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Ultra-high-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry-characterized extract of Aerides odorata Lour alleviates paracetamol-induced hepatotoxicity in animal model evidenced by biochemical,molecular,and computational studies

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Animal Models and Experimental Medicine 2024年第4期7卷 497-522页

作者： A.M.Abu Ahmed Md.Atiar Rahman Farjana Sharmen A.S.M.Ali Reza Md.Shahidul Islam Md.Mamunur Rashid Md.Khalid Juhani Rafi Tanvir Ahmed Siddiqui Md.Muzahid Ahmed Ezaj Srabonti Saha Md.Nazim Uddin Walla Alelwani department of Genetic Engineering and Biotechnology University of ChittagongChittagongBangladesh department of biochemistry and Molecular Biology University of ChittagongChittagongBangladesh department of Pharmacy International Islami University ChittagongChittagongBangladesh Institute of Food Science and Technology Bangladesh Council of Scientific and Industrial ResearchDhakaBangladesh department of biochemistry College of ScienceUniversity of JeddahJeddahSaudi Arabia

Background:Many kinds of orchids have significant health benefits although ade-quate research on their biological functions is yet to be carried *** study inves-tigated the paracetamol-induced liver damage-protecting effect of epiphytic Aerides odorata methanol extract(AODE).Methods:The protective effects of AODE were studied by analyzing its effect on liver function parameters,messenger RNA(mRNA)expression,and tissue histopatho-logical *** results were confirmed by ligand-receptor interaction of molecular docking and multitarget interaction of network pharmacological ***:AODE significantly(p<0.05)minimized the dose-dependent increase in acid phosphatase,aspartate aminotransferase,alanine aminotransferase,alkaline phos-phatase,γ-glutamyl transferase,lactate dehydrogenase,and total bilirubin compared to the reference drug *** level decreased,and the antioxidant genes catalase(CAT),superoxide dismutase(SOD),β-actin,paraoxonase-1(PON1),and phosphofructokinase-1(PFK-1)were upregulated in AODE-treated paracetamol-intoxicated rats.A total of 376 compounds comprising phenols and flavonoids were identified using ultra-high-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry(UPLC-qTOF-MS).The online toxicity assessment using SwissADME and admetSAR exhibited drug-like,nontoxic,and potential pharmaco-logical ***,in silico analysis showed that isoacteoside,one of the identified compounds,exhibited the best docking score(−11.42)with the liver pro-tein human pituitary adenylate cyclase-1(Protein Data Bank ID:3N94).Furthermore,network pharmacology analysis identified the top 10 hub genes,namely AKT1(protein kinase B),CTNNB1(catenin beta-1),SRC(proto-oncogene c-Src),TNF(tumor necrosis factor),EGFR(epidermal growth factor receptor),HSP90AA1(heat shock protein 90α),MAPK3(mitogen-activated protein kinase 3),STAT3(signal transducer and activator of transcription 3),CASP3(caspase protein),

关键词： Aerides odorata animal model mRNA expression PCM-induced hepatotoxicity UPLC-qTOF-MS

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Fucoxanthin promotes the chain lengthening reaction of polyunsaturated fatty acids in vivo by enhancing FADS2 enzyme activity

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Food Science and Human Wellness 2024年

作者： Xiao-Yue Li Tian-Xin Yang Ying-Cai Zhao Cheng-Cheng Wang Chang-Hu Xue Teruyoshi Yanagita Yu-Ming Wang Tian-Tian Zhang SKL of Marine Food Processing & Safety Control， college of Food Science and Engineering， Ocean University of China Laboratory of Nutrition biochemistry， department of Applied biochemistry and Food Science， Saga University

Alpha-linolenic acid (ALA) is capable of synthesizing EPA and DHA in vivo， but the conversion rate is hard to meet the body's need for rapid DHA supplementation. Studies have shown that fucoxanthin can increase DHA content in the liver of mice， but the mechanism is not clear. Moreover， the effect of fucoxanthin and its metabolite fucoxanthinol on the chain lengthening reaction of n-6 polyunsaturated fatty acids (PUFAs) is little studied. In this study， the effects of fucoxanthin and fucoxanthinol on the chain elongation of n-3 and n-6 series PUFAs were investigated in mice. Results showed that fucoxanthin and fucoxanthinol significantly increased the conversion of n-3 series ALA to DHA and n-6 series LA to AA in the serum， liver， small intestine， and heart of mice. In addition， fucoxanthin accelerated the rate of DHA supplementation by ALA in the brain. Further mechanistic studies revealed that the role of fucoxanthin in promoting PUFAs conversion was not regulated at transcriptional level， but by increasing the activity of fatty acid desaturase 2 (FADS2)， a key enzyme of chain elongation reaction of n-3 and n-6 PUFAs. This study fundamentally provided theoretical bases for a new strategy of dietary supplementation of n-3 and n-6 PUFAs.

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A Review on Security and Privacy Issues Pertaining to Cyber-Physical Systems in the Industry 5.0 Era

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Computers, Materials & Continua 2024年第9期80卷 3917-3943页

作者： Abdullah Alabdulatif Navod Neranjan Thilakarathne Zaharaddeen Karami Lawal department of Cybersecurity College of ComputerQassim UniversityBuraydah51452Saudi Arabia department of ICT Faculty of TechnologyUniversity of ColomboColombo00700Sri Lanka department of Computer Science Federal University DutseDutse720102Nigeria Faculty of Integrated Technologies Universiti Brunei DarussalamGadongBE1410Brunei Darusalam

The advent of Industry 5.0 marks a transformative era where Cyber-Physical Systems(CPSs)seamlessly integrate physical processes with advanced digital ***,as industries become increasingly interconnected and reliant on smart digital technologies,the intersection of physical and cyber domains introduces novel security considerations,endangering the entire industrial *** transition towards a more cooperative setting,including humans and machines in Industry 5.0,together with the growing intricacy and interconnection of CPSs,presents distinct and diverse security and privacy *** this regard,this study provides a comprehensive review of security and privacy concerns pertaining to CPSs in the context of Industry *** review commences by providing an outline of the role of CPSs in Industry 5.0 and then proceeds to conduct a thorough review of the different security risks associated with CPSs in the context of Industry ***,the study also presents the privacy implications inherent in these systems,particularly in light of the massive data collection and processing *** addition,the paper delineates potential avenues for future research and provides countermeasures to surmount these ***,the study underscores the imperative of adopting comprehensive security and privacy strategies within the context of Industry 5.0.

关键词： Cyber-physical systems CPS Industry 5.0 security data privacy human-machine collaboration data protection

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Universal insertion of molecules in ionic compounds under pressure

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National Science Review 2024年第1期11卷 120-128页

作者： Feng Peng Yanming Ma Chris J.Pickard Hanyu Liu Maosheng Miao college of Physics and Electronic Information Luoyang Normal University department of Chemistry and biochemistry California State University Northridge State Key Laboratory of Superhard Materials & Key Laboratory of Material Simulation Methods and Software of Ministry of Education College of Physics Jilin University International Center of Future Science Jilin University department of Materials Science & Metallurgy University of Cambridge Advanced Institute for Materials Research Tohoku University department of Earth Science University of California Santa Barbara

Using first-principles calculations and crystal structure search methods, we found that many covalently bonded molecules such as H2, N2, CO2, NH3, H2O and CH4may react with NaC l, a prototype ionic solid,and form stable compounds under pressure while retaining their molecular structure. These molecules,despite whether they are homonuclear or heteronuclear, polar or non-polar, small or large, do not show strong chemical interactions with surrounding Na and Cl ions. In contrast, the most stable molecule among all examples, N2, is found to transform into cyclo-N5-anions while reacting with NaC l under high pressures. It provides a new route to synthesize pentazolates, which are promising green energy materials with high energy density. Our work demonstrates a unique and universal hybridization propensity of covalently bonded molecules and solid compounds under pressure. This surprising miscibility suggests possible mixing regions between the molecular and rock layers in the interiors of large planets.

关键词： molecule-solid hybrid materials high-pressure crystal structure prediction density functional theory planet interior

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Secure and Energy-Efficient Multi-Factor-Based Resource Allocation in A Cloud Environment

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Journal of Harbin Institute of Technology(New series) 2024年

作者： Sureshbabu N Pragaladan R Kannadasan T department of Computer Science， Rajah Serfoji Government college department of Computer Science， sri Vasavi college department of Computer Science， Thanthai Periyar Government Arts and Science college (Autonomous)

The data centre’s energy-efficient and safe distribution of virtual machines is crucial to enable cloud users to profit from flexible and cost-effective computing. Due to the exponential growth in demand for cloud services， many physical servers have been deployed， leading to excessive energy consumption and inefficient use of resources. Optimizing resource use and reducing power usage have emerged as critical issues in any data centre. Cloud service providers use VM allocation strategies to maximize the utilization of distributed physical resources in the cloud. This paper proposes secure and energy-efficient Multi-factor-based Resource Allocation (MFRA) in the cloud. By maximizing resource use， the suggested framework guarantees an energy-efficient distribution of physical resources across virtual machines and prioritizes the safe and prompt execution of user applications. The suggested work has been implemented into practice using the CloudSim simulation tool kit， and a comparison with other well-known virtual machine allocation strategies in the cloud computing industry is done to verify the algorithm’s viability. According to the experimental simulation results， the suggested VM allocation policy outperformed existing VM allocation techniques.

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Flavonoid Myricetin as Potent Anticancer Agent: A Possibility towards Development of Potential Anticancer Nutraceuticals

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Chinese Journal of Integrative Medicine 2024年第1期30卷 75-84页

作者： Anchal Trivedi Adria Hasan Rumana Ahmad Sahabjada Siddiqui Aditi srivastava Aparna Misra Snober S.Mir department of biochemistry Era's Lucknow Medical College&HospitalEra UniversityLucknow(226003)India Molecular Cell Biology Laboratory Integral Information and Research Centre-4(IIRC-4)Department of BioengineeringFaculty of EngineeringIntegral UniversityLucknow(226026)India department of Biotechnology Era's Lucknow Medical College&HospitalEra UniversityLucknow(226003)India department of Biosciences Faculty of ScienceIntegral UniversityLucknow(226026)India

Good nutrition plays a crucial role in maintaining a balanced lifestyle. The beneficial effects of nutrition have been found to counteract nutritional disturbances with the expanded use of nutraceuticals to treat and manage cardiovascular diseases, cancer, and other developmental defects over the last decade. Flavonoids are found abundantly in plant-derived foods such as fruits, vegetables, tea, cocoa, and wine. Fruits and vegetables contain phytochemicals like flavonoids, phenolics, alkaloids, saponins, and terpenoids. Flavonoids can act as anti-inflammatory, anti-allergic, anti-microbial(antibacterial, antifungal, and antiviral) antioxidant, anti-cancer, and anti-diarrheal agents. Flavonoids are also reported to upregulate apoptotic activity in several cancers such as hepatic, pancreatic, breast, esophageal, and colon. Myricetin is a flavonol which is naturally present in fruits and vegetables and has shown possible nutraceutical value. Myricetin has been portrayed as a potent nutraceutical that may protect against cancer. The focus of the present review is to present an updated account of studies demonstrating the anticancer potential of myricetin and the molecular mechanisms involved therein. A better understanding of the molecular mechanism(s) underlying its anticancer activity would eventually help in its development as a novel anticancer nutraceutical having minimal side effects.

关键词： myricetin flavonoids anticancer nutraceuticals Chinese medicine Ayurveda complementary and alternative medicine

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Comparative study on glutathione transferases of rat brain and testis under the stress of phenobarbitol and β-methylcholanthrene

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2005年第8期6卷 759-769页

作者： THYAGARAJU K HEMAVATHI B VASUNDHARA K RAO A.D DEVI K.N department of biochemistry Sri Venkateswara UniversityTirupati 517 502 AP IndiaDepartment of Biochemistry Sri Venkateswara UniversityTirupati 517 502 AP IndiaDepartment of Biochemistry Sri Venkateswara UniversityTirupati 517 502 AP IndiaDepartment of Biochemistry Sri Venkateswara UniversityTirupati 517 502 AP IndiaDepartment of Biochemistry Sri Venkateswara UniversityTirupati 517 502 AP India

A comparative study was made on the tissue specific expression of glutathione transferases (GST) in brain and testis after exposure of rat to phenobarbitol (PB) and β-methylcholanthrene (MC). Glutathione transferases, a family of multifunctional proteins are involved in intracellular transport processes and in detoxication of electrophilic xenobiotics by catalyzing reactions such as conjugation, isomerization, reduction and thiolysis. On purification, the yield of GST proteins by affinity chromatography was 39% in testis and 32% in brain. The affinity purified testis GSTs were resolved by chromatofocusing into six anionic and four cationic isozymes, and in brain glutathione transferases were resolved into four anionic and three cationic isozymes, suggesting the presence of multiple isozymes with Yc, Yb, Yβ and Yδ in both of them. In testis and brain, these isozymes at identical pI values showed variable functions with a battery of substrates and the cationic isozymes of brain and testis showed identical properties in CHP (cumene hydroperoxide) at pH values of above 7.0. Substrate specificity studies and immunoblot analysis of testis and brain proteins revealed that they play a predominant role in the detoxication of phenobarbitol or β-methylcholanthrene. Expression of the isozymes in testis and brain on exposure to PB and MC indicated elevated subunit variation. In both testis and brain, Yδ of π class was expressed on PB treatment and Yc of α class and Yβ of μ class was expressed in MC treated testis and only Yc was predominantly expressed in MC treated brain. Thus these subunits expression is considered as markers for carcinogenesis and specific to chemical toxicity under phenobarbitol and β-methylcholanthrene stress.

关键词： Glutathione transferases Testis Brain Phenobarbitol β-Methylcholanthrene

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An Integrated Bipolar Picture Fuzzy Decision Driven System to Scrutinize Food Waste Treatment Technology through Assorted Factor Analysis

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2665-2687页

作者： Navaneethakrishnan Suganthi Keerthana Devi Samayan Narayanamoorthy Thirumalai Nallasivan Parthasarathy Chakkarapani Sumathi Thilagasree Dragan Pamucar Vladimir Simic Hasan Dinçer Serhat Yüksel department of Mathematics Bharathiar UniversityCoimbatore641046India department of Mathematics Sri Ramakrishna Mission Vidyalaya College of Arts and ScienceCoimbatore641020India department of Operations Research and Statistics Faculty of Organizational SciencesUniversity of BelgradeBelgrade11000Serbia college of Engineering Department of Industrial Engineering and ManagementYuan Ze UniversityTaoyuan City320315TaiwanChina Faculty of Transport and Traffic Engineering University of BelgradeVojvode Stepe 305Belgrade11000Serbia department of Computer Science and Engineering College of InformaticsKorea UniversitySeoul02841Republic of Korea School of Business Istanbul Medipol UniversityIstanbul34083Turkey department of Economics and Management Khazar UniversityBakuAzerbaijan

Food Waste(FW)is a pressing environmental concern that affects every country *** one-third of the food that is produced ends up as waste,contributing to the carbon ***,the FW must be properly treated to reduce environmental *** study evaluates a few available Food Waste Treatment(FWT)technologies,such as anaerobic digestion,composting,landfill,and incineration,which are widely used.A Bipolar Picture Fuzzy Set(BPFS)is proposed to deal with the ambiguity and uncertainty that arise when converting a real-world problem to a mathematical model.A novel Criteria Importance Through Intercriteria Correlation-Stable Preference Ordering Towards Ideal Solution(CRITIC-SPOTIS)approach is developed to objectively analyze FWT selection based on thirteen criteria covering the industry’s technical,environmental,and entrepreneurial *** CRITIC method is used for the objective analysis of the importance of each criterion in FWT *** SPOTIS method is adopted to rank the alternative hassle-free,following the *** proposed model offers a rank reversal-free model,i.e.,the rank of the alternatives remains unaffected even after the addition or removal of an *** addition,comparative and sensitivity analyses are performed to ensure the reliability and robustness of the proposed model and to validate the proposed result.

关键词： Fuzzy food waste treatment selection bipolar picture fuzzy set and decision-making

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Magnesium oxide(MgO)nanoadsorbents in wastewater treatment:A comprehensive review

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Journal of Magnesium and Alloys 2024年第5期12卷 1709-1773页

作者： H.C.S.Perera V.Gurunanthanan Anoop Singh M.M.M.G.P.G.Mantilaka G.Das Sandeep Arya department of Physics Khalifa UniversityAbu Dhabi12788United Arab Emirates Postgraduate Institute of Science University of PeradeniyaPeradeniyaSri Lanka department of Humanities and Sciences Guru Nanak Institutions Technical CampusIbrahimpatnamHyderabad501506India Centre for Global Health Research Saveetha Medical College and HospitalsSaveetha Institute of Medical and Technical SciencesChennai602105Tamil NaduIndia department of Physics University of JammuJammu and Kashmir180006India

Wastewater contamination by heavy metals and synthetic dyes presents a significant environmental challenge,necessitating effective and sustainable separation *** review article provides a detailed examination of magnesium oxide(MgO)nanoparticles as an innovative nanoadsorbent for wastewater treatment,with a specific focus on heavy metal and dye *** review comprehensively explores various aspects of MgO nanoparticles,including their structural characteristics and synthesis *** article delves into the morphology and crystallographic arrangement of MgO nanoparticles,offering insights into their structural *** the complexity of adsorption processes,the review identifies and analyzes parameters influencing the adsorption efficiency of MgO nanoparticles,such as temperature,pH,contact time,initial concentration,and co-existing *** interplay between these parameters and the adsorption capability of MgO nanoparticles emphasizes the importance of optimizing operational ***,the review assesses various synthesis methods for MgO nanoparticles,including sol-gel,hydrothermal,precipitation,green synthesis,solvothermal,and template-assisted *** discusses the advantages,limitations,and resulting nanoparticle characteristics of each method,enabling readers to grasp the implications of synthesis processes on adsorption *** comprehensive review consolidates current insights into the effectiveness of MgO nanoparticles as a potent nanoadsorbent for removing heavy metals and dyes from wastewater covering a wide spectrum of aspects related to MgO ***,there is a need to investigate the use of MgO in the treatment of actual wastewater or river water,in order to leverage its cost-effectiveness and high efficiency for practical water treatment applications in real-time.

关键词： MgO nanoparticles Nanoadsorbent Wastewater treatment Heavy metals Dye separation Adsorption Synthesis methods

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Vibrational Spectroscopic Study of N-[4-[1-Hydroxy-2-[(1-Methyl Ethyl)Amino]Ethyl]Phenyl]Methane Sulfonamide

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光谱学与光谱分析 2016年第3期36卷 880-886页

作者： N.Balamurugan S.Sampathkrishnan C.Charanya department of Physics Sri Lakshmi Ammaal Engineering College department of Physics Sri Venkateswara College of Engineering Research Scholar Department of PhysicsSri Venkateshwara College of Engineering

The vibrational spectral analysis was carried out by using FT-Raman and FT-IR spectroscopy in the range 4 000~400and 4 000~400cm-1 respectively,for N-[4-[1-hydroxy-2-[(1-methyl ethyl)amino]ethyl]phenyl]methane sulfonamide(HPAEPMS)*** calculations were performed by ab initio Density Functional Theory(DFT)method using 6-31G(d,p)basis *** complete vibrational assignments of wavenumbers were made on the basis of potential energy distribution(PED).The results of the calculations were applied to simulated spectra of the title compound,which show excellent agreement.

关键词： FT-IR FT-Raman DFT Vibrational analysis

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