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Activation of glutamatergic neurons in the somatosensory cortex promotes remyelination in ischemic vascular dementia

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Fundamental Research 2024年第1期4卷 188-198页

作者： Yi-Ting Zhou Da-Dao An Yi-Xin Xu Ying Zhou Qing-Qing Li Hai-Bin Dai Xiang-Nan Zhang Yi Wang Min Lou Zhong Chen Wei-Wei Hu department of Pharmacology and department of Pharmacy of the Second Affiliated Hospital NHC and CAMS Key Laboratory of Medical NeurobiologySchool of Basic Medical SciencesCollege of Pharmaceutical SciencesZhejiang University School of MedicineHangzhou 310058China department of Pharmacy Sir Run Run Shaw HospitalHangzhou 310012China Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhou 310053China department of Neurology the Second Affiliated Hospital of Zhejiang UniversitySchool of MedicineHangzhou 310003China

Chronic cerebral hypoperfusion can cause progressive demyelination as well as ischemic vascular dementia,however no effective treatments are ***,based on magnetic resonance imaging studies of patients with white matter damage,we found that this damage is associated with disorganized cortical *** a mouse model,optogenetic activation of glutamatergic neurons in the somatosensory cortex significantly promoted oligodendrocyte progenitor cell(OPC)proliferation,remyelination in the corpus callosum,and recovery of cognitive ability after cerebral *** therapeutic effect of such stimulation was restricted to the upper layers of the cortex,but also spanned a wide time window after ***,enhancement of glutamatergic neuron-OPC functional synaptic connections is required to achieve the protection effect of activating cortical glutamatergic ***,skin stroking,an easier method to translate into clinical practice,activated the somatosensory cortex,thereby promoting OPC proliferation,remyelination and cognitive recovery following cerebral *** summary,we demonstrated that activating glutamatergic neurons in the somatosensory cortex promotes the proliferation of OPCs and remyelination to recover cognitive function after chronic cerebral *** should be noted that this activation may provide new approaches for treating ischemic vascular dementia via the precise regulation of glutamatergic neuron-OPC circuits.

关键词： Chronic cerebral hypoperfusion Optogenetic stimulation Oligodendrocyte progenitor cellIschemic vascular dementia Glutamatergic neuron Remyelination

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Neural-based inexact graph de-anonymization

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High-Confidence Computing 2024年第1期4卷 52-59页

作者： Guangxi Lu Kaiyang Li Xiaotong Wang Ziyue Liu Zhipeng Cai Wei Li department of Computer Science Georgia State UniversityAtlantaUSA St.George’s School VancouerCanada

Graph de-anonymization is a technique used to reveal connections between entities in anonymized graphs,which is crucial in detecting malicious activities,network analysis,social network analysis,and *** its paramount importance,conventional methods often grapple with inefficiencies and challenges tied to obtaining accurate query graph *** paper introduces a neural-based inexact graph de-anonymization,which comprises an embedding phase,a comparison phase,and a matching *** embedding phase uses a graph convolutional network to generate embedding vectors for both the query and anonymized *** comparison phase uses a neural tensor network to ascertain node *** matching procedure employs a refined greedy algorithm to discern optimal node ***,we comprehensively evaluate its performance via well-conducted experiments on various real *** results demonstrate the effectiveness of our proposed approach in enhancing the efficiency and performance of graph de-anonymization through the use of graph embedding vectors.

关键词： Graph de-anonymization Graph convolutional network Neural tensor network

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Handheld bedside ultrasound in the diagnosis of myocarditis

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World Journal of Emergency Medicine 2024年第1期15卷 73-74页

作者： Frank Wheeler Robin Lahr James Espinosa Alan Lucerna Henry Schuitema department of Emergency Medicine Rowan University School of Osteopathic MedicineStratford 08084USA Emergency Medicine Residency Program Jeff erson HealthStratford 08084USA department of Emergency Medicine and Associate Chief Medical Offi cer Stratford 08084USA

Myocarditis is a disease process that every emergency physician fears *** severity can be mild to life-threatening,and many cases are likely undetected because they are subclinical with nonspecifi c signs.[1]Subtle cardiac signs may be overshadowed by systemic symptoms of the underlying infectious ***,myalgias,lethargy,symptoms commonly associated with viral syndrome,can mask the life-threatening myocarditis that may be *** fact,in the United States Myocarditis Treatment Trial,almost 90%of patients reported symptoms consistent with a viral prodrome.[2]Ammirati et al[3]reported that 27%of patients with myocarditis had either reduced left ventricular ejection fraction,ventricular arrhythmias,or low cardiac ***,we present a case report,in which handheld point-of-care ultrasound was utilized at the bedside to aid in the critical diagnosis of *** the additional information provided through this imaging modality,this patient was able to be transferred to the appropriate tertiary care facility in an expeditious manner and receive possible defi nitive treatment.

关键词： diagnosis myocarditis Fever

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Dual innervation method to preserve erectile function following prostatectomy

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Chinese Journal of Plastic and Reconstructive Surgery 2024年第3期6卷 159-160页

作者： Nadia Hui Shan Sim Allen Sim Dayna Sim Bien-Keem Tan Allen Wei-Jiat Wong Plastic Reconstructive and Aesthetic Surgery ServiceSengkang General Hospital544886Singapore department of Urology Mount Alvernia Hospital Singapore574623Singapore department of General Surgery Sengkang General Hospital544886Singapore department of Plastic Reconstructive and Aesthetic SurgerySingapore General Hospital169608Singapore

Prostate cancer is the second most prevalent cancer in ***-assisted radical prostatectomy(RARP)has altered the landscape of prostate cancer *** the excellent oncological outcomes associated with RARP,the rate of erectile dysfunction(ED)remains *** repair of disrupted cavernous nerves with interpositional nerve grafts has been described;however,the outcomes have been *** hypothesize that this is attributed to Schwann cell atrophy and axonal regeneration limitations caused by long nerve *** proposed the use of nerve transfer to support axonal regrowth via an inter-positional graft with additional donor axons.A cadaveric study was performed to evaluate the anatomical feasibility of a vastus lateralis nerve(VLN)transfer to the distal recipient cavernous nerve *** VLN is long with multiple branching patterns that allow tension-free coaptation of the cavernous *** postulate that a dual innervation method using VLN nerve transfer together with interpositional nerve graft repair of the transacted cavernous nerves may improve the outcomes of ED post-RARP.

关键词： Erectile dysfunction Prostatectomy Interposition nerve graft Nerve transfer Vastus lateralis nerve

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Drug-induced mucosal alterations observed during esophagogastroduodenoscopy

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World Journal of Gastroenterology 2024年第16期30卷 2220-2232页

作者： Masaya Iwamuro Seiji Kawano Motoyuki Otsuka department of Gastroenterology and Hepatology Okayama University Graduate School of MedicineDentistryand Pharmaceutical SciencesOkayama 700-8558Japan

Several features of drug-induced mucosal alterations have been observed in the upper gastrointestinal tract,i.e.,the esophagus,stomach,and *** include pill-induced esophagitis,desquamative esophagitis,worsening of gastroesophageal reflux,chemotherapy-induced esophagitis,proton pump inhibitor-induced gastric mucosal changes,medication-induced gastric erosions and ulcers,pseudomelanosis of the stomach,olmesartan-related gastric mucosal inflammation,lanthanum deposition in the stomach,zinc acetate hydrate tabletinduced gastric ulcer,immune-related adverse event gastritis,olmesartan-associated sprue-like enteropathy,pseudomelanosis of the duodenum,and lanthanum deposition in the *** endoscopists,acquiring accurate knowledge regarding these diverse drug-induced mucosal alterations is crucial not only for the correct diagnosis of these lesions but also for differential diag-nosis of other *** minireview aims to provide essential information on druginduced mucosal alterations observed on esophagogastroduodenoscopy,along with representative endoscopic images.

关键词： Diagnosis Esophagogastroduodenoscopy Non-neoplastic lesions Esophageal lesions Gastric lesions Duodenal lesions

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Federated Approach for Privacy-Preserving Traffic Prediction Using Graph Convolutional Network

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Journal of Shanghai Jiaotong university(Science) 2024年第3期29卷 509-517页

作者： LONARE Savita BHRAMARAMBA Ravi Pimpri Chinchwad College of Engineering Pune 411044India department of Computer Science and Engineering GITAMViskhapatnam 530045India

Existing traffic flow prediction frameworks have already achieved enormous success due to large traffic datasets and capability of deep learning ***,data privacy and security are always a challenge in every field where data need to be uploaded to the *** learning(FL)is an emerging trend for distributed training of *** primary goal of FL is to train an efficient communication model without compromising data *** traffic data have a robust spatio-temporal correlation,but various approaches proposed earlier have not considered spatial correlation of the traffic *** paper presents FL-based traffic flow prediction with spatio-temporal *** work uses a differential privacy(DP)scheme for privacy preservation of participant's *** the best of our knowledge,this is the first time that FL is used for vehicular traffic prediction while considering the spatio-temporal correlation of traffic data with DP *** proposed framework trains the data locally at the client-side with *** then uses the model aggregation mechanism federated graph convolutional network(FedGCN)at the server-side to find the average of locally trained *** results of the proposed work show that the FedGCN model accurately predicts the *** scheme at client-side helps clients to set a budget for privacy loss.

关键词： federated learning(FL) traffic flow prediction data privacy graph convolutional network(GCN) differential privacy(DP)

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Green building research in South Africa:A scoping review and future roadmaps

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Energy and Built Environment 2024年第2期5卷 316-335页

作者： Favour D.Agbajor Modupe Cecilia Mewomo department of Construction Management and Quantity Surveying Durban University of TechnologySteve Biko CampusDurban4001South Africa

The construction industry is recognised to pose serious environmental threats due to its anthropogenic *** confront this challenge,green building has been famed as an auspicious strategy to alleviate energy-related carbon emissions alongside climate change ***,it has birthed diverse empirical studies and holistic reviews by the research ***,these previous studies have been carried out from a global and continental viewpoint regardless of the green building development specifically in emerging *** present study seeks to fill the sparse research upshots on the synthesis of green building research at the country level with core focus on South *** this light,the current study provides a scoping overview of the intellectual exploration on green building research in the South African *** study’s findings highlight the varying growth regarding the subject matter,the drivers,drawbacks,and socio-economic issues confronting in developing green building projects in the *** optimize the advancement of green building in the region,this study recommends the implementation of financing schemes,utilization of advanced digital technologies,and promotion of green and sustainable building curricula across the institutions as well as post-occupancy-related studies within the green building spectrum towards a safe and salutogenic built-environment in the country.

关键词： Green building Sustainable construction Energy efficiency Review South Africa

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Magnesium-L-threonate treats Alzheimer's disease by modulating the microbiota-gut-brain axis

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Neural Regeneration Research 2024年第10期19卷 2281-2289页

作者： Wang Liao Jiana Wei Chongxu Liu Haoyu Luo Yuting Ruan Yingren Mai Qun Yu Zhiyu Cao Jiaxin Xu Dong Zheng Zonghai Sheng Xianju Zhou Jun Liu department of Neurology The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Special Medical Service Center Neuroscience CenterIntegrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangdongGuangdong ProvinceChina department of Rehabilitation The Second Affiliated HospitalGuangzhou Medical UniversityGuangzhouGuangdong ProvinceChina department of Neurology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina department of Neurology The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

Disturbances in the microbiota-gut-brain axis may contribute to the development of Alzheimer's disease. Magnesium-L-threonate has recently been found to have protective effects on learning and memory in aged and Alzheimer's disease model mice. However, the effects of magnesium-L-threonate on the gut microbiota in Alzheimer's disease remain unknown. Previously, we reported that magnesium-L-threonate treatment improved cognition and reduced oxidative stress and inflammation in a double-transgenic line of Alzheimer's disease model mice expressing the amyloid-β precursor protein and mutant human presenilin 1(APP/PS1). Here, we performed 16S r RNA amplicon sequencing and liquid chromatography-mass spectrometry to analyze changes in the microbiome and serum metabolome following magnesium-Lthreonate exposure in a similar mouse model. Magnesium-L-threonate modulated the abundance of three genera in the gut microbiota, decreasing Allobaculum and increasing Bifidobacterium and Turicibacter. We also found that differential metabolites in the magnesiumL-threonate-regulated serum were enriched in various pathways associated with neurodegenerative diseases. The western blotting detection on intestinal tight junction proteins(zona occludens 1, occludin, and claudin-5) showed that magnesium-L-threonate repaired the intestinal barrier dysfunction of APP/PS1 mice. These findings suggest that magnesium-L-threonate may reduce the clinical manifestations of Alzheimer's disease through the microbiota-gut-brain axis in model mice, providing an experimental basis for the clinical treatment of Alzheimer's disease.

关键词： Alzheimer's disease APP/PS1 double-transgenic Alzheimer's disease mouse model inflammation intestinal barrier dysfunction magnesium-L-threonate microbiome microbiota-gut-brain axis oxidative stress serum metabolites

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Fuzzy and IRLNC-based routing approach to improve data storage and system reliability in IoT

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Intelligent and Converged Networks 2024年第1期5卷 68-80页

作者： U.Indumathi A.R.Arunachalam the department of Computer Science and Engineering Dr.M.G.R.Educational and Research InstituteChennai 600095India

Internet of Things(IoT)based sensor network is largely utilized in various field for transmitting huge amount of data due to their ease and cheaper *** performing this entire process,there is a high possibility for data corruption in the mid of *** the other hand,the network performance is also affected due to various *** address these issues,an efficient algorithm that jointly offers improved data storage and reliable routing is ***,after the deployment of sensor nodes,the election of the storage node is achieved based on a fuzzy expert *** Random Linear Network Coding(IRLNC)is used to create an encoded *** encoded packet from the source and neighboring nodes is transmitted to the storage ***,to transmit the encoded packet from the storage node to the destination shortest path is found using the Destination Sequenced Distance Vector(DSDV)*** analysis of the proposed work is carried out by evaluating some of the statistical *** residual energy,packet delivery ratio,compression ratio and storage time achieved for the proposed work are 8.8%,0.92%,0.82%,and 69 *** on this analysis,it is revealed that better data storage system and system reliability is attained using this proposed work.

关键词： Internet of Things(IoT) data storage management fuzzy system improved random linear network coding energy utilization system reliability

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RSPSSL:A novel high-fidelity Raman spectral preprocessing scheme to enhance biomedical applications and chemical resolution visualization

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Light(Science & Applications) 2024年第2期13卷 366-386页

作者： Jiaqi Hu Gina Jinna Chen Chenlong Xue Pei Liang Yanqun Xiang Chuanlun Zhang Xiaokeng Chi Guoying Liu Yanfang Ye Dongyu Cui De Zhang Xiaojun yu Hong Dang Wen Zhang Junfan Chen Quan Tang Penglai Guo Ho-Pui Ho Yuchao Li Longqing Cong Perry Ping Shum State Key Laboratory of Optical Fiber and Cable Manufacture Technology Guangdong Key Laboratory of Integrated Optoelectronics IntellisenseDepartment of EEESouthern University of Science and TechnologyShenzhen 518055China College of Optical and Electronic Technology China Jiliang UniversityHangzhou 310018China department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangzhou 510060China department of Ocean Science and Engineering Southern University of Science and TechnologyShenzhen 518055China department of Nephrology Chaozhou People’s HospitalChaozhou 521011China Clinical Research Design Division Sun Yatsen Memorial HospitalGuangzhouGuangdong 510120China School of Automation Northwestern Polytechnical UniversityXi’anShaanxi 710072China department of Biomedical Engineering The Chinese University of Hong KongHong KongChina Guangdong Provincial Key Laboratory of Nanophotonic Manipulation Institute of NanophotonicsJinan UniversityGuangzhou 511443China

Raman spectroscopy has tremendous potential for material analysis with its molecular fingerprinting capability in many branches of science and *** is also an emerging omics technique for metabolic profiling to shape precision ***,precisely attributing vibration peaks coupled with specific environmental,instrumental,and specimen noise is *** Raman spectral preprocessing to remove statistical bias noise and sample-related errors should provide a powerful tool for valuable information ***,we propose a novel Raman spectral preprocessing scheme based on self-supervised learning(RSPSSL)with high capacity and spectral *** can preprocess arbitrary Raman spectra without further training at a speed of~1900 spectra per second without human *** experimental data preprocessing trial demonstrated its excellent capacity and signal fidelity with an 88%reduction in root mean square error and a 60%reduction in infinite norm(L__(∞))compared to established *** this advantage,it remarkably enhanced various biomedical applications with a 400%accuracy elevation(ΔAUC)in cancer diagnosis,an average 38%(few-shot)and 242%accuracy improvement in paraquat concentration prediction,and unsealed the chemical resolution of biomedical hyperspectral images,especially in the spectral fingerprint *** precisely preprocessed various Raman spectra from different spectroscopy devices,laboratories,and diverse *** scheme will enable biomedical mechanism screening with the label-free volumetric molecular imaging tool on organism and disease metabolomics profiling with a scenario of high throughput,cross-device,various analyte complexity,and diverse applications.

关键词： spectral scheme resolution

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