Soluble alpha-synuclein post-translational modifications:unexpected regulators of pathological alpha-synuclein amplification

作     者：Simran Kapila Yuhan Sun Chao Peng Shujing Zhang Simran Kapila;Yuhan Sun;Chao Peng;Shujing Zhang

作者机构：Department of NeurologyDavid Geffen School of MedicineUniversity of CaliforniaLos AngelesCAUSA Molecular Biology InstituteBrain Research InstituteMary S.Easton Center for Alzheimer’s ResearchUniversity of CaliforniaLos AngelesCAUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2024年第19卷第5期

页      面：959-960页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

主　　题：pathological diseases 

摘      要：The build-up of misfoldedα-synuclein(α-syn)in the central nervous system is the pathological hallmark of a number of neurodegenerative diseases that are known asα-*** include Parkinson’s disease(PD),Parkinson’s disease with dementia(PDD),dementia with Lewy body(LB),multiple system atrophy(MSA),and a subset of Alzheimer’s *** evidence underscores that the intercellular transmission and amplification of pathologicalα-syn are critical processes underlying the progression ofα-synucleinopathies(Peng et al.,2020),and as such,the study of these processes could lead to the identification of promising therapeutics to mitigate disease *** previous studies have focused solely on pathological seeds in relation to disease progression.