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Dietary yeast extract prevents alcoholic liver disease in mice via correcting gut dysbiosis and improving intestinal barrier function

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food Science and Human Wellness 2024年

作者： Hao Han Lei Tian Yajing Dong Yanyang Han Xiaoman Wang Qian Cheng Haibo Zhang Yan Zhang department of Nutrition and food Hygiene， School of Public Health， Shanxi Medical University Hubei Provincial Key Laboratory of Yeast Function Research Center of Nutrition and Health food Yichang School of Health Science and Engineering， Shanghai Engineering Research Center of food microbiology， University of Shanghai for Science and Technology

Alcoholic liver disease (ALD) is one of the major global public health problems. Yeast extract (YE)， a product prepared from yeast， has been proven to have antioxidant and anti-inflammatory properties. However， the potential role of YE in the prevention of ALD remains unclear. The present study aimed to investigate the protective effects of YE on ALD and explore the underlying mechanism based on gut microbiota. The result showed that YE supplementation significantly ameliorated chronic alcohol exposure-induced liver injury in mice. In addition， YE counteracted alcohol-induced gut dysbiosis， intestinal barrier dysfunction， lipopolysaccharide (LPS) leakage-induced inflammatory response in the liver. Moreover， microbiota depletion by a broad-spectrum antibiotic was sufficient to block the protective effect of YE on ALD， indicating the contribution of gut dysbiosis modulation to the hepatoprotective role of YE. Furthermore， we demonstrated the causal relationship between gut microbiota and hepatoprotective effects of YE with the fecal microbiota transplantation (FMT) experiment. Compared with the ALD-FMT mice， gut dysbiosis， intestinal barrier dysfunction， LPS/TLR4 signaling pathway activation， and liver inflammatory response were significantly improved in the YE-FMT mice. Together， our findings highlight that dietary YE protects against ALD through gut dysbiosis correction.

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Lactobacillus plantarum AR113 attenuates liver injury in D-galactose-induced aging mice via the inhibition of oxidative stress and endoplasmic reticulum stress

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food Science and Human Wellness 2024年第2期13卷 885-897页

作者： Yongjun Xia Yujie Gong Xiangna Lin Yijin Yang Xin Song Guangqiang Wang Zhiqiang Xiong Yangyang Qian Zhuan Liao Hui Zhang Lianzhong Ai School of Health Science and Engineering Shanghai Engineering Research Center of Food MicrobiologyUniversity of Shanghai for Science and TechnologyShanghai 200093China College of Life Sciences Linyi UniversityLinyi 276000China department of Gastroenterol. Digestive Endoscopy CenterChanghai HospitalShanghai 200082China

Probiotics could effectively eliminate excess reactive oxygen species(ROS)generated during aging or lipid metabolism disorders,but their mechanism is *** major purpose of this study was to investigate the mechanism of Lactiplantibacillus plantarun AR113 alleviating oxidative stress injury in the D-galactose induced aging *** result showed that pretreatment with *** AR113 significantly relieving H_(2)O_(2)induced cytotoxicity in HepG2 cells by maintain cell membrane integrity and increasing antioxidant enzyme *** D-galactose induced aging mice,*** AR113 could significantly attenuate liver damage and inflammatory infiltration by promoting endogenous glutathione(GSH)synthesis and activating the Nrf2/Keap1 signaling pathway in mice,and increasing the expression of regulated phaseⅡdetoxification enzymes and antioxidant *** analysis shown that gavage of *** AR113 could significantly reduce the expression of G protein-coupled receptor 78(GPR78)and C/EBP homologous protein(CHOP)proteins,and promote the restoration of endoplasmic reticulum(ER)homeostasis,thereby activating cell anti-apoptotic *** results were also confirmed in H_(2)O_(2)-treated HepG2 *** indicated that *** AR113 could inhibit D-galactose-induced liver injury through dual inhibition of ER stress and oxidative *** AR113 have good application potential in anti-aging and alleviating metabolic disorders.

关键词： Lactiplantibacillus plantarun AR113 HepG2 D-galactose Oxidative stress ER stress

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Bioactive compounds in Hericium erinaceus and their biological properties:a review

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food Science and Human Wellness 2024年第4期13卷 1825-1844页

作者： Yue Qiu Genglan Lin Weiming Liu Fuming Zhang Robert J.Linhardt Xingli Wang Anqiang Zhang College of food Science and Engineering Zhejiang University of TechnologyHangzhou 310014China Zhejiang Biosan Biotech Co. Ltd.Hangzhou 310052China department of Chemical and Biological Engineering Center for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroyNY 12180USA departments of Chemistry and Chemical Biology and Biomedical Engineering Biological ScienceCenter for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroyNY 12180USA

Hericium erinaceus is a nutritious edible and medicinal fungi,rich in a variety of functional active ingredients,with various physiological functions such as antioxidation,anticancer,and enhancing *** is also effective in protecting the digestive system and preventing neurodegenerative *** this review paper,we summarize the sources,structures and efficacies of the main active components in *** fruiting body,mycelium,and culture media,and update the latest research progress on their biological activities and the related molecular *** on this information,we provide detailed challenges in current research,industrialization and information on the active ingredients of *** for future studies and new applications of *** are proposed.

关键词： Hericium erinaceus Bioactive compounds Biological activities Antioxidation Neuroprotection Immunoregulation

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Unraveling the trans-epithelial absorption of novel dark blue pigment from Vaccinium bracteatum Thunb. leaves on the Caco-2 intestinal cell

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food Science and Human Wellness 2024年

作者： Mingcong Fan Weijia Lian Wenjun Yao Tingting Li Jiajia Zhao Qiang Li Yanming Guan Yan Li Haifeng Qian Zhiming Rao Li Wang School of food Science and Technology， State Key Laboratory of food Science and Technology， National Engineering Research Center for Functional food， Jiangnan University College of Cooking Science and Technology， Jiangsu College of Tourism School of biotechnology， Jiangnan University department of food Science and Engineering， College of Light Industry and food Engineering， Nanjing Forestry University China National Research Institute of food and Fermentation Industries Co.Ltd China National Institute of Standardization

The dark blue pigment (DBP) is a health ingredient from Vaccinium bracteatum Thunb. leaves used as a functional food supplement. However， the details of transepithelial absorption on the intestinal epithelial cells are barely understood. This study aimed to clarify the absorption properties of DBP in the Caco-2 cell monolayer model and evaluate the effect on the endo-metabolism and barrier function of Caco-2 cells. The results showed that the DBP did not show the dose-dependent toxic effect to Caco-2 cells between 0.25 and 1.5 mg/mL， which did not cause disorder in the normal cell metabolism and absorption activity. The Caco-2 cells monolayer model could absorb DBP by passive and active transport， and the absorptive pattern was dose-dependent when the concentration was more than 0.25 mg/mL. During DBP absorption， an increase in mRNA and protein expressions of glucose transporters demonstrated that the glucose transporters were the potential transporter of DBP. But the glucose transport amounts were significantly lowered after 30 min of DBP treatment， indicating that DBP owned the inhibitory effect on glucose transportation. Furthermore， DBP also owned protective effects on the barrier function of intestinal epithelial cells.

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Colorimetric indicator based on zwitterionic anti-freezing hydrogel and alizarin for visual monitoring of salmon fillets freshness

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Journal of Future foods 2024年第2期4卷 135-141页

作者： Yanan Liu Huan Li Jian Chen Jiesi Feng Renjie Lian Linglin Fu Yanbo Wang food Safety Key Laboratory of Zhejiang Province School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China Jinghai Group Co. Ltd.Rongcheng 264300China School of food and Health Beijing Technology and Business UniversityBeijing 100048China

Indicating hydrogels have shown the advantages of being fast, sensitive, and real-time in demonstrating the freshness of aquatic products due to their noticeable color change. In this work, an anti-freezing hydrogel embedded with pH-sensitive alizarin was developed as an original colorimetric indicator for monitoring the corruption of aquatic products at low temperatures. The anti-freezing hydrogel was prepared from 2-carboxyethyl acrylate, [2-(methacryloyloxy)ethyl]-trimethylammonium chloride, and 2-hydroxyethyl methacrylate monomers with triethylene glycol dimethacrylate as cross-linking agent. The hydrogel showed excellent anti-freezing capability, which was further incorporated with the pH-sensitive dye alizarin to gain the indicating capability. When applied in the indication of the freshness of salmon under low-temperature storage, it was found that the color changes of the indicator corresponded with the total volatile basic nitrogen contents of salmon, the correlation coefficient of which was 0.959 6. These results indicated the application potential of the hydrogels as freshness indicators during low-temperature storage or cold-chain transportation.

关键词： Colorimetric indicator Alizarin Zwitterionic hydrogel food freshness Visual monitoring

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Sperm function, mitochondrial activity and in vivo fertility are associated to their mitochondrial DNA content in pigs

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Journal of Animal Science and biotechnology 2024年第4期15卷 1550-1558页

作者： Marc Llavanera Yentel Mateo‑Otero Estel Vinolas‑Vergés Sergi Bonet Marc Yeste Unit of Cell Biology Department of BiologyFaculty of SciencesUniversity of GironaGirona ES‑17003Spain biotechnology of Animal and Human Reproduction(TechnoSperm) Institute of Food and Agricultural TechnologyUniversity of GironaGirona ES‑17003Spain Catalan Institution for Research and Advanced Studies(ICREA) Barcelona ES‑08010Spain

Background Despite their low abundance in sperm, mitochondria have diverse functions in this cell type, includ-ing energy production, signalling and calcium regulation. In humans, sperm mitochondrial DNA content(mtDNAc) has been reported to be negatively linked to sperm function and fertility. Yet, the association between mtDNAc and sperm function in livestock remains unexplored. For this reason, this study aimed to shed some light on the link between mtDNAc and sperm function and fertilising potential in pigs. A qPCR method for mtDNAc quantification was optimised for pig sperm, and the association of this parameter with sperm motility, kinematics, mitochondrial activity, and fertility was subsequently *** First, the q PCR method was found to be sensitive and efficient for mtDNAc quantification in pig sperm. By using this technique, mtDNAc was observed to be associated to sperm motility, mitochondrial activity and in vivo, but not in vitro, fertility outcomes. Specifically, sperm with low mtDNAc were seen to exhibit greater motility but decreased mitochondrial activity and intracellular reactive oxygen species. Interestingly, samples with lower mtD-NAc showed higher conception and farrowing rates, but similar in vitro fertilisation rates and embryo development, when compared to those with greater *** These findings enrich our comprehension of the association of mtDNAc with sperm biology, and lay the foundation for future research into employing this parameter as a molecular predictor for sperm function and fer-tility in livestock.

关键词： Fertility Mitochondria Motility mtDNA copy number qPCR Sperm

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Identification and Molecular Docking Mechanism of Novel Anti-Inflammatory Peptides from Lactobacillus paraplantarum Fermented Cannabis sativa L. (hemp) Seeds

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food Science and Human Wellness 2024年

作者： LingYue Shan Akanksha Tyagi HunJu Ham Deog Hwan Oh department of food Science and biotechnology， College of Agriculture and Life Sciences， Kangwon National University Future F Biotech Co.， Ltd department of Biological Environment， College of Agriculture and Life Sciences， Kangwon National University

The inflammatory response is a crucial physiological process that can lead to tissue damage and is considered a causative factor for various chronic diseases， such as rheumatoid arthritis. Recent research has focused on exploring valuable nutrients derived from Cannabis sativa L. (hemp) seeds， particularly hemp seed proteins. Therefore， this study aimed to investigate the release of anti-inflammatory peptides from Lactobacillus paraplantarum-fermented hemp seed proteins. To confirm the complete hydrolysis of hemp seed proteins during the fermentation process， SDS-PAGE was employed. Further， the isolation and purification of peptides were achieved through ultrafiltration. The identity of peptides was nextly established using ultra-high-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS). The results revealed a total of 39 identified peptides in fermented hemp seeds， with 9 peptides selected based on their relative quantity. Notably， AAELIGVP (P1)， AAVPYPQ (P2)， VFPEVAP (P4)， DVIGVPLG (P6)， and PVPKVL (P9) demonstrated strong anti-inflammatory abilities in LPS-induced Raw 264.7 macrophage cells. Molecular docking was used to understand the potential anti-inflammatory mechanism of these five peptides， and in silico results indicated that P1， P2， P4， P6， and P9 could bind to the active sites of TLR-4， NF-kB， and IKK with higher binding energies. Overall， these findings indicate that hemp seeds have potential to be a source of bioactive peptides for functional foods with anti-inflammatory properties.

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Glutamate oxidase-integrated biomimetic Fe_(3)O_(4) hybrids as cascade nanozymes for glutamate detection

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Particuology 2024年第5期88卷 192-200页

作者： Peikun Li Yanchao Wang Xiuyan Luo Zixin Geng Jiahui Jia Ruirui Wang Jiandong Cui Hongjie Bian Shiru Jia State Key Laboratory of food Nutrition and Safety Laboratory of Industrial Fermentation MicrobiologyMinistry of EducationTianjin University of Science and TechnologyTianjin300457China Sports department Hebei University of Science and TechnologyShijiazhang050000China Research Center for Fermentation Engineering of Hebei College of Bioscience and BioengineeringHebei University of Science and TechnologyShijiazhang050000China

Herein,a new nanozyme/natural enzyme hybrid biosensor was established for ultrasensitive l-glutamic acid(L-Glu)*** Fe_(3)O_(4) nanoparticles with peroxidase-like activity and stability was used as a nanozyme and carrier for immobilizing l-Glutamate oxidase(GLOD)through Schiffff base reaction to construct a chem-enzyme cascade *** resultant Fe_(3)O_(4)-GOLD exhibited a wide linear range(10−500μM)and a low detection limit of 6.03μM for L-Glu ***,the Fe_(3)O_(4)-GOLD exhibited excellent pH stability,thermal stability,reusability and storage *** repeated nine cycles,Fe_(3)O_(4)-GOLD still retained 70%of its initial ***,Fe_(3)O_(4)-GOLD maintained 50%of its initial activity after storage for 20 days,while free GLOD only retained 20%of its initial *** strategy of integrating biomimetic Fe 3 O4 and natural enzymes for cascade catalysis makes it possible to design an efficient and stable chemo-enzyme composite catalysts,which are promising for applications in biosensing and biomimetic catalysis.

关键词： Fe_(3)O_(4) nanozyme GLOD Chemo-enzymes Glutamate detection

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Synergistic effects of the entomopathogenic fungus Isaria javanica and low doses of dinotefuran on the efficient control of the rice pest Sogatella furcifera

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Journal of Integrative Agriculture 2024年第2期23卷 621-638页

作者： Tingting Zhou Qian Zhao Chengzhou Li Lu Ye Yanfang Li Nemat OKeyhani Zhen Huang department of Entomology College of Plant ProtectionSouth China Agricultural UniversityGuangzhou 510642China Guangdong Provincial Key Laboratory of High Technology for Plant Protection Plant Protection Research InstituteGuangdong Academy of Agricultural SciencesGuangzhou 510642China department of microbiology and Cell Science Institute of Food and Agricultural SciencesUniversity of FloridaFL 32611USA

The rice planthopper,Sogatella furcifera,is a piercing-sucking insect pest of rice,Oryza *** is responsible for significant crop yield losses,and has developed moderate to high resistance to several commonly used chemical *** investigated the effects of the insect fungal pathogen Isaria javanica,alone and in combination with the chemical insecticide dinotefuran,on *** under both laboratory and field *** results show that *** displays high infection efficiency and mortality for different stages of ***,reducing adult survival,female oviposition and ovary *** bioassays showed that the combined use of *** with a low dose(4-16 mg L^(-1))of dinotefuran resulted in higher mortality in *** than the use of *** or dinotefuran *** combined treatment also had more significant effects on several host enzymes,including superoxide dismutase,catalase,peroxidase,and prophenol oxidase *** field trials,*** effectively suppressed populations of rice planthoppers to low levels(22-64%of the level in untreated plots).Additional field experiments showed synergistic effects,i.e.,enhanced efficiency,for the control of *** populations using the combination of a low dose of ***(1×10^(4) conidia mL^(-1))and a low dose of dinotefuran(~4.8-19.2%of normal field use levels),with control effects of>90%and a population level under 50 insects per 100 hills at 3-14 days *** findings indicate that the entomogenous fungus *** offers an attractive biological control addition as part of the integrated pest management(IPM)practices for the control of rice plant pests.

关键词： Isaria javanica Sogatella furcifera entomopathogenic fungus white planthopper rice synergistic effect on pest control

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Photoluminescence,structural and antibacterial properties of co-dopedβ-Ca_(3)(PO_(4))_(2)-type phosphates Ca_(8)CuRE(PO_(4))_(7)(RE=Eu-Er)

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Journal of Rare Earths 2024年第9期42卷 1658-1668,I0002页

作者： Ivan V.Nikiforov Ekaterina V.Iliin Bogdan I.Lazoryak Sergey M.Aksenov Pavel V.Slukin Dina V.Deyneko department of Chemistry Lomonosov Moscow State University119991MoscowRussia Laboratory of Arctic Mineralogy and Material Sciences Kola Science CentreRussian Academy of Sciences184209ApatityRussia Geological Institute Kola Science CentreRussian Academy of Sciences184209ApatityRussia State Scientific Center of Applied microbiology and biotechnology of Rospotrebnadzor 24 Block A142279ObolenskRussia

Novel Ca_(8)CuRE(PO_(4))_(7)where RE^(3+)=Eu^(3+),Tb^(3+),Dy^(3+),Ho^(3+)and Er^(3+)were synthesized by a solid-state method in *** structures of the samples were characterized by powder X-ray diffraction using Rietveld refinement to determine the occupation of crystal *** samples are found to have a centrosymmetric structure with space group R3c,as shown by dielectric *** synthesized Ca_(8)CuRE(PO_(4))_(7)samples have multifunctional *** Cu^(2+)ions provide antibacterial properties,while the rare earth elements ions exhibit luminescence properties,and theβ-Ca_3(PO_(4))_(2)-type host is *** photoluminescence properties of RE^(3+)ions were studied and compared with other simmilar Ca_(8)MRE(PO_(4))_(7)phosphates,where M is a divalent *** photoluminescence intensity quenching in terms of energy transfer from RE^(3+)to Cu^(2+)is *** bioactive properties were studied in relation to antibacterial activity against *** and *** syntesized Ca_(8)CuRE(PO_(4))_(7)samples demonstrate very high and stable inhibition of bacteria *** correlation between crystal structure and properties is *** combining multiple approaches to the directio nal design of such materials,several important properties within a single chemical compound to achieve biovisualization and bioactive properties simultaneously can be combined.

关键词： β-Ca_(3)(PO_(4))_(2) Whitlockite-type structure Bioactive phosphates TCP Photoluminescence Rare earths

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