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Passive activity enhances residual control ability in patients with complete spinal cord injury

Neural Regeneration Research 2025年第8期20卷 2337-2347页

作者： Yanqing Xiao Mingming Gao Zejia He Jia Zheng Hongming Bai Jia-Sheng Rao Guiyun Song Wei Song Xiaoguang Li beijing Key Laboratory for Biomaterials and Neural Regeneration Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina department of Rehabilitation Evaluation China Rehabilitation Research CenterBeijingChina cardiac Center Beijing Children’s HospitalCapital Medical UniversityBeijingChina The State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijingChina department of Rehabilitation Engineering China Rehabilitation Science InstituteBeijingChina

Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury ***,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface *** this study,we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord *** patients with chronic complete thoracic spinal cord injury were *** electromyography data from eight major leg muscles were acquired and compared before and after the passive activity *** results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of *** the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity,the difference was not statistically *** findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury.

关键词： complete spinal cord injury cycle training epidural electrical stimulation motor training passive activity physiological state spinal cord circuit surface electromyography volitional control task

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Long-term outcomes of PCI vs. CABG for ostial/midshafl lesions in unprotected left main coronary artery

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Journal of Geriatric Cardiology 2017年第4期14卷 254-260页

作者： Cheng-Long GUO Xian-Peng YU Bang-Guo YANG Meng-Meng LI Ji-Qiang HE Quan LI Cheng-Xiong GU Shu-Zheng LYU Jian-Zeng DONG department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing China department of cardiac surgery Beijing Anzhen Hospital Capital Medical University Beijing China

Background There are limited data on long-term （〉 5 years） outcomes of drug-eluting stent （DES） implantation compared with coro- nary artery bypass grafting （CABG） for ostial/rnidshaft left main coronary artery （LMCA） lesions. Methods Of the 259 consecutive pa- tients in beijing anzhen hospital with ostial/midshaff LMCA lesions, 149 were treated with percutaneous coronary intervention （PCI） with DES and 110 were with CABG. The endpoints of the study were death, repeat revascularization, myocardial infarction （MI）, stroke, the composite of cardiac death, and major adverse cardiac and cerebrovascular events （MACCE, the composite of cardiac death, MI, stroke or repeat revascularization）.The duration of follow-up is 7.1 years （interquartile range 5.3 to 8.2 years）. Results There is no significant differ- ence between the PCI and CABG group during the median follow-up of 7.1 years （interquartile range： 5.3-8.2 years） in the occurrence of death （HR： 0.727, 95% CI： 0.335-1.578; P = 0.421）, the composite endpoint of cardiac death, MI or stroke （HR： 0.730, 95% CI： 0.375-1.421; P = 0.354）, MACCE （HR： 1.066, 95% CI： 0.648-1.753; P = 0.801）, MI （HR： 1.112, 95% CI： 0.414-2.987; P = 0.833）, stroke （HR： 1.875, 95% CI： 0.528-6.659; P = 0.331）, and repeat revascularization （HR： 1.590, 95% CI： 0.800-3.161; P = 0.186）. These results remained after multivariable adjusting. Conclusion During a follow-up up to 8.2 years, we found that DES implantation had similar endpoint outcomes compared with CABG.

关键词： Coronary artery bypass graft Drug-eluting stent Percutaneous coronary intervention

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Risk factors for acute kidney injury following coronary artery bypass graft surgery in a Chinese population and development of a prediction model

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Journal of Geriatric Cardiology 2021年第9期18卷 711-719页

作者： Yang LI Xue-Jian HOU Tao-Shuai LIU Shi-Jun XU Zhu-Hui HUANG Peng-Yun YAN Xiao-Yu XU Ran DONG department of cardiac surgery Beijing Anzhen HospitalCapital Medical UniversityBeijingChina department of pharmacy Beijing Anzhen HospitalCapital Medical UniversityBeijingChina

BACKGROUND Acute kidney injury(AKI)after coronary artery bypass graft(CABG)surgery is associated with significant morbidity and *** retrospective study aimed to establish a risk score for postoperative AKI in a Chinese *** A total of 1138 patients undergoing CABG were collected from September 2018 to May 2020 and divided into a derivation and validation *** was defined according to the Kidney Disease Improving Global Outcomes(KDIGO)*** logistic regression analysis was used to determine the independent predictors of AKI,and the predictive ability of the model was determined using a receiver operating characteristic(ROC)*** The incidence of cardiac surgery–associated acute kidney injury(CSA-AKI)was 24.17%,and 0.53%of AKI patients required dialysis(AKI-D).Among the derivation cohort,multivariable logistic regression showed that age≥70 years,body mass index(BMI)≥25 kg/m2,estimated glomerular filtration rate(eGFR)≤60 mL/min per 1.73 m2,ejection fraction(EF)≤45%,use of statins,red blood cell transfusion,use of adrenaline,intra-aortic balloon pump(IABP)implantation,postoperative low cardiac output syndrome(LCOS)and reoperation for bleeding were independent *** predictive model was scored from 0 to32 points with three risk *** AKI frequencies were as follows:0-8 points(15.9%),9-17 points(36.5%)and≥18 points(90.4%).The area under of the ROC curve was 0.730(95%CI:0.691-0.768)in the derivation *** predictive index had good discrimination in the validation cohort,with an area under the curve of 0.735(95%CI:0.655-0.815).The model was well calibrated according to the Hosmer-Lemeshow test(P=0.372).CONCLUSION The performance of the prediction model was valid and accurate in predicting KDIGO-AKI after CABG surgery in Chinese patients,and could improve the early prognosis and clinical interventions.

关键词： AKI red Risk factors for acute kidney injury following coronary artery bypass graft surgery in a Chinese population and development of a prediction model

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Transvenous versus open chest lead placement for resynchronization therapy in patients with heart failure： comparison of ventricular electromechanical synchronicity

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Journal of Geriatric Cardiology 2017年第4期14卷 261-265页

作者： Hai-Bo ZHANG Xu MENG Jie HAN Yan LI Ye ZHANG Teng-Yong JIANG Ying-Xin ZHAO Yu-Jie Zhou cardiac surgery department Beijing Anzhen Hospital Capital Medical University Beijing China Echocardiography department Beijing Anzhen Hospital Capital Medical University Beijing China Cardiology department Beijing Anzhen Hospital Capital Medical University Beijing China

Background Transvenous lead placement is the standard approach for left ventricular （LV） pacing in cardiac resynchronization ther- apy （CRT）, while the open chest access epicardial lead placement is currently the most frequently used second choice. Our study aimed to compare the ventricular electromechanical synchronicity in patients with heart failure after CRT with these two different LV pacing tech- niques. Methods We enrolled 33 consecutive patients with refractory heart failure secondly to dilated cardiomyopathy who were eligible for CRT in this study. Nineteen patients received transvenous （TV group） while 14 received open chest （OP group） LV lead pacing. Intraand inter-ventricular electromechanical synchronicity was assessed by tissue Doppler imaging （TDI） before and one year after CRT procedure. Results Before CRT procedure, the mean QRS-duration, maximum time difference to systolic peak velocity among 12 left ventricle segments （LV Ts-12）, standard deviation of time difference to systolic peak velocity of 12 left ventricle segments （LV Ts-SD）, and inter-ventficular mechanical delay （IVMD） in OP and TV group were 166 ± 17 ms and 170 ± 21 ms, 391 ±42 ms and 397 ± 36 ms, 144 ± 30 ms and 148 ± 22 ms, 58 ± 25 ms and 60 ± 36 ms, respectively （all P 〉 0.05）. At one year after the CRT, the mean QRS-duration, LV Ts-12, LV Ts-SD, and IVMD in TV and OP group were 128 ± 14 ms and 141 ± 22 ms （P = 0.031）, 136 ± 37 ms and 294 ± 119 ms （P = 0.023）, 50± 22 ms and 96 ± 34 ms （P = 0.015）, 27 ± 11 ms and 27 ± 26 ms （P = 0.86）, respectively. The LV lead implantation procedure time was 53.4±16.3 rain for OP group and 136 ± 35.1 min for TV group （P = 0.016）. The mean LV pacing threshold increased significantly from 1.7 ± 0.6 V/0.5 ms to 2.3 ± 1.6 V/0.5 ms （P 〈 0.05） in TV group while it remained stable in the OP group. Conclusions Compared to conventional endovascular approach, open chest access of LV pacing for CRT leads to better improvement of the intraventricular synchroniza

关键词： Heart failure Resynchronization Tissue Doppler imaging

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Timing, distribution, and microbiology of infectious complications after necrotizing pancreatitis

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World Journal of Gastroenterology 2019年第34期25卷 5162-5173页

作者： Jiong-Di Lu Feng Cao Yi-Xuan Ding Yu-Duo Wu Yu-Lin Guo Fei Li department of General surgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China department of cardiac surgery Beijing Anzhen Hospital Affiliated to Capital University of Medical SciencesBeijing 100029China

BACKGROUND Acute pancreatitis(AP)is a common acute abdominal disease worldwide,and its incidence rate has increased *** 20%of AP patients develop into necrotizing pancreatitis(NP),and 40%to 70%of NP patients have infectious complications,which usually indicate a worse *** is an important sign of complications in NP *** To investigate the difference in infection time,infection site,and infectious strain in NP patients with infectious *** The clinical data of AP patients visiting the department of General surgery of Xuanwu hospital of Capital Medical University from January 1,2014 to December 31,2018 were collected *** computerized tomography or magnetic resonance imaging findings in patients with NP were included in the *** analysis of infectious bacteria,infection site,and infection time in NP patients with infectious complications was performed,because knowledge about pathogens and their antibiotic susceptibility patterns is essential for selecting an appropriate *** addition,the factors that might influence the prognosis of patients were *** In this study,539 strains of pathogenic bacteria were isolated from 162 patients with NP infection,including 212 strains from pancreatic infections and 327 strains from extrapancreatic ***-negative bacteria were the main infectious species,the most common of which were Escherichia coli and Pseudomonas *** extrapancreatic infection time(9.1±8.8 d)was earlier than the pancreatic infection time(13.9±12.3 d).Among NP patients with early extrapancreatic infection(14 d),bacteremia(15.94%),respiratory tract infection(7.74%),and urinary tract infection(7.71%)were *** sensitivity analysis showed that *** was sensitive to enzymatic penicilli

关键词： Necrotizing pancreatitis Extrapancreatic infection Pathogenic bacteria Drug sensitivity test

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Unplanned J-valve implantation during open heart surgery for severe valvular annulus and ventricle calcification

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Journal of Geriatric Cardiology 2022年第12期19卷 1003-1006页

作者： Tian-Ge LUO Bo LI Jie HAN Hai-Bo ZHANG cardiac Valve Centre Department of Cardiac SurgeryBeijing Anzhen HospitalCapital Medical UniversityBeijing Institute of Heart Lung and Blood Vessel DiseaseBeijingChina department of cardiac surgery People’s Hospital of Liaoning ProvinceShenyangChina

Aortic annulus calcification(AC)and mitral AC are common in patients with cardiac valvular disease.[1]Procedures to resect or debride aortic AC and mitral AC may lead to cerebral emboli,heart failure,arrhythmia,coronary artery lesions,and even ventricular rupture.[2]Therefore,it is often a challenge for surgeons to choose an appropriate surgical strategy for patients with severe valvular AC.[3,4]A sutureless valve is a good choice,doing away with the need to take time to remove the AC,but many countries do not have this *** aortic valve implantation(TAVI)and transcatheter mitral valve replacement(TMVR)have developed rapidly during recent years.

关键词： mitral implantation calcification

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Combined cesarean delivery and repair of acute aortic dissection at 34 weeks of pregnancy during COVID-19 outbreak:A case report

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World Journal of Clinical Cases 2021年第15期9卷 3644-3648页

作者： Li-Wei Liu Lan Luo Lu Li Yu Li Mu Jin Jun-Ming Zhu department of Anesthesiology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China department of Anesthesiology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China department of Radiology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China department of cardiac surgery Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China

BACKGROUND Since the outbreak of the coronavirus disease 2019(COVID-19)pandemic,the exclusion of a patient from COVID-19 should be performed before ***,patients with type A acute aortic dissection(AAD)during pregnancy can seriously endanger the health of either the mother or fetus that requires emergency surgical treatment without the test for *** SUMMARY A 38-year-old woman without Marfan syndrome was admitted to the hospital because of chest pain in the 34th week of *** has diagnosed as having a Stanford type-A AAD involving an aortic arch and descending aorta via aortic computed tomographic *** patient was transferred to the isolated negative pressure operating room in one hour and underwent cesarean delivery and ascending aorta *** medical staff adopted third-level medical protection measures throughout the patient transfer and surgical *** surgery,the patient was transferred to the isolated negative pressure intensive care unit *** nucleic acid test and anti-COVID-19 immunoglobulin(Ig)G and IgM were performed and were *** patient and infant were discharged without complication nine days later and recovered *** The results indicated that the procedure that we used is feasible in patients with a combined cesarean delivery and surgery for Stanford type-A AAD during the COVID-19 outbreak,which was mainly attributed to rapid multidisciplinary consultation,collaboration,and quick decision-making.

关键词： Acute aortic dissection Pregnancy COVID-19 outbreak Case report

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Importance must be attached to correcting unhealthy lifestyles in prevention and control of hypertension

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Journal of Geriatric Cardiology 2019年第3期16卷 176-177页

作者： Zhao-Su WU department of Epidemiology Beijing Anzhen Hospital

On the macro level,the ‘2018 Chinese Guidelines for Prevention and Treatment of Hypertension’[1] provides a detailed overview on the population strategies for hypertension prevention as well as the principles and methods of community standardized management for hypertension control,with particular emphasis on the significance of correcting unhealthy lifestyles for the prevention and control of hypertension and its complications.?

关键词： Hypertension treatment Lifestyle modification Unhealthy lifestyles

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Characterization of coronary atherosclerotic plaques in a homozygous familial hypercholesterolemia visualized by optical coherence tomography

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Journal of Geriatric Cardiology 2018年第12期15卷 738-743页

作者： Ze-Sen LIU Jie PENG Shi-Long WANG Tao JIANG Jie LIN Kang MENG department of Cardiology Beijing Anzhen Hospital.Capital Medical UniversityBeijingChina department of Atherosclerosis.beijing anzhen hospital Capital Medical UniversityBeijingChina department of Radiology Beijing Anzhen HospitalCapital Medical UniversityBeijingChina

Familial hypercholesterolemia(FH)is an autosomal dominant genetic disorder,which resulted in severe elevations in low-density lipoprotein cholesterol(LDL-C)and a markedly increased risk of early-onset coronary disease.[1]t is most frequently caused by loss-of-function mutations in genes affecting the LDL receptor,which clears LDL particles from plasma.

关键词： Coronary atherosclerotic plaques Homozygous familial hypercholesterolemia Optical coherence tomography

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Association between stress hyperglycemia ratio and in-hospital outcomes:findings from the improving Care for Cardiovascular Disease in China-Acute Coronary Syndrome(CCC-ACS)Project

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Journal of Geriatric Cardiology 2024年第6期21卷 658-668页

作者： Wen-Jie WANG Ke-Xin WANG Jia-Long NIU Yi-Xuan LIU Hai-Long GE Hua SHEN On behalf of CCC-ACS investigators department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijingChina

BACKGROUND Stress hyperglycemia ratio(SHR)could provide accurate information on the acute status of *** relationship between SHR and acute coronary syndrome(ACS)prognosis remains *** study was conducted to identity the association between SHR and in-hospital outcomes in patients with *** A total of 12,010 patients were eventually enrolled in the *** relationship between SHR and in-hospital major adverse cardiovascular events(MACEs)was then modeled by restricted cubic spline(RCS)curves,and all patients were divided into three groups according to the *** multivariate logistic regression analysis was used to determine the associations between the SHR and in-hospital outcomes,described as odds ratios(ORs)and 95%confidence intervals(CIs).Subgroup analyses were also performed on different *** The median age of this cohort was 63(54,71)years old,and 8942(74.5%)were *** 1 was defined as SHR1(n=5763).Compared with Group 2,Group 1(OR=1.891,95%CI:1.028-3.479,Phospital *** was associated with higher risks of in-hospital MACEs in the subgroups of DM[OR=2.282,95%CI:1.477-3.524).CONCLUSIONS Both low and high SHR levels were independently associated with in-hospital *** males with DM,hypertension,and decreased renal function had much higher risks of suffering from SHR-correlated MACEs.

关键词： acute cardiovascular finding

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