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Role of copper chelating agents: between old applications and new perspectives in neuroscience

Neural Regeneration Research 2025年第3期20卷 751-762页

作者： Rosalba Leuci Leonardo Brunetti Vincenzo Tufarelli Marco Cerini Marco Paparella Nikola Puvača Luca Piemontese department of Pharmacy-Pharmaceutical Science University of Bari Aldo MoroBariItaly department of Precision and Regenerative Medicine and Jonian Area(DiMePRe-J) Section of Veterinary Science and Animal ProductionUniversity of Bari Aldo MoroBariItaly department of Engineering management in Biotechnology Faculty of Economics and Engineering Management in Novi SadUniversity Business Academy in Novi SadNovi SadSerbia

The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.

关键词： agriculture Alzheimer's disease chelators copper feed supplements multi-target

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A test on adverse selection of farmers in crop insurance:Results from Inner Mongolia,China

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Journal of Integrative Agriculture 2017年第2期16卷 478-485页

作者： ZHAO Yuan-feng CHAI Zhi-hui Michael S.Delgado Paul V.Preckel College of economics and management Inner Mongolia Agricultural University department of agricultural economics Purdue University

Adverse selection is an operating risk of crop insurance. Based on survey data on crop insurance collected by questionnaires in Inner Mongolia, China, the paper uses non-parametric analysis and econometric models to estimate the relationship between conditions for crop production and farmers＇ insurance decision in order to test the existence of farmers＇ adverse selection. The results show farmers＇ adverse selection does exist, but settling a claim by negotiation and premium subsidy from governments at all levels can defuse farmers＇ adverse selection under the current system of crop insurance. Risk regionalization, heterogeneous insurance contract and product innovation may decrease adverse selection to some extent.

关键词： crop insurance farmers adverse selection

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Price transmission in hog and feed markets of China

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Journal of Integrative Agriculture 2015年第6期14卷 1122-1129页

作者： ZHOU De Dieter Koemle College of economics and management Nanjing Agricultural University department of agricultural economics and Rural Development University of Gttingen

There is an increasing demand for feed as the industrialization of hog production in China. Land scarcity limits China＇s ability to continue increasing its hog production without feed imports, particularly soybean, and the feed markets are increasingly integrated into the global market. This study performs an analysis of price transmission between the hog price in China and feed prices, specifically domestic maize price and international soybean price, from January 2000 to April 2014. We identified a long-term stable equilibrium relationship between the three markets. However, further analyses show that there is no significant Granger causality between hog and feed market, and the long-run equilibrium partially results from Granger causality between the international soybean market and domestic maize market. This suggests that the domestic hog market has been distorted by different policies. The results also indicate that the efficiency of price transmission is very low and it takes about 11 months to correct one-half of any long-run disequilibrium for the hog market in China. Therefore, to stabilize hog price in China, only market intervention to regulate the maize and soybean markets would be insufficient and comprehensive measures need to be taken into account such as hog production modernization, agricultural insurance, epidemic surveillance etc.

关键词： soybean maize prices surveillance scarcity imports modernization insurance agricultural stabilize

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What determines irrigation efficiency when farmers face extreme weather events? A field survey of the major wheat producing regions in China

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Journal of Integrative Agriculture 2018年第8期17卷 1888-1899页

作者： SONG Chun-xiao Les Oxley MA Heng-yun College of economics and management Henan Agricultural University department of economics and Finance University of Waikato

Water availability is a major constraint on grain production in China, therefore, improving irrigation efficiency is particularly important when agriculture faces extreme weather events. This paper first calculates irrigation efficiency with a translog stochastic frontier production function and then investigates what happens when extreme weather events occur via a Tobit model. The estimated results reveal several important features of irrigation practices: i) irrigation efficiency is lower when extreme weather events occur; ii) large variations in irrigation efficiency occur across irrigation facilities; iii) the farm plots exhibit an extreme distribution across efficiency levels; and iv) water-saving techniques, technology adoption, and the maintenance of farmers’ economic resilience are major determinants of irrigation efficiency. Based on these results we propose the following recommendations: i) farmers should balance crop yield and water use; undertake relevant training programs and adopt water-saving techniques; ii) local governments and researchers should help farmers to find the optimal level of irrigation water use based on their own circumstances and provide better water-saving techniques and training programs rather than simply encouraging farmers to invest in irrigation facilities in the most extreme weather years; and iii) the income level of farm households should be increased so as to improve their resilience to natural disasters.

关键词： irrigation efficiency determinants irrigation facilities water-saving techniques extreme weather events

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The puzzle of the missing meat: Food away from home and China's meat statistics

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Journal of Integrative Agriculture 2015年第6期14卷 1033-1044页

作者： XIAO Hong-bo CHEN Qiong WANG Ji-min Les Oxley MA Heng-yun School of economics and management Beijing University of Agriculture Institute of Rural Economy and agricultural Regional Planning Tianjin Academy of Agricultural Sciences Institute of agricultural economics and Development Chinese Academy of Agricultural Sciences department of economics University of Waikato College of economics and management Henan Agricultural University

From 1985, an increasing gap has emerged between the official statistical measures of meat production and meat consumption in China, which has raised concerns from many researchers using such data. In this paper we report the results of 428 observations（survey of 107 urban and rural households×4 quarters） from 7 provinces conducted in 2010, and compare them with the official statistical data from the National Bureau of Statistics of China（NBSC）. We conclude that the main reason for the discrepancy is due to the underreporting of consumption, which is due mainly to the omission of consumption away from home.

关键词： consumed quarters capita official household income missing puzzle Bureau raised

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Productivity effect and overuse of pesticide in crop production in China

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Journal of Integrative Agriculture 2015年第9期14卷 1903-1910页

作者： ZHANG Chao Guanming Shi SHEN Jian HU Rui-fa School of management and economics Beijing Institute of Technology department of agricultural and Applied economics University of Wisconsin

Chinese farmers are often accused of overusing pesticides that play a crucial role in enhancing crop yield by reducing losses to crop pests. Pesticide overuse has caused a series of negative health and environmental externalities. This paper quantiifes the productivity effect and the optimal amount of pesticides in rice, cotton and maize production in China from the economic perspective. Using survey data col ected in 2012 and 2013, both Cobb-Douglas and Weibul damage control speciifcations are used to estimate the production function. Results show that pesticides have statistical y signiifcant pro-ductivity effect on crop yield. On the condition of Weibul damage control speciifcations, the marginal products of 1 kg of the active ingredients of pesticides for rice, cotton and maize are 71.06, 22.73 and 98.45 kg, respectively. However, 57, 64 and 17%of the actual amount of pesticides are overused for rice, cotton and maize, respectively. Moreover, the productivity effect of pesticides would be overestimated using Cobb-Douglas speciifcation without incorporating a damage control agent.

关键词： productivity effect damage control agent pesticide overuse marginal product

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Improve access to the EU market by identifying French consumer preference for fresh fruit from China

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Journal of Integrative Agriculture 2018年第6期17卷 1463-1474页

作者： WANG Er-peng Zhifeng Gao Yan Heng School of economics and management Nanjing Tech University College of economics and management Jilin Agricultural University Food and Resource economics department University of Florida

Most previous studies have investigated country-of-origin effect for agricultural products from the economically developed country, but few have focused on the impact of country-of-origin on agricultural products from economically developing countries. Using a national online survey in France, we determine French consumers＇ perceptions and preferences for fresh fruit from China. Results of ordered logit models show that fresh fruit from China was perceived as low quality and unsafe. Respondents who care about country-of-origin were less likely to purchase fresh fruit from China, while those who care about brand were more likely to buy Chinese fresh fruit. Risk perception and quality perception both had a significant impact on the purchase of Chinese fresh fruit. Results of latent class models obtained with key consumer demographics show that heterogeneous preferences exist among different consumer groups. The results provide critical information to both China and other economically developing countries in their efforts to improve market penetration in economically developed countries.

关键词： country of origin perception consumer preference fresh fruit China

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Technical efficiency and its determinants in China's hog production

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Journal of Integrative Agriculture 2015年第6期14卷 1057-1068页

作者： TIAN Xu SUN Fei-fei ZHOU Ying-heng College of economics and management Nanjing Agricultural University

China＇s hog production is undergoing a great transformation due to the soaring demand and changing raising system. Regarding the essential role of pork in Chinese diet, a systematic analysis on the productivity and efficiency of hog production can provide significant implications for policy makers. This paper investigates the productivity and efficiency of hog production and the determinants of technical efficiency in China using a household level panel data（2004–2010）. A stochastic frontier translog production function with scaling property in inefficiency term is adopted for hog production analysis, and the determinants of technical efficiency are incorporated in a one-step estimation using maximum likelihood estimation. Our results show that the average technical efficiency of hog production in China is 0.5914. More importantly, we find that specialized farmers have higher technical efficiency than others, and technical efficiency in the eastern region is higher than that in Central and West China.

关键词： frontier specialized household stochastic productivity panel raising husbandry scaling incorporated

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Factors influencing hybrid maize farmers' risk attitudes and their perceptions in Punjab Province,Pakistan

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Journal of Integrative Agriculture 2018年第6期17卷 1454-1462页

作者： Shoaib Akhtar LI Gu-cheng Raza Ullah Adnan Nazir Muhammad Amjed Iqbal Muhammad Haseeb Raza Nadeem Iqbal Muhammad Faisal College of economics & management Huazhong Agricultural University Institute of agricultural and Resource economics University of Agriculture Faisalabad The management School Lancaster University

Hybrid maize farmers have to face diverse kinds of climate, biological, price and financial risks. Farmers＇ risk perceptions and risk attitudes are essential elements influencing farm operations and management decisions. However, this important issue has been overlooked in the contemporary studies and therefore there is a dearth of literature on this important issue. The present research is therefore, an attempt to fill this gap. This study aims to quantify hybrid maize farmers＇ perceptions of disastrous risks, their attitudes towards risk and to explore the impacts of various farm and farm household factors on farmers＇ risk attitudes and risk perceptions. The present study is conducted in four hybrid maize growing districts of Punjab Province, Pakistan, using cross-sectional data of 400 hybrid maize farmers. Risk matrix and equally likely certainty equivalent （ELCE） method are used to rank farmers＇ perceptions of four catastrophic risk sources including climate, biological, price and financial risks and to investigate farmers＇ risk aversion attitudes, respectively. Furthermore, probit regression is used to analyze the determinants affecting farmers＇ risk attitudes and risk perceptions. The results of the study showed that majority of farmers are risk averse in nature and perceive price, biological and climate to be potential sources of risks to their farm enterprise. In addition, analysis divulges that distance from farm to main market, off-farm income, location dummies for Sahiwal and Okara, age, maize farming experience, access to extension agent, significantly （either negatively or positively） influence farmers＇ risk attitudes and risk perceptions. The study delivers valuable insights for farmers, agricultural insurance sector, extension services researchers and agricultural policy makers about the local understanding of risks to hybrid maize crop in developing countries, like Pakistan, and have implications for research on farmers＇ adaptation to exposed risks.

关键词： risk perceptions risk attitude hybrid maize determinants Punjab Pakistan

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Demographics, societal aging, and meat consumption in China

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Journal of Integrative Agriculture 2015年第6期14卷 995-1007页

作者： MIN Shi BAI Jun-fei James Seale Jr. Thomas Wahl Institute of Development and agricultural economics Leibniz University Hannover College of economics and management China Agricultural University department of Food and Resource economics University of Florida department of Agribusiness and Applied economics North Dakota State University

Drawn on the data collected by surveying 1 340 urban households from six cities in China, this paper estimates the impacts of demographic structure and population aging on household meat consumption, by jointly considering meat consumed at home and away from home. Based on the trajectories of population, a simple simulation on meat demand trend in China is conducted subsequently. The results suggest： 1） Meat consumed away from home averagely accounts for near 30% of household total meat consumption in terms of quantity, so that its omission likely leads to a significant underestimate of total meat consumption and misunderstanding the driving forces; 2） population aging significantly and negatively affects per capita meat consumption, suggesting that the expected meat demand in China without considering population aging will be overestimated. The findings from this study have important implications for better understanding the relative issues on China＇s meat consumption under the situation of population aging.

关键词： capita household consumed income demographic jointly likely surveying estimates proportion

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