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Neural Regeneration research 2024年第5期19卷 959-960页

作者： Simran Kapila Yuhan Sun Chao Peng Shujing Zhang department of Neurology David Geffen School of MedicineUniversity of CaliforniaLos AngelesCAUSA Molecular Biology Institute Brain Research InstituteMary S.Easton Center for Alzheimer’s ResearchUniversity of CaliforniaLos AngelesCAUSA

The build-up of misfoldedα-synuclein(α-syn)in the central nervous system is the pathological hallmark of a number of neurodegenerative diseases that are known asα-*** include Parkinson’s disease(PD),Parkinson’s disease with dementia(PDD),dementia with Lewy body(LB),multiple system atrophy(MSA),and a subset of Alzheimer’s *** evidence underscores that the intercellular transmission and amplification of pathologicalα-syn are critical processes underlying the progression ofα-synucleinopathies(Peng et al.,2020),and as such,the study of these processes could lead to the identification of promising therapeutics to mitigate disease *** previous studies have focused solely on pathological seeds in relation to disease progression.

关键词： pathological diseases

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高分子囊泡领域面临的挑战和未来研究方向

Science China Materials 2024年第1期67卷 18-30页

作者：石隽秋孙青梅王文立李畅尹海洋李浩澜滕润鑫范震朱云卿杜建忠 department of Gynaecology and Obstetrics Shanghai Key Laboratory of Anesthesiology and Brain Functional ModulationClinical Research Center for Anesthesiology and Perioperative MedicineTranslational Research Institute of Brain and Brain-Like IntelligenceShanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghai 200434China department of Polymeric Materials School of Materials Science and EngineeringTongji UniversityShanghai 201804China

作为细胞中的主要运输系统,天然囊泡在物质的定点输运过程中具有至关重要的作用.高分子囊泡是与之结构相似的一种人工囊泡,具有优异的膜稳定性和胶体稳定性、高药物负载率、低膜穿透性、优异的可修饰性和长循环时间等优势,在生物医用领... 详细信息

作为细胞中的主要运输系统,天然囊泡在物质的定点输运过程中具有至关重要的作用.高分子囊泡是与之结构相似的一种人工囊泡,具有优异的膜稳定性和胶体稳定性、高药物负载率、低膜穿透性、优异的可修饰性和长循环时间等优势,在生物医用领域具有广泛的应用前景.然而,目前该领域尚面临一系列重要挑战,如合成和制备方法较为复杂、生物相容性较难预测、功能和递送途径有限等,限制了其临床转化之路.本文从囊泡的构建模块合成、自组装技术和潜在的生物医学应用等角度,提出了设计和制备下一代高分子囊泡需要解决的五个关键科学问题,指出了未来面临的重要挑战和发展方向,例如简化设计和合成过程,优化和规范自组装过程,拓展潜在的应用前景.

关键词：生物医学应用胶体稳定性自组装技术运输系统膜稳定性输运过程穿透性高分子

Artificial intelligence meets body sense: task-driven neural networks reveal computational principles of the proprioceptive pathway

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3147-3149页

作者： Leonard E.van Dyck Frank Bremmer Katharina Dobs department of Psychology Justus Liebig University GiessenGiessenGermany Max Planck Institute for Human Cognitive and brain Sciences LeipzigGermany Center for Mind Brain and BehaviorUniversities of MarburgGiessenand DarmstadtMarburgGermany department of Neurophysics Philipps-Universitat MarburgMarburgGermany

In a recent study published in Cell,Marin Vargas and Bisi et al.1 present an innovative approach to unravel the computational principles underlying proprioceptive processing in non-human *** findings showcase the utility of task-driven modeling in advancing neuroscience and offer translational potential by providing seminal insights into the goals and mechanisms by which the brain encodes body position and movements.

关键词： networks neural principles

The immune system:uncharted pathways between senses and the brain

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Neural Regeneration research 2024年第6期19卷 1173-1174页

作者： Noelia Casares Mar Cuadrado-Tejedor Ana García-Osta Juan JoséLasarte Immunology and Immunotherapy Program Centre for Applied Medical Research(CIMA)University of NavarraIDISNAPamplonaSpain Division of Gene Therapy for Neurological Disorders Centre for Applied Medical Research(CIMA)University of NavarraIDISNAPamplonaSpain Pathology Anatomy and Physiology DepartmentSchool of MedicineUniversity of NavarraIDISNAPamplonaSpain

Humans and animals use the classic five senses-sight,hearing,touch,smell,and taste-to detect and monitor their environment,with the sense of position and movement often referred to as the sixth *** perception of external signals through the senses is essential to an organism's survival,transmitting signals to the central nervous system(CNS)and prompting physiological changes in other biological *** addition to the direct effects of sense-induced mediators in the brain.

关键词： prompt system transmitting

Retinoic acid receptor responder 2 and lipid metabolic reprogramming:A new insight into brain metastasis

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Cancer Innovation 2024年第6期3卷 42-44页

作者： Lulu Wang Yan Gao department of Human anatomy School of Basic Medical SciencesCapital Medical UniversityBeijingChina Beijing Key Laboratory of Cancer Invasion and Metastasis research BeijingChina

The brain is one of the most common metastatic sites for carcinoma,especially for breast cancer,the second leading cause of brain metastases(BrM)after lung cancer[1].During organ‐tropic metastases,cancer cells have to survive and expand in target organs through a process involving a complex interplay between invading cells and the microenvironment.

关键词： brain metastases breast cancer lipid metabolism retinoic acid receptor responder 2

Assembly of functional carboxymethyl cellulose/polyethylene oxide/anatase TiO_(2) nanocomposites and tuning the dielectric relaxation, optical, and photoluminescence performances

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Journal of Semiconductors 2024年第7期45卷 26-38页

作者： Asmaa M.Ismail Abeer A.Reffaee Fawzy G.El Desouky Spectroscopy department Physics Research InstituteNational Research CentreGizaCairo 12622Egypt Microwave Physics and Dielectrics department National Research CentreDokkiCairoEgypt Solid State Physics department Physics Research InstituteNational Research CentreGizaCairo 12622Egypt

Nanocomposite films consisting of carboxymethyl cellulose,polyethylene oxide(CMC/PEO),and anatase titanium diox-ide(TO)were produced by the use of sol-gel and solution casting ***2 nanocrystals were effectively incorporated into CMC/PEO polymers,as shown by X-ray diffraction(XRD)and attenuated total reflectance fourier transform infrared(ATR-FTIR)*** roughness growth is at high levels of TO nanocrystals(TO NCs),which means increasing active sites and defects in CMC/*** differential scanning calorimetry(DSC)thermograms,the change in glass transition temperature(Tg)val-ues verifies that the polymer blend interacts with TO *** increment proportions of TO NCs have a notable impact on the dielectric performances of the nanocomposites,as *** electrical properties of the CMC/PEO/TO nanocomposite undergo significant *** nanocomposite films exhibit a red alteration in the absorption edge as the concentration of TO NCs increases in the polymer *** decline in the energy gap is readily apparent as the weight percentage of TO NCs *** photoluminescence(PL)emission spectra indicate that the sites of the luminescence peak maximums show slight variation;peaks get wider,while their intensities decrease dramatically as the concentration of TO *** nanocomposite materials show potential for multifunctional applications including optoelectronics,antireflection coatings,pho-tocatalysis,light emitting diodes,and solid polymer electrolytes.

关键词： anatase TiO_(2) CMC/PEO nanocomposites optical photoluminescent electrical optoelectronics

Trogocytosis of CAR molecule regulates CAR-T cell dysfunction and tumor antigen escape

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Signal Transduction and Targeted Therapy 2024年第1期9卷 326-337页

作者： You Zhai Yicong Du Guanzhang Li Mingchen Yu Huimin Hu Changqing Pan Di Wang Zhongfang Shi Xu Yan Xuesong Li Tao Jiang Wei Zhang department of Molecular Neuropathology Beijing Neurosurgical InstituteCapital Medical UniversityBeijingPR China department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijingPR China department of Urology Peking University First HospitalInstitute of UrologyPeking UniversityNational Urological Cancer CenterBeijingPR China department of Pathophysiology Beijing Neurosurgical InstituteCapital Medical UniversityBeijingPR China China National Clinical research Center for Neurological Diseases BeijingPR China Center of brain Tumor Beijing Institute for Brain DisordersBeijingPR China research Unit of Accurate Diagnosis Treatmentand Translational Medicine of Brain TumorsChinese Academy of Medical SciencesBeijingPR China Chinese Glioma Genome Atlas Network(CGGA)and Asian Glioma Genome Atlas Network(AGGA) BeijingPR China

Chimeric antigen receptor(CAR)T-cell therapy has demonstrated clinical response in treating both hematologic malignancies and solid *** instances of rapid tumor remissions have been observed in animal models and clinical trials,tumor relapses occur with multiple therapeutic resistance ***,while the mechanisms underlying the long-term therapeutic resistance are well-known,short-term adaptation remains less ***,more views shed light on short-term adaptation and hold that it provides an opportunity window for long-term *** this study,we explore a previously unreported mechanism in which tumor cells employ trogocytosis to acquire CAR molecules from CAR-T cells,a reversal of previously documented *** mechanism results in the depletion of CAR molecules and subsequent CAR-T cell dysfunction,also leading to short-term antigen loss and antigen *** type of intercellular communication is independent of CAR downstream signaling,CAR-T cell condition,target antigen,and tumor cell ***,it is mainly dependent on antigen density and CAR sensitivity,and is associated with tumor cell cholesterol *** mitigation of this trogocytosis-induced CAR molecule transfer can be achieved by adaptively administering CAR-T cells with antigen density-individualized CAR ***,our study reveals a dynamic process of CAR molecule transfer and refining the framework of clinical CAR-T therapy for solid tumors.

关键词： Together instance depletion

Cellular interplay to 3D in vitro microphysiological disease model:cell patterning microbiota-gut-brain axis

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Bio-Design and Manufacturing 2024年第3期7卷 320-357页

作者： Kamare Alam Lakshmi Nair Souvik Mukherjee Kulwinder Kaur Manjari Singh Santanu Kaity Velayutham Ravichandiran Sugato Banerjee Subhadeep Roy department of Pharmacology and Toxicology National Institute of Pharmaceutical Education and ResearchKolkataWest Bengal 700054India department of Pharmaceutical Sciences Assam UniversitySilchar 788011India department of Pharmaceutical Sciences Guru Ghasidas UniversityKoniBilaspur 495009C.G.India School of Pharmacy and Biomolecular Sciences RCSI University of Medicine and Health SciencesDublin D02 YN77Ireland Tissue Engineering research Group Department of Anatomy and Regenerative MedicineRCSI University of Medicine and Health SciencesDublin D02 YN77Ireland department of Pharmaceutics National Institute of Pharmaceutical Education and ResearchKolkataWest Bengal 700054India department of Natural Products National Institute of Pharmaceutical Education and ResearchKolkataWest Bengal 700054India

The microbiota-gut-brain axis(MGBA)has emerged as a key prospect in the bidirectional communication between two major organ systems:the brain and the *** between the two organ systems allows the body to function without disease,whereas dysbiosis has long-standing evidence of etiopathological *** most common communication paths are the microbial release of metabolites,soluble neurotransmitters,and immune ***,each pathway is intertwined with a complex *** the emergence of in vitro models and the popularity of three-dimensional(3D)cultures and Transwells,engineering has become easier for the scientific understanding of neurodegenerative *** paper briefly retraces the possible communication pathways between the gut microbiome and the *** further elaborates on three major diseases:autism spectrum disorder,Parkinson’s disease,and Alzheimer’s disease,which are prevalent in children and the *** diseases also decrease patients’quality of ***,understanding them more deeply with respect to current advances in in vitro modeling is crucial for understanding the *** of MGBA in the laboratory uses many molecular technologies and biomaterial *** and organoids provide a more realistic picture of the cell and tissue structure than *** them with the Transwell system offers the advantage of compartmentalizing the two systems(apical and basal)while allowing physical and chemical cues between ***-edge technologies,such as bioprinting and microfluidic chips,might be the future of in vitro modeling,as they provide dynamicity.

关键词： Microbiota-gut-brain axis Neurodegeneration 3D disease model Organoid Transwell system

Intelligent speed adaptation for visibility technology affects drivers’speed selection along curves with sight limitations

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第1期11卷 16-27页

作者： Abrar Hazoor Alberto Terrafino Leandro L.Di Stasi Marco Bassani department of Environment Landand Infrastructure EngineeringPolitecnico di TorinoTorino 10129Italy Road Traffic Division Nord UniversityStjørdal 7502Norway Mind Brainand Behavior Research Centre(CIMCYC)University of GranadaGranada 18071Spain

Sight obstructions along road curves can lead to a crash if the driver is not able to stop the vehicle in *** is a particular issue along curves with limited available sight,where speed management is necessary to avoid unsafe situations(e.g.,driving off the road or invading the other traffic lane).To solve this issue,we proposed a novel intelligent speed adaptation(ISA)system for visibility,called V-ISA(intelligent speed adaptation for visibility).It estimates the real-time safe speed limits based on the prevailing sight conditions.V-ISA comes with three variants with specific feedback modalities(1)visual and(2)auditory information,and(3)direct intervention to assume control over the vehicle ***,we investigated the efficiency of each of the three V-ISA variants on driving speed choice and lateral behavioural response along road curves with limited and unsafe available sight distances,using a driving *** also considered curve road geometry(curve direction:rightward ***).Sixty active drivers were recruited for the *** half of them(experimental group)tested the three V-ISA variants(and a V-ISA off condition),the other half always drove with the V-ISA off(validation group).We used a linear mixed-effect model to evaluate the influence of V-ISA on driver *** V-ISA variants were efficient at reducing speeds at entrance points,with no discernible negative impact on driver lateral *** rightward curves,the V-ISA intervening variant appeared to be the most effective at adapting to sight *** of the current study implies that V-ISA might assist drivers to adjust their operating speed as per prevailing sight conditions and,consequently,establishes safer driving conditions.

关键词： Sight distance Intelligent speed adaptation Driver behaviour Road safety Driving simulation Advanced driver assistance systems

Construction of millimeter-scale vascularized engineered myocardial tissue using a mixed gel

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Regenerative Biomaterials 2024年第3期3卷 56-67页

作者： Ming Ke Wenhui Xu Yansha Hao Feiyang Zheng Guanyuan Yang Yonghong Fan Fangfang Wang Zhiqiang Nie Chuhong Zhu department of anatomy Third Military Medical UniversityChongqing 400038China State Key Laboratory of Trauma Burn and Combined InjuryChongqing 400038China department of Plastic and Aesthetic Surgery Southwest HospitalThird Military Medical UniversityChongqing 400038China Engineering research Center of Tissue and Organ Regeneration and Manufacturing Ministry of EducationChongqing 400038China

Engineering myocardium has shown great clinal potential for repairing permanent myocardial ***,the lack of perfusing blood vessels and difficulties in preparing a thick-engineered myocardium result in its limited clinical *** prepared a mixed gel containing fibrin(5 mg/ml)and collagen I(0.2 mg/ml)and verified that human umbilical vein endothelial cells(HUVECs)and human-induced pluripotent stem cell-derived cardiomyocytes(hiPSC-CMs)could fom microvascular lumens and myocardial cell clusters by harnessing the low-hardness and hyperelastic characteristics of ***-CMs and HUVECs in the mixed gel formed self-organized cell clusters,which were then cultured in different media using a three-phase *** successfully constructed vascularized engineered myocardial tissue had a spherical structure and final diameter of *** tissue exhibited autonomous beats that occured at a frequency similar to a normal human heart *** internal microvascular lumen could be maintained for 6 weeks and showed good results during preliminary surface re-vascularization in vitro and vascular remodeling in *** summary,we propose a simple method for constructing vascularized engineered myocardial tissue,through phased cultivation that does not rely on high-end manufacturing equipment and cutting-edge preparation *** constructed tissue has potential value for clinical use after preliminary evaluation.

关键词： engineered myocardium vascularized hiPSC-CM HUVEC fibrin