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Bacterial microcompartment-mimicking Pickering emulsion droplets for detoxification of chemical threats under sweet conditions

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Science China Chemistry 2024年第9期67卷 3039-3049页

作者： Xiao Xu Wenqi Xie Ting Wu Chen Chen Xiaoning Chen Yuheng Yang Hao Lian Hao Chen Xiaofeng Cheng Zhitong Chen Guojun Chen Chaoqun Liu Lanlan Chen Yu He Zhaowei Chen Bernard P.Binks Huanghao Yang New Cornerstone Science Laboratory MOE Key Laboratory for Analytical Science of Food Safety and Biology College of ChemistryFuzhou University Institute of Biomedical and Health engineering Shenzhen Institute of Advanced Technology Chinese Academy of Sciences department of Biomedical engineering and the Rosalind & Morris Goodman Cancer Research Institute Mc Gill University School of Pharmacy Henan University department of Chemistry University of Hull

chemical warfare agents represent a severe threat to mankind and their efficient decontamination is a global necessity. However,traditional disposal strategies have limitations, including high energy consumption, use of aggressive reagents and generation of toxic byproducts. Here, inspired by the compartmentalized architecture and detoxification mechanism of bacterial microcompartments, we constructed oil-in-water Pickering emulsion droplets stabilized by hydrogen-bonded organic framework immobilized cascade enzymes for decontaminating mustard gas simulant(2-chloroethyl ethyl sulfide, CEES) under sweet conditions. Two exemplified droplet systems were developed with two-enzyme(glucose oxidase/chloroperoxidase) and threeenzyme(invertase/glucose oxidase/chloroperoxidase) cascades, both achieving over 6-fold enhancement in decontamination efficiency compared with free enzymes and >99% selectivity towards non-toxic sulfoxide. We found that the favored mass transfer of sugars and CEES from their respective phases to approach the cascade enzymes located at the droplet surface and the facilitated substrate channeling between proximally immobilized enzymes were key factors in augmenting the decontamination efficacy. More importantly, the robustness of immobilized enzymes enabled easy reproduction of both the droplet formation and detoxification performance over 10 cycles, following long-term storage and in far-field locations.

关键词： Pickering emulsion biomimetics chemical warfare agent bacterial microcompartment biocatalysis

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Andrias davidianus bone peptides alleviates hyperuricemia-induced kidney damage in vitro and in vivo

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food Science and Human Wellness 2024年第4期13卷 1886-1905页

作者： Wei Li Haihong Chen Hongliang Chen Ziyin Li Wei Hu Qinxuan Zhou Bing Xu Yi Wang Xinhui Xing Institute of Biopharmaceutical and Health engineering Tsinghua Shenzhen International Graduate SchoolShenzhen 518055China Institute of Biomedical Health Technology and engineering Shenzhen Bay LaboratoryShenzhen 440300China Key Laboratory for Industrial Biocatalysis Ministry of EducationInstitute of Biochemical EngineeringDepartment of Chemical EngineeringBeijing 100084China Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084China Affiliated Dongguan Hospital Southern Medical University(Dongguan People’s Hospital)Dongguan 523059China

Hyperuricemia(HUA)is a vital risk factor for chronic kidney diseases(CKD)and development of functional foods capable of protecting CKD is of *** paper aimed to explore the amelioration effects and mechanism of Andrias davidianus bone peptides(ADBP)on HUA-induced kidney *** the present study,we generated the standard ADBP which contained high hydrophobic amino acid and low molecular peptide *** vitro results found that ADBP protected uric acid(UA)-induced HK-2 cells from damage by modulating urate transporters and antioxidant *** vivo results indicated that ADBP effectively ameliorated renal injury in HUA-induced CKD mice,evidenced by a remarkable decrease in serum UA,creatinine and blood urea nitrogen,improving kidney UA excretion,antioxidant defense and histological kidney *** analysis highlighted 14 metabolites that could be selected as potential biomarkers and attributed to the amelioration effects of ADBP on CKD mice kidney ***,ADBP restored the gut microbiome homeostasis in CKD mice,especially with respect to the elevated helpful microbial abundance,and the decreased harmful bacterial *** study demonstrated that ADBP displayed great nephroprotective effects,and has great promise as a food or functional food ingredient for the prevention and treatment of HUA-induced CKD.

关键词： Andrias davidianus bone peptides Hyperuricemia Uric acid Chronic kidney disease Gut microbiota

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Optical sensor array for the discrimination of liquors

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未来食品学报(英文) 2024年第1期4卷 48-60页

作者： Yang Yu Fangfang Shi Yi Zhang Fei Li Jinsong Han State Key Laboratory of Natural Medicines National R&D Center for Chinese Herbal Medicine ProcessingDepartment of Food Quality and SafetyCollege of EngineeringChina Pharmaceutical UniversityNanjing 210009China

The discrimination of liquors plays a vital role in our daily life as a large amount of cheap alcoholic beverages and low-quality counterfeits greatly damage the health of ***-based optical sensors have been developed as a fast and effective tool to discriminate multi-analytes or complex mixtures with similar structures,such as acids,esters,aldehydes and *** the past decades,optical sensor arrays have demonstrated remarkable capabilities in fast and accurate detection of diverse types,qualities,and authentic *** identification strategy mainly focuses on the specific/non-specific interactions of flavor compounds in liquors with sensor *** cross-reactive optical signal readouts from the combination of sensor elements with liquors and multiple machine learning algorithms are essential to ensure the discriminatory capability of sensing *** this review,we discuss the advantages and recent advances in pattern recognition of liquors in terms of the design of various types of sensing materials and the construction strategies of sensor arrays.

关键词： Sensor array chemical tongue chemical nose Liquors Fluorescent Colorimetric Pattern recognition Machine learning algorithm

Discrimination of polysorbate 20 by high-performance liquid chromatography-charged aerosol detection and characterization for components by expanding compound database and library

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Journal of Pharmaceutical Analysis 2024年第5期14卷 722-732页

作者： Shi-Qi Wang Xun Zhao Li-Jun Zhang Yue-Mei Zhao Lei Chen Jin-Lin Zhang Bao-Cheng Wang Sheng Tang Tom Yuan Yaozuo Yuan Mei Zhang Hian Kee Lee Hai-Wei Shi Jiangsu Institute for food and Drug Control Nanjing210019China School of Pharmacy China Pharmaceutical UniversityNanjing211112China School of Pharmacy Nanjing University of Chinese MedicineNanjing210046China Chinese Pharmacopoeia Commission Beijing100061China Nanjing Well Pharmaceutical Group Co. Ltd.Nanjing210018China School of Environmental and chemical engineering Jiangsu University of Science and TechnologyZhenjiangJiangsu212003China University of Massachusetts Amherst Amherst01003USA department of Chemistry National University of SingaporeSingapore117543Singapore

Analyzing polysorbate 20(PS20)composition and the impact of each component on stability and safety is crucial due to formulation variations and individual *** similar structures and polarities of PS20 components make accurate separation,identification,and quantification *** this work,a high-resolution quantitative method was developed using single-dimensional high-performance liquid chromatography(HPLC)with charged aerosol detection(CAD)to separate 18 key components with multiple *** separated components were characterized by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UHPLC-Q-TOF-MS)with an identical gradient as the HPLC-CAD *** polysorbate compound database and library were expanded over 7-time compared to the commercial *** method investigated differences in PS20 samples from various origins and grades for different dosage forms to evaluate the composition-process ***-Q-TOF-MS identified 1329 to 1511 compounds in 4 batches of PS20 from different *** method observed the impact of 4 degradation conditions on peak components,identifying stable components and their tendencies to ***-CAD and UHPLC-Q-TOF-MS results provided insights into fingerprint differences,distinguishing quasi products.

关键词： Polysorbate 20 Component Database Discrimination Degradation

Freezing-directed construction of enzyme/nano interfaces:Reagentless conjugation,superior activity,and better stability

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Chinese chemical Letters 2024年第1期35卷 471-474页

作者： Ke Quan Jiajie Tong Lifang Chen Shuyao Fang Mengjiao Li Linlin Wu Zhihe Qing Hunan Provincial Key Laboratory of Cytochemistry School of Food and BioengineeringSchool of Chemistry and Chemical EngineeringChangsha University of Science and TechnologyChangsha 410114China department of Oncology Tengzhou Central People’s Hospital Affiliated Xuzhou Medical UniversityTengzhou 277500China

Immobilizing enzyme to nano interfaces has demonstrated to be a favorable strategy for prompting the industrialized application of *** tremendous endeavor has been devoted to using gold nanoparticles(AuNPs)as conjugation matrix due to its fascinating physico-chemical properties,maintaining enzymatic activity while circumventing cumbersome modification remains a formidable ***,the freezing-directed conjugation of enzyme/nano interfaces was constructed without extra *** the proof of concept,glucose oxidase(GOx)was chosen as model *** one-pot conjugation process can be facilely completed at−20°C under aqueous ***,with the loading of GOx on AuNP at freezing,the enzyme exhibited superior catalytic activity and stability upon thermal and pH *** mechanism of boosted activity was then discussed in *** was found that higher loading density under freezing condition and more enzyme tending to bind AuNPs via Au-S bond were the main factors for the superior *** importantly,this methodology was universal and can also be applied to other enzyme which contains natural cysteine,such as horseradish peroxidase(HRP)and *** facile conjugation strategy accompanied by remarkable bioactivity expand the possibilities for enzymatic biosensing,microdevice and even drug delivery.

关键词： Enzyme conjugation Freezing AuNPs Catalytic activity

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Discovery and mechanism of anti-hypertensive effect of a novel tripeptide(SYP) from medicinal fungus Ganoderma lingzhi

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food Science and Human Wellness 2024年

作者： Qiang Wu Feijun Luo Jia Huang Ping Huang Yongnan Liu Xiaoling Wang Gaoqiang Liu Hunan Provincial Key Laboratory of Forestry Biotechnology and International Cooperation Base of Science and Technology Innovation on Forest Resource Biotechnology Central South University of Forestry and Technology Microbial Variety Creation Center Laboratory of Yuelushan Seed Industry College of food and chemical engineering Shaoyang University Laboratory of Molecular Nutrition National engineering Laboratory for Rice and Byproducts Central South University of Forestry and Technology

Ganoderma lingzhi is a new species of the prize medicinal mushroom Ganoderma (Agaricomycetes). Using angiotensin I-converting enzyme (ACE) as a target， a tripeptide Ser-Tyr-Pro (SYP) was discovered with preponderant ACE inhibitory activity with an 50% inhibiting concentration (IC50) value of 62.50 μg/mL attribute to the formed salt bridge and hydrogen bonds between SYP and ACE. SYP even maintained superior bioactivity after intestinal digestion， and exerted no cytotoxicity， but presented incomplete bioavailability in blood of spontaneous hypertensive rats (SHRs). Furthermore， it performed antihypertensive effect in vivo by inhibiting the influx of Ca2+through activating endothelial NO synthase (eNOS)/NO/guanosine 3’，5’-cyclic monophosphate (cGMP) pathway， accompanied by attenuating angiotensin Ⅱ (Ang Ⅱ)/NADPH oxidase (NOX)/ROS pathway. This work not only discoverers a novel pharmacological ingredient from medicinal mushroom G. lingzhi for hypertension therapy， but also provides an insight into molecular mechanism of the ACE inhibitory peptide (ACEIP) on lowering blood pressure.

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Consumers’ Perception and Knowledge of food Additives in Senegal: A Pilot Study

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Open Journal of Applied Sciences 2024年第1期14卷 38-50页

作者： Alé Kane Hamidou Mbodji Papa Mamadou Dit Doudou Sylla Alioune Sow Abdoulaye Tamba Malick Mbengue Mady Cissé Laboratory of Biological Agronomic and Food Sciences and Complex Systems Modelling (LABAAM) University Gaston Berger (UGB) Saint-Louis Senegal UFR of Agronomic Sciences Aquaculture and Food Technology (UFR S2ATA) UGB Saint-Louis Senegal department of chemical engineering and Applied Biology University Cheikh Anta Diop of Dakar Dakar Senegal

food safety has become a major concern for consumers, as well as a priority for regulatory authorities. Faced with the growing industrial and domestic use of food additives, many questions are being asked and concerns are being felt by consumers around the world. Consumer perception defines the acceptability or rejection of food products, and has an impact on consumption patterns and behavior. To assess the level of knowledge and perception of food additives, a pilot study was carried out on a sample of 200 people in Dakar and Saint-Louis. A questionnaire was used to assess the acceptance or rejection, use and impact of food additives by consumers in Senegal. The results revealed several aspects. On the whole, the people surveyed expressed great mistrust and even rejection of these substances added to food products. This consumer perception is shared throughout the world, as indicated in numerous surveys. It also emerges from this study that, although most consumers are aware of the existence of these additives and their uses in the home, they feel that the use of these substances in industrial production is too excessive. What’s more, consumers associate food additives with numerous pathologies such as cancer, diabetes, hypertension, stroke and even sexual impotence. For some of these indexed pathologies, scientific studies have reached the same conclusions, although controversy still persists. On the other hand, for some of the other adverse effects mentioned, no cause-and-effect relationship has been scientifically demonstrated. In these latter cases, it seems that negative communication, misinformation and misconceptions have a major influence on consumer perception of food additives.

关键词： Consumer Survey food Additives Knowledge Perception Senegal

Intelligent design and construction of novel APN-based theranostic probe driven by advanced computational methods

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Chinese chemical Letters 2024年第2期35卷 352-357页

作者： Yingli Zhu Jie Qian Kunqian Yu Jing Hou Yeshuo Ma Fei Chen Jie Dong Wenbin Zeng Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410083China National engineering Research Center of Rice and Byproduct Deep Processing School of Food Science and EngineeringCentral South University of Forestry and TechnologyChangsha 410004China State Key Laboratory of Drug Research Drug Discovery and Design CenterShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China department of Geriatrics Third Xiangya HospitalCentral South UniversityChangsha 410013China

Multifunctional molecules with both optical signal and pharmacological activity play an important role in drug development,disease diagnosis,and basic theoretical *** N(APN),as a representative tumor biomarker with anti-tumor potential,still lacks a high-precision theranostic probe specifically targeting *** this study,a novel quaternity design strategy for APN theranostic probe was *** proposed strategy utilizes advanced machine learning and molecular dynamics simulations,and cleverly employs the strategy of conformation-induced fluorescence recovery to achieve multi-objective optimization and integration of functional *** this strategy,a unique“Off-On”theranostic probe,ABTP-DPTB,was ingeniously constructed to light up APN through fluorescence restoration,relying on conformation-induced effects and solvent *** from the common diagnostic probes,the intelligent design with non-substrated linkage makes ABTP-DPTB for long-term in-situ *** fabricated probe was used for detecting and inhibiting APN in various environments,with a better in vitro inhibitory than golden-standard drug bestatin.

关键词： Theranostic probe Artificial intelligence Conformational restriction Fluorescence restoration Design strategy

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Quantitative and Qualitative Responses of Hydroponic Tomato Production to Different Levels of Salinity

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Phyton-International Journal of Experimental Botany 2024年第6期93卷 1311-1323页

作者： Khalid A.Al-Gaadi Ahmed M.Zeyada ElKamil Tola Abdullah M.Alhamdan Khalid A.M.Ahmed Rangaswamy Madugundu Mohamed K.Edrris department of agricultural engineering College of Food and Agriculture SciencesKing Saud UniversityRiyadh11451Saudi Arabia Precision agriculture Research Chair Deanship of Scientific ResearchKing Saud UniversityRiyadh11451Saudi Arabia Chair of Dates Industry&Technology Deanship of Scientific ResearchKing Saud UniversityRiyadh11451Saudi Arabia agricultural Research Centre Agricultural Engineering Research Institute(AEnRI)Giza12619Egypt

From economic and nutritional points of view,tomato is,historically,considered one of the most important *** signiﬁcant yield reduction,most commercial cultivars of tomato crops are sensitive to moderate levels of ***,high levels of salt stress can negatively affect the yield and quality of tomato ***,this study was conducted to evaluate the yield and fruit quality of three tomato cultivars(Forester,Ghandowra-F1,and Feisty-Red)cultivated hydroponically,under three different levels of nutrient solution *** of tomato fruits was performed based on quantity(number and weight of fruits,and total fruit yield),physical quality(color andﬁrmness),and chemical quality(refractometric index“Brix”,pH,EC,K^(+),Na^(+),and NO_(3)-).Experiments were conducted using three salinity levels of the nutrient solution with electrical conductivity values(dSm^(-1))of 2.5(control),6.0,and *** showed that the studied tomato cultivars were signiﬁcantly inﬂuenced by high salinity(9.5 dSm^(-1))in comparison to the low(2.5 dSm^(-1))and medium(6.0 dSm^(-1))levels of *** average,the highest fruit weight per plant of 1944.84 g and total fruit yield of 4.42 kgm^(-2) were observed at the low salinity level;however,no signiﬁcant differences were obtained in the two yield factors(single fruit weight and total fruit yield)for the low and medium salinity *** the other hand,a signiﬁcant reduction in tomato yield(31%)was associated with the high salinity level compared to the yield at low and medium salinity *** of physical quality parameters showed highly signiﬁcant differences among all salinity *** average,the maximum value of color change(1.72)was associated with the medium salinity level,and the maximum value ofﬁrmness(9.61 Ncm^(-1))was recorded at the high salinity *** levels and tomato cultivars introduced signiﬁcant differences in chemical quality parameters;however,no signiﬁcant differences in these

关键词： Quality cultivars yield color ﬁrmness brix