 2025年第4期17卷 347-362页

作者： Junhui Tang Renyang Zhu Ya-Hsin Pai Yan Zhao Chen Xu Ziqi Liang department of Materials Science Fudan UniversityShanghai 200433People’s Republic of China Spine Center Department of OrthopedicsShanghai Changzheng HospitalNaval Medical UniversityShanghai 200003People’s Republic of China

Emerging two-dimensional MXenes have been extensively studied in a wide range of fields thanks to their superior electrical and hydrophilic attributes as well as excellent chemical stability and mechanical *** them,the ultrahigh electrical conductivity(σ)and tunable band structures of benchmark Ti_(3)C_(2)T_(x) MXene demonstrate its good potential as thermoelectric(TE)***,both the large variation ofσreported in the literature and the intrinsically low Seebeck coefficient(S)hinder the practical ***,this study has for the first time systematically investigated the TE properties of neat Ti_(3)C_(2)T_(x) films,which are finely modulated by exploiting different dispersing solvents,controlling nanosheet sizes and constructing ***,deionized water is found to be superior for obtaining closely packed MXene sheets relative to other polar ***,a simultaneous increase in both S andσis realized via elevating centrifugal speed on MXene aqueous suspensions to obtain small-sized nanosheets,thus yielding an ultrahigh power factor up to~156μW m^(-1) K^(-2).Third,S is significantly enhanced yet accompanied by a reduction inσwhen constructing MXene-based nanocomposites,the latter of which is originated from the damage to the intimate stackings of MXene ***,a correlation between the TE properties of neat Ti_(3)C_(2)T_(x) films and the stacking of nanosheets is elucidated,which would stimulate further exploration of MXene TEs.

关键词： MXene Nanosheet stacking Electrical conductivity Seebeck coefficient Thermoelectrics

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Ultrasonic humidifier aerosols:Observed high heavy metal enrichment and a new emission control method

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Journal of Environmental Sciences 2025年第2期148卷 298-305页

作者： Tao Zhang Xiaohui Lu Ruoyu Zhang Xinghua Jiang Shanye Yang Xiewen Ma Qianqian Gao Xiaofei Wang shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention Department of Environmental Science and EngineeringFudan UniversityShanghai 200433China shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China

Ultrasonic humidifiers are commonly used in households to maintain indoor humidity and generate a large number of droplets or spray ***,there have been various health concerns associated with humidifier use,largely due to aerosols generated during ***,we investigated the size distribution,chemical composition,and charged fraction of aerosol particles emitted from commercial ultrasonic *** metals in water used for humidifiers were found to be highly enriched in the ultrasonic humidifier aerosols(UHA),with the enrichment factors ranging from 102 to *** enrichment may pose health concerns for the building occupants,as UHA concentrations of up to 106 particles/cm^(3) or 3 mg/m^(3) were ***,approximately 90%of UHA were observed to be electrically charged,for the first time according to our *** on this discovery,we proposed and tested a newmethod to remove UHA by using a simple electrical *** designed electrical field in this work can efficiently remove 81.4%of ***,applying this electrical field could be an effective method to significantly reduce the health risks by UHA.

关键词： Ultrasonic humidifier aerosols Water-to-Air transfer Heavy metal Enrichment factor Electrical field

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Decision making module based on stochastic magnetic tunnel junctions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期68卷 198-205页

作者： Yifan Miao Li Zhao Yajun Zhang Zhe Yuan Center for Advanced Quantum Studies and department of Physics Beijing Normal UniversityBeijing 100875China Institute for Nanoelectric Devices and Quantum Computing Fudan UniversityShanghai 200433China Interdisciplinary Center for Theoretical Physics and Information Sciences Fudan UniversityShanghai 200433China

In biological neural systems,noise is ubiquitous but does not affect the correct decisions made in the complex cognitive ***-making in biological neural system is typically achieved by accumulating input information over a period of *** by recent developments in neurosciences,we design a decision-making module based on spintronic devices,utilizing superparamagnetic tunnel junctions as artificial *** feasibility of this decision-making module is verified through circuit *** a multi-layer perceptron as an example,the module significantly improves the accuracy of the perceptron in the handwritten digit recognition ***,the spintronic decision-making module offers advantages over the conventional pooling methods,such as adaptive decision time,high performance and the absence of analog-to-digital *** decision-making module is flexible to be integrated into artificial neural networks and provides a general yet effective solution to enhance performance against device noise.

关键词： neuromorphic computing spintronics magnetic tunnel junction neural networks

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Hollow cerium nanoparticles synthesized by one-step method for multienzyme activity to reduce colitis in mice

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World Journal of Gastroenterology 2025年第5期31卷 94-104页

作者： Lin Mi Kai Zhang Jian-Xia Ma Jian-Feng Yao Yi-Li Tong Zhi-Jun Bao department of General Medicine Huadong HospitalFudan UniversityShanghai 200040China department of Gastroenterology Huadong HospitalFudan UniversityShanghai 200040China

BACKGROUND Inflammatory bowel disease(IBD)is a common chronic intestinal inflammatory *** oxidative stress is a treatment target for *** oxide(CeO2)nanomaterials as nanozymes with antioxidant activity are potential drugs for the treatment of *** To synthesize hollow cerium(H-CeO2)nanoparticles by one-step method and to validate the therapeutic efficacy of H-CeO2 in *** H-CeO2 was synthesized by one-step method and examined its characterization and nanoenzymatic ***,we constructed dextran sulfate so-dium(DSS)-induced colitis in mice to observe the effects of H-CeO2 on colonic *** effects of H-CeO2 on colon inflammation and reactive oxygen species(ROS)levels in IBD mice were detected by hematoxylin and eosin staining and dichlorofluorescein diacetate staining,***,the biological sa-fety of H-CeO2 on mice was evaluated by hematoxylin and eosin staining,blood routine,and blood *** H-CeO2 nanoparticles prepared by the one-step method were uniform,monodi-sperse and hollow.H-CeO2 had a good ability to scavenge ROS,∙OH and∙OOH.H-CeO2 reduced DSS-induced decreases in body weight and colon length,colonic epithelial damage,inflammatory infiltration,and ROS accumulation.H-CeO2 administration reduced the disease activity index of DSS-induced animals from about 8 to 5.H-CeO2 had no significant effect on body weight,total platelet count,hemoglobin,white blood cell,and red blood cell counts in healthy *** significant damage to major organs was observed in healthy mice following H-CeO2 *** The one-step synthesis of H-CeO2 nanomaterials had good antioxidant activity,biosafety,and inhibited deve-lopment of DSS-induced IBD in mice by scavenging ROS.

关键词： Inflammatory bowel disease Nanozymes Hollow cerium nanoparticles One-step method Cerium oxide biosafety

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Vitreous amyloidosis caused by Lys55Asn mutation in TTR with peripheral neuropathy onset:a case report of FAP-related complications

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 184-186页

作者： Yi-Wen Xue Yi-Qin Xiao department of Ophthalmology Huashan HospitalFudan UniversityShanghai 200040China

Dear Editor,We present a case of vitreous amyloidosis in a patient who was previously confirmed as familial amyloidosis polyneuropathy(FAP)because of peripheral neuropathy symptom *** though the patient had already undergone liver transplantation 5y prior,the extracellular deposition of amyloid in vitreous body greatly infected the patient’s visual function.

关键词： amyloid neuropathy function.

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Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo Qi Han Tang Jianian Hu Siying Kang Song Qin department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

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Self-assembly of highly stable uniform single-molecule porphyrin nanomicelles for enhanced photodynamic therapy

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Science China chemistry 2025年

作者： Danying Ma Jiangshan Zhang Yueyang Liu Lingyu Zhang Zizhen Zhao Qihan Lin Yifei Lei Jiabin Xing Hui Wang Jia Tian Danwei Zhang Wei Zhou Zhanting Li department of chemistry Fudan University State Key Laboratory of Organometallic chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesUniversity of Chinese Academy of Sciences

Porphyrin aggregation has long been reported to weaken its ability for photosensitizing the generation of1O2for photodynamic therapy,but cannot be avoided for yet reported single molecule *** address this challenge,we here report the design and synthesis of a new series of amphiphilic porphyrin compounds that bear three sulfonate groups and one aliphatic *** light scattering and transmission electron microscopic imaging experiments show that one of the compounds,TSC18P,that bears the longest hydrophobic stearamide unit undergoes ordered H-aggregation to form highly stable uniform single molecule nanomicelles in both water and the solid ***-vis,fluorescence and electron spin resonance experiments support that the formation of the single molecule nanomicelles significantly increases the ability of TSC18P in photosensitizing the generation of1O2and also enables important intracellular *** vivo test demonstrates that TSC18P has an excellent biocompatibility,a therapeutic index of 17.5 and can achieve remarkably higher anti-tumor photodynamic therapeutic activity compared with aggregation-free porphyrin control.

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