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Chinese Medicine Combined with Adjuvant Chemotherapy for Improving Myelosuppression in Colorectal Cancer Patients:A Systematic Review and Network Meta-Analysis

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Chinese Journal of Integrative Medicine 2024年第7期30卷 643-652页

作者： LI Rui ZHANG Tong YAN Shao-hua YAN Yun-zi DING Ya-cong WANG Yan-song YANG Yu-fei department of Oncology China Academy of Chinese Medical SciencesXiyuan HospitalBeijing100091China department of Oncology Dongfang Hospital Beijing University of Chinese MedicineBeijing100078China Graduate School Beijing University of Chinese MedicineBeijing100029China

Objective To assess the effectiveness of Chinese herbal medicine(CHM)combined with adjuvant chemotherapy on myelosuppression for colorectal cancer(CRC)patients using network meta-analysis(NMA).Methods Literature searches in both international(PubMed,Embase,Web of Science,and Cochrane Library)and Chinese(China Science and Technology Journal Database,Wanfang Data,China National Knowledge Infrastructure)databases for relevant randomized controlled trials(RCTs)were conducted from inception until October 10,*** included RCTs of patients who received CHM combined with chemotherapy,including FOLFOX,XELOX,FOLFIRI,and other relevant regimens in the CHM treatment *** outcomes included the incidence of myelosuppression,leukopenia,hemoglobin reduction,and *** reviewers independently screened the databases,extracted the data,and assessed the risk of bias and credibility of *** 5.4.1 software and STATA 14.0 were used to perform the *** A total of 31 RCTs were included,published from 2008 to 2021 in *** these,2,314 participants comparing the following 9 CHMs were identified:Shengbai Recipe(SBR),Bazhen Decoction(BZD),Jianpi Jiedu Recipe(JJR),Jianpi Recipe(JR),Compound Cantharis Capsule(CCC),Zaofan Pill(ZFP),Guilu Erxian Gel(GL),Buzhong Tiaogan Decoction(BZ),and Qiamagu Capsule(QM).The results of NMA found an indirect *** on the surface under the cumulative ranking curve(SUCRA),the ZFP+chemotherapy group had the lowest incidence of myelosuppression,with an odds ratio(OR)of 0.08[95%confidence interval(CI):0.01,0.76],whereas the GL+chemotherapy group had the lowest incidence of leukopenia,hemoglobin reduction,and thrombocytopenia,with an OR of 5.25(95%CI:2.41,11.43),4.66(95%CI:2.23,9.72),and 0.27(95%CI:0.13,0.54),***,BZD+chemotherapy could alleviate leukopenia,hemoglobin reduction,and thrombocytopenia(P<0.01).Pairwise comparison showed that there was no difference in the efficacy among the 8 CHMs+c

关键词： Chinese herbal medicine colorectal cancer network meta-analysis systematic review myelosuppression chemotherapy

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Predicting Acute Mountain Sickness Using Regional Sea-Level Cerebral Blood Flow

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Biomedical and Environmental Sciences 2024年第8期37卷 887-896页

作者： Hao Zhang Jie Feng Shiyu Zhang Wenjia Liu Lin Ma Chinese PLA Medical School Beijing 100853China department of Radiology First Medical CenterChinese PLA General HospitalBeijing 100853China department of Radiology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

Objective To investigate the role of sea-level cerebral blood flow(CBF)in predicting acute mountain sickness(AMS)using three-dimensional pseudo-continuous arterial spin labeling(3D-pCASL).Methods Forty-eight healthy volunteers reached an altitude of 3,650 m by air after undergoing a head magnetic resonance imaging(MRI)including 3D-pCASL at sea *** CBF values of the bilateral anterior cerebral artery(ACA),middle cerebral artery(MCA),posterior cerebral artery(PCA),and posterior inferior cerebellar artery(PICA)territories and the laterality index(LI)of CBF were compared between the AMS and non-AMS *** analyses were performed to determine the relationship between CBF and AMS,and the predictive performance was assessed using receiver operating characteristic(ROC)*** The mean cortical CBF in women(81.65±2.69 mL/100 g/min)was higher than that in men(74.35±2.12 mL/100 g/min)(P<0.05).In men,the cortical CBF values in the bilateral ACA,PCA,PICA,and right MCA were higher in patients with AMS than in those *** CBF in the right PCA best predicted AMS(AUC=0.818).In women,the LI of CBF in the ACA was different between the AMS and non-AMS groups and predicted AMS with an AUC of *** Although the mechanism and prediction of AMS are quite complicated,higher cortical CBF at sea level,especially the CBF of the posterior circulatory system,may be used for prediction in male volunteers using non-invasive 3D-pCASL.

关键词： Acute mountain sickness High-altitude headache Cerebral blood flow Arterial spin labeling Magnetic resonance imaging

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Knockout of C6orf120 in Rats Alleviates Concanavalin A-induced Autoimmune Hepatitis by Regulating Macrophage Polarization

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Biomedical and Environmental Sciences 2024年第6期37卷 594-606页

作者： Xin Wang Yuqi Wang Hui Liu Yingying Lin Peng Wang Yunyun Yi Xin Li department of Center of Integrated Traditional Chinese and Western Medicine Peking University Ditan Teaching HospitalBeijing 100015China department of Center of Integrated Traditional Chinese and Western Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China department of Center of Infectious Disease Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

Objective The effect of the functionally unknown gene C6orf120 on autoimmune hepatitis was investigated on C6orf120 knockout rats(C6orf120^(-/-))and THP-1 *** Six–eight-week-old C6orf120^(-/-)and wild-type(WT)SD rats were injected with Con A(16 mg/kg),and euthanized after 24 *** sera,livers,and spleens were ***-1 cells and the recombinant protein(rC6ORF120)were used to explore the mechanism in *** frequency of M1 and M2 macrophages was analyzed using flow *** blotting and PCR were used to detect macrophage polarization-associated *** C6orf120 knockout attenuated Con A-induced autoimmune *** cytometry indicated that the proportion of CD68^(+)CD86^(+)M1 macrophages from the liver and spleen in the C6orf120^(-/-)rats decreased.C6orf120 knockout induced downregulation of CD86 protein and the mRNA levels of related inflammatory factors TNF-α,IL-1β,and IL-6 in the liver.C6orf120 knockout did not affect the polarization of THP-1 ***,rC6ORF120 promoted the THP-1 cells toward CD68^(+)CD80^(+)M1 macrophages and inhibited the CD68^(+)CD206^(+)M2 *** C6orf120 knockout alleviates Con A-induced autoimmune hepatitis by inhibiting macrophage polarization toward M1 macrophages and reducing the expression of related inflammatory factors in C6orf120^(-/-)rats.

关键词： C6orf120 Autoimmune hepatitis Macrophage polarization M1 macrophages

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Hongjin Xiaojie Capsule, a Chinese patent medicine, for treating moderate to severe cyclical breast pain: A single-blind randomized controlled trial

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Journal of Integrative Medicine 2024年第5期22卷 552-560页

作者： Qiong Zhang Ying-yi Fan Xue-qing Wu Yan-dan Huo Chun-hui Wang Shi-bing Liang Ting Wang Rong Zhong Xuan Wang Bao-yong Lai Xiao-hua Pei Jian-ping Liu Graduate School Beijing University of Chinese Medicine department of Breast Beijing University of Chinese Medicine Third Affiliated Hospital department of Breast Shuguang HospitalShanghai University of Traditional Chinese Medicine department of Breast Sichuan Second Hospital of Traditional Chinese Medicine department of Breast Xiamen HospitalBeijing University of Chinese Medicine Center for Evidence-Based Chinese Medicine Beijing University of Chinese Medicine

Background: Moderate to severe breast pain has major effects on the quality of life for patients. Patent Chinese medicines are widely used in the treatment of breast pain due to their stable dosage form and good ***: To evaluate the beneficial effects and safety of Hongjin Xiaojie Capsule(HJXJC), a Chinese patent medicine, for the treatment of cyclical breast ***, setting, participants and intervention: This is a multicenter, single-blind randomized controlled trial conducted in 3 medical centers in China from 2019 to 2021. Patients with moderate to severe cyclic breast pain were randomly divided into the intervention group(who took HJXJC, four capsules per dose,three times a day for 12 weeks) and the control group(waiting for the treatment) in a 1:1 *** outcome measures: The primary outcome was pain duration, and the patients recorded measurements at baseline and at the end of weeks 4, 8, 12 and 16 on a patient log ***: The full analysis set(FAS) population included 298 participants(intervention group, n = 150;control group, n = 148), while the per-protocol analysis set(PPS) included 274 participants. After12 weeks, the duration of breast pain was significantly shorter in the intervention group(FAS: mean difference, –6.69; 95% CI, –7.58 to –5.80; P < 0.01, vs control. PPS: mean difference, –7.09; 95% CI, –8.01 to –6.16; P < 0.01, vs control). The Short-form McGill Pain Questionnaire(SF-MPQ) scores were significantly lower in the intervention group(FAS: mean difference, –12.55; 95% CI, –13.90 to –11.21; P < 0.01, vs control. PPS: mean difference, –13.07; 95% CI, –14.48 to –11.66; P < 0.01, vs control). The above indicators continued to be significantly different through week 16. Moreover, in the intervention group, breast lumps shrank after 12 weeks and the size of breast lumps was statistically smaller than that in the control group(P < 0.05), whereas the sizes of breast nodules and uterine fibroid showed no statistically sign

关键词： Hongjin Xiaojie Capsule Cyclical breast pain Randomized controlled trial Traditional Chinese medicine

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Biophysical-driven piezoelectric and aligned nanofibrous scaffold promotes bone regeneration by re-establishing physiological electrical microenvironment

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Nano Research 2024年第8期17卷 7376-7393页

作者： Aoao Wang Xinbo Ma Yafeng Yang Guoliang Shi Liwei Han Xiantong Hu Rui Shi Jun Yan Quanyi Guo Yantao Zhao Senior department of Orthopedics the Fourth Medical Center of PLA General HospitalBeijing 100048China department of Chemistry Capital Normal UniversityBeijing 100048China National Center for Orthopaedics Beijing Research Institute of Traumatology and OrthopaedicsBeijing Jishuitan HospitalCapital Medical UniversityBeijing 100035China Xijing 986 hospital department The Fourth Military Medical UniversityXi'an 710032China Institute of Orthopedics Chinese PLA General HospitalBeijing Key Laboratory of Regenerative Medicine in OrthopedicsKey Laboratory of Musculoskeletal Trauma&War Injuries PLABeijing 100853China

The initial healing stages of bone fracture is a complex physiological process involving a series of spatially and temporally overlapping events,including pathogen clearance,immunological modulation,and *** this study,we have developed a piezoelectric and aligned nanofibrous scaffold composed of ZnO@PCL/PVDF with multiple antibacterial,immunomodulatory,and osteogenic effects using electrospinning *** scaffold’s piezoelectric signal output under ultrasound(US)control can be similar to the physiological electrical signals of healthy bone tissue,creating a truly biomimetic electrical microenvironment in the bone *** vitro studies have shown that ZnO@PCL/PVDF scaffold significantly enhances the proliferation,migration,and osteogenic differentiation of MC3T3-E1 cells under piezoelectric drive provided by ***,the scaffold exhibits inhibitory effects on the growth of *** and ***,as well as the ability to induce M2 macrophage polarization,indicating potent antibacterial and immunomodulatory *** vivo experiments demonstrated that the ZnO@PCL/PVDF scaffold can accelerate the repair of mandibular defects in rats,effectively inhibit bacterial colonization,and reduce inflammatory ***,this study confirms that the newly developed ZnO@PCL/PVDF scaffold effectively promotes bone repair by truly mimicking the endogenous electrical microenvironment and precisely regulating the temporospatial disorders of initial bone healing,thus providing a simple and effective solution for bone defects.

关键词： piezoelectricity bone defect bacterial infection ZnO nanoparticles immunomodulation osteogenesis

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International standard of Traditional Chinese Medicine techniques: the operating specifications for Chinese medicated bath(2022)

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Journal of Traditional Chinese Medicine 2024年第4期44卷 851-854页

作者： ZHANG Jing WANG Chunhui JIN Xinyan YU Miao FAN Yingyi HAN Xiaoli PEI Xiaohua department of dermatology Beijing University of Chinese Medicine Third Affiliated HospitalBeijing 100029China department of Chest and Breast Surgery Beijing University of Chinese Medicine Xiamen HospitalXiamen361001China Center for Evidence-Based Medicine Beijing University of Chinese MedicineBeijing 100029China department of General surgery Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical UniversityBeijing 100010China department of Breast Surgery Beijing University of Chinese Medicine Third Affiliated HospitalBeijing 100029China

Chinese medicated bath is one of the external therapies in Traditional Chinese Medicine(TCM),which has been widely used ***“International Standard of Traditional Chinese Medicine Techniques:The Operating Specifications for Chinese Medicated Bath”is drawn up by the beijing University of Chinese Medicine Third Affiliated hospital and beijing University of Chinese Medicine Xiamen hospital in collaboration with domestic TCM universities and *** specification includes definition,operating process,points for attention and *** is targeted to provide reference for TCM providers at home and abroad with TCM background in clinical decision-making.

关键词： Chinese medicated bath international standard traditional Chinese medical technology operating specifications

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Efficacy of acupuncture in refractory irritable bowel syndrome patients:a randomized controlled trial

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Frontiers of Medicine 2024年第4期18卷 678-689页

作者： Jun Zhao Hui Zheng Xin Wang Xuefei Wang Yunzhou Shi Chaorong Xie Qingfeng Tao Da Li Jingwen Sun Junjian Tian Junxia Gao Huimin Liu Suhua Shi Jinxia Ni Rongdan Xue Hui Hu Min Chen Shuguang Yu Zhigang Li School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing100029China The Third hospital/Acupuncture and Tuina School Chengdu University of Traditional Chinese MedicineChengdu610000China beijing hospital of Traditional Chinese Medicine Capital Medical UniversityBeijing100010China department of Acupuncture and Moxibustion Dongzhimen Hospital Affiliated to Beijing University of Chinese MedicineBeijing100700China department of Rehabilitation The Third Affiliated Hospital of Beijing University of Chinese MedicineBeijing100029China department of Acupuncture and Moxibustion Dongfang Hospital Affiliated with Beijing University of Chinese MedicineBeijing100078China Anorectal Disease department Hospital of Chengdu University of Traditional Chinese MedicineChengdu610075China department of Integrated Traditional and Western Medicine West China HospitalSichuan UniversityChengdu610044China

Previous studies have confirmed that acupuncture for irritable bowel syndrome(IBS)provided an additional benefit over usual care ***,we performed a multicenter,randomized,sham-controlled trial to assess the efficacy and safety of acupuncture versus sham acupuncture for refractory IBS in patients in the context of conventional *** in the acupuncture and sham acupuncture groups received real or sham acupuncture treatment in 3 sessions per week for a total of 12 *** primary outcome was a change in the IBS–Symptom Severity Scale(IBS-SSS)score from baseline to week 4.A total of 521 participants were screened,and 170 patients(85 patients per group)were enrolled and included in the intention-to-treat *** characteristics were comparable across the two *** baseline to 4 weeks,the IBS-SSS total score decreased by 140.0(95%CI:126.0 to 153.9)in the acupuncture group and 64.4(95%CI:50.4 to 78.3)in the sham acupuncture *** between-group difference was 75.6(95%CI:55.8 to 95.4).Acupuncture efficacy was maintained during the 4-week follow-up *** were no serious adverse *** conclusion,acupuncture provided benefits when combined with treatment as usual,providing more options for the treatment of refractory IBS.

关键词： acupuncture functional gastrointestinal disorders irritable bowel syndrome clinical trial

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Transient elastography with controlled attenuation parameter for the diagnosis of colorectal polyps in patients with nonalcoholic fatty liver disease

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World Journal of Clinical Cases 2024年第12期12卷 2050-2055页

作者： Lan Wang Yan-Fei Li Li-Feng Dong department of Gastroenterology Beijing Chuiyangliu HospitalBeijing 100022China

BACKGROUND The severity of nonalcoholic fatty liver disease(NAFLD)and lipid metabolism are related to the occurrence of colorectal ***-controlled attenuation parameters(liver-CAPs)have been established to predict the prognosis of hepatic steatosis *** To explore the risk factors associated with colorectal polyps in patients with NAFLD by analyzing liver-CAPs and establishing a diagnostic *** Patients who were diagnosed with colorectal polyps in the department of Gastroenterology of our hospital between June 2021 and April 2022 composed the case group,and those with no important abnormalities composed the control *** area under the receiver operating characteristic curve was used to predict the diagnostic *** were considered statistically significant when P0.05).When the liver-CAP was greater than 291 dB/m,colorectal polyps were more likely to *** The levels of TG and liver-CAP in patients with colorectal polyps are significantly greater than those patients without ***-CAP alone can be used to diagnose NAFLD with colorectal polyps.

关键词： Colorectal polyps Nonalcoholic fatty liver disease Liver-controlled attenuation parameter Liver fibroscan Diagnostic model

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Efficacy of Daoyin combined with lower limb robot as a comprehensive rehabilitation intervention for stroke patients: a randomized controlled trial

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Journal of Traditional Chinese Medicine 2024年第3期44卷 530-536页

作者： TIAN Haolin YANG Yuanbin ZHANG Hu ZHAO Wenjing ZHOU Jing TIAN Jingfeng HE Long LI Xuechao SHEN Qinxuan SHUAI Mei department of First Rehabilitation Wangjing Hospital of China Academy of Chinese Medical SciencesBeijing100102 department of Rehabilitation Shunyi HospitalBeijing Traditional Chinese Medicine HospitalBeijing101300China School of Biological Science and Medical Engineering Beihang UniversityBeijing100191China

OBJECTIVE: To assess the effectiveness of a comprehensive rehabilitation approach combining Traditional Chinese Medicine Daoyin with lower limb robotics during the recovery phase of stroke ***: Stroke patients meeting the specified criteria were randomly assigned to one of four groups using a random number table: Control group, Daoyin group, lower limb robot group(LLR group), and Daoyin and lower limb robot group(DLLR group). Each group received distinct treatments based on conventional rehabilitation *** treatment duration spanned two weeks with two days of rest per week. Pre-and post-intervention assessments included various scales: Fugl-Meyer Assessment(FMA),Berg balance scale(BBS), Barthel index(BI), Fatigue Scale-14(FS-14), Pittsburgh sleep quality index(PSQI),Hamilton Anxiety Scale(HAMA), and Hamilton Depression Scale(HAMD).RESULTS: Statistically significant differences were observed in the lower limb function measured by FAM between the Control group(15 ± 5) and the DLLR group(18 ± 5)(P = 0.049). In the Barthel index, a statistically significant difference was noted between the Control group(54 ± 18) and the DLLR group(64 ± 11)(P = 0.041).Additionally, significant differences were found in the Berg balance scale between the Control group(21 ± 10)and the DLLR group(27 ± 8)(P = 0.024), as well as between the Control group(21 ± 10) and the LLR group(26 ± 10)(P = 0.048).CONCLUSION: The findings of this study suggest that the combined use of Daoyin and robotics not only enhances motor function in stroke patients but also has a positive impact on fatigue, sleep quality, and mood. This approach may offer a more effective rehabilitation strategy for stroke patients.

关键词： stroke rehabilitation Daoyin lower limb robot randomized controlled trial

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Multiomics and blood-based biomarkers of moyamoya disease: protocol of Moyamoya Omics Atlas (MOYAOMICS)

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中华神经外科杂志(英文) 2024年第3期10卷 1-9页

作者： Ge Peicong Yin Zihan Tao Chuming Zeng Chaofan Yu Xiaofan Lei Shixiong Li Junsheng Zhai Yuanren Ma Long He Qiheng Liu Chenglong Liu Wei Zhang Bojian Zheng Zhiyao Mou Siqi Zhao Zhikang Wang Shuang Sun Wei Guo Min Zheng Shuai Zhang Jia Deng Xiaofeng Liu Xingju Ye Xun Zhang Qian Wang Rong Zhang Yan Zhang Shaosen Wang Chengjun Yang Ziwen Zhang Nijia Wu Mingxing Sun Jian Zhou Yujia Shi Zhiyong Ma Yonggang Zhou Jianpo Yu Shaochen Li Jiaxi Lu Junli Gao Faliang Wang Wenjing Chen Yanming Zhu Xingen Zhang Dong Zhao Jizong department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing China China National Clinical Research Center for Neurological Diseases Beijing China department of Neurosurgery Beijing Hospital National Center of Gerontology Beijing China department of Radiology Beijing Tiantan Hospital Beijing China department of Ultrasound Beijing Tiantan Hospital Capital Medical University Beijing China department of Neurology Beijing Tiantan Hospital Beijing China department of Neurosurgery Beijing Friendship Hospital Capital Medical University Beijing China department of Neurosurgery Beijing Chaoyang Hospital Capital Medical University Beijing China department of Neurosurgery Beijing Childrens Hospital Capital Medical University Beijing China department of Neurosurgery The Affiliated Children’s Hospital Capital Institute of Pediatrics Beijing China department of Neurosurgery Beijing Changping District Hospital Beijing China department of Neurosurgery Dongfang Hospital Beijing University of Chinese Medicine Beijing China department of Neurosurgery Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing China department of NeuroInterventional Surgery Binzhou Medical University Hospital Binzhou Shandong China department of Neurosurgery Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai China department of Neurosurgery The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China department of Neurosurgery The First Affiliated Hospital of Xi’an Jiaotong University Shaanxi Xi’an China department of Neurosurgery West China Hospital Sichuan University Chengdu China department of Neurosurgery Center for Rehabilitation Medicine Zhejiang Provincial Peoples Hospital Affiliated Peoples Hospital Hangzhou Medical College Hangzhou Zhejiang China beijing Institute of Hepatology Beijing YouAn Hospital Capital Medical University Beijing China department of Neu

Background Moyamoya disease (MMD) is a rare and complex cerebrovascular disorder characterized by the progressive narrowing of the internal carotid arteries and the formation of compensatory collateral vessels. The etiology of MMD remains enigmatic, making diagnosis and management challenging. The MOYAOMICS project was initiated to investigate the molecular underpinnings of MMD and explore potential diagnostic and therapeutic *** The MOYAOMICS project employs a multidisciplinary approach, integrating various omics technologies, including genomics, transcriptomics, proteomics, and metabolomics, to comprehensively examine the molecular signatures associated with MMD pathogenesis. Additionally, we will investigate the potential influence of gut microbiota and brain-gut peptides on MMD development, assessing their suitability as targets for therapeutic strategies and dietary interventions. Radiomics, a specialized field in medical imaging, is utilized to analyze neuroimaging data for early detection and characterization of MMD-related brain changes. Deep learning algorithms are employed to differentiate MMD from other conditions, automating the diagnostic process. We also employ single-cellomics and mass cytometry to precisely study cellular heterogeneity in peripheral blood samples from MMD *** The MOYAOMICS project represents a significant step toward comprehending MMD’s molecular underpinnings. This multidisciplinary approach has the potential to revolutionize early diagnosis, patient stratification, and the development of targeted therapies for MMD. The identification of blood-based biomarkers and the integration of multiple omics data are critical for improving the clinical management of MMD and enhancing patient outcomes for this complex disease.

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