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Therapeutic targeting of cellular prion protein: toward the development of dual mechanism anti-prion compounds

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Neural Regeneration Research 2025年第4期20卷 1009-1014页

作者： Antonio Masone Chiara Zucchelli Enrico Caruso Giovanna Musco Roberto Chiesa Laboratory of Prion Neurobiology Department of NeuroscienceIstituto di Ricerche Farmacologiche Mario Negri IRCCSMilanItaly Biomolecular NMR Unit Division of Genetics and Cell BiologyIRCCS Ospedale San RaffaeleMilanItaly department of biotechnology and Life Sciences University of InsubriaVareseItaly

PrPSc,a misfolded,aggregation-prone isoform of the cellular prion protein(PrPC),is the infectious prion agent responsible for fatal neurodegenerative diseases of humans and other *** adopt different pathogenic conformations(prion strains),which can be resistant to potential drugs,or acquire drug resistance,posing challenges for the development of effective *** PrPCis the obligate precursor of any prion strain and serves as the mediator of prion neurotoxicity,it represents an attractive therapeutic target fo r prion *** this minireview,we briefly outline the approaches to target PrPCand discuss our recent identification of Zn(Ⅱ)-Bn PyP,a PrPC-targeting porphyrin with an unprecedented bimodal mechanism of *** argue that in-depth understanding of the molecular mechanism by which Zn(Ⅱ)-Bn PyP targets PrPCmay lead toward the development of a new class of dual mechanism anti-prion compounds.

关键词： anti-prion drug anti-PrPC antibody antisense oligonucleotide neurodegeneration pharmacological chaperone porphyrin prion disease PrPC degrader PrPC shedding zinc finger repressor

Effect of chromium on growth attributes in sunflower(Helianthus annuus L.)

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Journal of Environmental Sciences 2008年第12期20卷 1475-1480页

作者： FOZIA Andaleeb MUHAMMAD Anjum Zia MUHAMMAD Ashraf ZAFAR Mahmood Khalid National Institute for biotechnology and Genetic Engineering department of Chemistry and Biochemistry University of Agriculture department of botany University of Agriculture

Heavy metal soil pollution takes place when the metal concentration of soil exceeds natural background level and causes ecological destruction and deterioration of the *** the present study,a pot experiment was conducted to evaluate the effect of chromium-contaminated soil in sunflower(Helianthus annuus L.)growth *** different levels of chromium(Cr)i.e.,20, 40,and 60 mg/kg were applied to three varieties of sunflower(G-3,G-9,and G-59).The results of morphological,chemical,and yield p...

关键词： Helianthus annuus L. soil chromium growth attributes

Role of copper chelating agents: between old applications and new perspectives in neuroscience

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Neural Regeneration Research 2025年第3期20卷 751-762页

作者： Rosalba Leuci Leonardo Brunetti Vincenzo Tufarelli Marco Cerini Marco Paparella Nikola Puvača Luca Piemontese department of Pharmacy-Pharmaceutical Science University of Bari Aldo MoroBariItaly department of Precision and Regenerative Medicine and Jonian Area(DiMePRe-J) Section of Veterinary Science and Animal ProductionUniversity of Bari Aldo MoroBariItaly department of Engineering Management in biotechnology Faculty of Economics and Engineering Management in Novi SadUniversity Business Academy in Novi SadNovi SadSerbia

The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.

关键词： agriculture Alzheimer's disease chelators copper feed supplements multi-target

Antimicrobial activity of Cannabis sativa,Thuja orientalis and Psidium guajava leaf extracts against methicillin-resistant Staphylococcus aureus

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Journal of Integrative Medicine 2018年第5期16卷 350-357页

作者： Shohini Chakraborty Nashra Afaq Neelam Singh Sukanta Majumdar department of Microbiology Saaii College of Medical Science and Technology Microbiology and Microbial biotechnology Laboratory Department of BotanyUniversity of Gour Banga

Objective： This study examined the antimicrobial activity of Cannabis sativa, Thuja orientalis and Psidium guajava against methicillin-resistant Staphylococcus aureus （MRSA） and used a standardized purification protocol to determine the presence and abundance of bioactive compounds in the leaf extracts. Methods： In vitro antimicrobial activities of the ethanolic extracts of C sativa, T. orientalis and P. guajava were tested against MRSA. The presence of bioactive molecules in these three leaves was evaluated using biochemical assays and high-performance thin-layer chromatography （HPTLC）. Results： Resistance to methicillin, penicillin, oxacillin and cefoxitin was observed in each of the clinical and nonclinical MRSA isolates. However, they were still vulnerable to vancomydn. Used individually, the 50% extract of each plant leaf inhibited MRSA growth. A profound synergism was observed when C sativa was used in combination with T. orientalis （1：1 ） and when P. guajava was used in combination with T. orientalis （1：1 ）. This was shown by larger zones of inhibition. This synergism was probably due to the combined inhibitory effect of phenolics present in the leaf extracts （i.e., quercetin and gallic acid） and catechin, as detected by HPTLC. Conclusion： The leaf extracts of C sativa, T. orientalis and P. guajava had potential for the control of both hospital- and community-acquired MRSA. Moreover, the inhibitory effect was enhanced when extracts were used in combination.

关键词： Methicillin-resistant Staphy lococcus aureus Antimicrobial activity Plant extracts Synergistic effect High-performance thin-layer chromatography

Effects of chitosan coatings fused with medicinal plant extracts on postharvest quality and storage stability of purple passion fruit(Passiflora edulis ***)

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Food Quality and Safety 2022年第1期6卷 93-111页

作者： Kwanele A.Nxumalo Olaniyi A.Fawole Postharvest Research Laboratory Department of Botany and Plant BiotechnologyUniversity of JohannesburgAuckland ParkJohannesburgSouth Africa

Chitosan edible coating(Ch;2%,mass concentration)enriched with 2%of 0.1 mg/L Bidens pilosa(Ch+B),Lippia javanica(Ch+L),Syzygium cordatum(Ch+S),or Ximenia caffra(Ch+X)was applied as a composite edible coating in alleviating shrivel and maintaining the quality of purple passion fruit(Passiflora edulis ***).Treated fruit was dipped for 3 min in the coating solution,and control fruit was dipped in distilled *** fruit were stored at(8±2)℃and 90%±5%relative humidity(RH)for 32 *** was done every 8 d plus 3 d(20±2)℃and(50%±5%)RH to simulate retail *** of medicinal plant extracts in the chitosan matrix varied;lower ethylene production(82.42μL C_(2)H_(4)/(kg·h))was seen in fruit coated with Ch+S,and the lowest respiration rate(75 mL CO_(2)/(kg·h))was observed in fruit coated with Ch+*** control fruit showed the highest ethylene production(84.90μL C_(2)H_(4)/(kg·h))and respiration rate(117.98 mL CO_(2)/(kg·h)).Fruit coated with Ch+B had the lowest weight loss(41.67%),higher juice content(60.13%)and BrimA(3.31);while the control fruit had the highest weight loss(88.03%),lowest juice content(21.90%),and BrimA(2.49).Shrivel incidence was lowest(23.70%)on fruit coated with Ch+L and highest(83.30%)on the control *** coated with Ch+X had the lowest electrolyte leakage(71.40%),while the control fruit had the highest(91.97%).Fruit coated with chitosan alone performed better than the control fruit but did not exceed the quality of composite chitosan-coated *** on the principal component analysis,it can be concluded that passion fruit coated with Ch+B was more effective in alleviating shrivel incidence,better maintained the quality ofpassion fruit duringstorage,andshows potential for commercial applications.

关键词： Quality attributes anthocyanins perishability respiration granadilla

Anti-enteric bacterial activity and phytochemical analysis of the seed kernel extract of Mangifera indica Linnaeus against Shigella dysenteriae(Shiga,corrig.) Castellani and Chalmers

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Asian Pacific Journal of Tropical Medicine 2011年第4期4卷 294-300页

作者： Rajan S Thirunalasundari T Jeeva S department of Microbiology Srimad Andavan Arts and Science College department of biotechnology Bharathidasan University Centre for Biodiversity and biotechnology Department of BotanyN.M.Christian College

Objective:To evaluate the phytochemical and anti-bacterial efficacy of the seed kernel extract of Mangifera indica(***) against the enteropathogen,Shigella dysenteriae(***), isolated from the diarrhoeal stool ***:The preliminary phytochemical screening was performed by the standard methods as described by *** extraction method was employed to extract the bioactive compounds from mango seed *** diffusion method was adopted to screen antibacterial *** inhibitory concentration(MIC) was evaluated by agar dilution *** crude extracts were partially purified by thin layer chromatography(TLC) and the fractions were analyzed by high performance thin layer chromatography(HFTLC) to identify the bioactive ***:Phytochemical scrutiny of *** indicated the presence of phytochemical constituents such as alkaloids,gums, flavanoids,phenols,saponins,steroids,tannins and *** activity was observed in two crude extracts and various fractions ***,benzene,chlor of orm,methanol and *** of methanol fraction was found to be(95±11.8)μg/*** of other fractions ranged from 130-380μg/mL Conclusions:The present study confirmed that each crude extracts and fractions of *** have significant antimicrobial activity against the isolated pathogen 5. *** antibacterial activity may be due to the phytochemical constituents of the mango seed *** phytochemical tannin could be the reason for its antibacterial activity.

关键词： Antibacterial activity Mangifera indica(seed kernel) Minimum inhibitory concentration Phytochemistry Shigella dysenteriae

A review on the ambit and prospects of C_3 and C_4 plants in Nigeria

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Research in Cold and Arid Regions 2017年第6期9卷 587-598页

作者： Abdulwakeel Ayokun-nun Ajao Oludare Oladipo Agboola Sefiu Adekilekun Saheed department of botany Obafemi Awolowo University department of botany and Plant biotechnology University of Johannesburg department of botany University of Lagos

Despite the enormous applications of photosynthesis in global carbon budget and food security, photosynthesis research has not been adequately explored as a research focus in Nigeria. Previous works on C3 and C4 plants in Nigeria were mainly on the use of anatomical characteristics to delimit plant species into their respective pathways, with no attention being paid to its applications. In this review, past and present knowledge gaps in this area of study are elucidated. Information used in this review were sourced from referred research articles and books in reputable journals. The results revealed that C3 and C4 plants are distributed among 21 genera and 11 families in Nigeria. In addition there is dearth of informatio such that only three genera have been classified based on diverse photosynthetic pathways with no information found on the physiological and biochemical characterization of these genera. Moreover, further research is also suggested for tackling new challenges in the area of food productivity and climate change.

关键词： biofuel bundle shealth climate change Kranz tissue mesophyll

Alginate encapsulation in Glycyrrhiza glabra *** phyto-chemical profiling of root extracts of in vitro converted plants using GC-MS analysis

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Asian Pacific Journal of Tropical Biomedicine 2017年第10期7卷 855-861页

作者： Rakhshanda Akhtar Anwar Shahzad Plant biotechnology Section Department of BotanyAligarh Muslim UniversityAligarh 202002Uttar PradeshIndia

Objective: To investigate the conversion potential of alginate encapsulated nodes of Glycyrrhiza glabra with phyto-chemical evaluation of root extract of field transferred ***: The excised axenic nodal segments were encapsulated in alginate matrix planted on Murashige and Skoog(1962) medium with different supplementation and formulations of PGRs. The two year old field transferred plants were evaluated for phytocompounds analysis using GC-MS ***: Varied responses were observed during the study, maximum conversion95.83% ± 2.40% was obtained in these encapsulates when planted on MS medium containing 2.5 m M Kinetin and 0.5 m M a-Naphthalene acetic acid, which eventually developed into complete plantlets in a single step. Further, GC-MS analysis showed the presence of different phyto-compounds in the methanolic root extracts of in vitro converted plants. The results obtained revealed the presence of about 47 phyto-compounds along with various potential bioactive compounds useful for industrial and pharmaceutical ***: This study investigates high frequency regeneration and conversion of Glycyrrhiza glabra in a single step in short time. Also, the in vitro raised plants are analysed for bioactive compounds after field transfer, which shows the presence of numerous compounds useful for commercial and pharmacological purposes.

关键词： Synseeds Conservation Licorice Morphogenic Chemopreventive

Phytochemical analysis,antioxidant,acetylcholinesterase,andα-amylase inhibitors from Hippeastrum hybridum extract

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Journal of Traditional Chinese Medicine 2024年第3期44卷 496-504页

作者： Naila Sher Mushtaq Ahmed Nadia Mushtaq department of biotechnology University of Science and Technology Bannu-KPK 28100Pakistan department of botany University of Science and Technology Bannu-KPK 28100Pakistan

OBJECTIVE:To investigate the effects of Hippeastrum hybridum(HH)as a free radical scavenger,and an inhibitor of the two enzymes i-e Alpha-amylase(α-amylase)and acetylcholinesterase(AChE).METHODS:In this study,HH plant was preliminary analyzed for phytochemical screening and then tested for its antioxidant,anti-α-amylase,and anti-AChE efficiency via standard ***:Phytochemical analysis shows the existence of different compounds;while Coumarins and quinones were *** total phenolic,flavonoid,and tannins content were found to be(78.52±0.69)mg GAE/g,(2.01±0.04)mg RUE/g,and(58.12±0.23)mg TAE/g of plant extract respectively.28.02%±0.02%alkaloid and 2.02%±0.05%saponins were present in the HH *** HH extract showed the anti-oxidant property with IC50(50%inhibition)of(151.01±0.13)(HH),(79.01±0.04)(Ascorbic acid)for ferric reducing,(91.48±0.13)(HH),(48.02±0.11)(Ascorbic acid)against Ammonium molybdenum,(156.02±0.31)(HH),(52.38±0.21)(Ascorbic acid)against DPPH,136.01±0.21(HH),52.02±0.31(Ascorbic acid)against H_(2)O_(2),and 154.12±0.03(HH),(40.05±0.15)(Ascorbic acid)μg/mL against ABTS *** analysis indicated that HH caused a competitive type of inhibition ofα-amylase(V_(max)remained constant and Km increases from 10.65 to84.37%)while Glucophage caused the un-competitive type of inhibition i-e both Km and V_(max)decreased from40.49 to 69.15%and 38.86 to 69.61%*** K_(i),(inhibition constant);K_(I),(dissociation constant),K_(m),(Michaelis-Menten constant),and IC50 were found to be62,364,68.1,and 38.08±0.22 for HH and 12,101.05,195,34.01±0.21 for ***,HH causes an anon-competitive type of inhibition of AChE i-e Km remains constant while V_(max)decreases from 60.5%to74.1%.The calculated K_(i),K_(I),K_(m),and IC50 were found to be 32,36.2,0.05,and 18.117±***:From the current results,it is concluded that HH extract contains bioactive compounds,and could be a good alternative to controlling oxidant

关键词： Hippeastrum hybridum phytochemicals antioxidant alpha-amylase acetylcholinesterase