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A comprehensive review of phytochemical approaches in treatment of acute myeloid leukemia:Associated pathways and molecular mechanisms

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Chinese Herbal Medicines 2025年第1期17卷 41-55页

作者： Mouvanal Sajana T.S.Gopenath Basalingappa M.Kanthesh Division of Molecular biology School of Life SciencesJSS AHER department of Biotechnology and bioinformatics School of Life SciencesJSS AHER

Acute myeloid leukemia(AML) is a type of cancer that affects the blood and bone *** review conducts a thorough analysis of AML, addressing its genetic *** examination extends to the current therapeutic approaches employed for AML,shedding light on their efficacy and the notable side effects experienced by patients undergoing these treatments,leading to a low overall survival ***,exploring alternative treatments,such as phytochemicals,is ***,the review explores the complex landscape of phytochemicals,categorizing them based on their diverse properties,which include alkaloids,phenols,terpenoids,organo-sulfur compounds,and other compounds,including quinones,and elucidating their mechanisms of *** emphasis is placed on their involvement in critical signaling pathways,with a particular focus on how these phytochemicals impact AML when evaluated across a spectrum of cell *** in-depth exploration aims to uncover potential targets within the molecular landscape of AML where phytochemicals can exert their therapeutic *** review investigates the potential role of plant-derived phytochemicals as adjunctive therapies for *** exploration encompasses the identification of specific phytochemicals that exhibit promising anti-leukemic properties and evaluates their potential in clinical *** conventional treatments,the review explores the integration of complementary and alternative medicine as a holistic approach to managing *** examination encompasses the synergy between conventional therapies and alternative interventions,exploring how these combined strategies may enhance overall therapeutic outcomes and mitigate side *** a forward-looking perspective,the overarching goal is to contribute to the evolving landscape of AML treatment by considering innovative approaches that harness the therapeutic potential of phytochemicals,both independently and in conjunction with establishe

关键词： cell death complementary and alternative medicine leukemia phytochemicals signaling pathways therapeutic targets

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Functions of nuclear factor Y in nervous system development,function and health

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Neural Regeneration Research 2025年第10期20卷 2887-2894页

作者： Pedro Moreira Roger Pocock Development and Stem Cells program Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental BiologyMonash UniversityMelbourneVICAustralia

Nuclear factor Y is a ubiquitous heterotrimeric transcription factor complex conserved across eukaryotes that binds to CCAAT boxes,one of the most common motifs found in gene promoters and *** the last 30 years,research has revealed that the nuclear factor Y complex controls many aspects of brain development,including differentiation,axon guidance,homeostasis,disease,and most recently ***,a complete understanding of transcriptional regulatory networks,including how the nuclear factor Y complex binds to specific CCAAT boxes to perform its function remains *** this review,we explore the nuclear factor Y complex’s role and mode of action during brain development,as well as how genomic technologies may expand understanding of this key regulator of gene expression.

关键词： axon guidance CCAAT boxes neuronal degeneration neuronal differentiation neuronal regeneration nuclear factor Y complex transcription factor transcriptional regulation

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Small extrachromosomal circular DNA in amyotrophic lateral sclerosis matter

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Neural Regeneration Research 2025年第5期20卷 1411-1413页

作者： Marcos J.Arauzo-Bravo Daniela Gerovska Matthias Schwab Alexandra Kretz Computational biology and Systems Biomedicine Biodonostia Health Research InstituteSan SebastianSpain Basque Foundation for Science IKERBASQUEBilbaoSpainMax Planck Institute for Molecular BiomedicineComputational Biology and Bioinformatics GroupMünsterNorth Rhine-WestphaliaGermany department of Cell biology and Histology Faculty of Medicine and NursingUniversity of Basque Country(UPV/EHU)LeioaSpain department of Neurology Jena University HospitalJenaThuringiaGermany

Comprehensive studies identify motor neuron spectrum disorders including amyotrophic lateral sclerosis(ALS)as globally rising fatal disorders with the highest prevalence in aging populations,influenced by ethnicity and ancestry(GBD 2016 Motor Neuron Disease Colla borators,2018).While~10% of diagnoses involve a family history(fALS),most cases are considered sporadic(sALS).However,population-based studies suggest that even cases without a common index mutation impart heritability(Ryan et al.,2019),indicating a crucial role of rare and as yet unknown genetic denominators.

关键词： amyotrophic sclerosis

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A lead role for a“secondary”axonal injury response

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Neural Regeneration Research 2025年第2期20卷 469-470页

作者： Melissa A.Rudy Trent A.Watkins Division of Neuroimmunology and Glial biology Department of NeurologyUniversity of California at San FranciscoSan FranciscoCAUSA Development Disease Modelsand Therapeutics Graduate ProgramBaylor College of MedicineHoustonTXUSA

Stress signaling following axon injury stimulates a transcriptional program for regeneration that might be exploited to promote central nervous system ***,this stress response drives neuronal apoptosis in non-regenerative *** duality presents a quandary for the development of therapeutic interventions:manipulating stress signaling to enhance recovery of damaged neurons risks accelerating neurodegeneration or restricting regenerative *** dichotomy is well illustrated by the fates of retinal ganglion cells(RGCs)following optic nerve *** this central nervous system injury model,disruption of a stress-activated MAP kinase(MAPK)cascade blocks the extensive apoptosis of RGCs that occurs in wild-type mice(Watkins et al.,2013;Welsbie et al.,2017).

关键词： injury axonal stress

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miR-2940-1 is involved in the circadian regulation of oviposition in Aedes albopictus

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Insect Science 2025年第1期32卷 69-79页

作者： Xiaolin Xiao Ling Kong Zhensheng Xie Hongkai Liu Lijun Cai Siyu Zhao Jiayong Zhou Shuang Liu Jing Wu Yiming Wu Peilin Wu Anthony A.James Xiao-Guang Chen department of Pathogen biology Institute of Tropical MedicineSchool of Public HealthSouthern Medical UniversityGuangzhouChina department of Microbiology&Molecular Genetics University of CaliforniaIrvineCAUSA department of Molecular biology&Biochemistry University of CaliforniaIrvineCAUSA

The vast majority of all global species have circadian rhythm cycles that allow them to adapt to natural *** regular rhythms are regulated by core clock genes and recent studies have also implicated roles for microRNAs in this *** is an important circadian behavior in the reproductive cycle of insect vectors of diseases,and little is known about the rhythm or its regulation in *** albopictus is a diurnal mosquito that transmits arboviruses and is the major cause of outbreaks of dengue fever in *** analyzed the oviposition rhythm patterns of *** under different light/dark conditions and show that the mosquitoes have an oviposition peak between zeitgeber time 9(ZT 9)and ZT ***,the antagomir-mediated knockdown of expression of the microRNA miR-2940-1 affected the oviposition rhythm of *** data support the conclusion that miR-2940-1 is involved in the regulation of oviposition rhythm in *** and provide a foundation for using oviposition rhythms as a new target for vector mosquito control.

关键词： Aedes albopictus miR-2940-l oviposition rhythm regulation

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Treatment of spinal cord injury with biomaterials and stem cell therapy in non-human primates and humans

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Neural Regeneration Research 2025年第2期20卷 343-353页

作者： Ana Milena Silva Olaya Fernanda Martins Almeida Ana Maria Blanco Martinez Suelen Adriani Marques PhD program in Pathological Anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Biomedical Science Institute Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate program in Pathological Anatomy Federal University of Rio de JaneiroRio de JaneiroBrazil Graduate program in Pathological Anatomy(PPGAP/UFRJ) Department of Neurobiology/Institute of BiologyCampus do GragoatáNiteróiRio de JaneiroBrazil

Spinal cord injury results in the loss of sensory,motor,and autonomic functions,which almost always produces permanent physical ***,in the search for more effective treatments than those already applied for years,which are not entirely efficient,researches have been able to demonstrate the potential of biological strategies using biomaterials to tissue manufacturing through bioengineering and stem cell therapy as a neuroregenerative approach,seeking to promote neuronal recovery after spinal cord *** of these strategies has been developed and meticulously evaluated in several animal models with the aim of analyzing the potential of interventions for neuronal repair and,consequently,boosting functional *** the majority of experimental research has been conducted in rodents,there is increasing recognition of the importance,and need,of evaluating the safety and efficacy of these interventions in non-human primates before moving to clinical trials involving therapies potentially promising in *** article is a literature review from databases(PubMed,Science Direct,Elsevier,Scielo,Redalyc,Cochrane,and NCBI)from 10 years ago to date,using keywords(spinal cord injury,cell therapy,non-human primates,humans,and bioengineering in spinal cord injury).From 110 retrieved articles,after two selection rounds based on inclusion and exclusion criteria,21 articles were ***,this review arises from the need to recognize the experimental therapeutic advances applied in non-human primates and even humans,aimed at deepening these strategies and identifying the advantages and influence of the results on extrapolation for clinical applicability in humans.

关键词： bioengineering biomaterials cell therapy humans non-human primates spinal cord injury stem cell therapy

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General expert consensus on the application of network pharmacology in the research and development of new traditional Chinese medicine drugs

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Chinese Journal of Natural Medicines 2025年第2期23卷 129-142页

作者： Shao Li Wei Xiao Institute of TCM-X/MOE Key Laboratory of bioinformatics Bioinformatics Division BNRist/Department of Automation Tsinghua University State Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture Jiangsu Kanion Pharmaceutical Co. Ltd.

The research and development of new traditional Chinese medicine(TCM) drugs have progressively established a novel system founded on the integration of TCM theory, human experience, and clinical trials(termed the “Three Combinations”). However, considering TCM's distinctive features of “syndrome differentiation and treatment” and “multicomponent formulations and complex mechanisms”, current TCM drug development faces challenges such as insufficient understanding of the material basis and the overall mechanism of action and an incomplete evidence chain system. Moreover, significant obstacles persist in gathering human experience data, evaluating clinical efficacy, and controlling the quality of active ingredients, which impede the innovation process in TCM drug development. Network pharmacology, centered on the “network targets” theory, transcends the limitations of the conventional“single target” reductionist research model. It emphasizes the comprehensive effects of disease or syndrome biological networks as targets to elucidate the overall regulatory mechanism of TCM prescriptions. This approach aligns with the holistic perspective of TCM, offering a novel method consistent with TCM's holistic view for investigating the complex mechanisms of TCM and developing new TCM drugs. It is internationally recognized as a “next-generation drug research model”. To advance the research of new tools, methods, and standards for TCM evaluation and to overcome fundamental, critical, and cutting-edge technical challenges in TCM regulation, this consensus aims to explore the characteristics, progress, challenges, applicable pathways, and specific applications of network pharmacology as a new theory, method, and tool in TCM drug development. The goal is to enhance the quality of TCM drug research and development and accelerate the efficiency of developing new TCM products.

关键词： Expert consensus Network pharmacology Research and development of new traditional Chinese medicine drugs

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Single-cell technologies: current and near future

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Science China(Life Sciences) 2025年第1期68卷 1-4页

作者： Chenfei Wang Qi Liu Xiaohui Fan Tieliu Shi KeyLaboratory of Spine and Spinal CordInjury Repairand Regeneration Ministry of EducationOrthopedics DepartmentTongji HospitalBioinformatics DepartmentSchoolofLifeSciencesandTechnologyTongji UniversityShanghai 200082China Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji UniversityShanghai 200092China Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji UniversityShanghai 200082China Research Institute of Intelligent Computing Zhejiang LabHangzhou 311121China Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314103China Center for bioinformatics and Computational biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai 200241China Key Laboratory of Advanced Theory and Application in Statistics and Data Science(MOE) School of StatisticsEast China Normal UniversityShanghai 200062China

Single-cell technologies enable the indepth exploration of multiple biological hierarchies at the scale of individual cells,which have deepened our knowledge of cellular diversity,tissue organization,and overall organism function(Sun et al.,2024).In 2009,single-cell RNA sequencing(scRNA-seq)was first developed as a powerful tool to dissect gene expression and uncover transcriptional *** the rapid advancement of technology,single-cell approaches have expanded to encompass other omics,such as genomics,epigenomics,proteomics,and ***,multimodal technologies including spatially resolved transcriptomics and clustered regularly interspaced short palindromic repeats(CRISPR)screening at the single-cell level further advanced our ability to comprehensively understand cellular ***-cell methods provide deeper insights into disease mechanisms across various conditions,including cancer,developmental disorders,and aging-associated *** this issue,we focus on topics related to single-cell methods,covering the following four aspects:(i)single-cell multi-omic sequencing technology;(ii)single-cell spatial technology;(iii)singlecell CRISPR screening technology;(iv)applications of single-cell technology.

关键词： expanded enable insight

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Cryopreservation of bovine sperm causes single‑strand DNA breaks that are localized in the toroidal regions of chromatin

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Journal of Animal Science and Biotechnology 2025年第1期16卷 92-106页

作者： Jordi Ribas‑Maynou Rodrigo Muiño Carolina Tamargo Marc Yeste Biotechnology of Animal and Human Reproduction(TechnoSperm) Institute of Food and Agricultural TechnologyUniversity of GironaS17003 GironaSpain Unit of Cell biology Department of BiologyFaculty of SciencesUniversity of GironaS17003 GironaSpain Present Address:Unit of Cell biology and Medical Genetics Department of Cell BiologyPhysiology and ImmunologyAutonomous University of BarcelonaS08193 BellaterraSpain department of Animal Pathology Faculty of Veterinary MedicineUniversity of Santiago de CompostelaS15705 LugoSpain department of Animal Selection and Reproduction The Regional Agri-Food Research and Development Service of Asturias(SERIDA)S33394 GijónSpain Catalan Institution for Research and Advanced Studies(ICREA) S08010 BarcelonaSpain

Background Sperm cryopreservation is widely used in the cattle industry,as it allows for disassociating the localiza-tion of sires and the collection of semen from the timing of artificial *** freeze-thawing is known to impair sperm DNA integrity,whether the damage induced consists of single-(SSB)or double-strand breaks(DSB)has not been *** addition,no previous study has addressed if DNA breaks preferentially reside in specific genome regions such as those forming the toroid linker regions,or are rather spread throughout the regions linked to *** main aim of the present work,therefore,was to elucidate the type and localization of the DNA damage generated by cryopreservation and to evaluate its impact on artificial insemination outcomes in *** The incidence of SSB and DSB was evaluated in 12 ejaculates before and after cryopreservation with the Comet assay,and the localization of the DNA breaks was assessed using pulsed-field gel electrophoresis(PFGE).Before cryopreservation,the incidence of SSB was 10.99%±4.62%and involved 20.56%±3.04%of sperm cells,whereas these figures significantly(P0.990)before and after cryopreservation(before:incidence of 13.91%±1.75%of sperm DNA affecting 56.04%±12.49%of sperm cells;after:incidence of 13.55%±1.55%of sperm DNA involving 53.36%±11.00%of sperm cells).Moreover,PFGE revealed that the percentage of sperm DNA fragments whose length was shorter than a toroid(<31.5 kb)was greater(P<0.0001)after(27.00%±4.26%)than before freeze-thawing(15.57%±4.53%).These differences indicated that the DNA breaks induced by cryopreservation affect the regions condensed in protamines,which are structured in *** the other hand,in vivo fertility rates were associated to the incidence of SSB and DSB in frozen-thawed sperm(P=0.032 and P=0.005),but not w

关键词： Cattle DNA damage Fertility Sperm Toroid linker regions

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Graph based recurrent network for context specific synthetic lethality prediction

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Science China(Life Sciences) 2025年第2期68卷 527-540页

作者： Yuyang Jiang Jing Wang Yixin Zhang ZhiWei Cao Qinglong Zhang Jinsong Su Song He Xiaochen Bo Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjin 300072China department of bioinformatics Institute of Health Service and Transfusion MedicineBeijing 100850China School of Medicine Tsinghua UniversityBeijing 100084China School of Informatics Xiamen UniversityXiamen 361005China

The concept of synthetic lethality(SL)has been successfully used for targeted *** further explore SL for cancer therapy,identifying more SL interactions with therapeutic potential are ***,graph neural network-based deep learning methods have been proposed for SL prediction,which reduce the SL search space of wet-lab based ***,these methods ignore that most SL interactions depend strongly on genetic context,which limits the application of the predicted *** this study,we proposed a graph recurrent network-based model for specific context-dependent SL prediction(SLGRN).In particular,we introduced a Graph Recurrent Network-based encoder to acquire a context-specific,low-dimensional feature representation for each node,facilitating the prediction of novel *** leveraged gate recurrent unit(GRU)and it incorporated a context-dependent-level state to effectively integrate information from all *** a result,SLGRN outperforms the state-of-the-arts models for SL *** subsequently validate novel SL interactions under different contexts based on combination therapy or patient survival *** in vitro experiments and retrospective clinical analysis,we emphasize the potential clinical significance of this context-specific SL prediction model.

关键词： synthetic lethality graph recurrent network context-specific graph combination therapy

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