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Microphallus early management in infancy saves adulthood sensual life:A comprehensive review

World Journal of Clinical Pediatrics 2024年第2期13卷 16-37页

作者： Mohammed al-Beltagi Nermin Kamal Saeed Adel Salah Bediwy Majed A Shaikh Reem Elbeltagi department of Pediatric Faculty of MedicineTanta UniversityTanta 31511Egypt department of Pediatric University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671Bahrain department of Pediatric University Medical CenterSulaiman Al Habib Medical GroupManama 26671Bahrain department of Medical Microbiology Section and Pathology Salmaniya Medical ComplexMinistry of HealthKingdom of BahrainManama 12Bahrain department of Medical Microbiology Section and Pathology Irish Royal College of SurgeonBusaiteen 15503Bahrain department of Pulmonology Faculty of MedicineTanta UniversityTanta 31527Egypt department of Pulmonology University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671Bahrain department of Pulmonology University Medical CenterSulaiman Al Habib Medical GroupManama 26671Bahrain department of Pediatrics Ibn Al Nafees HospitalManama 54533Bahrain department of Medicine The Royal College of Surgeons in Ireland-BahrainBusiateen 15503Bahrain

Microphallus/Micropenis is a rare condition with significant physical and psychological implications for affected *** article comprehensively reviews micropenis,its etiology,epidemiology,and various treatment *** conducted a thorough literature review to collect relevant information on micropenis and microphallus,as well as related *** primary databases were PubMed,Medline,and Google *** searched for articles published in English between 2000 and *** analysis included 67 review articles,56 research studies,11 case reports,one guideline,and one *** search terms included"microphallus","micropenis","congenital hypogonadotropic hypogonadism","androgen insensitivity syndrome","pediatric management of micropenis","testosterone therapy",and"psychosocial implications of micropenis".We focused on diagnosing micropenis and related conditions,including hormonal assessments,medical and surgical treatment options,psychosocial and psychological well-being,sexual development of adolescents,and sociocultural influences on men's perceptions of penile ***,we explored parenting and family dynamics in cases of micropenis and disorders of sex development,implications of hormonal treatment in neonates,and studies related to penile augmentation procedures and their *** article highlights the importance of early diagnosis and intervention in addressing the physical and psychological well-being of individuals with *** procedures,such as penile lengthening and girth enhancement,and non-surgical approaches like hormonal therapy are *** significance of psychological support,education,and lifestyle modifications is *** management and comprehensive care are crucial for individuals with micropenis,from infancy to adolescence and beyond.A multidisciplinary approach involving urologists,endocrinologists,and mental health professionals is *** assessment of treatment e

关键词： Microphallus Micropenis Hypogonadism Children Adults Sensual life Testosterone therapy

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Scenario-Based Assessment of the Water-Energy-Food Nexus in Kuwait: Insights for Effective Resource Management

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Computational Water, Energy, and Environmental Engineering 2024年第1期13卷 38-57页

作者： Amani al-Adwani ali Karnib alaa Elsadek Waleed al-Zubari department of Natural Resources and Environment College of Graduate Studies Arabian Gulf University Manama Kingdom of Bahrain department of Liberal Education School of Arts and Sciences Lebanese American University Beirut Lebanon

The interdependency among water, food, and energy (WEF) in the GCC countries is strongly and closely interlinked, and is intensifying as demand for resources increases with population growth and changing consumption patterns, and are expected to be further compounded by the impacts of climate change. Therefore, integrated management of the three sectors is crucial to reduce trade-offs and build synergies among them. This paper presents a comprehensive framework to assess the WEF nexus in Kuwait as a representative case for the GCC countries. The framework consists of three main steps: 1) evaluating the influence of socio-economic development and climate change on water, energy, and food resources;2) generating scenario-based projections;and 3) conducting an extensive quantitative nexus analysis. The WEF interlinkages in Kuwait are modelled quantitatively using the Q-Nexus model, and current critical interdependencies are evaluated. Then, various WEF-Nexus scenarios were conducted for the year 2035 to explore the effects of management interventions in one sector on the other two sectors. The main findings are that per capita municipal water consumption is a major influencer on the WEF-nexus due to the heavy reliance on thermal desalination in municipal water supply in Kuwait, which is attributed to its energy intensity, financial cost, GHGs emissions, and environmental impacts on the marine and air environments. To reduce WEF trade-offs, mitigate risks, and build synergies among the three sectors, it is important to shift the current policy focus on supply-side management approach to the demand-side management and efficiency approaches.

关键词： Climate Change Socio-Economic development Municipal Water Consumption Agricultural Water Consumption Renewable Energy Desalination Technology

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Gastrointestinal tolerability of organic infant formula compared to traditional infant formula: A systematic review

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World Journal of Clinical Pediatrics 2024年第1期13卷 125-140页

作者： Mohammed al-Beltagi Nermin Kamal Saeed Adel Salah Bediwy Reem Elbeltagi Mohamed Basiony Hamza department of Pediatric Faculty of MedicineTanta UniversityTanta 31511AlghrabiaEgypt department of Pediatric University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityDr.Sulaiman Al Habib Medical GroupManama 26671ManamaBahrain Medical Microbiology Section Department of PathologySalmaniya Medical ComplexMinistry of HealthKingdom of BahrainManama 12ManamaBahrain Medical Microbiology Section Department of PathologyIrish Royal College of SurgeonBusaiteen 15503MuharraqBahrain department of Pulmonology Faculty of MedicineTanta UniversityTanta 31527AlghrabiaEgypt department of Pulmonology University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityDr.Sulaiman Al Habib Medical GroupManama 26671ManamaBahrain department of Medicine The Royal College of Surgeons in Ireland-BahrainBusiateen 15503MuharraqBahrain department of Pediatric Faculty of MedicineTanta UniversityTanta 31511AlgahrbiaEgypt

BACKGROUND Infants'nutrition significantly influences their growth,development,and overall *** the increasing demand for organic infant formula driven by the perception of health benefits and growing awareness of natural feeding options,it is crucial to conduct a comparative analysis of the gastrointestinal tolerability between organic and traditional infant *** To provide a concise and precise analysis of the gastrointestinal tolerability of organic infant formula compared to traditional infant *** to limited direct comparisons,the review synthesizes available literature on each formula type,presenting insights into their potential effects on infants'digestive *** An extensive literature search was conducted,compiling studies on organic and traditional infant formulas,their compositions,and reported effects on gastrointestinal *** searched academic databases such as PubMed and Google Scholar and specialized nutrition,paediatrics,and infant health journals using relevant keywords till October 1,*** although specific comparative studies are scarce and formula heterogeneity is a significant limitation,this systematic review provides an in-depth understanding of organic infant formulas'composition and potential *** scientific evidence directly comparing gastrointestinal tolerability is limited,organic formulas strive to use carefully selected organic ingredients to imitate breast milk *** benefits include improved lipid profiles,higher methionine content,and decreased antibiotic-resistant bacteria *** the gastrointestinal tolerability of organic and traditional infant formulas is crucial for parents and healthcare providers to make informed *** Despite limitations in direct comparisons,this systematic review provides insights into the composition and potential benefits of organic infant *** emphasizes the need for further research to eluci

关键词： Organic infant formula Traditional infant formula Gastrointestinal tolerability Formula ingredients Digestive health Infant nutrition Organic farming

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Gut microbiota in various childhood disorders:Implication and indications

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World Journal of Gastroenterology 2022年第18期28卷 1875-1901页

作者： Nermin Kamal Saeed Mohammed al-Beltagi Adel Salah Bediwy Yasser El-Sawaf Osama Toema Medical Microbiology Section Department of PathologySalmaniya Medical ComplexMinistry of HealthManama 12Bahrain Microbiology Section Department of PathologyIrish Royal College of SurgeonBusaiteen 15503Bahrain department of Pediatrics University Medical CenterArabian Gulf UniversityDr.Sulaiman Al Habib Medical GroupManama 26671Bahrain department of Pediatrics Faculty of MedicineTanta UniversityTanta 31511Egypt department of Chest Disease Faculty of MedicineTanta UniversityTanta 31527Egypt department of Pulmonology University Medical CenterArabian Gulf UniversityDr.Sulaiman Al Habib Medical GroupManama 26671Bahrain department of Tropical Medicine Faculty of MedicineTanta UniversityTanta 31527Egypt department of Gastroenterology University Medical CenterArabian Gulf UniversityDr.Sulaiman Al-Habib Medical GroupManama 26671Bahrain

Gut microbiota has a significant role in gut development,maturation,and immune system *** exerts considerable effects on the child's physical and mental *** gut microbiota composition and structure depend on many host and microbial *** host factors include age,genetic pool,general health,dietary factors,medication use,the intestine's pH,peristalsis,and transit time,mucus secretions,mucous immunoglobulin,and tissue oxidation-reduction *** microbial factors include nutrient availability,bacterial cooperation or antagonism,and bacterial *** part of the gut has its microbiota due to its specific *** gut microbiota interacts with different body parts,affecting the pathogenesis of many local and systemic *** is a common finding in many childhood disorders such as autism,failure to thrive,nutritional disorders,coeliac disease,Necrotizing Enterocolitis,helicobacter pylori infection,functional gastrointestinal disorders of childhood,inflammatory bowel diseases,and many other gastrointestinal *** is also observed in allergic conditions like atopic dermatitis,allergic rhinitis,and *** can also impact the development and the progression of immune disorders and cardiac disorders,including heart *** supplements could provide some help in managing these ***,we are still in need of more *** this narrative review,we will shed some light on the role of microbiota in the development and management of common childhood disorders.

关键词： Gut microbiota Dysbiosis Children Gastrointestinal disorders Immune disorders allergic disorders Cardiac disorders

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Insulin-resistance in paediatric age:Its magnitude and implications

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World Journal of Diabetes 2022年第4期13卷 282-307页

作者： Mohammed al-Beltagi Adel Salah Bediwy Nermin Kamal Saeed department of Pediatrics Faculty of MedicineTanta UniversityTanta 31511Egypt department of Pediatrics University Medical CenterArabian Gulf UniversityDr.Sulaiman Al Habib Medical GroupManama 26671Bahrain department of Chest Disease Faculty of MedicineTanta UniversityTanta 31527Egypt department of Pulmonology University Medical CenterArabian Gulf UniversityDr.Sulaiman Al Habib Medical GroupManama 26671Bahrain Medical Microbiology Section Department of PathologySalmaniya Medical ComplexMinistry of HealthManama 12Bahrain Microbiology Section Department of PathologyIrish Royal College of SurgeonBusaiteen 15503Bahrain

Insulin resistance(IR)is insulin failure in normal plasma levels to adequately stimulate glucose uptake by the peripheral *** is becoming more common in children and adolescents than *** is a strong association between obesity in children and adolescents,IR,and the metabolic syndrome *** shows marked variation among different races,crucial to understanding the possible cardiovascular risk,specifically in high-risk races or ethnic *** causes of IR include insulin receptor mutations,mutations that stimulate autoantibody production against insulin receptors,or mutations that induce the formation of abnormal glucose transporter 4 molecules or plasma cell membrane glycoprotein-1 molecules;all induce abnormal energy pathways and end with the development of *** parallel increase of IR syndrome with the dramatic increase in the rate of obesity among children in the last few decades indicates the importance of environmental factors in increasing the rate of *** patients with IR do not develop diabetes mellitus(DM)***,IR is a crucial risk factor to develop DM type-II in *** standards for IR in children are not yet established due to various *** measures of insulin sensitivity include the hyperinsulinemia euglycemic glucose clamp and the insulin-suppression *** model analysis of frequently sampled intravenous glucose tolerance test and oral glucose tolerance test provide an indirect estimate of metabolic insulin sensitivity/*** main aim of the treatment of IR in children is to prevent the progression of compensated IR to decompensated IR,enhance insulin sensitivity,and treat possible *** are three main lines for treatment:Lifestyle and behavior modification,pharmacotherapy,and *** review will discuss the magnitude,implications,diagnosis,and treatment of IR in children。

关键词： Insulin resistance Children Diabetes mellitus Obesity Genetic Acquired

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Role of gastrointestinal health in managing children with autism spectrum disorder

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世界临床儿科杂志 2023年第4期12卷 171-196页

作者： Mohammed al-Beltagi Nermin Kamal Saeed Adel Salah Bediwy Reem Elbeltagi Rawan alhawamdeh Pediatric department Faculty of MedicineTanta UniversityAlgharbiaTanta 31511Egypt Pediatrics Univeristy Medical CenterKing Abdulla Medical CityArabian Gulf UniversityDr.Sulaiman Al Habib Medical GroupManamaManama 26671Bahrain Medical Microbiology Section Pathology DepartmentSalmaniya Medical ComplexMinistry of HealthManamaManama 12Bahrain Medical Microbiology Section Pathology DepartmentIrish Royal College of SurgeonBahrainMuharraqBusaiteen 15503Bahrain Pulmonology department Faculty of MedicineTanta UniversityAlgharbiaTanta 31527Egypt Pulmonology department University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityDr.Sulaiman Al Habib Medical GroupManamaManama 26671Bahrain Medicine The Royal College of Surgeons in Ireland-BahrainMuharraqBusiateen 15503Bahrain Pediatrics Research and Development DepartmentGenomics Creativity and Play CenterManamaManama 0000Bahrain Pediatrics Research and Development DepartmentSENSORYME Dubai 999041United Arab Emirates

Children with autism spectrum disorders(ASD)or autism are more prone to gastrointestinal(GI)disorders than the general *** disorders can significantly affect their health,learning,and development due to various factors such as genetics,environment,and *** causes of GI disorders in children with ASD can include gut dysbiosis,immune dysfunction,food sensitivities,digestive enzyme deficiencies,and sensory processing *** studies suggest that numerous children with ASD experience GI problems,and effective management is *** autism is typically done through genetic,neurological,functional,and behavioral assessments and observations,while GI tests are not consistently *** GI tests may increase the risk of developing ASD or exacerbating *** GI issues in individuals with ASD can improve their overall well-being,leading to better behavior,cognitive function,and educational *** management can improve digestion,nutrient absorption,and appetite by relieving physical discomfort and *** GI symptoms can improve sleep patterns,increase energy levels,and contribute to a general sense of well-being,ultimately leading to a better quality of life for the individual and improved family *** primary goal of GI interventions is to improve nutritional status,reduce symptom severity,promote a balanced mood,and increase patient independence.

关键词： Gastrointestinal disorders Autism spectrum disorders,Children Gut microbiota Ketogenic diet Gluten-free casein-free diet,Dietary management

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Effects of COVID-19 on children with autism

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World Journal of Virology 2022年第6期11卷 411-425页

作者： Mohammed al-Beltagi Nermin Kamal Saeed Adel Salah Bediwy Rawan alhawamdeh Samara Qaraghuli department of Pediatrics Faculty of MedicineTanta UniversityTanta 31527AlghrabiaEgypt department of Pediatrics University Medical CenterArabian Gulf UniversityKing Abdulla Medical CityArabian Gulf UniversityManama 26671ManamaBahrain department of Pediatrics University Medical CenterDr.Sulaiman Al-Habib Medical GroupManama 26671ManamaBahrain department of Medical Microbiology Section Pathology DepartmentSalmaniya Medical ComplexMinistry of HealthKingdom of BahrainManama 12ManamaBahrain department of Microbiology Section Pathology DepartmentIrish Royal College of SurgeonBusiateen 15503MuharraqBahrain department of Chest Disease Faculty of MedicineTanta UniversityTanta 31527AlghrabiaEgypt department of Pulmonology University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671ManamaBahrain department of Pulmonology University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityDr.Sulaiman Al-Habib Medical GroupManama 26671ManamaBahrain Research and development department Pediatric Occupational Therapist and NeuropsychologistGenomics Development and Play Center(Genomisc WLL)0000ManamaBahrain Research and development department Pediatric Occupational Therapist and NeuropsychologistSensory Middle East(SENSORYME DWC-LLC)282228 DubaiUnited Arab Emirates department of Pharmacognosy and Medicinal Plants Faculty of PharmacyAl-Mustansiriya UniversityBaghdad 14022BaghdadIraq

The coronavirus disease 2019(COVID-19)pandemic affects all countries and populations worldwide,significantly impacting people with autism with a high risk of morbidity and mortality due to *** 25%of children with autism have an asymptomatic or symptomatic immune deficiency or *** addition,they frequently have various comorbid conditions that increase the severity of *** addition,severe COVID-19 during pregnancy may increase the risk of autism in the ***,severe acute respiratory syndrome coronavirus 2 could target human nervous system tissues due to its neurotrophic *** COVID-19 pandemic intensely impacts many patients and families in the autism community,especially the complex management of autism-associated disorders during the complete *** the complete lockdown,children with autism had difficulties coping with the change in their routine,lack of access to special education services,limited physical space available,and problems related to food and ***,children with autism or intellectual disabilities are more liable to be abused by others during the pandemic when the standard community supports are no longer functioning to protect *** detection and vaccination of children with autism against COVID-19 are highly *** should be prioritized for testing,vaccination,and proper management of COVID-19 and other infectious *** this review,we discuss the various effects of COVID-19 on children with autism,the difficulties they face,the increased risk of infection during pregnancy,how to alleviate the impact of COVID-19,and how to correct the inequalities in children with autism.

关键词： Autism ASD Autism Spectrum Disorder Children COVID-19 Testing Vaccination Neurotropism SARS-CoV-2

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Cow’s milk-induced gastrointestinal disorders:From infancy to adulthood

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World Journal of Clinical Pediatrics 2022年第6期11卷 437-454页

作者： Mohammed al-Beltagi Nermin Kamal Saeed Adel Salah Bediwy Reem Elbeltagi department of Pediatrics Faculty of MedicineTanta UniversityTanta 31511AlgharbiaEgypt department of Pediatrics University Medical CenterArabian Gulf UniversityManama 26671Bahrain department of Pathology Microbiology SectionSalmaniya Medical ComplexManama 26671Bahrain department of Pathology Microbiology SectionRoyal College of Surgeons in Ireland-BahrainBusaiteen 15503MuharraqBahrain department of Chest Diseases Faculty of MedicineTanta UniversityTanta 31527AlgharbiaEgypt department of Chest Diseases University Medical CenterArabian Gulf UniversityManama 26671Bahrain department of Medicine The Royal College of Surgeons in Ireland-BahrainBusiateen 15503MuharraqBahrain

Milk is related to many gastrointestinal disorders from the cradle to the grave due to the many milk ingredients that can trigger gastrointestinal discomfort and ***’s milk protein allergy(CMPA)is the most common food allergy,especially in infancy and childhood,which may persist into *** are three main types of CMPA;immunoglobulin E(IgE)-mediated CMPA,non-IgEmediated CMPA,and mixed *** appears before the first birthday in almost all *** may start even during the neonatal period and can be severe enough to simulate neonatal ***(often non-IgE mediated)can present with symptoms of gastroesophageal reflux,eosinophilic esophagitis,hemorrhagic gastritis,food protein-induced protein-losing enteropathy,and food protein-induced enterocolitis *** CMPAs are benign and outgrown during *** is not as common in adults as in children,but when present,it is usually severe with a protracted *** intolerance is a prevalent condition characterized by the development of many symptoms related to the consumption of foods containing *** intolerance has four typical types:developmental,congenital,primary,and *** intolerance and CMPA may be the underlying pathophysiologic mechanisms for many functional gastrointestinal disorders in children and *** are also common in inflammatory bowel *** consumption may have preventive or promoter effects on cancer *** may also become a source of microbial infection in humans,causing a wide array of diseases,and may help increase the prevalence of antimicrobial *** editorial summarizes the common milk-related disorders and their symptoms from childhood to adulthood.

关键词： Cow’s milk Adults Children Functional gastrointestinal disorders Cow’s milk protein allergy Lactose intolerance,Inflammatory bowel disease Zoonosis

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Effects of Mesopotamian Marsh (Iraq) desiccation on the cultural knowledge and livelihood of Marsh arab women

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Ecosystem Health and Sustainability 2016年第3期2卷 14-30页

作者： Nadia al-Mudaffar Fawzi Kelly P.Goodwin Bayan A.Mahdi Michelle L.Stevens department of biological development of shatt al-arab and north arabian gulf Marine Science CentreUniversity of BasrahBasrahIraq Millennium Relief and development Services Nongovernmental OrganizationBasrahIraq Environmental Studies department California State UniversitySacramentoCalifornia 95819 USA

In this study,we evaluate ecological and cultural resiliency in response to desertification of the Mesopotamian Marshes of Southern *** research illustrates that the desiccation of the marshes has caused a drastic change in how Marsh arab women interact with their environment;specifically,in comparison to the predesiccation period,women’s roles are increasingly limited to domestic rather than marsh-dependent *** the exception of raising water buffalo and limited horticulture activities,most families today have little opportunity to utilize women’s ability to generate income by applying their traditional ecological knowledge and ***,these women are no longer transmitting their marsh-specific knowledge and skills to the next generation,and these valuable and ancient cultural memories are being *** dam construction,drought,and regional climate change is depriving Marsh arab communities of marsh eco-system services such as potable water,water buffalo forage,fish yields,and reed *** marsh areas,where enough water remains to sustain ecosystem services(such as in Chibayish and the Iraq Marshlands Na-tional Park),cultural knowledge has been retained and passed on to the next *** recommend that programs be implemented to preserve these traditional skills,to develop a market for handicrafts to support women and their families,and to support cultural ***,with the passing of the older genera-tion,these remnants of ancient Sumerian knowledge systems and traditional ways of life will soon be forgotten.

关键词： cultural resilience ecosystem services historic ecology Iraq Marsh arab women Mesopotamian Marshes traditional ecological knowledge

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Insulin pumps in children-a systematic review

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World Journal of Clinical Pediatrics 2022年第6期11卷 463-484页

作者： Mohammed al-Beltagi Nermin Kamal Saeed Adel Salah Bediwy Reem Elbeltagi department of Pediatrics Faculty of MedicineTanta UniversityTanta 31511AlgharbiaEgypt department of Pediatrics University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671ManamaBahrain department of Pediatrics University Medical CenterDr.Sulaiman Al Habib Medical GroupManamaBahrainManama 26671ManamaBahrain Medical Microbiology Section Department of PathologySalmaniya Medical ComplexMinistry of HealthKingdom of BahrainManama 12ManamaBahrain department of Microbiology Irish Royal College of SurgeonBahrainBusaiteen 15503MuharraqBahrain department of Chest Disease Faculty of MedicineTanta UniversityTanta 31527AlghrabiaEgypt department of Chest Disease University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityDr.Sulaiman Al Habib Medical GroupManama 26671ManamaBahrain department of Medicine The Royal College of Surgeons in Ireland-BahrainBusiateen 15503MuharraqBahrain

BACKGROUND Insulin pump therapy is a real breakthrough in managing diabetes Mellitus,particularly in children. It can deliver a tiny amount of insulin and decreases the need for frequent needle injections. It also helps to maintain adequate and optimal glycemic control to reduce the risk of metabolic derangements in different *** are suitable candidates for pump therapy as they need a more freestyle and proper metabolic control to ensure adequate growth and ***, children and their caregivers should have proper education and training and understand the proper use of insulin pumps to achieve successful pump therapy. The pump therapy continuously improves to enhance its performance and increase its simulation of the human pancreas. Nonetheless, there is yet a long way to reach the desired *** To review discusses the history of pump development, its indications, types, proper use, special conditions that may enface the children and their families while using the pump, its general care,and its advantages and *** We conducted comprehensive literature searches of electronic databases until June 30, 2022,related to pump therapy in children and published in the English *** We included 118 articles concerned with insulin pumps, 61 were reviews, systemic reviews, and meta-analyses, 47 were primary research studies with strong design, and ten were *** The insulin pump provides fewer needles and can provide very tiny insulin doses, a convenient and more flexible way to modify the needed insulin physiologically, like the human pancreas, and can offer adequate and optimal glycemic control to reduce the risk of metabolic derangements in different tissues.

关键词： Insulin pump Children Diabetes mellitus Keto-acidosis Continuous glucose monitoring Insulin therapy

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