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Adrenal pheochromocytoma impacts three main pathways: cysteine-methionine, pyrimidine, and tyrosine metabolism

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第5期25卷 410-421页

作者： Chong LAI Qingling YANG Yunuo ZHANG Renjie GONG Majie WANG Jiankang LI Maode LAI Qingrong SUN department of Urology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China School of Basic Medical sciences and Clinical Pharmacy China Pharmaceutical UniversityNanjing 210009China department of Laboratory Medicine the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Laboratory of Behavioral Neuroscience Ningbo Kangning HospitalNingbo Institute of Microcirculation and HenbaneSchool of MedicineNingbo UniversityNingbo 315201China Xi'an Key Laboratory of Stem Celland Regenerative Medicine Institute of Medical ResearchNorthwestern Polytechnical UniversityXi'an 710072China department of Pathology Research Unit of Intelligence Classification of Tumor Pathology and Precision TherapyChinese Academy of Medical Sciences Key Laboratory of Disease Proteomics of Zhejiang ProvinceZhejiang University School of MedicineHangzhou 310058China

Pheochromocytomas and paragangliomas(PPGLs)cause symptoms by altering the circulation levels of catecholamines and peptide ***,the diagnosis of PPGLs relies on diagnostic imaging and the detection of *** this study,we used ultra-performance liquid chromatography(UPLC)/quadrupole time-of-flight mass spectrometry(Q-TOF MS)analysis to identify and measure the perioperative differential metabolites in the plasma of adrenal pheochromocytoma *** identified differentially expressed genes by comparing the transcriptomic data of pheochromocytoma with the normal adrenal *** conducting two steps of metabolomics analysis,we identified 111 differential metabolites between the healthy group and the patient group,among which 53 metabolites were *** integrating the information of differential metabolites and differentially expressed genes,we inferred that the cysteine-methionine,pyrimidine,and tyrosine metabolism pathways were the three main metabolic pathways altered by the *** analysis of transcription levels revealed that the tyrosine and cysteine-methionine metabolism pathways were downregulated in pheochromocytoma,whereas the pyrimidine pathway showed no significant ***,we developed an optimized diagnostic model of two metabolites,L-dihydroorotic acid and *** results for these metabolites suggest that they may serve as potential clinical biomarkers and can be used to supplement and improve the diagnosis of pheochromocytoma.

关键词： Pheochromocytoma and paraganglioma(PPGL) Metabolomics Gene set variation analysis L-Dihydroorotic acid Vanylglycol

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Centroid Hom-associative Algebras and Centroid Hom-Lie Algebras

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Acta Mathematica Sinica,English Series 2024年第4期40卷 935-961页

作者： Yu Xiu BAI Leonid A.BOKUT Yu Qun CHEN Ze Rui ZHANG department of Mathematics Teaching Guangzhou Civil Aviation CollegeGuangzhou 510403P.R.China Sobolev Institute of Mathematics Novosibirsk 630090Russia Novosibirsk State University Novosibirsk 630090Russia School of Mathematical sciences South China Normal UniversityGuangzhou 510631P.R.China

In this article,we construct free centroid hom-associative algebras and free centroid hom-Lie *** also construct some other relatively free centroid hom-associative algebras by applying the Gr?bner-Shirshov basis theory for(unital)centroid hom-associative ***,we prove that the"Poincaré-Birkhoff-Witt theorem"holds for certain type of centroid hom-Lie algebras over a field of characteristic 0,namely,every centroid hom-Lie algebra such that the eigenvectors of the mapβlinearly generates the whole algebra can be embedded into its universal enveloping centroid hom-associative algebra,and the linear basis of the universal enveloping algebra does not depend on the multiplication table of the centroid hom-Lie algebra under consideration.

关键词： Centroid hom-Lie algebra centroid hom-associative algebra Gr?bner-Shirshov basis

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Enhancing photocatalytic CO_(2)reduction with TiO_(2)-based materials:Strategies,mechanisms,challenges,and perspectives

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Environmental Science and Ecotechnology 2024年第4期20卷 18-33页

作者： Zhimin Yuan Xianglin Zhu Xianqiang Gao Changhua An Zheng Wang Cheng Zuo Dionysios D.Dionysiou Hong He Zaiyong Jiang School of Chemistry&Chemical Engineering and Environmental Engineering Weifang UniversityWeifang261061PR China State Key Joint Laboratory of Environment Simulation and Pollution Control Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100085PR China Institute for Energy Research School of Chemistry and Chemical EngineeringJiangsu UniversityZhenjiang212013PR China Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion School of Chemistry and Chemical EngineeringTianjin University of TechnologyTianjin300384PR China Environmental Engineering and Science Program Department of Chemical and Environmental Engineering(DChEE)University of CincinnatiCincinnatiOH45221-0012USA College of Forestry Shandong Agricultural UniversityTaian271018PR China

The concentration of atmospheric CO_(2)has exceeded 400 ppm,surpassing its natural variability and raising concerns about uncontrollable shifts in the carbon cycle,leading to significant climate and environmental impacts.A promising method to balance carbon levels and mitigate atmospheric CO_(2)rise is through photocatalytic CO_(2)*** dioxide(TiO_(2)),renowned for its affordability,stability,availability,and eco-friendliness,stands out as an exemplary catalyst in photocatalytic CO_(2)*** strategies have been proposed to modify TiO_(2)for photocatalytic CO_(2)reduction and improve catalytic activity and product ***,few studies have systematically summarized these strategies and analyzed their advantages,disadvantages,and current ***,we comprehensively review recent advancements in TiO_(2)engineering,focusing on crystal engineering,interface design,and reactive site construction to enhance photocatalytic efficiency and product *** discuss how modifications in TiO_(2)'s optical characteristics,carrier migration,and active site design have led to varied and selective CO_(2)reduction *** enhancements are thoroughly analyzed through experimental data and theoretical ***,we identify current challenges and suggest future research directions,emphasizing the role of TiO_(2)-based materials in understanding photocatalytic CO_(2)reduction mechanisms and in designing effective *** review is expected to contribute to the global pursuit of carbon neutrality by providing foundational insights into the mechanisms of photocatalytic CO_(2)reduction with TiO_(2)-based materials and guiding the development of efficient photocatalysts.

关键词： summarized dioxide neutral

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An Advanced Image Processing Technique for Backscatter-Electron Data by Scanning Electron Microscopy for Microscale Rock Exploration

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Journal of Earth Science 2024年第1期35卷 301-305页

作者： Zhaoliang Hou Kunfeng Qiu Tong Zhou Yiwei Cai Frontiers Science Center for Deep-time Digital Earth China University of GeosciencesBeijing 100083China department of Geology University of ViennaVienna 1090Austria State Key Laboratory of Geological Processes and Mineral Resources School of Earth Sciences and ResourcesChinaUniversity of GeosciencesBeijing 100083China

Backscatter electron analysis from scanning electron microscopes(BSE-SEM)produces high-resolution image data of both rock samples and thin-sections,showing detailed structural and geochemical(mineralogical)*** allows an in-depth exploration of the rock microstructures and the coupled chemical characteristics in the BSE-SEM image to be made using image processing *** image processing is a powerful tool for revealing the more subtle data“hidden”in a picture,it is not a commonly employed method in geoscientific microstructural ***,we briefly introduce the general principles of image processing,and further discuss its application in studying rock microstructures using BSE-SEM image data.

关键词： Image processing rock microstructures electron-based imaging data mining

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Polyoxidovanadates a new therapeutic alternative for neurodegenerative and aging diseases

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Neural Regeneration Research 2024年第3期19卷 571-577页

作者： Sonia Irais Gonzalez-Cano Gonzalo Flores Jorge Guevara Julio Cesar Morales-Medina Samuel Treviño Alfonso Diaz Faculty of Chemical sciences Benemerita Autonomous University of PueblaPueblaMexico Institute of Physiology Benemerita Autonomous University of PueblaPueblaMexico department of Biochemistry Faculty of MedicineNational Autonomous University of MexicoMexico CityMexico Animal Reproduction Research Center CINVESTAV-Autonomous University of TlaxcalaTlaxcalaMexico

Aging is a natural phenomenon characterized by a progressive decline in physiological integrity,leading to a deterioration of cognitive function and increasing the risk of suffering from chronic-degenerative diseases,including cardiovascular diseases,osteoporosis,cancer,diabetes,and *** is considered the major risk factor for Parkinson’s and Alzheimer’s disease ***,diabetes and insulin resistance constitute additional risk factors for developing neurodegenerative ***,no treatment can effectively reverse these neurodegenerative ***,some antidiabetic drugs have opened the possibility of being used against neurodegenerative *** the previous framework,Vanadium species have demonstrated a notable antidiabetic *** research group evaluated polyoxidovanadates such as decavanadate and metforminium-decavanadate with preventive and corrective activity on neurodegeneration in brain-specific areas from rats with metabolic *** results suggest that these polyoxidovanadates induce neuronal and cognitive restoration *** review aims to describe the therapeutic potential of polyoxidovanadates as insulin-enhancer agents in the brain,constituting a therapeutic alternative for aging and neurodegenerative diseases.

关键词： Alzheimer’s disease antidiabetic brain cognition diabetes insulin neurodegeneration neuroinflammation oxidative stress Vanadium species

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Effects of using sinusoidal porous object(SPO)and perforated porous object(PPO)on the cooling performance of nano-enhanced multiple slot jet impingement for a conductive panel system

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Propulsion and Power Research 2024年第2期13卷 166-177页

作者： Fatih Selimefendigil Faiza Benabdallah Kaouther Ghachem Hind Albalawi Badr MAlshammari Lioua Kolsi department of Mechanical Engineering College of EngineeringKing Faisal UniversityAl Ahsa 31982Saudi Arabia department of Mechanical Engineering Celal Bayar UniversityManisa 45140Turkey department of Industrial Engineering and Systems College of EngineeringPrincess Nourah Bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia department of Physics College of SciencesPrincess Nourah Bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia department of Electrical Engineering College of EngineeringUniversity of Ha’ilHa’il City 81451Saudi Arabia department of Mechanical Engineering College of EngineeringUniversity of Ha’ilHa’il City 81451Saudi Arabia

Cooling system design for thermal management of electronic equipment,batteries and photovoltaic(PV)modules is important for increasing the efﬁciency,safety operation,and long life span the *** the present study,two different cooling systems are proposed with nano-enhanced multiple impinging jets for a conductive *** present cooling systems can be used in electronic cooling and PV *** porous object(PPO)and sinusoidal porous object(SPO)are used in the jet cooling system.2D numerical analysis usingﬁnite volume method is conducted considering different values of permeability of the objects(Darcy number(Da)between 10^(-6) and 10^(-1)).When PPO is used in the cooling system,num-ber of cylinders(between 1 and 6),and size of the cylinders(between 0.015 and 0.075)are *** the case of using SPO,amplitude(between 0.1 and 2)and wave number(be-tween 1 and 12)are ***-water nanoﬂuid with cylindrical shaped nanoparticles is used as the heat transferﬂ*** permeability is changed for PPO,the average temper-ature increases by roughly 3.89℃ for a single cylinder and drops by roughly 0.57℃ for a six-cylinder *** the size of the cylinder in the PPO case at highest permeability results in temperature drop of 5.3℃.When changing the number of cylinders,cooling rate varies by about 3.6%.Wave number of SPO is more inﬂuential on the cooling performance enhancement as compared to amplitude and permeability of the *** average surface temperature drops by 12.4℃ when the wave number is increased to *** compared to reference case of jet impingement cooling without porous object,using PPO and SPO along with the nanoﬂuid result in temperature drop of 12.3℃ and 14.4℃.

关键词： Thermal management Jet impingement Perforated porous

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Impact of sex on the outcomes of deceased donor liver transplantation

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World Journal of Transplantation 2024年第1期14卷 120-129页

作者： Oya M Andacoglu Isabel S Dennahy Nicole C Mountz Luisa Wilschrey Arzu Oezcelik Division of Transplantation and Advanced Hepatobiliary Surgery University of UtahSalt Lake CityUT 84112United States department of Surgery University of EssenEssen D-45122Germany department of Surgery The University of Oklahoma Health Sciences CenterOklahoma CityOK 73117United States department of Surgery University of Oklahoma College of MedicineOklahoma CityOK 73117United States

BACKGROUND Data examining the impact of sex on liver transplant(LT)outcomes are *** is clear that further research into sex-related differences in transplant patients is necessary to identify areas for *** of these differences may help to identify specific areas of focus to improve on the organ matching process,as well as the peri-and post-operative care of these *** To utilize data from a high-volume Eurotransplant center to compare characteristics of male and female patients undergoing liver transplant and assess association between sex-specific variables with short-and long-term post-transplant *** A retrospective review of the University of Essen’s transplant database was performed with collection of baseline patient characteristics,transplant-related data,and short-term *** of these data were made with Shapiro-Wilk,Mann-Whitney U,χ2 and Bonferroni tests applied where appropriate.A P value of<0.05 was accepted as statistically *** Of the total 779 LT recipients,261(33.5%)were *** patients suffered higher incidences of acute liver failure and lower incidences of alcohol-related or viremic liver disease(P=0.001).Female patients were more likely to have received an organ from a female donor with a higher donor risk index score,and as a high urgency offer(all P<0.05).Baseline characteristics of male and female recipients were also significantly *** multivariate hazard regression analysis,recipient lab-Model for End-Stage Liver Disease score and donor cause of death were associated with long-term outcomes in ***-operative diagnosis of hepatocellular carcinoma,age at time of listing,duration of surgery,and units transfused during surgery,were associated with long-term outcomes in *** of complications was associated with long-term outcomes in both *** survival was similar in both males and females;however,when stratified by age,females<50 y

关键词： Liver transplant Outcomes Survival Peri-and post-operative care

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Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk

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Genes & Diseases 2024年第1期11卷 103-134页

作者： Kevin Qin Michael Yu Jiaming Fan Hongwei Wang Piao Zhao Guozhi Zhaoo Wei Zeng Connie Chen Yonghui Wang Annie Wang Zander Schwartz Jeffrey Hong Lily Song William Wagstaff Rex C.Haydon Hue H.Luu Sherwin H.Ho Jason Strelzow Russell R.Reid Tong-Chuan He Lewis L.Shi Chicago Medical School Rosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Ministry of Education Key Laboratory of Diagnostic Medicine and Department of Clinical BiochemistryThe School of Laboratory MedicineChongqing Medical UniversityChongqing 400016China departments of Orthopaedic Surgery and Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China department of Interventional Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China department of Clinical Laboratory Medicine Shanghai Jiaotong University School of MedicineShanghai 200000China School of biomedical Engineering Vanderbilt UniversityNashvilleTN 37235USA Laboratory of Craniofacial Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA

Wnt signaling plays a major role in regulating cell proliferation and *** Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and LRP5/6 coreceptors and transducing the signal either throughβ-catenin in the canonical pathway or through a series of other proteins in the nonca-nonical *** of the individual components of both canonical and noncanonical Wnt signaling have additional functions throughout the body,establishing the complex interplay between Wnt signaling and other signaling *** crosstalk between Wnt signaling and other pathways gives Wnt signaling a vital role in many cellular and organ ***-regulation of this system has been implicated in many diseases affecting a wide array of organ systems,including cancer and embryological defects,and can even cause embryonic *** complexity of this system and its interacting proteins have made Wnt signaling a target for many therapeutic ***,both stimulatory and inhibitory treatments come with potential risks that need to be *** review synthesized much of the current knowl-edge on the Wnt signaling pathway,beginning with the history of Wnt *** thoroughly described the different variants of Wnt signaling,including canonical,noncanonical Wnt/PCP,and the noncanonical Wnt/Ca2+*** description involved each of its components and their involvement in other cellular ***,this review explained the various other pathways and processes that crosstalk with Wnt signaling.

关键词： β-catenin Canonical Wnt Noncanonical Wnt Signal transduction Signaling crosstalk

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Advances in the research of intestinal fungi in Crohn's disease

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World Journal of Gastroenterology 2024年第39期30卷 4318-4323页

作者： Mo-Wei Kong Yang Yu Peng Wang Ying Wan Yu Gao Chun-Xiang Zhang department of Cardiology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina department of General Surgery Xinqiao HospitalArmy Medical UniversityChongqing 400037China School of Basic Medical sciences Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina department of Endocrinology Affiliated Hospital of Chengde Medical UniversityChengde 067000Hebei ProvinceChina

This article reviews of the original research published by Wu et al in the World Journal of Gastroenterology,delving into the pivotal role of the gut microbiota in the pathogenesis of Crohn's disease(CD).Insights were gained from fecal microbiota transplantation(FMT)in mouse models,revealing the intricate interplay between the gut microbiota,mesenteric adipose tissue(MAT),and creeping *** study uncovered the characteristics of inflammation and fibrosis in the MAT and intestinal tissues of patients with CD;moreover,through the FMT mouse model,it observed the impact of samples from healthy patients and those with CD on *** pathogenesis of CD is complex,and its etiology remains unclear;however,it is widely believed that gut microbiota dysbiosis plays a significant ***,with the development and application of next-generation sequen-cing technology,research on the role of fungi in the pathogenesis and chronicity of CD has *** editorial serves as a supplement to the research by Wu et al who discussed advances related to the study of fungi in CD.

关键词： Intestinal microbiota Crohn's disease pathogenesis Fecal microbiota trans-plantation Mesenteric adipose tissue Gut fungal dynamics

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Inflammatory and nutritional markers in colorectal cancer: Implications for prognosis and treatment

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World Journal of Clinical Oncology 2024年第10期15卷 1264-1268页

作者： Mesut Tez department of Surgery University of Health SciencesAnkara City HospitalAnkara 06800Türkiye

The prognosis of colorectal cancer(CRC)patients with peritoneal metastasis remains poor despite advancements in detection and *** inflammatory and nutritional markers have emerged as significant predictors of prognosis in CRC,potentially guiding treatment decisions and improving patient *** editorial explores the prognostic value of markers such as the neutrophil-to-lymphocyte ratio,hemoglobin,and serum albumin *** integrating these markers into prognostic models,clinicians can better stratify patients,personalize treatment strategies,and ultimately enhance clinical *** review highlights the importance of these markers in providing a comprehensive assessment of patient condition and underscores the need for further research to validate their clinical utility and uncover underlying mecha-nisms.

关键词： Colorectal cancer Peritoneal metastasis Neutrophil-to-lymphocyte ratio Hemoglobin Serum albumin Inflammatory markers Nutritional markers Prognosis Preoperative markers Personalized treatment

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