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Decoding molecular mechanisms:brain aging and Alzheimer's disease

Neural Regeneration Research 2025年第8期20卷 2279-2299页

作者： Mahnoor Hayat Rafay Ali Syed Hammad Qaiser Mohammad Uzair Khalid Al-Regaiey Roaa Khallaf Lubna Abdullah Mohammed Albassam Imdad Kaleem Xueyi Wang Ran Wang Mehwish SBhatti Shahid Bashir Atta-ur-Rahman School of Applied biosciences(ASAB) National University of Sciences and Technology(NUST)IslamabadPakistan department of Biotechnology Quaid-i-Azam UniversityIslamabadPakistan department of biological sciences Faculty of Basic&Applied SciencesInternational Islamic University Islamabad(IIUI)IslamabadPakistan department of Bioengineering King Fahd University of Petroleum and MineralsDhahranSaudi Arabia department of Physiology College of MedicineKing Saud UniversityRiyadhSaudi Arabia department of Neurology Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia department of Mental Health Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia department of biosciences Commission on Science and Technology for Sustainable Development in the South(COMSATS University)IslamabadPakistan department of Psychiatry The First Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Mental Health institute of Hebei Medical University ShijiazhuangHebei ProvinceChina department of Neurobiology and Behavior University of CaliforniaIrvineCAUSA Neuroscience Center King Fahad Specialist Hospital DammamDammamSaudi Arabia

The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for *** aging process alters the brain structure that affects functions and cognitions,but the worsening of such processes contributes to the pathogenesis of neurodegenerative disorders,such as Alzheimer's *** these observable,mild morphological shifts,significant functional modifications in neurotransmission and neuronal activity critically influence the aging *** these changes is important for maintaining cognitive health,especially given the increasing prevalence of age-related conditions that affect *** review aims to explore the age-induced changes in brain plasticity and molecular processes,differentiating normal aging from the pathogenesis of Alzheimer's disease,thereby providing insights into predicting the risk of dementia,particularly Alzheimer's disease.

关键词： Alzheimer’s disease brain aging cognitive health dementia molecular mechanisms neuronal activity neuroplasticity neurotransmission

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Movement analysis in the diagnosis and management of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 485-486页

作者： Johannes Burtscher Nicolas Bourdillon Jules MJanssen Daalen Aurélien Patoz Julien FBally Martin Kopp Davide Malatesta Bastiaan RBloem institute of Sport sciences University of LausanneLausanneSwitzerland Radboud University Medical Center Department of NeurologyDonders Institute for BrainCognition and BehaviorCenter of Expertise for Parkinson and Movement DisordersNijmegenThe Netherlands Radboud University Medical Center Department of Medical BioSciencesNijmegenThe Netherlands Research and Development department Volodalen Swiss Sport LabAigleSwitzerland Service of Neurology Department of Clinical NeurosciencesLausanne University Hospital(CHUV)and University of Lausanne(UNIL)LausanneSwitzerland department of Sport Science University of InnsbruckInnsbruckAustria

Challenges in the diagnosis and treatment of Parkinson’s disease:Parkinson’s disease(PD)is an increasingly prevalent neurodegenerative disease,at first sight primarily characterized by motor symptoms,although non-motor symptoms also constitute a major part of the overall ***,this disease cannot be diagnosed reliably until a large part of the vulnerable dopaminergic neurons has been irretrievably lost,and the disease progresses *** biological criteria for PD have been proposed recently and might eventually improve early diagnosis,but they require further validation,and their use will initially be restricted to a research environment(Darweesh et al.,2024).

关键词： diagnosis Clinical eventually

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Delving into the recent advancements of spinal cord injury treatment: a review of recent progress

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Neural Regeneration Research 2022年第2期17卷 283-291页

作者： Joseph A.Flack Krishna Deo Sharma Jennifer Yanhua Xie department of Basic sciences New York Institute of Technology College of Osteopathic Medicine at Arkansas State UniversityJonesboroARUSA department of biological sciences and arkansas biosciences institute Arkansas State UniversityJonesboroARUSA

Spinal cord injury(SCI) research is a very complex field lending to why reviews of SCI literatures can be beneficial to current and future researchers. This review focuses on recent articles regarding potential modalities for the treatment and management of SCI. The modalities were broken down into four categories: neuroprotectionpharmacologic, neuroprotection-non-pharmacologic, neuroregeneration-pharmacologic, neuroregeneration-non-pharmacologic. Peer-reviewed articles were found using Pub Med with search terms: "spinal cord injury", "spinal cord injury neuroregeneration", "olfactory ensheathing cells spinal cord injury", "rho-rock inhibitors spinal cord injury", "neural stem cell", "scaffold", "neural stem cell transplantation", "exosomes and SCI", "epidural stimulation SCI", "brain-computer interfaces and SCI". Most recent articles spanning two years were chosen for their relevance to the categories of SCI management and treatment. There has been a plethora of pre-clinical studies completed with their results being difficult to replicate in clinical studies. Therefore, scientists should focus on understanding and applying the results of previous research to develop more efficacious preclinical studies and clinical trials.

关键词： brain-computer interface epidural stimulation exosomes neuroprotection neuroregeneration scaffolds spinal cord injury management stem cells transplantation

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Can color vision variation explain sex differences in invertebrate foraging by capuchin monkeys?

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Current Zoology 2010年第3期56卷 300-312页

作者： Amanda D.MELIN Linda M.FEDIGAN Hilary C.YOUNG Shoji KAWAMURA department of Anthropology University of Calgary department of biological sciences University of Calgary department of Integrated biosciences Graduate School of Frontier SciencesUniversity of Tokyo

Invertebrates are the main source of protein for many small-to-medium sized monkeys. Prey vary in size, mobility, degree of protective coveting, and use of the forest, i.e. canopy height, and whether they are exposed or embed themselves in substrates. Sex-differentiation in foraging patterns is well documented for some monkey species and recent studies find that color vision phenotype can also affect invertebrate foraging. Since vision phenotype is polymorphic and sex-linked in most New World monkeys - males have dichromatic vision and females have either dichromatic or trichromatic vision - this raises the possibility that sex differences are linked to visual ecology. We tested predicted sex differences for invertebrate foraging in white-faced capuchins Cebus capucinus and conducted 12 months of study on four free-ranging groups between January 2007 and September 2008. We found both sex and color vision effects. Sex： Males spent more time foraging for invertebrates on the ground. Females spent more time consuming embedded, colonial invertebrates, ate relatively more ＂soft＂ sedentary invertebrates, and devoted more of their activity budget to invertebrate foraging. Color Vision： Dichromatic monkeys had a higher capture efficiency of ex- posed invertebrates and spent less time visually foraging. Trichromats ate relatively more ＂hard＂ sedentary invertebrates. We con- elude that some variation in invertebrate foraging reflects differences between the sexes that may be due to disparities in size, strength, reproductive demands or niche preferences. However, other intraspecific variation in invertebrate foraging that might be mistakenly attributed to sex differences actually reflects differences in color vision [Current Zoology 56 （3）： 300-312, 2010].

关键词： Male Foraging Female Foraging Cebus Dichromacy Trichromaey Invertebrate Foraging

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Subspecific variation in sperm morphology and performance in the Long-tailed Finch (Poephila acuticauda)

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Chinese Birds 2015年第4期6卷 225-234页

作者： Melissah Rowe Simon C.Griffith Antje Hofgaard Jan T.Lifjeld Natural History Museum University of Oslo Centre for Ecological and Evolutionary Synthesis Department of BiosciencesUniversity of Oslo department of biological sciences Macquarie University Electron Microscopical Unit for biological sciences Department of BiosciencesUniversity of Oslo

Background: Evolutionary biology endeavours to explain biological diversity,and as such it is critical to develop an understanding of the adaptive and functional significance of trait *** exhibit remarkable levels of morphological ***,our understanding of the evolutionary causes and functional significance of this variation is limited,especially at the intraspecific ***: We quantified variation in sperm morphology and performance between two subspecies of Long-tailed Finch(Poephila acuticauda acuticauda and ***),a small grassfinch found in tropical northern *** a zone of secondary contact,these subspecies are maintained as two distinct forms: *** occurs in the western part of the species' range and has a yellow bill,while *** exhibits a red bill and is found in the eastern part of the ***: We found small,but significant differences in sperm size between these subspecies(*** had longer and narrower sperm than ***),which was surprising given the recent evolutionary origins of these two taxa(i.e.0.3 million years ago).Additionally,both subspecies exhibited high values of between- and within-male variation in sperm morphology,though in the case of sperm midpiece length this variation was significantly lower in *** relative to ***: We suggest these observed differences in sperm morphology are the result of genetic drift and reflect historical processes associated with divergence between the eastern and western populations of these two ***,we discuss the potential implications of our findings for the process of population divergence and reproductive isolation.

关键词： Passerine Reproductive barriers Sperm evolution Structure-function relationships

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Is there a window of opportunity for the therapeutic use of vitamin D in multiple sclerosis?

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Neural Regeneration Research 2022年第9期17卷 1945-1954页

作者： Sofia Fernanda Gonçalves Zorzella-Pezavento Luiza Ayumi Nishiyama Mimura Marina Bonifácio Denadai William Danilo Fernandes de Souza Thais Fernanda de Campos Fraga-Silva Alexandrina Sartori department of Chemical and biological sciences Institute of BiosciencesSão Paulo State University(UNESP)BotucatuSão PauloBrazil

Multiple sclerosis is an autoimmune treatable but not curable *** are a multiplicity of medications for multiple sclerosis therapy,including a class entitled disease-modifying drugs that are mainly indicated to reduce the number and severity of disease *** all patients respond well to these therapies,and minor to severe adverse effects have been *** D,called sunshine vitamin,is being studied as a possible light at the end of the *** this review,we recapitulated the similar immunopathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis,the immunomodulatory and neuroprotective potential of vitamin D and the state-of-art concerning its supplementation to multiple sclerosis ***,based on our and other groups’experimental findings,we analyzed the need to consider the relevance of the route and the different time-point administration aspects for a more rational indication of this vitamin to multiple sclerosis patients.

关键词： central nervous system cytokines experimental autoimmune encephalomyelitis immunomodulation immunopathogenesis inflammation multiple sclerosis neuroprotection regulatory T cells vitamin D

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Pistacia chinensis:Strong antioxidant and potent testicular toxicity amelioration agent

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Asian Pacific Journal of Tropical Medicine 2017年第4期10卷 359-369页

作者： Farah Noureen Muhammad Rashid Khan Naseer Ali Shah Rahmat Ali Khan Kiran Naz Saadia Sattar department of Biochemistry Faculty of Biological SciencesQuaid-i-Azam University department of biosciences COMSATS Institute of Information Technology department of Biotechnology UST Bannu KPK

Objective:To evaluate in ritro and in riro antioxidant potency of Pistacia chinensis(***) bark and leaves extracts along with its protective role against CCl_4 induced toxicity in testis of the *** Various in vitro models such as DPPH,ABTS,hydrogen peroxide,superoxide,hydroxyl and nitric oxide scavenging activities,anti-lipid peroxidation activity,phospho-molybdenum activity.β carotene bleaching assay was used for analysis of antioxidant *** groups for in riro study were:Group Ⅰ(control)*** Ⅱ(Vehicle control).Group Ⅲ(1 mL/kg b.w 30%CCl_4).Group Ⅳ(1 mL/kg b.w CCk_4+Silymarin).Group Ⅴ(200 mg/kg b.w PCBE+CCl_4),Group Ⅵ(400 mg/kg b.w PCBE+CCl_4) and Group Ⅶ(400 mg/kg b.w PCBE alone).Results:In ritro antioxidant assays displayed significant results and the highest activity was not specified to a specific ***,ethyl acetate extract of bark(PCBF) showed highest results in most of the antioxidant assays ***-carotene bleaching,hydroxyl radical *** peroxidation and superoxide radical scavenging *** this base,this fraction was selected for in riro antioxidant *** tissues were analyzed to observe the protective effects of PCBE on antioxidant enzymes:cataluse,superoxide *** reductase,glutathione peroxidase and quinone reductase activities and glutathione(GSH) as well as nitrite *** of plasma testosterone was also compared to various *** suggests a protective role of *** against CCl_4induced ***:It is concluded that some bioactive antioxidants of *** bark might be a good source to isolate the potent antioxidant components.

关键词： Pislacia chinensis Plasma testosterone Glutathione-S-transferase Antioxidant enzymes

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Analysis of the genotoxic potential of low concentrations of Malathion on the Allium cepa cells and rat hepatoma tissue culture

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Journal of Environmental sciences 2015年第10期27卷 102-111页

作者： Jaqueline Bianchi Mario Sérgio Mantovani Maria Aparecida Marin-Morales department of Biology Institute of BiosciencesSao Paulo State University(UNESP) department of General Biology Biological Science CentreUniv Estadual de Londrina

Based on the concentration of Malathion used in the field, we evaluated the genotoxic potential of low concentrations of this insecticide on meristematic and F1 cells of Allium cepa and on rat hepatoma tissue culture（HTC cells）. In the A. cepa, chromosomal aberrations（CAs）, micronuclei（MN）, and mitotic index（MI） were evaluated by exposing the cells at 1.5,0.75, 0.37, and 0.18 mg/m L of Malathion for 24 and 48 hr of exposure and 48 hr of recovery time. The results showed that all concentrations were genotoxic to A. cepa cells. However,the analysis of the MI has showed non-relevant effects. Chromosomal bridges were the CA more frequently induced, indicating the clastogenic action of Malathion. After the recovery period, the higher concentrations continued to induce genotoxic effects, unlike the observed for the lowest concentrations tested. In HTC cells, the genotoxicity of Malathion was evaluated by the MN test and the comet assay by exposing the cells at 0.09, 0.009, and0.0009 mg/5 m L culture medium, for 24 hr of exposure. In the comet assay, all the concentrations induced genotoxicity in the HTC cells. In the MN test, no significant induction of MN was observed. The genotoxicity induced by the low concentrations of Malathion presented in this work highlights the importance of studying the effects of low concentrations of this pesticide and demonstrates the efficiency of these two test systems for the detection of genetic damage promoted by Malathion.

关键词： HTC Chromosomal aberration Micronuclei Comet assay Pesticide

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Agrobacterium-Mediated Transformation of Rice: Constraints and Possible Solutions

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Rice science 2019年第3期26卷 133-146页

作者： Sulaiman MOHAMMED Azman Abd SAMAD Zaidah RAHMAT department of Biotechnology and Medical Engineering Faculty of Biosciences and Medical Engineering Universiti Teknologi Malaysia department of biological sciences Faculty of Science Gombe State University

Genetic transformation of rice(Oryza sativa L.) by introducing beneficial traits is now a central research instrument in plant physiology and a practical tool for plant improvement. Many approaches are verified for stable introduction of foreign genes into the plant genome. The review examined the different constraints that limit the success of rice genetic transformation via Agrobacterium-mediated approach and suggested possible solutions. Explant identification, gene transfer technique and construct to tailor the integration, transgene expression without collateral to genetic damage and transformant selection are among the technical challenges affecting the rice transformation. Despite the contests, Agrobacteriummediated transformation system has been a better option for producing transgenic rice varieties because of its exact T-DNA processing and simple integration of low copy-number transgene. This information is necessary for improving the transformation system for recalcitrant rice varieties.

关键词： rice Agrobacterium-mediated transformation tissue culture gene transfer T-DNA integration

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Elevational distribution of butterflies in the Himalayas: a case study from Langtang National Park, Nepal

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Journal of Mountain Science 2017年第7期14卷 1384-1390页

作者： Ranjit PANDEY Kapil K KHADKA Anuj GHIMIRE Puja JHA Umesh PATHAK Oklahoma State University Department of Integrative Biology University of arkansas Department of Biological Sciences Tribhuvan University Central Department of Zoology Oklahoma State University Tribhuvan University Central Department of Environmental Sciences

Mountain ecosystems are relatively more vulnerable to climate change since human induced climate change is projected to be higher at high altitudes and latitudes. Climate change induced effects related to glacial response and water hazards have been documented in the Himalayas in recent years, yet studies regarding species' response to climate change are largely lacking from the mountains and Himalayas of Nepal. Changes in distribution and latitudinal/altitudinal range shift, which are primary adaptive responses to climate change in many species,are largely unknown due to unavailability of adequate data from the past. In this study, we explored the elevational distribution of butterflies in Langtang Village Development Committee(VDC) of Langtang National park; a park located in the high altitudes of Nepal. We found a decreasing species richness pattern along the elevational gradient considered ***, elevation did not appear to have a significant effect on the altitudinal distribution ofbutterflies at family level. Also, distribution of butterflies in the area was independent of habitat type,at family level. Besides, we employed indicator group analysis(at family level) and noticed that butterfly families Papilionidae, Riodinidae, and Nymphalidae are significantly associated to high, medium and low elevational zone making them indicator butterfly family for those elevational zones, respectively. We expect that this study could serve as a baseline information for future studies regarding climate change effects and range shifts and provide avenues for further exploration of butterflies in the high altitudes of Nepal.

关键词： Butterflies Indicator species Nepal Range shift Climate change Himalayas

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