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Pharmacological action of quercetin against testicular dysfunction:A mini review

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Journal of Integrative Medicine 2022年第5期20卷 396-401页

作者： Damilare E.Rotimi Tomilola D.Olaolu Oluyomi S.Adeyemi SDG 03 Group–Good Health&Well-being Landmark UniversityOmu-Aran 251101Kwara StateNigeria department of biochemistry Medicinal BiochemistryNanomedicine&Toxicology LaboratoryLandmark UniversityOmu-Aran 251101Kwara StateNigeria

The testis is an immune-privileged organ susceptible to oxidative stress and inflammation,two major factors implicated in male infertility.A reduction in the concentration and activities of testicular function biomarkers has been shown to correlate with impaired hypothalamic-pituitary-testicular axis and oxidative ***,the use of natural products to ameliorate these oxidative stress-induced changes may be essential to improving male reproductive *** possesses several pharmacological activities that may help to combat cellular reproduction-related assaults,such as altered sperm function and reproductive hormone dysfunction,and dysregulated testicular apoptosis,oxidative stress,and *** have shown that quercetin ameliorates testicular toxicity,largely by inhibiting the generation of reactive oxygen species,with the aid of the two antioxidant pharmacophores present in its ring *** radical-scavenging property of quercetin may alter signal transduction of oxidative stress-induced apoptosis,prevent inflammation,and increase sperm quality in relation to the hormonal *** this review,the therapeutic potential of quercetin in mediating male reproductive health is discussed.

关键词： Antioxidants Apoptosis Oxidative stress Quercetin Sperm Testicular function

The challenge of molecular selection in liver-limited metastatic colorectal cancer for surgical resection: a systematic review and meta-analysis in the context of current and future approaches

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Oncology Research 2024年第9期32卷 1407-1422页

作者： ROSSANA RONCATO JERRY POLESEL FEDERICA TOSI ELENA PERUZZI ERIKA BRUGUGNOLI CLAUDIA LAURIA PANTANO MARIA FURFARO FILIPPO DI GIROLAMO ALESSANDRO NANI ARIANNA PANI NOEMI MILAN ELENA DE MATTIA ANDREA SARTORE-BIANCHI ERIKA CECCHIN Experimental and Clinical Pharmacology Unit Centro di Riferimento Oncologico di Aviano(CRO)IRCCSAviano33081Italy department of Medicine(DMED) University of UdineUdine33100Italy Unit of Cancer Epidemiology Centro di Riferimento Oncologico di Aviano(CRO)IRCCSAviano33081Italy department of Oncology and Hemato-Oncology Universitàdegli Studi di MilanoMilan20122Italy department of Hematology Oncologyand Molecular MedicineGrande Ospedale Metropolitano NiguardaMilan20122Italy Oncology Pharmacy Unit IRCCS Istituto Romagnolo per lo Studio dei Tumori Dino AmadoriMeldola47014Italy Pharmacy Unit Fondazione IRCCS Istituto Tumori di MilanoMilan20122Italy department of Pharmacy Ca’Foncello Treviso Regional HospitalPiazzale Ospedale 1Treviso31100Italy department of Medical Surgical and Health Sciences University of TriesteTrieste34127Italy Hospital Pharmacy Cattinara HospitalAzienda Sanitaria Universitaria Giuliano IsontinaTrieste34148Italy department of Oncology and Onco-Hematology Postgraduate School of Clinical Pharmacology and ToxicologyUniversity of MilanMilan20122Italy

Objectives:Treatment of metastatic colorectal cancer(mCRC)includes resection of liver metastases(LM),however,no validated biomarker identifies patients most likely to benefit from this *** meta-analysis aimed to assess the impact of the most relevant molecular alterations in cancer-related genes of CRC(i.e.,RAS,BRAF,SMAD4,PIK3CA)as prognostic markers of survival and disease recurrence in patients with mCRC surgically treated by LM ***:A systematic literature review was performed to identify studies reporting data regarding survival and/or recurrence in patients that underwent complete liver resection for CRC LM,stratified according to RAS,BRAF,PIK3CA,and SMAD4 mutational *** ratios(HRs)from multivariate analyses were pooled in the meta-analysis and various adjustment strategies for confounding factors were *** search was conducted in numerous databases,including MEDLINE(PubMed),Embase,Cumulative Index to Nursing and Allied Health Literature(CINAHL)(EBSCO host),and WHO Global Index Medicus,through March 18th,***-analyses,editorials,letters to the editor,case reports,studies on other primary cancers,studies with primary metastatic sites other than the liver,studies lacking specific oncological outcome variables or genetic data,non-English language studies,and studies omitting residual disease data from liver metastasectomy were *** remaining 47 studies were summarized in a descriptive table which outlines the key characteristics of each study and final results were graphically ***:RAS mutation status was negatively associated with overall survival(OS)(HR,1.68;95%CI,1.54–1.84)and recurrence free survival(RFS)(HR,1.46;95%CI,1.33–1.61).A negative association was also found for BRAF regarding OS(HR,2.64;95%CI,2.15–3.24)and RFS(HR,1.89;95%CI,1.32–2.73)and SMAD4 regarding OS(HR,1.93;95%CI,1.56–2.38)and RFS(HR,1.95;95%CI,1.31–2.91).For PIK3CA only three studies were eligible and no significant associati

关键词： Metastasectomy Liver metastases RAS BRAF SMAD4 PIK3CA Colorectal

Knowledge, Attitudes and Practices Relating to HIV among Motorbike Taxi Drivers in Parakou, Benin, in 2021

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Open Journal of Epidemiology 2024年第2期14卷 260-272页

作者： Luc Béhanzin Anicette Yénoukounmè Mahoutin Akodjetin Yessito Corine Nadège Houéhanou-Sonou Virginie Mongbo Phinées Adégbola Menakpo Ferdinand Adounkpè Maurice Togbédji Agonnoudé David Houéto Thierry Adoukonou School of Public Health and Epidemiology University of Parakou (ENATSE) Parakou Benin department of Health Systems and Policies Regional Institute of Public Health Alfred Comlan QUENUM (IRSP) of Ouidah University of Abomey Calavi Abomey Calavi Benin National Laboratory of Narcotics and toxicology (LNST) Beninese Center for Scientific Research and Innovation (CBRST) University of Abomey-Calavi Abomey Calavi Benin

Background and Objective: HIV infection is a major global Public Health threat worldwide, particularly in Sub-Saharan Africa of which Benin. The level of knowledge determines the attitudes and behaviors of the populations towards this infection. The study objective was to assess knowledge, attitudes and practices related to HIV infection among motorbike taxi drivers (MTD) in Parakou in 2021. Methods: This was a descriptive cross-sectional study targeting MTD in Parakou in 2021. Participants were selected by cluster sampling. Pretested Digitized questionnaire using KoboCollect@ applicationserved as a data collection tool. Knowledge, attitudes and practices variable were treated on a score scale. A knowledge score was considered to reflect a good knowledge of HIV if at least two-thirds of the knowledge statements had been correctly answered provided the subject recognized the sexual route as one of modes of HIV transmission, identified at least one preventive measure and meant the incurability of the disease. Quantitative and qualitative variables were appropriately described using the EPI Info 7.***.3.3 software. The participant was classified at positive attitude/practice for HIV prevention, when it has a score of at least 80% and suggests a good preventive measure face a risk of exposure to HIV. Results: A total of 374 subjects were recruited into the study. The mean age was 31.51 ± 7.76 years. Most participants (86.06%) had good knowledge of condom use as an HIV prevention method. The sources of information mentioned were mainly the media (77.07%), relatives or friends (63.38%), and field-workers from non-governmental organizations (37.26%). Routine HIV testing was 50.53%. Among participants, 76.10% reported at least two different sexual partners. Condom use was 59.18 % during the casual sexual intercourse. Within the client-provider relationship with female sex workers, 33.17% had had sexual intercourse with them. The sexual route was the most cited (92.

关键词： Knowledge Practice HIV Motorbike Taxi Drivers Benin

COVID-19 and hepatic injury: cellular and molecular mechanisms in diverse liver cells

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World Journal of Gastroenterology 2023年第3期29卷 425-449页

作者： Fares E M Ali Mostafa K Abd El-Aziz Mahmoud M Ali Osama M Ghogar Adel G Bakr department of Pharmacology and toxicology Faculty of PharmacyAl-Azhar UniversityAssiut 71524Egypt department of Pharmacology Al-Azhar UniversityAssiut 71524Egypt department of biochemistry Faculty of Pharmacy Badr University in AssiutEgypt

The coronavirus disease 2019(COVID-19)represents a global health and economic *** injuries have been approved to be associated with severe acute respiratory syndrome coronavirus(SARS-CoV-2)*** viral tropism pattern of SARS-CoV-2 can induce hepatic injuries either by itself or by worsening the conditions of patients with hepatic ***,other factors have been reported to play a crucial role in the pathological forms of hepatic injuries induced by SARS-CoV-2,including cytokine storm,hypoxia,endothelial cells,and even some treatments for *** the other hand,several groups of people could be at risk of hepatic COVID-19 complications,such as pregnant women and *** present review outlines and discusses the interplay between SARS-CoV-2 infection and hepatic injury,hepatic illness comorbidity,and risk ***,it is focused on the vaccination process and the role of developed vac-cines in preventing hepatic injuries due to SARS-CoV-2 infection.

关键词： COVID-19 Hepatic injury Viral tropism COVID-19 comorbidity Vaccination

In-vitro antioxidant and anti-inflammatory activities of ethanol stem-bark extract of Blighia sapida ***

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Journal of Pharmaceutical Analysis 2022年第2期12卷 350-354页

作者： Mukaila B.Adekola Jacob O.Areola Oladapo F.Fagbohun Funke T.Asaolu Gbenga E.Ogundepo Adeniyi O.Fajobi Olubunmi O.Babalola department of Environmental Management and toxicology Federal University of AgricultureAbeokuta110001Nigeria department of Medical biochemistry Obafemi Awolowo UniversityIle-Ife230001Nigeria department of Biomedical Engineering First Technical University IbadanOyo StateIbadan200001Nigeria department of biochemistry and Molecular Biology Obafemi Awolowo UniversityIle-Ife230001Nigeria

Blighia sapida(***)***(Family Sapindaceae)is a branchless straight bole approximately 15 m in *** study evaluated the antioxidant and anti-inflammatory activities of ethanol extract and fractions of *** stem-bark using in vitro *** extract and its fractions were investigated for 1,1-diphenyl-2-picrylhydrazyl(DPPH)radical scavenging activity,ferric reducing antioxidant power(FRAP),total antioxidant capacity(TAC),and quantitative phenolic and flavonoid ***-inflammatory activity was evaluated using albumin denaturation and membrane stabilization *** extract and its fractions exhibited radical scavenging and anti-inflammatory *** ethyl acetate fraction possessed maximum phenolic and flavonoid contents(136.67±1.55 gallic acid equivalent mg/g and 75.76±4.03 quercetin equivalent mg/g,respectively).Antioxidant studies revealed that the ethyl acetate fraction displayed superior activity with an IC_(50)=0.09±0.03 mg/mL DPPH,and values of 146.96±3.81 ascorbic acid equivalent(AAE)mg/g and 359.20±4.98 AAE mg/g for FRAP and TAC,***,the anti-inflammatory activity was revealed by inhibition of heatinduced albumin denaturation and red blood cell membrane stabilization at concentrations of 200 -1000 mg/mL and 50-250 mg/mL,*** ethanol extract and fractions exhibited antioxidant and anti-inflammatory activities,with ethyl acetate fraction showing superior activity,which could be attributed to secondary metabolites,mainly phenolic ***,the antioxidant and antiinflammatory activities of *** can be exploited by ethnomedicinal users.

关键词： Blighia sapida Extract Anti-inflammatory Antioxidant Radical scavenging

Elucidating regulatory processes of intense physical activity by multi-omics analysis

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Military Medical Research 2024年第4期11卷 479-499页

作者： Ernesto S.Nakayasu Marina A.Gritsenko Young-Mo Kim Jennifer E.Kyle Kelly G.Stratton Carrie D.Nicora Nathalie Munoz Kathleen M.Navarro Daniel Claborne Yuqian Gao Karl K.Weitz Vanessa L.Paurus Kent J.Bloodsworth Kelsey A.Allen Lisa M.Bramer Fernando Montes Kathleen A.Clark Grant Tietje Justin Teeguarden Kristin E.Burnum-Johnson Biological Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Environmental and Molecular Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthWestern States DivisionDenverCO 80204USA Computational Analytics Division Pacific Northwest National LaboratoryRichlandWA 99352USA National Security Directorate Pacific Northwest National LaboratoryRichlandWA 99352USA Los Angeles County Fire department Los AngelesCA 90063USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthRespiratory Health DivisionMorgantownWV 26505USA Environmental and Molecular toxicology Oregon State UniversityCorvallisOR 97331USA

Background:Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations,such as firefighting,law enforcement,military,and sports.A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work ***:To study regulatory processes in intense physical activity simulating real-life conditions,we performed a multi-omics analysis of 3 biofluids(blood plasma,urine,and saliva)collected from 11 wildland firefighters before and after a 45 min,intense exercise *** profiles ***-exercise were compared by Student’s t-test followed by pathway analysis and comparison between the different omics ***:Our multi-omics analysis identified and quantified 3835 proteins,730 lipids and 182 metabolites combining the 3 different types of *** blood plasma analysis revealed signatures of tissue damage and acute repair response accompanied by enhanced carbon metabolism to meet energy *** urine analysis showed a strong,concomitant regulation of 6 out of 8 identified proteins from the renin-angiotensin system supporting increased excretion of catabolites,reabsorption of nutrients and maintenance of fluid *** saliva,we observed a decrease in 3 pro-inflammatory cytokines and an increase in 8 antimicrobial peptides.A systematic literature review identified 6 papers that support an altered susceptibility to respiratory ***:This study shows simultaneous regulatory signatures in biofluids indicative of homeostatic maintenance during intense physical activity with possible effects on increased infection susceptibility,suggesting that caution against respiratory diseases could benefit workers on highly physical demanding jobs.

关键词： Multi-omics analysis Intense exercise Human performance Biofluids Metabolism Immunity

Histopathological,histochemical and biochemical postmortem changes in induced fatal hypothermia in rats

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Forensic Sciences Research 2022年第2期7卷 211-227页

作者： Mahrous Abdelbasset Ibrahim Sally Salem Mohammed Hany Goda Tammam Rehab Ibrahim Abdel-Karim Medhat Mohammed Farag Forensic Medicine&Clinical toxicology College of MedicineJouf UniversitySakakahSaudi Arabia Forensic Medicine&Clinical toxicology department Faculty of MedicineSuez Canal UniversityIsmailiaEgypt Histology and Cell Biology department Faculty of MedicineSuez Canal UniversityIsmailiaEgypt Forensic Medicine and Clinical toxicology department Faculty of MedicineAl-Azhar UniversityCairoEgypt Medical biochemistry department College of MedicineShaqra UniversityShaqraaSaudi Arabia Medical biochemistry&Molecular Biology department Faculty of MedicineBenha UniversityBenhaEgypt

Reaching a postmortem diagnosis of hypothermia is challenging in forensic ***,this study was conducted to detect the histopathological,histochemical and biochemical changes that occur in adult albino rats following exposure to induced fatal ***-four adult albino rats were divided into the negative control,moderate hypothermia,severe hypothermia and hypoxia *** in the control group were euthanized when those in the moderate hypothermic group *** samples were collected via heart puncture,and the cerebrum,heart,suprarenal gland,kidney,liver and skeletal muscle were removed to investigate the biochemical,histochemical and histopathological *** assessment depicted significant changes in lipid peroxidation,represented by increased malondialdehyde levels in the studied organs of the rats in hypothermic and hypoxia *** examination of the rats’organs revealed degeneration and necrosis in the hypothermia and hypoxia *** taken from the severe hypothermic rats revealed a loss of normal cardiac tissue architecture,necrotic changes in the pyramidal cells in the cerebral cortex,and massive necrosis,mainly in the tubules of the renal cortex and *** findings suggest that histological changes might be used as biochemical markers for postmortem diagnosing of fatal hypothermia,particularly in severe hypothermic conditions.

关键词： Forensic sciences forensic medicine legal medicine autopsy forensic pathology histochemical hypothermia

Building bioorthogonal click-release capable artificial receptors on cancer cell surface for imaging,drug targeting and delivery

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药学学报:英文版 2023年第6期13卷 2736-2746页

作者： Jing Chen Peng Ji Giri Gnawali Mengyang Chang Feng Gao Hang Xu Wei Wang department of Pharmacology and toxicology University of ArizonaTucsonAZ 85721USA department of Chemistry and biochemistry University of ArizonaTucsonAZ 85721USA BIO5 Institute and University of Arizona Cancer CenterUniversity of ArizonaTucsonAZ 85721USA

The current targeting drug delivery mainly relies on cancer cell surface ***,in many cases,binding affinities between protein receptors and homing ligands is relatively low and the expression level between cancer and normal cells is not *** from conventional targeting strategies,we have developed a general cancer targeting platform by building artificial receptor on cancer cell surface via a chemical remodeling of cell surface glycans.A new tetrazine(Tz)functionalized chemical receptor has been designed and efficiently installed on cancer cell surface as“overexpressed”biomarker through a metabolic glycan *** from the reported bioconjugation for drug targeting,the tetrazine labeled cancer cells not only locally activate TCO-caged prodrugs but also release active drugs via the unique bioorthogonal Tz-TCO click-release *** studies have demonstrated that the new drug targeting strategy enables local activation of prodrug,which ultimately leads to effective and safe cancer therapy.

关键词： Artificial receptor Click and release Local activation Protein degradation

Impact of alpha-synuclein pathology on adult neurogenesis: evidence for multilayered mechanisms

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Neural Regeneration Research 2022年第7期17卷 1491-1492页

作者： Jana Bonsberger Franziska Richter Milos Stanojlovic department of Pharmacology Toxicology and PharmacyUniversity of Veterinary MedicineHannoverGermany

Parkinson’s disease(PD)is the second most common neurodegenerative disease affecting 8–10 million people ***,PD is the fastest-growing neurodegenerative disease and it is predicted that the number of patients will double in the next thirty ***,PD is characterized by the presence of protein aggregations called Lewy bodies(LB)and by degeneration of dopaminergic neurons in the substantia nigra pars compacta.

关键词： degeneration pathology Impact