Characterization of coronary atherosclerotic plaques in a homozygous familial hypercholesterolemia visualized by optical coherence tomography
作者机构:Department of CardiologyBeijing Anzhen Hospital.Capital Medical UniversityBeijingChina Department of Atherosclerosis.Beijing Anzhen HospitalCapital Medical UniversityBeijingChina Department of RadiologyBeijing Anzhen HospitalCapital Medical UniversityBeijingChina
出 版 物:《Journal of Geriatric Cardiology》 (老年心脏病学杂志(英文版))
年 卷 期:2018年第15卷第12期
页 面:738-743页
核心收录:
基 金:the National Natural Science Foundation of China(No.81370443&No.81170793)
主 题:Coronary atherosclerotic plaques Homozygous familial hypercholesterolemia Optical coherence tomography
摘 要:Familial hypercholesterolemia(FH)is an autosomal dominant genetic disorder,which resulted in severe elevations in low-density lipoprotein cholesterol(LDL-C)and a markedly increased risk of early-onset coronary disease.[1]t is most frequently caused by loss-of-function mutations in genes affecting the LDL receptor,which clears LDL particles from plasma.