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Prevalence and Factors Associated with Hypertension among People Living with HIV Receiving Care in Three Large HIV Clinics in Nasarawa State, Nigeria

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World Journal of AIDS 2024年第1期14卷 1-17页

作者： Prosper Okonkwo Oluseye Ajayi Deborah Babatunde Dimas Mercy Ezekiel Program department APIN Public Health Initiatives Abuja Nigeria Community Medicine department Bingham University Karu Nigeria Prevention and Community Service Directorate APIN Public Health Initiatives Abuja Nigeria Health System Strengthening Directorate APIN Public Health Initiatives Abuja Nigeria

In the last decade, the long-term survival among people living with HIV (PLHIV) has significantly improved. This is accompanied by an increased burden of non-communicable diseases such as hypertension due to the combined effect of the aging population and the metabolic effect of the Human Immuno-deficiency Virus (HIV) virion and antiretroviral therapy. This study aims to assess the prevalence and factors associated with hypertension among people living with HIV in three large health facilities in Nasarawa State, Nigeria. A descriptive cross-sectional study employed a multistage sampling technique to select 309 adults with HIV, 18 years and above, receiving HIV care in three large health facilities in Nasarawa State. The outcome variable was the participants’ self-reported history of hypertension, confirmed through a positive history of hypertension treatment. Exposure variables included the participant’s socio-demographic characteristics, lifestyle factors, and HIV care and treatment history. Data were presented using frequency tables. Factors associated with hypertension were assessed using binary logistic regression at a 0.05 level of statistical significance. A total of 309 adults living with HIV were sampled. A larger percentage of the participants were married 228 (73.8%), female, 191 (61.8%), within the age group 41 - 50 years, 141 (45.6%). Most of the participants had no family history of hypertension, 188 (60.8%). The prevalence of self-reported hypertension was 11.0% (34/309). Factors associated with hypertension at the bivariate level were age group 21 - 30 years, 41 - 50 years, being widow/widower, divorced, retired from employment or with family history of hypertension. Only participants age group 31 - 40 years [Adjusted Odd Ratio (AOR): 0.18, 95%CI: 0.04 - 0.91, p = 0.04] and family history of hypertension [(AOR): 83.44, 95%CI: 15.75 - 442.11, p < 0.01] were found to predict hypertension among the study participants after adjusting for confounders. In c

关键词： HIV HIV Care Hypertension Hypertension Prevalence Nigeria PLHIV

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Lecanemab Unveiled:Exploring Alzheimer’s Treatment Advancements,Assessing Strengths,Limitations,and Its Therapeutic Landscape Position

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Biomedical and Environmental Sciences 2024年第4期37卷 428-431页

作者： VICTOR Abiola Adepoju OKECHUKWU Innocent Onyezue SAFAYET Jamil OLALEKAN John Okesanya DON Eliseo Lucero-Prisno Ⅲ department of HIV and Infectious Diseases Jhpiegoan affiliate of John Hopkins UniversityAbujaNigeria department of Prevention and Community Directorate APIN Public Health InitiativesAbujaNigeria department of Public Health Daffodil International UniversityDhaka-1216Bangladesh department of Public Health and Maritime Transport University of ThessalyVolosGreece department of Global Health and Development London School of Hygiene and Tropical MedicineLondonUnited Kingdom

In the ever-evolving landscape of Alzheimer’s treatment,lecanemab(Leqembi)has emerged as a promising *** conventional therapies that merely alleviate symptoms,lecanemab is a humanized monoclonal antibody with a distinct *** targets protofibrils,insoluble fibrils,amyloid oligomers,and soluble amyloid-beta protofibrils,which are known to be especially damaging to neurons,with high accuracy.

关键词： Alzheimer amyloid Therapeutic

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COVID-19 Vaccination Uptake and Associated Factors in Selected Communities in Two Southwestern States in Nigeria

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Advances in Infectious Diseases 2024年第1期14卷 260-278页

作者： Oluseye Ayodele Ajayi Olabanjo Okunlola Ogunsola Ajibola Idowu Oluwaseun Kikelomo Ajayi Kucheli Wudiri Rita Asoka-Ikechukwu Prosper Okonkwo APIN Public Health initiatives Abuja Nigeria department of Community Medicine Bowen University Teaching Hospital Ogbomosho Nigeria department of Community Medicine University College Hospital Ibadan Nigeria

Introduction: COVID-19 vaccine uptake and acceptance have been a major global concern due to the prevalent misinformation and disinformation that has characterized the vaccine rollout worldwide. This study aimed to assess COVID-19 vaccine uptake and acceptance, and associated factors among selected community members in two states in southwestern Nigeria. Method: We conducted a cross-sectional study using a multistage sampling technique. Fifty catchment settlements of 10 health facilities in each of Oyo and Ogun States targeted for a COVID-19 infection prevention and control intervention were randomly selected. Four households were targeted per settlement. All households that refused access were replaced, to ensure a minimum of four households randomly selected per settlement. The primary household decision-maker was interviewed in each household. Information elicited included respondents’ sociodemographic characteristics, health history, knowledge, risk and benefit perception about the COVID-19 vaccine, vaccine uptake, and willingness to be vaccinated. The study was conducted from July–August 2021. Data were analyzed using SPSS IBM version 23. Result: Four hundred household decision-makers were surveyed in Oyo and Ogun states, after replacement. The mean age of the respondents was 43.0 ± 11.0 years. The majority, 346 (86.5%) had heard about COVID-19 vaccination, but only 47 (13.6%) had received a COVID-19 vaccination. Of the 299 respondents who reported not receiving a COVID-19 vaccination, 166 (55.5%) were willing to be vaccinated. In univariate analysis, respondents who were female had tertiary education, perceived that COVID-19 vaccines are free and accessible, perceived that COVID-19 vaccines have minimal side effects, and perceived higher benefits of COVID-19 vaccination had higher odds of being vaccinated. In contrast, younger respondents, respondents with higher knowledge scores on COVID-19 preventive measures, and with chronic illness had lower likelihoods

关键词： COVID-19 Vaccination Vaccine Vaccine Uptake

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Sexual and Reproductive Service Interventions for Menstrual Regulation, Safe Abortion, and Post-abortion Care and Their Effectiveness During Disaster Response: A Global Systematic Review

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International Journal of Disaster Risk Science 2024年第3期15卷 359-373页

作者： Nibedita S.Ray-Bennett Winifred Ekezie Isha Biswas Nimra Iqbal Choudhary David Cowie Lasith Dissanayake Lauren Macleod Azukaeogo Nnaji Madhulika Sahoo School of Business University of Leicester Avoidable Deaths Network University of Leicester Diabetes Research Centre Leicester General Hospital University of Leicester School of Social Sciences and Humanities Aston University Lifespan and Population Health School of Medicine University of Nottingham School of Public Health and Interdisciplinary Studies Auckland University of Technology Faculty of Life Sciences and Education University of South Wales West African Regional ECHO (WARE) APIN Public Health Initiatives department of Anthropology Kalahandi University

Sexual and reproductive health(SRH) services are crucial for women especially during disasters, to reduce maternal mortality and morbidity from miscarriages, unsafe abortions, and post-abortion complications. This study explored the SRH interventions provided during disaster response. A systematic review was conducted to identify what menstrual regulation(MR), safe abortion(SA), and post-abortion care(PAC) approaches/interventions exist to promote resilience in the health system in disaster settings; what intervention components were most eff ective; and challenges and opportunities to meeting SRH rights. Five electronic databases were searched, resulting in 4194 records. Following the screening process, seven publications were included. The intervention-related information in each publication was assessed based on availability,accessibility, acceptability, and quality. Two SRH approaches/interventions were found. The eff ectiveness of intervention components could not be conducted due to the limited number of relevant studies. Challenges were found at facility and community levels, and opportunities included overcoming them, making MR, SA, and PAC integral to the mitigation phase,and policy change to overcome barriers related to unaff ordability and inaccessibility. Recommendations are provided to encourage research and policy towards improving neglected SRH in disaster settings to realize Sustainable Development Goal 3 and the Global Strategy and Sendai Framework's priority to promote disaster-resilient health systems.

关键词： Abortion Disasters Sendai framework Sexual and reproductive health Sustainable development goal

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Fe_(3)O_(4)对黄铜矿在酸性硫酸铁溶液中铜溶解氧化还原反应的影响

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Transactions of Nonferrous Metals Society of China 2024年第6期34卷 1965-1975页

作者： Kolela J NYEMBWE Elvis FOSSO-KANKEU Frans WAANDERS Martin MKANDAWIRE Didier K NYEMBWE Bhekie B MAMBA Water Pollution Monitoring and Remediation initiatives Research Group School of Chemical and Minerals EngineeringFaculty of EngineeringNorth-West UniversityPotchefstroomSouth Africa department of Mining Engineering College of Science Engineering and TechnologyUniversity of South AfricaFlorida Science CampusJohannesburgSouth Africa department of Metallurgy Faculty of Engineering and Built EnvironmentUniversity of JohannesburgDoornfonteinJohannesburgSouth Africa department of Chemistry School of Science and TechnologyCape Breton UniversityCanada School of Mining Metallurgy and Chemical EngineeringFaculty of Engineering and the Built EnvironmentUniversity of JohannesburgJohannesburgSouth Africa Institute for Nanotechnology and Water Sustainability College of Science Engineering and TechnologyUniversity of South AfricaFlorida Science CampusJohannesburgSouth Africa

由于钝化层的形成,黄铜矿(CuFeS_(2))在氧化条件下浸出通常具有溶解速率缓慢的特点。为了将黄铜矿浸出过程中的钝化效应降至最低并提高铜的回收率,研究了CuFeS_(2)在不同pH值(1.0、1.5和1.8)和温度(25和50℃)条件下浸出时,向Fe_(2)(SO_(... 详细信息

由于钝化层的形成,黄铜矿(CuFeS_(2))在氧化条件下浸出通常具有溶解速率缓慢的特点。为了将黄铜矿浸出过程中的钝化效应降至最低并提高铜的回收率,研究了CuFeS_(2)在不同pH值(1.0、1.5和1.8)和温度(25和50℃)条件下浸出时,向Fe_(2)(SO_(4))_(3)−H_(2)SO_(4)浸出剂中添加磁铁矿(Fe_(3)O_(4))对铜溶解速率的影响。结果表明,溶液pH值、电位和温度在溶解过程中起着关键作用。在pH 1.8、50℃和400 mV的条件下,Fe_(3)O_(4)−CuFeS_(2)混合体系中铜的回收率达到最大值(70%),而未添加Fe_(3)O_(4)时,CuFeS_(2)中铜的回收率较低(48%)。添加Fe_(3)O_(4)有助于维持较高的氧化还原值。添加Fe_(3)O_(4)还使活化能从79.04 kJ/mol降低到53.69 kJ/mol。这表明,当Fe_(3)O_(4)存在时,由于形成了更易溶解的中间体斑铜矿(Cu_(5)FeS_(4))和辉铜矿(Cu_(2)S),CuFeS_(2)更易被氧化。两种溶解过程都受到矿物表面的化学控制。此外,对浸出残渣的矿物学分析表明,当无Fe_(3)O_(4)存在时,作为表面钝化物的黄钾铁矾浓度较高。因此,添加Fe_(3)O_(4)减少了钝化层的形成,提升了铜的回收率。

关键词：黄铜矿溶解磁铁矿电偶钝化

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Biological function of miRNA-145-5p in angiotensin II induced renal inflammation

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BIOCELL 2024年第4期48卷 601-611页

作者： BIN LI YUCHENG SHENG XIAOYING XU SHENGCUN WANG HONGYAN SONG JINGYUAN LI HAONAN JI QINGHUA WANG XIAODI ZHOU LONGJU QI department of Pediatrics Affiliated Hospital of Nantong UniversityNantong226001China department of Science and Education Affiliated Nantong Hospitalof Nantong UniversityNantong226001China Laboratory Animal Center Nantong UniversityNantong226001China department of Gynecology and Obstetrics and department of Oncology Hai’an Hospital Affiliated to Nantong UniversityNantong226600China

Objective:Chronic kidney disease(ckd)is a progressive disorder characterized by intricate structural and functional alterations in the kidneys,attributable to diverse causative ***,the therapeutic promise of miR-145-5p in addressing renal pathologies has been *** investigation seeks to elucidate the functional role of miR-145-5p in injured kidneys by subjecting human glomerular mesangial cells(HGMCs)to stimulation with Angiotensin II(AngII).Materials and Methods:Cellular viability and the levels of inﬂammatory mediators were evaluated utilizing Cell Counting Kit-8(CCK-8),quantitative real-time polymerase chain reaction(qRT-PCR),and western blot methodologies,both in the presence of AngII incubation and in scenarios of miR-145p overexpression and ***,the cell cycle dynamics were elucidated through Fluorescence-activated Cell Sorting(FACS)***:AngII incubation induced an upregulation of miR-145-5p and inﬂammatory factors including Intercellular Adhesion Molecule 1(ICAM-1),Interleukin 6(IL-6),Interleukin 8(IL-8),and Interleukin 1β(IL-1β).Additionally,it elevated the expression of Cyclin A2,Cyclin D1,and the G2/M cell cycle ***,inhibition of miR-145-5p heightened the levels of inﬂammatory factors and cell cycle regulators induced by AngII *** expression of miR-145-5p correlated with a downregulation of Interleukin 10(IL-10)expression,concurrently promoting HGMC proliferation under AngII ***,ectopic miR-145-5p expression demonstrated a reduction in inﬂammatory factors,cell cyclin regulators,G2/M cell cycle ratio,and overall ***:MiR-145-5p exhibited inhibitory effects on the inﬂammatory response and proliferation induced by Angiotensin II in HGMCs,showcasing its potential as a therapeutic avenue for the treatment of kidney injury.

关键词： miR-145-5p Kidney Angiotensin II Cell cycle Inflammation

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Cost burden following esophagectomy:A single centre observational study

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2255-2269页

作者： Vered Buchholz Dong Kyu Lee David S Liu Ahmad Aly Stephen A Barnett Riley Hazard Peter Le Benjamin Kioussis Vijayaragavan Muralidharan Laurence Weinberg department of Surgery Austin HealthMelbourne 3084VictoriaAustralia department of Anesthesiology and Pain Medicine Dongguk University Ilsan HospitalSeoul 14566GoyangSouth Korea department of Surgery Austin HealthThe University of MelbourneMelbourne 3084VictoriaAustralia department of Anesthesia Austin HealthMelbourne 3084VictoriaAustralia department of Anesthesia Austin HospitalHeidelberg 3084VictoriaAustralia department of Critical Care The University of MelbourneMelbourne 3084VictoriaAustralia

BACKGROUND Cost analyses of patients undergoing esophagectomy is valuable for identifying modifiable expenditure drivers to target and curtail costs while improving the quality of *** aimed to define the cost-complication relationship after esophagectomy and delineate the incremental contributions to *** To assess the relationship between the hospital costs and potential cost drivers post esophagectomy and investigate the relationship between the cost-driving variables(predicting variables)and hospital costs(dependent variable).METHODS In this retrospective single center study,the severity of complications was graded using the Clavien-Dindo(CD)classification *** esophagectomy complications were categorized and defined according to consensus *** costing data included the in-hospital costs of the index admission and any unplanned admission within 30 postoperative *** used correlation analysis to assess the relationship between key clinical variables and hospital costs(in United States dollars)to identify cost drivers.A mediation model was used to investigate the relationship between these variables and hospital *** A total of 110 patients underwent primary esophageal *** median admission cost was $47822.7(interquartile range:35670.2-68214.0).The total effects on costs were $13593.9(95%CI:10187.1-17000.8,Pinitiatives and strategies are needed to enhance patient outcomes and minimize costs.

关键词： Anesthesia Esophagectomy Complications Cancer Surgery

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Epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China:a hospital-based retrospective study

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Neural Regeneration Research 2024年第5期19卷 1126-1132页

作者： Hengxing Zhou Yongfu Lou Lingxiao Chen Yi Kang Lu Liu Zhiwei Cai David BAnderson Wei Wang Chi Zhang Jinghua Wang Guangzhi Ning Yanzheng Gao Baorong He Wenyuan Ding Yisheng Wang Wei Mei Yueming Song Yue Zhou Maosheng Xia Huan Wang Jie Zhao Guoyong Yin Tao Zhang Feng Jing Rusen Zhu Bin Meng Li Duan Zhongmin Zhang Desheng Wu Zhengdong Cai Lin Huang Zhanhai Yin Kainan Li Shibao Lu Shiqing Feng department of Orthopedics The Second HospitalCheeloo College of MedicineShandong UniversityShandongChina department of Orthopedics Shandong University Center for OrthopedicsQilu HospitalCheeloo College of MedicineShandong UniversityShandongChina department of Orthopedics Tianjin Medical University General HospitalInternational Science and Technology Cooperation Base of Spinal Cord InjuryTianjin Key Laboratory of Spine and Spinal CordTianjinChina Faculty of Medicine and Health The Back Pain Research TeamSydney Musculoskeletal HealthThe Kolling InstituteUniversity of SydneySydneyNSWAustralia department of Spine Surgery Honghui HospitalXi’an Jiaotong UniversityXi’anShaanxi ProvinceChina department of Burns and Plastic Surgery The Fourth Medical Center of Chinese PLA General HospitalBeijingChina Faculty of Medicine and Health School of Health SciencesUniversity of SydneyNSWAustralia Sydney Spine Institute BurwoodSydneyNSWAustralia Laboratory of Epidemiology Tianjin Neurological InstituteDepartment of NeurologyTianjin Medical University General Hospital&Tianjin Neurological InstituteKey Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous SystemMinistry of Education and Tianjin CityTianjinChina department of Orthopedics Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina department of Spinal Surgery The Third Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina department of Orthopedics The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina department of Spine Surgery Zhengzhou Orthopedics HospitalZhengzhouHenan ProvinceChina department of Orthopedic Surgery and Orthopedic Research Institute West China HospitalSichuan UniversityChengduSichuan ProvinceChina department of Orthopedics Xinqiao HospitalArmy Medical UniversityChongqingChina department of Orthopedics The First Affiliated Hospital of China Medical UniversityShenyangLiaoning ProvinceChina department of Spinal Surgery Shengj

Traumatic spinal cord injury is potentially catastrophic and can lead to permanent disability or even *** has the largest population of patients with traumatic spinal cord *** studies of traumatic spinal cord injury in China have mostly been regional in scope;national-level studies have been *** the best of our knowledge,no national-level study of treatment status and economic burden has been *** retrospective study aimed to examine the epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China at the national *** included 13,465 traumatic spinal cord injury patients who were injured between January 2013 and December 2018 and treated in 30 hospitals in 11 provinces/municipalities representing all geographical divisions of *** epidemiological and clinical features,treatment status,and total and daily costs were *** in the percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department and cost of care were assessed by annual percentage change using the Joinpoint Regression *** percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department did not significantly change overall(annual percentage change,-0.5%and 2.1%,respectively).A total of 10,053(74.7%)patients underwent *** 2.8%of patients who underwent surgery did so within 24 hours of injury.A total of 2005(14.9%)patients were treated with high-dose(≥500 mg)methylprednisolone sodium succinate/methylprednisolone(MPSS/MP);615(4.6%)received it within 8 *** total cost for acute traumatic spinal cord injury decreased over the study period(-4.7%),while daily cost did not significantly change(1.0%increase).Our findings indicate that public health initiatives should aim at improving hospitals’ability to complete early surgery within 24 ho

关键词： China clinical features costs epidemiology methylprednisolone sodium succinate methylprednisolone retrospective study traumatic spinal cord injury treatment

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Correlation between rate-pressure product or pressure-rate quotient and urinary albumin-creatinine ratio in the Chinese older population:The REACTION study

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Chinese Medical Journal 2024年第2期137卷 238-240页

作者： Linghuan Wang Peixin Wu Kang Chen Binqi Li Jie Wang Yiming Mu department of Endocrinology The First Medical CenterChinese PLA General HospitalNational Key Laboratory of Kidney DiseasesBeijing 100853China department of Medicine School Nankai UniversityTianjin 300071China department of Endocrinology Beijing Chao-Yang HospitalBeijing 100020China

To the Editor:Chronic kidney disease(ckd)is a critical health *** elevated urinary albumin-creatinine ratio(UACR)is a marker of impaired renal function and is a key risk factor for cardiovascular *** rate-pressure product(RPP)[1]and pressure rate quotient(PRQ)are widely used as methods to quantify cardiac load and hemodynamic response to exercise in clinical ***,to better predict ckd,it is of great signicance to explore the relationships between RPP or PRQ and UACR.

关键词： urinary impaired creatinine

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Neutrophil-to-lymphocyte ratio associated with renal function in type 2 diabetic patients

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World Journal of Clinical Cases 2024年第14期12卷 2308-2315页

作者： Jin-Li Gao Jue Shen Li-Ping Yang Li Liu Kai Zhao Xiao-Rong Pan Lei Li Ji-Ji Xu department of Prevention and Health Care Community Health Service Center of Miaohang TownShanghai 200443China department of Prevention and Health Care Community Health Service Center of Songnan TownShanghai 200434China department of General Practice Community Health Service Center of Songnan TownShanghai 200434China department of Administrative Community Health Service Center of Songnan TownShanghai 200434China

BACKGROUND Type 2 diabetes mellitus(T2DM)is a leading risk factor for the development and progression of chronic kidney disease(ckd).However,an accurate and con-venient marker for early detection and appropriate management of ckd in in-dividuals with T2DM is *** studies have demonstrated a strong correlation between the neutrophil-to-lymphocyte ratio(NLR)and ***-theless,the predictive value of NLR for renal damage in type 2 diabetic patients remains *** study included 1040 adults aged 65 or older with T2DM from Shanghai's Community Health Service *** total number of neutrophils and lym-phocytes was detected,and NLR levels were *** was defined as an estimated glomerular filtration rate≤60 mL/min/1.73 m².Participants were di-vided into four groups based on NLR *** clinical data and biochemical characteristics were compared among groups.A multivariate logistic regression model was used to analyze the association between NLR levels and *** Significant differences were found in terms of sex,serum creatinine,blood urea nitrogen,total cholesterol,and low-density lipoprotein cholesterol among patients with T2DM in different NLR groups(Pckd(P for trend=0.0011).Multivariate logistic regression analysis indicated that a high NLR was an independent risk factor for ckd in T2DM patients even after adjustment for important clinical and pathological parameters(P=0.0001,odds ratio=1.41,95%confidence intervals:1.18-1.68).CONCLUSION An elevated NLR in patients with T2DM is associated with higher prevalence of ckd,suggesting that it could be a marker for the detection and evaluation of diabetic kidney disease.

关键词： Type 2 diabetes mellitus Neutrophil-to-lymphocyte ratio Chronic kidney disease Logistic regression Diabetes mellitus

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