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Unleashing the Potential of Electroactive Hybrid Biomaterials and Self‑Powered systems for Bone Therapeutics

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Nano-Micro Letters 2025年第2期17卷 463-497页

作者： Shichang Liu Farid Manshaii Jinmiao Chen Xinfei Wang Shaolei Wang Junyi Yin Ming Yang Xuxu Chen Xinhua Yin Yunlei Zhou Honghui Hospital Xi’an Jiaotong UniversityXi’an 710018People’s Republic of China department of bioengineering Henry Samueli School of Engineering and Applied ScienceUniversity of California Los AngelesLos Angeles 90095USA Hangzhou Institute of Technology Xidian UniversityHangzhou 311231People’s Republic of China

The incidence of large bone defects caused by traumatic injury is increasing worldwide,and the tissue regeneration process requires a long recovery time due to limited self-healing *** bioelectrical phenomena have been well recognized as critical biophysical factors in bone remodeling and *** by bioelectricity,electrical stimulation has been widely considered an external intervention to induce the osteogenic lineage of cells and enhance the synthesis of the extracellular matrix,thereby accelerating bone *** ongoing advances in biomaterials and energy-harvesting techniques,electroactive biomaterials and self-powered systems have been considered biomimetic approaches to ensure functional recovery by recapitulating the natural electrophysiological microenvironment of healthy bone *** this review,we first introduce the role of bioelectricity and the endogenous electric field in bone tissue and summarize different techniques to electrically stimulate cells and ***,we highlight the latest progress in exploring electroactive hybrid biomaterials as well as self-powered systems such as triboelectric and piezoelectric-based nanogenerators and photovoltaic cell-based devices and their implementation in bone tissue ***,we emphasize the significance of simulating the target tissue’s electrophysiological microenvironment and propose the opportunities and challenges faced by electroactive hybrid biomaterials and self-powered bioelectronics for bone repair strategies.

关键词： Electroactive biomaterials Self-powered bioelectronics Bone regeneration Bone tissue

Radiomic features from computed tomography to differentiate invasive pulmonary adenocarcinomas from non-invasive pulmonary adenocarcinomas appearing as part-solid groundglass nodules

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Chinese Journal of Cancer Research 2019年第2期31卷 329-338页

作者： Ting Luo Ke Xu Zheng Zhang Lina Zhang Shandong Wu department of Radiology the First Affiliated Hospital of China Medical University departments of Radiology Biomedical Informatics Bioengineering and Intelligent Systems University of Pittsburgh

Objective:We aim to investigate radiomic imaging features extracted in computed tomography(CT)images to differentiate invasive pulmonary adenocarcinomas(IPAs)from non-IPAs appearing as part-solid ground-glass nodules(GGNs),and to incorporate significant radiomic features with other clinically-assessed features to develop a diagnostic nomogram model for ***:This retrospective study was performed,with Institutional Review Board approval,on 88 patients with a total of 100 part-solid nodules(56 IPAs and 44 non-IPAs)that were surgically confirmed between February 2014and November 2016 in the First Affiliated Hospital of China medical *** radiomic features were computed automatically on 3D nodule volume segmented from arterial-phase contrast-enhanced CT images.A set of regular risk factors and visually-assessed qualitative CT imaging features were compared with the radiomic features using logistic regression *** diagnostic models,i.e.,a basis model using the clinical factors and qualitative CT features,a radiomics model using significant radiomic features,and a nomogram model combining all significant features,were built and compared in terms of receiver operating characteristic(ROC)*** curve analysis was performed for the nomogram model to explore its potential clinical ***:In addition to three visually-assessed qualitative imaging features,another three quantitative features selected from hundreds of radiomic features were found to be significantly(all P<0.05)associated with *** diagnostic nomogram model showed a significantly higher performance[area under the ROC curve(AUC)=0.903]in differentiating IPAs from non-IPAs than either the basis model(AUC=0.853,P=0.0009)or the radiomics model(AUC=0.769,P<0.0001).Decision curve analysis indicates a potential benefit of using such a nomogram model in clinical ***:Quantitative radiomic features provide additional information over clinically-as

关键词： Radiomics lung adenocarcinomas tomography X-ray computed

Protein adsorption onto diethylaminoethyl dextran modified anion exchanger:Effect of ionic strength and column behavior

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Chinese Journal of Chemical Engineering 2018年第2期26卷 259-267页

作者： Shu Bai Lingli Gong Detao Han Yutong Li Linling Yu Yan Sun department of Biochemical Engineering and Key Laboratory of systems bioengineering of Ministry of Education School of Chemical Engineering and TechnologyTianjin University

Our previous studies on bovine serum albumin （BSA） adsorption to diethylaminoethyl dextran （DEAE dextran, DexD, grafting-ligand） and DEAE （D, surface-ligand） modified Sepharose FF resins found that all the grafted resins （FF-DexD and FF-D-DexD） exhibited extremely fast uptake rate （effective diffusivity, De, De/Do 〉 1.4）, which was six times greater than the ungrafted resins （De/Do 〈 0.3）. In this work, the influence of ionic strength （IS） on 6 typical DEAE dextran-grafted resins was investigated. Bath adsorption equilibria and kinetics, breakthrough, and linear gradient elution experiments were conducted. Commercial DEAE Sepharose FF was used for comparison. It is found that protein adsorption capacities on DEAE dextran-FF resins and the commercial resin decreased with increasing IS, but DEAE dextran-FF resins exhibited much higher capacity sensitivity to salt concentration. Besides, steeper decrease of adsorption capacities could be obtained at higher graftingligand or surface-ligand density. It is worth noting that the facilitating role of surface-ligand to the ＂chain delivery＂ effect was weakened after adding salt, leading to the less improvement in uptake rate by increasing surface-ligand density at higher IS. Although the uptake rates of the DEAE dextran-FF resins increased first and then decreased with increasing fS, they kept the extremely high level of De values （De/Do 〉 1.1 ） at the their working/binding IS range. Moreover, the DEAE dextran-FF resin displayed much higher adsorption capacities and De values than commercial ungrafted resin in their working condition. Furthermore, the column results of DEAE dextran-FF resins presented higher dynamic binding capacities than and similar elution ISs with DEAE Sepharose FF to achieve similar （or even higher） recoveries suggest the excellent chromatographic column performance of the DEAE dextran-FF resins. Finally, both high recovery and purity of BSA and γ-globulin could be easily achieved using the typical DEAE

关键词： Ion exchange chromatography DEAE dextran Protein adsorption Uptake kinetics Ionic strength

Comment on“In vivo flow cytometry reveals a circadian rhythm of circulating tumor cells”

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Light(Science & Applications) 2021年第10期10卷 1998-1999页

作者： Amber L.Williams Jessica E.Fitzgerald Fernando Ivich Eduardo DSontag Mark Niedre department of bioengineering Northeastern UniversityBostonMAUSA department of Electrical and Computer Engineering Northeastern UniversityBostonMAUSA Laboratory of systems Pharmacology Harvard Medical SchoolBostonMAUSA

Dear Editor,Circulating tumor cells(CTCs)are instrumental in hematogenous metastasis and are widely studied using liquid biopsy *** involve analysis and characterization of CTCs from fractionally small blood samples drawn from *** biopsy implicitly assumes that the number and phenotypical distribution of CTCs in small blood samples is representative of the full peripheral blood volume,and furthermore that CTC numbers are approximately constant over the days and hours surrounding the blood draw.

关键词： biopsy metastasis furthermore

A topology-based bounded rationality day-to-day traffic assignment model

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Communications in Transportation Research 2022年第1期2卷 298-313页

作者： Enrico Siri Silvia Siri Simona Sacone department of Informatics BioengineeringRobotics and Systems EngineeringUniversity of GenovaGenova16145Italy

This paper analyzes the day-to-day adjustment process of users’behaviors in a transport network which is affected by relevant alterations such as disruptions due to critical events which cause the impossibility to use one or more *** representing the progressive adjustment of the flows on the network to reach a new equilibrium,a dayto-day discrete-time model is proposed,based on the idea that people are bounded rational in their choices,*** often do not behave according to the optimal solution but they accept solutions they consider ***,in their choice process,are influenced by the topological similarity between the route they are currently using and *** means that they tend to prefer the solutions that are more similar to the one they are already *** parallel,users exhibit a myopic behavior,i.e.,they tend to overestimate the goodness of a route if,when using it,they suddenly experience a significant reduction in travel time compared to what they are used *** the paper it is shown that such route choice behaviour implies that the steady state of the system corresponds to a Bounded Rational User Equilibrium,i.e.,a state that does not diverge from the user equilibrium more than a certain value which increases when the relative importance given to the topological similarity *** model also assumes that these biases vanish,at least with respect to those routes that are most frequently used by users,after a sufficient amount of *** certain conditions,it is then shown that the steady state can eventually collapse into a User *** effectiveness of the proposed model is assessed via simulation results in which two test networks are analyzed in detail to show the evolution of the users’behaviour in a transport network after a disruption.

关键词： Traffic Assignment Day-to-day traffic assignment Bounded rationality

Linear Precoding Design for MIMO-PLC systems

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Tsinghua Science and Technology 2015年第2期20卷 155-163页

作者： Jisheng Peng the State Key Lab of Control and Simulation of Power systems and Generation equipment Department of Electrical Engineering Tsinghua Uinversity

In this paper, we consider the design of linear precoding in Multiple Input Multiple Output （MIMO） Power Line Communication （PLC） systems with finite-alphabet input. First, we derive mutual information of MIMO-PLC systems with impulsive noise. Considering the non-concavity of the objective function and the low-cost requirement of PLC systems, we choose the lower bound of the mutual information as the objective function. Subsequently, we propose a novel approach to design the precoding scheme to reduce computational complexity. Specifically, our work primarily includes the following two contributions：（1） We design the right unitary matrix that is a product of two fixed unitary matrices, which only depends on the modulation mode. Hence, the results can be saved and require less computations. （2） For the power allocation matrix, we first reduce the space of power allocation using constraints of the optimal power allocation policy. Consequently, we propose a non-linear search method to obtain the optimal power allocation in small space. In regards to the computational complexity of the analysis, we conclude that the proposed precoding matrix design scheme has low complexity and is easy to implement. Moreover, the numerical results are proven to demonstrate the performance of the proposed precoding design scheme.

关键词： precoding design MIMO-PLC impulsive noise finite-alphabet input

Small activating RNA delivery in vivo:Challenges,prospects,and lessons learned from siRNA delivery

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Nano Research 2024年第10期17卷 8990-9002页

作者： Shalini Pandey Patrick T.Bednarz Matthias A.Oberli Omid Veiseh department of bioengineering William Marsh Rice UniversityHouston 77030USA Xibus systems 199 Dexter AveWatertown 02472USA

Over the last two decades,small activating RNAs(saRNAs)have quickly moved from discovery to clinical *** as 20 nucleotide long,double stranded RNA,saRNAs have the unique ability to increase gene transcription at the chromatin *** therapeutic modality has great potential as a safe and redosable alternative to gene therapy by increasing target protein expression without changing the genetic *** describe the successful in vivo saRNA delivery vectors and found that similar to small interfering RNA(siRNA)and mRNA targeting tissues outside the liver works best at the end of a *** highlight nanoparticle vectors and RNA-conjugates,where some success has been reported for non-hepatic delivery of saRNAaptamers.

关键词： small activating RNA hepatic bias lipid nanoparticles RNA-conjugates

Insights into the cross-amyloid aggregation of Aβ_(40) and its N-terminal truncated peptide Aβ_(11-40) affected by epigallocatechin gallate

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Chinese Journal of Chemical Engineering 2022年第5期35卷 284-293页

作者： Yue Liang Wenjuan Wang Yan Sun Xiaoyan Dong department of Biochemical Engineering and Key Laboratory of systems bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300354China

Inhibition of protein misfolding and aggregation is a great challenge in the field of biochemical and biopharmaceutical ***’s disease(AD)is a protein-misfolding disease,and the interactions between 40-amino-acid-residueβ-amyloid peptide(Aβ_(40)) and its N-terminal truncated peptide Aβ_(11-40) demonstrate that Aβ_(11-40) may play an important role in the pathological process of ***,the effect of inhibitors on Aβ_(11-40) aggregation and on the cross-amyloid aggregation(coassembly)between Aβ_(40) and Aβ_(11-40) has never been ***,coaggregation and seeding interactions between Aβ_(40) and Aβ_(11-40) as well as the effect of epigallocatechin gallate(EGCG),a small molecule inhibitor,on the cross-amyloid aggregation have been investigated by extensive *** is found that Aβ_(11-40) participates in the aggregation of Aβ_(40) and leads to the formation of coaggregates that contain lessβ-sheet structures than pure Aβ_(40) *** aggregation kinetics along with morphologies and secondary structures of the coaggregates are also significantly affected by the Aβ_(40)/Aβ_(11-40) *** accelerates the nucleation of Aβ_(40) but retards that of Aβ_(11-40) by affecting their elongation and secondary nucleation processes in solution and on solid ***,EGCG makes the conformations of the seeding-induced Aβaggregates more compact,especially for the homologous *** titration calorimetry measurement indicates that hydrophobic interactions mainly contribute to the inhibition of the two Aβisoforms by *** findings of this research have provided new insights into Aβaggregation and the effect of an important inhibitor and the results would benefit in the development of potent inhibitors against co-assembly of different amyloid proteins.

关键词： Protein Aggregation Kinetics Nucleation Elongation Molecular interactions

Fabrication and characterization of epoxylated zwitterionic copolymergrafted silica nanoparticle as a new support for lipase immobilization

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Chinese Journal of Chemical Engineering 2020年第4期28卷 1129-1135页

作者： Ning Chen Chunyu Zhang Xiaoyan Dong Yan Sun department of Biochemical Engineering and Key Laboratory of systems bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300354China

Our previous work proved that the thermal stability of Candida rugosa lipase(CRL)immobilized on zwitterionic polymer(poly(carboxybetaine methacrylate))grafted silica nanoparticle(SNP)was much higher than that on poly(glycidyl methecrylate)(pGMA)grafted SNP,while the latter showed significantly increased *** by the research,we have herein proposed to synthesize copolymers of zwitterionic sulfobetaine methacrylate(SBMA)and GMA for CRL *** copolymers were grafted onto SNP surface at three GMA/SBMA(G/S)molar ratios(G100/S0,G50/S50,G10/S90),followed by the covalent coupling of CRL to the surface *** immobilized CRLs on the corresponding supports were denoted as p(G100-S0)-CRL,p(G50-S50)-CRL and p(G10-S90)-*** enzyme loading increased with the increase of GMA content in the copolymer,while the activity varied with the grafted copolymer *** study proved the improvement of enzyme-substrate affinity after *** comparison to p(G100-S0)-CRL,p(G50-S50)-CRL and p(G10-S90)-CRL presented remarkably enhanced thermal stability and pH tolerance,and p(G10-S90)-CRL showed the highest *** results suggest that the copolymer design is promising for development as a versatile platform for enzyme immobilization.

关键词： Lipase Immobilization Zwitterionic copolymer Interfacial activation Stabilization