Characterization of coronary atherosclerotic plaques in a homozygous familial hypercholesterolemia visualized by optical coherence tomography

作     者：Ze-Sen LIU Jie PENG Shi-Long WANG Tao JIANG Jie LIN Kang MENG 

作者机构：Department of CardiologyBeijing Anzhen Hospital.Capital Medical UniversityBeijingChina Department of Atherosclerosis.Beijing Anzhen HospitalCapital Medical UniversityBeijingChina Department of RadiologyBeijing Anzhen HospitalCapital Medical UniversityBeijingChina 

出 版 物：《Journal of Geriatric Cardiology》 (老年心脏病学杂志（英文版）)

年 卷 期：2018年第15卷第12期

页      面：738-743页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：the National Natural Science Foundation of China(No.81370443&No.81170793) 

主　　题：Coronary atherosclerotic plaques Homozygous familial hypercholesterolemia Optical coherence tomography 

摘      要：Familial hypercholesterolemia(FH)is an autosomal dominant genetic disorder,which resulted in severe elevations in low-density lipoprotein cholesterol(LDL-C)and a markedly increased risk of early-onset coronary disease.[1]t is most frequently caused by loss-of-function mutations in genes affecting the LDL receptor,which clears LDL particles from plasma.