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Genetics of coronary heart disease with reference to ApoAICⅡI-AIV gene region

World Journal of Cardiology 2014年第8期6卷 755-763页

作者： Suraksha Agrawal Sarabjit Mastana department of Medical Genetics Sanjay Gandhi Post Graduate Institute of Medical SciencesLucknow UP 226014India Human Genomics Lab School of SportExercise and Health SciencesLoughborough UniversityLoughborough LE11 3TUUnited Kingdom

Cardiovascular diseases are affected by multiple factors like genetic as well as environmental hence they reveal factorial nature. The evidences that genetic factors are susceptible for developing cardiovascular diseases come from twin studies and familial aggregation. Different ethnic populations reveal differences in the prevalence coronary artery disease(CAD) pointing towards the genetic susceptibility. With progression in molecular techniques different developments have been made to comprehend the disease physiology. molecular markers have also assisted to recognize genes that may provide evidences to evaluate the role of genetic factors in causation of susceptibility towards CAD. Numerous studies suggest the contribution of specific "candidate genes", which correlate with various roles/pathways that are involved in the coronary heart disease. Different studies have revealed that there are large numbers of genes which are involved towards the predisposition of CAD. However, these reports are not consistent. One of the reasons could be weak contribution of genetic susceptibility of these genes. Genome wide associations show different chromosomal locations which dock, earlier unknown, genes which may attribute to CAD. In the present review different ApoAI-CⅡI-AIV gene clusters have been discussed.

关键词： ApoAI-CⅡI-AIV gene cluster Haplotype analysis Single nucleotide polymorphism Candidate gene study Genome wide association studies

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老化晶体的基因表达下调:发生老年性白内障的可能致病因素

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世界核心医学期刊文摘（眼科学分册） 2005年第6期1卷 39-39页

作者： Segev F. Mor O. Segev A. 宋虎平 department of Ophthalmology TorontoWestern Hospital399 Bathurst Street Toronto Ont. M5T 2S8 Canada

Purpose. To study the molecular characteristics of lens epithelial cells frompatients with senile cataract by cDNA microarray technique. Methods. Lens epithelial cells adhering to anterior capsules taken during cataract surgery collected from 108 patients, aged 56- 92 years (senile cataract group), were pooled. Pooled epithelial cells of normal, noncataractous lenses from one patient with ocular trauma, one patient with lens subluxation, and 25 cadaveric eyes, all under the age of 55 years, served as a control. Total RNA was extracted by conventional methods from the two groups of cells, and a fluorescent probe was prepared for each group. The probes were hybridized on 9700 known human cDNA clones. Hybridized clones were analysed using a scanning laser and the results were processed by GEM Tools (Incyte Genomics) software. Results. A total of 1827 clones hybridized with the two probes. Of these, 400 showed differences of more than two-fold in gene expression between the two probes. Relative to controls, gene expression in the senile cataract lenses was upregulated in318 clones and downregulated in 82. Three genes-filensin, in wardly rectifying potassium channel (IRPC), and pigment epithelium-derived factor (PEDF) were strongly downregulated (by 41.3- , 6.8- , and 5.9- fold, respectively) in senile cataract. Conclusions. Cataractogenesis is associated with numerous changes in the genetic profile of the lens epithelial cells. Since filensin, IRPC, and PEDF genes are known to have important roles in the physiology and morphology of the transparent lens, substantial downregulation of their expression might contribute to the formation of senile cataract.

关键词：老年性白内障基因表达白内障手术上皮细胞前囊激光仪眼外伤克隆杂交分子特征半脱位

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Excited States and Free Radicals in Biology and Medicine——Contributions from Flash Photolysis and Pulse Radiolysis

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激光生物学报 1993年第4期 383-383页

作者： R.V.Bensasson,E.J.Land,T.G.Truscott Diresteur de Recherche au CNRS Laboratoire de Biophysique CNRS UA 481 INSERM U201 Museum National d'Histoire Naturelle Paris Senior Scientist CRC department of Biophysical Chemistry Paterson Institute for Cancer Research Christie Hospital NHS Trust Manchester Professor of Physical Chemistry Keele University.

Excited states and free radicals are involved in the normal physiology of living systems; in pathological processes including lipid peroxidation, inflammation, Parkinson's disease, cancer, and ageing; in the mechanism of action of drugs, such as quinone antitumour agents, and in photochemotherapies such as the PUVA therapy of skin diseases and PDT of cancer. The chief aim of this text is to introduce the reader to this rapidly expanding field, which lies at the borderlines of physics, chemistry, biology, pharmacology, and medicine, and, in particular, to explore how time—resolved spectroscopic methods have found solutions at the molecular level to biological and medical problems.

关键词： In PDT Contributions from Flash Photolysis and Pulse Radiolysis Excited States and Free Radicals in Biology and Medicine

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