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Evaluation of erastin synergized cisplatin anti-nasopharyngeal carcinoma effect with a glutathione-activated near-infrared fluorescent probe

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Chinese Chemical Letters 2024年第2期35卷 311-316页

作者： Rong He Dandan Tang Ningge Xu Heng Liu Kun Dou Xuejun Zhou Fabiao Yu department of Otolaryngology Head and Neck SurgeryThe First Affiliated Hospital of Hainan Medical UniversityHaikou 570102China Key Laboratory of Hainan Trauma and Disaster Rescue Key Laboratory of Emergency and TraumaMinistry of EducationEngineering Research Center for Hainan Bio-Smart Materials and Bio-Medical DevicesCollege of Emergency and TraumaHainan Medical UniversityHaikou 571199China Sichuan Provincial General Hospital of Judicial Police Chengdu 610225China

Nasopharyngeal carcinoma(NPC),a malignant tumor originating from the nasopharynx,is one of the common malignant tumors of the head and *** are significant geographical differences in the incidence of nasopharyngeal carcinoma,with a high incidence in China and Southeast Asian ***,we designed and synthesized a novel near-infrared fluorescent(NIRF)probe to detect glutathione(GSH)in cellular and tumor environments using semi-naphthofluorescein(SNAFL)as the fluorescent molecular backbone and 2-fluoro-4-nitrobenzenesulfonate as the recognition *** reaction with GSH,SNAFL-GSH emitted a fluorescence signal,and its emission wavelength at 650 nm was remarkably *** results of selectivity experiments indicated that SNAFL-GSH was able to discriminate GSH from Cys,Hcy,and H_(2) ***,SNAFL-GSH could image both endogenous and exogenous GSH and distinguish normal and cancer cells by fluorescence signal *** the cellular level,cisplatin(DDP)-induced ferroptosis and inhibition of proliferation of various NPC cell lines(CNE2,CNE1,5-8F cells)by erastin combined with DDP were visualized with the help of *** a mouse tumor xenograft model,we successfully employed SNAFL-GSH for the evaluation of the efficacy of erastin combined with DDP in the treatment of *** importantly,the probe could image cancerous tissue sections from NPC patients with an imaging depth of approximately 80µ*** was foreseen that SNAFL-GSH offered great potential for application in the diagnosis and evaluation of the therapeutic efficacy of NPC,and these results would also provide new ideas for the clinical treatment of NPC.

关键词： Glutathione NIRF probe Ferroptosis Anti-tumor therapy evaluation bioimaging

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Constructing a biofunctionalized 3D-printed gelatin/sodium alginate/chitosan tri-polymer complex scaffold with improvised biological andmechanical properties for bone-tissue engineering

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bio-Design and Manufacturing 2024年第1期7卷 57-73页

作者： Amit Kumar Singh Krishna Pramanik Amit Biswas Centre of Excellence in Tissue engineering Department of Biotechnology and Medical EngineeringNational Institute of TechnologyRourkela 769008India

Sodium alginate(SA)/chitosan(CH)polyelectrolyte scaffold is a suitable substrate for tissue-engineering *** present study deals with further improvement in the tensile strength and biological properties of this type of scaffold to make it a potential template for bone-tissue *** experimented with adding 0%–15%(volume fraction)gelatin(GE),a protein-based biopolymer known to promote cell adhesion,proliferation,and *** resulting tri-polymer complex was used as bioink to fabricate SA/CH/GEmatrices by three-dimensional(3D)*** studies using scanning electron microscopy revealed the microfibrous porous architecture of all the structures,which had a pore size range of 383–419μm.X-ray diffraction and Fourier-transform infrared spectroscopy analyses revealed the amorphous nature of the scaffold and the strong electrostatic interactions among the functional groups of the polymers,thereby forming polyelectrolyte complexes which were found to improve mechanical properties and structural *** scaffolds exhibited a desirable degradation rate,controlled swelling,and hydrophilic characteristics which are favorable for bone-tissue *** tensile strength improved from(386±15)to(693±15)kPa due to the increased stiffness of SA/CH scaffolds upon addition of *** enhanced protein adsorption and in vitro bioactivity(forming an apatite layer)confirmed the ability of the SA/CH/GE scaffold to offer higher cellular adhesion and a bone-like environment to cells during the process of tissue *** vitro biological evaluation including the MTT assay,confocal microscopy analysis,and alizarin red S assay showed a significant increase in cell attachment,cell viability,and cell proliferation,which further improved biomineralization over the scaffold *** addition,SA/CH containing 15%gelatin designated as SA/CH/GE15 showed superior performance to the other fabricated 3D structures,demonstrating its pote

关键词： Scaffold biomaterial Sodium alginate Chitosan Gelatin 3D printing Tissue engineering

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Enhancement of Solar PV Panel Efficiency Using Double Integral Sliding Mode MPPT Control

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Tsinghua Science and Technology 2024年第1期29卷 271-283页

作者： Immadisetty Rahul Raju Hariharan department of Electrical and Electronics engineering Saveetha School of EngineeringSaveetha Institute of Medical and Technical Sciences(SIMATS)Chennai 602105India

The extraction of maximum power from the solar panels,using the sliding mode control scheme,becomes popular for partial weather atmospheric conditions due to its effective dynamic duty cycle ***,the sliding mode control scheme was sophisticated with single integral and double integral sliding mode control scheme,which offer enhanced maximum power extraction and support enhanced solar panel efficiency in partial weather *** operation of the sliding mode control scheme depends on the selection of a sliding surface selection based on the atmospheric weather condition,which enables the effective sliding duty cycle ratio operation for the DC/DC boost *** duty cycle ratio of the sliding mode control resembles the usual dynamic behavior to achieve enhanced efficiency compared to the various maximum power point tracking(MPPT)*** major limitation of the sliding mode control scheme is to achieve the steady state voltage error of the solar panel in minimum settling time *** single integral sliding mode control scheme achieves the expected steady state voltage error limit but fails to achieve minimum settling time ***,the single integral sliding mode control is extended to a double integral sliding mode control scheme to achieve both steady state voltage error limits within the minimum settling time *** double integral sliding mode control scheme allows us to obtain the higher sliding surface duty cycle ratio which acts as the input signal to the boost *** activates the enhanced stable and reliable system operation,and nullifies the lacuna of maximum solar panel efficiency under partial weather ***,this paper aims to present the design and performance operation of the double integral sliding mode(DISM)MPPT control *** validate the performance analysis of the proposed DISM MPPT control scheme,the MATLAB/Simulink model is designed and ***,the performance analysis of the pr

关键词： maximum power point tracking(MPPT)schemes sliding mode controller(SMC) double integral sliding mode controller(DISMC) pulse width modulation(PWM) photovoltaic(PV)system

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The secondary injury cascade after spinal cord injury: an analysis of local cytokine/chemokine regulation

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Neural Regeneration Research 2024年第6期19卷 1308-1317页

作者： Daniel J.Hellenbrand Charles M.Quinn Zachariah J.Piper Ryan T.Elder Raveena R.Mishra Taylor L.Marti Phoebe M.Omuro Rylie M.Roddick Jae Sung Lee William L.Murphy Amgad S.Hanna department of Neurosurgery University of Wisconsin-Madison School of Medicine and Public Health department of biomedical engineering University of Wisconsin-Madison department of Orthopedics and Rehabilitation University of Wisconsin-Madison department of Materials Science and engineering University of Wisconsin-Madison Forward bio Institute University of Wisconsin-Madison

After spinal cord injury, there is an extensive infiltration of immune cells, which exacerbates the injury and leads to further neural degeneration. Therefore, a major aim of current research involves targeting the immune response as a treatment for spinal cord injury. Although much research has been performed analyzing the complex inflammatory process following spinal cord injury, there remain major discrepancies within previous literature regarding the timeline of local cytokine regulation. The objectives of this study were to establish an overview of the timeline of cytokine regulation for 2 weeks after spinal cord injury, identify sexual dimorphisms in terms of cytokine levels, and determine local cytokines that significantly change based on the severity of spinal cord injury. Rats were inflicted with either a mild contusion, moderate contusion, severe contusion, or complete transection, 7 mm of spinal cord centered on the injury was harvested at varying times post-injury, and tissue homogenates were analyzed with a Cytokine/Chemokine 27-Plex assay. Results demonstrated pro-inflammatory cytokines including tumor necrosis factor α, interleukin-1β, and interleukin-6 were all upregulated after spinal cord injury, but returned to uninjured levels within approximately 24 hours post-injury, while chemokines including monocyte chemoattractant protein-1 remained upregulated for days post-injury. In contrast, several anti-inflammatory cytokines and growth factors including interleukin-10 and vascular endothelial growth factor were downregulated by 7 days post-injury. After spinal cord injury, tissue inhibitor of metalloproteinase-1, which specifically affects astrocytes involved in glial scar development, increased more than all other cytokines tested, reaching 26.9-fold higher than uninjured rats. After a mild injury, 11 cytokines demonstrated sexual dimorphisms; however, after a severe contusion only leptin levels were different between female and male rats. In conclus

关键词： astrocytes chemokines cytokines inflammation macrophages microglia secondary damage spinal cord injury

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Therapeutic strategies of targeting nonapoptotic regulated cell death (RCD) with smallmolecule compounds in cancer

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2815-2853页

作者： Xin Jin Wenke Jin Linlin Tong Jia Zhao Lan Zhang Na Lin department of Ultrasound Department of Medical Oncology and Department of Hematologythe First Hospital of China Medical UniversityChina Medical UniversityShenyang 110001China Sichuan engineering Research Center for biomimetic Synthesis of Natural Drugs School of Life Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China

Regulated cell death(RCD)is a controlled form of cell death orchestrated by one or more cascading signaling pathways,making it amenable to pharmacological *** subroutines can be categorized as apoptotic or non-apoptotic and play essential roles in maintaining homeostasis,facilitating development,and modulating *** evidence has recently revealed that RCD evasion is frequently the primary cause of tumor *** non-apoptotic RCD subroutines have garnered attention as promising cancer therapies due to their ability to induce tumor regression and prevent relapse,comparable to ***,they offer potential solutions for overcoming the acquired resistance of tumors toward apoptotic *** an increasing understanding of the underlying mechanisms governing these non-apoptotic RCD subroutines,a growing number of small-molecule compounds targeting single or multiple pathways have been discovered,providing novel strategies for current cancer *** this review,we comprehensively summarized the current regulatory mechanisms of the emerging non-apoptotic RCD subroutines,mainly including autophagy-dependent cell death,ferroptosis,cuproptosis,disulfidptosis,necroptosis,pyroptosis,alkaliptosis,oxeiptosis,parthanatos,mitochondrial permeability transition(MPT)-driven necrosis,entotic cell death,NETotic cell death,lysosome-dependent cell death,and immunogenic cell death(ICD).Furthermore,we focused on discussing the pharmacological regulatory mechanisms of related small-molecule *** brief,these insightful findings may provide valuable guidance for investigating individual or collaborative targeting approaches towards different RCD subroutines,ultimately driving the discovery of novel small-molecule compounds that target RCD and significantly enhance future cancer therapeutics.

关键词： Regulated cell death(RCD) Non-apoptotic RCD subroutine Autophagy Ferroptosis Necroptosis Regulatory mechanism Small-molecule compound Cancer therapy

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Performance and Emission Characteristics of a CRDI Diesel Engine Fuelled by SiO_(2) Nanoparticle-Waste Fat biodiesel Blends

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China Petroleum Processing & Petrochemical Technology 2024年第1期26卷 56-66页

作者： Babu Aurtherson P Dinesh Babu Munuswamy Ravikumar Jayabal Yuvarajan Devarajan department of Mechanical engineering Mahat Amma Institute of Engineering and TechnologyPudukkottaiTamil NaduIndia department of Mechanical engineering Rajalakshmi Institute of TechnologyChennaiTamil NaduIndia department of Thermal engineering Saveetha School of EngineeringSaveetha Institute of Medical and Technical SciencesChennaiTamil NaduIndia

This study investigates the use of waste fat biodiesel(WFB)from the leather industry as a substitute for diesel ***,it examines the diesel engine performance of WFB,a blend of WFB and diesel(B50),and different blends of WFB and silicon dioxide(SiO_(2))nanoparticles(B50SiO_(2)40,B50SiO_(2)80,and B50SiO_(2)120μg/g).The results indicate that the B50SiO_(2)120 blend increases brake thermal efficiency by 10.03%compared to pure biodiesel but falls 1.93%short of neat ***,the B50SiO_(2)120 mixture reduces smoke,hydrocarbon,and carbon monoxide emissions by 31.87%,34.14%,and 43.97%respectively,compared to ***,the B50SiO_(2)120 blend shows a 4.91%increase in nitrogen oxide emissions compared to diesel.

关键词： waste fat transesterification biodiesel silicon dioxide emission

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Engineered exosome hybrid copper nanoscale antibiotics facilitate simultaneous self-assembly imaging and elimination of intracellular multidrug-resistant superbugs

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Chinese Chemical Letters 2024年第7期35卷 319-324页

作者： Zengchao Guo Weiwei Liu Tengfei Liu Jinpeng Wang Hui Jiang Xiaohui Liu Yossi Weizmann Xuemei Wang State Key Laboratory of Digital medical engineering School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China department of Chemistry Ben-Gurion University of the NegevBeer-Sheva 8410501Israel

With the increasing emergence of bacterial infections,especially multidrug-resistant(MDR)bacteria,poses an urgent *** study demonstrated a novel multifunctional nanotheranostics platform developed by the strategic integration of both in-situ bio-assembly imaging and target bacteria *** the introduction of copper ions into bacteria,the Cu^(2+)could spontaneously bio-selfassembled into a multifunctional copper nanoclusters(NCs)which efficiently enhanced epigallocatechin gallate(EGCG)uptake into *** visualizing the bacteria,the developed theranostic nanoplatform exhibited highly efficient disinfection activities with negligible side effects as reflected by higher cell viability and insignificant hemolytic ***,the exosomal formulation of EGCG integrated with Cu^(2+)showed an increased intracellular antibacterial activity,which could eliminate most of the methicillin-resistant Staphylococcus aureus(MRSA)phagocytosed by macrophages,guide macrophages toward M2-like phenotype polarization and alleviate inflammation,without exhibiting obvious cytotoxicity on host *** regimen could be viewed as an effective strategy for the sterilization of intractable bacterial infections.

关键词： In situ self-assembled Exosome Antibacterial agents bioimaging Intracellular infection

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Film Flow of Nano-Micropolar Fluid with Dissipation Effect

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Computer Modeling in engineering & Sciences 2024年第9期140卷 2487-2512页

作者： Abuzar Abid Siddiqui Mustafa Turkyilmazoglu department of Basic Sciences&Humanities Faculty of Engineering&TechnologyBahauddin Zakariya UniversityMultanPakistan department of Mathematics Hacettepe UniversityAnkaraTürkiye department of medical Research China Medical University HospitalChina Medical UniversityTaichungTaiwan

The physical problem of the thin film flow of a micropolar fluid over a dynamic and inclined substrate under the influence of gravitational and thermal forces in the presence of nanoparticles is *** different types of nanoparticle samples are accounted for in this current study,namely gold Au,silver Ag,molybdenum disulfide MoS2,aluminum oxide Al2O3,and silicon dioxide ***,a micropolar fluid,serves as the common base *** exact closed-form solution for this problem is derived for the first time in the *** results are particularly validated against those for the Newtonian fluid and show excellent *** was found that increasing values of the spin boundary condition and micropolarity lead to a reduction in both the thermal and momentum boundary layers.A quantitative decay in the Nusselt number for a micropolar fluid,as compared to a Newtonian one for all the tested nanoparticles,is *** and silver nanoparticles(i)intensify in the flow parameter as the concentration of nanoparticles increases(ii)yield a higher thermal transfer rate,whereas molybdenum disulfide,aluminum oxide,and silicon dioxide exhibit a converse attitude for both Newtonian and micropolar *** reduction in film thickness for fluid comprising gold particles,as compared to the rest of the nanoparticles,is remarkable.

关键词： Thin film flow micropolar fluid nanoparticles molybdenum disulfide inclined substrate

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Falcon Optimization Algorithm-Based Energy Efficient Communication Protocol for Cluster-Based Vehicular Networks

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Computers, Materials & Continua 2024年第3期78卷 4243-4262页

作者： Youseef Alotaibi B.Rajasekar R.Jayalakshmi Surendran Rajendran department of Software engineering College of ComputingUmm Al-Qura UniversityMakkah21955Saudi Arabia department of Electronics and Communication engineering Sathyabama Institute of Science and TechnologyChennai600119India department of Computer Science and engineering Panimalar Engineering CollegeChennai600123India department of Computer Science and engineering Saveetha School of EngineeringSaveetha Institute of Medical and Technical ScienceChennai602105India

Rapid development in Information Technology(IT)has allowed several novel application regions like large outdoor vehicular networks for Vehicle-to-Vehicle(V2V)*** networks give a safe and more effective driving experience by presenting time-sensitive and location-aware *** communication occurs directly between V2V and Base Station(BS)units such as the Road Side Unit(RSU),named as a Vehicle to Infrastructure(V2I).However,the frequent topology alterations in VANETs generate several problems with data transmission as the vehicle velocity differs with ***,the scheme of an effectual routing protocol for reliable and stable communications is *** research demonstrates that clustering is an intelligent method for effectual routing in a mobile ***,this article presents a Falcon Optimization Algorithm-based Energy Efficient Communication Protocol for Cluster-based Routing(FOA-EECPCR)technique in *** FOA-EECPCR technique intends to group the vehicles and determine the shortest route in the *** accomplish this,the FOA-EECPCR technique initially clusters the vehicles using FOA with fitness functions comprising energy,distance,and trust *** the routing process,the Sparrow Search Algorithm(SSA)is derived with a fitness function that encompasses two variables,namely,energy and distance.A series of experiments have been conducted to exhibit the enhanced performance of the FOA-EECPCR *** experimental outcomes demonstrate the enhanced performance of the FOA-EECPCR approach over other current methods.

关键词： Vehicular networks communication protocol clustering falcon optimization algorithm routing

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Multi-omics analysis of adamantinomatous craniopharyngiomas reveals distinct molecular subgroups with prognostic and treatment response significance

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Chinese medical Journal 2024年第7期137卷 859-870页

作者： Xianlong Wang Chuan Zhao Jincheng Lin Hongxing Liu Qiuhong Zeng Huadong Chen Ye Wang Dapeng Xu Wen Chen Moping Xu En Zhang Da Lin Zhixiong Lin department of bioinformatics School of Medical Technology and EngineeringKey Laboratory of Medical BioinformaticsKey Laboratory of Ministry of Education for Gastrointestinal CancerFujian Medical UniversityFuzhouFujian 350122China department of Neurosurgery Sanbo Brain HospitalCapital Medical UniversityBeijing 100093China

Background:Adamantinomatous craniopharyngioma(ACP)is the commonest pediatric sellar *** effective drug is available and interpatient heterogeneity is *** study aimed to identify distinct molecular subgroups of ACP based on the multi-omics profiles,imaging findings,and histological features,in order to predict the response to anti-inflammatory treatment and ***:Totally 142 Chinese cases diagnosed with craniopharyngiomas were profiled,including 119 ACPs and 23 papillary ***-exome sequencing(151 tumors,including recurrent ones),RNA sequencing(84 tumors),and DNA methylome profiling(95 tumors)were *** clustering and non-negative matrix factorization were used for subgrouping,and Cox regression were utilized for prognostic evaluation,***:Three distinct molecular subgroups were identified:WNT,ImA,and *** WNT subgroup showed higher Wnt/β-catenin pathway activity,with a greater number of epithelial cells and more predominantly solid *** ImA and ImB subgroups had activated inflammatory and interferon response pathways,with enhanced immune cell infiltration and more predominantly cystic ***-activated protein kinases(MEK/MAPK)signaling was activated only in ImA samples,while IL-6 and epithelial-mesenchymal transition biomarkers were highly expressed in the ImB group,mostly consisting of *** degree of astrogliosis was significantly elevated in the ImA group,with severe finger-like protrusions at the invasive front of the *** molecular subgrouping was an independent prognostic factor,with the WNT group having longer event-free survival than ImB(Cox,P=0.04).ImA/ImB cases were more likely to respond to immune checkpoint blockade(ICB)therapy than the WNT group(P<0.01).In the preliminary screening of subtyping markers,CD38 was significantly downregulated in WNT compared with ImA and ImB(P=0.01).Conclusions:ACP comprises three molecular subtypes with distinct

关键词： Craniopharyngioma Central nervous system tumor Precision medicine beta Catenin Proto-Oncogene Proteins B-raf

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