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Role of copper chelating agents: between old applications and new perspectives in neuroscience

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Neural Regeneration Research 2025年第3期20卷 751-762页

作者： Rosalba Leuci Leonardo Brunetti Vincenzo Tufarelli Marco Cerini Marco Paparella Nikola Puvača Luca Piemontese department of Pharmacy-Pharmaceutical Science University of Bari Aldo MoroBariItaly department of Precision and Regenerative Medicine and Jonian Area(DiMePRe-J) Section of Veterinary Science and Animal ProductionUniversity of Bari Aldo MoroBariItaly department of Engineering Management in biotechnology Faculty of Economics and Engineering Management in Novi SadUniversity Business Academy in Novi SadNovi SadSerbia

The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.

关键词： agriculture Alzheimer's disease chelators copper feed supplements multi-target

The CONSTANS-like 4 transcription factor,AtCOL_4,positively regulates abiotic stress tolerance through an abscisic acid-dependent manner in Arabidopsis

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Journal of Integrative Plant Biology 2015年第3期57卷 313-324页

作者： Ji-Hee Min Jung-Sung Chung Kyeong-Hwan Lee Cheol Soo Kim department of Plant biotechnology Chonnam National University department of Agronomy Gyeongsang National University department of Rural and biosystems Engineering Chonnam National University

The precise roles of the B-box zinc finger family of transcription factors in plant stress are poorly *** analysis was performed on AtCOL4,an Arabidopsis thaliana ***-like 4 protein that is a putative novel transcription factor,and which contains a predicted transcriptional activation *** of an AtCOL4 promoter-b-glucuronidase（GUS） construct revealed substantial GUS activity in whole *** expression of AtCOL4 was strongly induced by abscisic acid（ABA）,salt,and osmotic *** in atcol4 resulted in increased sensitivity to ABA and salt stress during seed germination and the cotyledon greening *** contrast,AtCOL4-overexpressing plants were less sensitive to ABA and salt stress compared to the wild ***,in the presence of ABA or salt stress,the transcript levels of other ABA biosynthesis and stress-related genes were enhanced induction in AtCOL4-overexpressing and WT plants,rather than in the atcol4 ***,AtCOL4 is involved in ABA and salt stress response through the ABA-dependent signaling *** together,these findings provide compelling evidence that AtCOL4 is an important regulator for plant tolerance to abiotic stress.e

关键词： Abscisic acid B-box zinc finger family transcription factor salt stress

Late effects of the treatment of childhood cancer

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World Journal of Clinical Cases 2025年第7期13卷 6-12页

作者： Jelena Roganovic department of Pediatric Oncology and Hematology Children's Hospital ZagrebZagreb 10000Croatia Faculty of biotechnology and Drug Development University of RijekaRijeka 51000Croatia

Excellent progress has been made in the last few decades in the cure rates of pediatric malignancies,with more than 80%of children with cancer who have access to contemporary treatment being ***,the therapies responsible for this survival can also produce adverse physical and psychological long-term outcomes,referred to as late effects,which appear months to years after the completion of cancer *** has shown that 60%to 90%of childhood cancer survivors(CCSs)develop one or more chronic health conditions,and 20%to 80%of survivors experience severe or life-threatening complications during ***,understanding the late side effects of such treatments is important to improve the health and quality of life of the growing population of CCSs.

关键词： Survivorship Cancer Children Treatment Late effects

BLUNT CRACK-TIP ELASTOPLASTIC ZONE OF MIXED MODE FRACTURE

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Acta Mechanica Solida Sinica 2014年第5期27卷 531-541页

作者： Mehdi Khojastehpour department of biosystems Engineering Ferdowsi University of Mashhad

This article discusses the characterization of fracture process zone at the tip of a blunt crack in elastoplastic materials under mixed mode loading. The analysis includes the description of elastoplastic zone geometry around the blunt crack tip for predicting crack growth direction. The deformed zone appearing at the crack front is described by presenting a criterion based on the subloading surface concept falling within the framework of unconventional plasticity. The mixed mode crack propagates along the minimum value of the elastoplastic region. The present solutions are reduced to those previously reported in literature, when the elastic perfectly plastic material is considered.

关键词： crack fracture elastic plastic materials stress concentration

Flow-mode synthesis of biodiesel under simultaneous microwave–magnetic irradiation

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Chinese Journal of Chemical Engineering 2019年第10期27卷 2551-2559页

作者： Behzad Khedri Mostafa Mostafaei Seyed Mohammad Safieddin Ardebili Mechanics of biosystems Engineering department Razi UniversityKermanshahIran biosystems Engineering department Shahid Chamran University of AhvazAhvazIran

In this study,aiming at optimization of a novel continuous biodiesel production system was developed by combining technologies based on microwaves and magnetic *** affecting microwave-assisted biodiesel(alkyl esters)production reaction were analyzed in this *** factors included magnetic field intensity(0,0.225 and 0.450 T),microwave power(400,821,and 1181 W),percentages of KOH and Na OH catalysts at constant concentrations of 1 wt%(0,50%and 100%),and percentages of ethanol and methanol at a constant molar ratio of 6:1(0,50%and 100%).Response Surface Methodology(RSM)was used to optimize the reaction ***-based analysis indicated that,all independent parameters had significant effects on the reaction *** of the investigations reveal that the largest effects on the conversion efficiency were due to type of alcohol and magnetic field *** optimized conditions were found to be a magnetic field intensity of 0.331 T,a microwave power of 677.77 W,catalyst percentages of 30.35%and 69.65%for KOH and Na OH,respectively,and alcohol percentages of 80.47%and 19.53%for methanol and ethanol,*** the optimal conditions,yield of the reaction was 96.2%.

关键词： Biodiesel Microwave Magnetic field Transesterification Waste cooking oil

Variations in quantifying patient reported outcome measures to estimate treatment effect

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World Journal of Methodology 2025年第2期15卷 44-53页

作者： Sathish Muthu Srujun Vadranapu department of Orthopaedics Orthopaedic Research GroupCoimbatore 641045Tamil NaduIndia department of Orthopaedics Government Medical CollegeKarur 639004Tamil NaduIndia department of biotechnology Karpagam Academy of Higher EducationCoimbatore 641021Tamil NaduIndia department of Orthopaedics Royal Care Super Speciality HospitalCoimbatore 641062Tamil NaduIndia

In the practice of healthcare,patient-reported outcomes(PROs)and PRO measures(PROMs)are used as an attempt to observe the changes in complex clinical *** guide us in making decisions based on the evidence regarding patient care by recording the change in outcomes for a particular treatment to a given condition and finally to understand whether a patient will benefit from a particular treatment and to quantify the treatment *** any PROM to be usable in health care,we need it to be reliable,encapsulating the points of interest with the potential to detect any real *** structured outcome measures routinely in clinical practice helps the physician to understand the functional limitation of a patient that would otherwise not be clear in an office interview,and this allows the physician and patient to have a meaningful conver-sation as well as a customized plan for each *** mentioned the rationale and the benefits of PROMs,understanding the quantification process is crucial before embarking on management decisions.A better interpretation of change needs to identify the treatment effect based on clinical relevance for a given *** are a multiple set of measurement indices to serve this effect and most of them are used interchangeably without clear demarcation on their *** article details the various quantification metrics used to evaluate the treatment effect using PROMs,their limitations and the scope of usage and implementation in clinical practice.

关键词： Patient-reported outcome measures Treatment effect Minimal clinical important difference Patient-accepted symptom state Minimum detectable change Orthopedics

Gut virome:New key players in the pathogenesis of inflammatory bowel disease

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World Journal of Methodology 2025年第2期15卷 27-43页

作者： Helal F Hetta Rehab Ahmed Yasmin N Ramadan Hayam Fathy Mohammed Khorshid Mohamed M Mabrouk Mai Hashem department of Medical Microbiology and Immunology Faculty of MedicineAssiut UniversityAssiut 71515Egypt Division of Microbiology Immunology and BiotechnologyFaculty of pharmacyUniversity of TabukTabuk 71491Saudi Arabia Division of Microbiology Immunology and BiotechnologyDepartment of Natural Products and Alternative MedicineFaculty of PharmacyUniversity of TabukTabuk 71491Saudi Arabia department of Internal Medicine Division HepatogastroenterologyAssiut UniversityAssiut 71515Egypt department of Clinical Research Egyptian Developers of Gastroenterology and Endoscopy FoundationCairo 11936Egypt department of Internal Medicine Faculty of Medicine.Tanta UniversityTanta 31527Egypt department of Tropical Medicine Gastroenterology and HepatologyAssiut University HospitalAssiut 71515Egypt

Inflammatory bowel disease(IBD)is a chronic inflammatory illness of the *** the mechanism underlying the pathogenesis of IBD is not fully under-stood,it is believed that a complex combination of host immunological response,environmental exposure,particularly the gut microbiota,and genetic suscept-ibility represents the major *** gut virome is a group of viruses found in great frequency in the gastrointestinal tract of *** gut virome varies greatly among individuals and is influenced by factors including lifestyle,diet,health and disease conditions,geography,and *** majority of research has focused on the significance of gut bacteria in the progression of IBD,although viral populations represent an important component of the *** conducted this review to highlight the viral communities in the gut and their expected roles in the etiopathogenesis of IBD regarding published research to date.

关键词： Inflammatory bowel disease Pathogenesis Gut virome Bacteriophage Eukaryotic viruses

Prediction of shelled shrimp weight by machine vision

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Journal of Zhejiang University-Science B(Biomedicine & biotechnology) 2009年第8期10卷 589-594页

作者： Peng-min PAN Jian-ping LI Gu-lai LV Hui YANG Song-ming ZHU Jian-zhong LOU department of biosystems Engineering School of Biosystems Engineering and Food Science Zhejiang University Hangzhou 310029 China

The weight of shelled shrimp is an important parameter for grading *** weight prediction of shelled shrimp by contour area is not accurate enough because of the ignorance of the shrimp *** this paper,a multivariate prediction model containing area,perimeter,length,and width was established.A new calibration algorithm for extracting length of shelled shrimp was proposed,which contains binary image thinning,branch recognition and elimination,and length reconstruction,while its width was calculated during the process of length *** model was further validated with another set of images from 30 shelled *** a comparison purpose,artificial neural network(ANN) was used for the shrimp weight *** ANN model resulted in a better prediction accuracy(with the average relative error at 2.67%),but took a tenfold increase in calculation time compared with the weight-area-perimeter(WAP) model(with the average relative error at 3.02%).We thus conclude that the WAP model is a better method for the prediction of the weight of shelled red shrimp.

关键词： Shelled shrimp Image Feature Length extracting Weight prediction Weight-area-perimeter (WAP) model

Biofilter:a promising tool for mitigating methane emission from manure storage

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Journal of Arid Land 2011年第1期3卷 61-70页

作者： Nazim CICEK Danny MANN department of biosystems Engineering University of Manitoba

Liquid manure storage may contribute to methane （CH4） emission and this emission can be greatly reduced if appropriate management practices are applied. Biofiltration has been used in other fields for mitigating greenhouse gas （GHG） emission （e.g., landfill） and shown promise for mitigation OH4 emis- sion from liquid manure storage. It has been reported that biofilter was capable of reducing 80% of CH4 emissions from manure storage. The OH4 removal efficiency is influenced by many factors, including OH4 and 02 concentrations, temperature, moisture, composition of the filter bed, nutrient, and empty bed resi- dency time （EBRT）. Biological conversion of methane of a biofilter is a slow process due to the low water solubility of methane. The residence times （EBRT） between 5 min and 5 h have been used, whereas a typical EBRT of 25 s is used for common biofilter applications. Temperature at which methanotrophic bac- teria are active ranges from 10℃ to 45℃. The maximum activity is found at around 30℃. The optimal filter bed water content depends on both the gas flow rate and the type of filter bed （soil, compost, etc.） and ranges from 30%-70% of the water holding capacity. Compost is the best material for filter bed. The optimal pH for methanotrophic bacteria is neutral to slightly acidic. Copper and nitrogen compounds especially nitrate are important nutrients to methanotrophic bacteria but their optimal concentrations have not been founded. Phosphorus and other elements such as potassium and manganese are reported to affect the performance of methanotrophic bacteria but need further confirmation.

关键词： biofilter greenhouse gas methane manure storage