检索结果-南通市图书馆

Impact of umbelliprenin-containing niosome nanoparticles on VEGF-A and CTGF genes expression in retinal pigment epithelium cells

引用

International Journal of Ophthalmology(English edition) 2024年第1期17卷 7-15页

作者： Farzad Dastaviz Akram Vahidi Teymoor Khosravi Ayyoob Khosravi Mehdi Sheikh Arabi Abouzar Bagheri Mohsen Rashidi Morteza Oladnabi Stem Cell Research Center Golestan University of Medical SciencesGorgan ***Iran department of Medical Genetics School of Advanced Technologies in MedicineGolestan University of Medical SciencesGorgan ***Iran Student Research Committee Golestan University of Medical SciencesGorgan ***Iran department of Molecular Medicine Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran department of Medical Nanotechnology Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran department of Clinical Biochemistry and Genetics Faculty of MedicineMazandaran University of Medical SciencesSari ***Iran department Pharmacology Faculty of MedicineMazandaran University of Medical SciencesSari ***Iran Gorgan Congenital Malformations Research Center Golestan University of Medical SciencesGorgan ***Iran

AIM:To investigate the impact of niosome nanoparticles carrying umbelliprenin(UMB),an anti-angiogenic and anti-inflammatory plant compound,on the expression of vascular endothelial growth factor(VEGF-A)and connective tissue growth factor(CTGF)genes in a human retinal pigment epithelium(RPE)-like retina-derived cell ***:UMB-containing niosomes were created,optimized,and ***-like cells were treated with free UMB and UMB-containing *** IC_(50)values of the treatments were determined using an MTT *** expression of VEGF-A and CTGF was evaluated using real-time polymerase chain reaction after RNA extraction and cDNA ***’characteristics,including drug entrapment efficiency,size,dispersion index,and zeta potential were *** UMB had an IC_(50)of 96.2μg/mL,while UMB-containing niosomes had an IC_(50)of 25μg/***:Treatment with UMB-containing niosomes and free UMB resulted in a significant reduction in VEGF-A expression compared to control cells(P=0.001).Additionally,UMB-containing niosomes demonstrated a significant reduction in CTGF expression compared to control cells(P=0.05).However,there was no significant reduction in the expression of both genes in cells treated with free ***:Both free UMB and niosome-encapsulated UMB inhibits VEGF-A and CTGF genes ***,the latter demonstrates significantly greater efficacy,potentially due to the lower UMB dosage and gradual *** findings have implications for anti-angiogenesis therapeutic approaches targeting age-related macular degeneration.

关键词： umbelliprenin niosome age-related macular degeneration vascular endothelial growth factor-A connective tissue growth factor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Survey and Experimental Review on Data Distribution Strategies for Parallel Spatial Clustering Algorithms

引用

Journal of Computer Science & Technology 2024年第3期39卷 610-636页

作者： Jagat Sesh Challa Navneet Goyal Amogh Sharma Nikhil Sreekumar Sundar Balasubramaniam Poonam Goyal advanced Data Analytics and Parallel technologies Laboratory Birla Institute of Technology and Science Pilani 333031India Uber New York 11101U.S.A. Computer Science and Engineering department University of MinnesotaMinneapolis 55455U.S.A.

The advent of Big Data has led to the rapid growth in the usage of parallel clustering algorithms that work over distributed computing frameworks such as MPI,MapReduce,and *** important step for any parallel clustering algorithm is the distribution of data amongst the cluster *** step governs the methodology and performance of the entire *** typically use random,or a spatial/geometric distribution strategy like kd-tree based partitioning and grid-based partitioning,as per the requirements of the ***,these strategies are generic and are not tailor-made for any specific parallel clustering *** this paper,we give a very comprehensive literature survey of MPI-based parallel clustering algorithms with special reference to the specific data distribution strategies they *** also propose three new data distribution strategies namely Parameterized Dimensional Split for parallel density-based clustering algorithms like DBSCAN and OPTICS,Cell-Based Dimensional Split for dGridSLINK,which is a grid-based hierarchical clustering algorithm that exhibits efficiency for disjoint spatial distribution,and Projection-Based Split,which is a generic distribution *** of these preserve spatial locality,achieve disjoint partitioning,and ensure good data load *** experimental analysis shows the benefits of using the proposed data distribution strategies for algorithms they are designed for,based on which we give appropriate recommendations for their usage.

关键词： parallel data mining data distribution parallel clustering spatial locality preservation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Energy and blast performance of beryllium in a model thermobaric composition in comparison with aluminum and magnesium

引用

Defence Technology（防务技术） 2024年第6期36卷 13-19页

作者： Thomas M.Klapotke Stanisław Cudziło Waldemar A.Trzcinski Jozef Paszula Energetic Materials Research Department of ChemistryUniversity of Munich(LMU)Butenandtstrasse 5-13(D)81377MunichGermany Military University of Technology Faculty of Advanced Technologies and ChemistrySylwester Kaliski Str.200-908WarsawPoland

A direct comparison is made between the effectiveness of Al,Mg,and Be powders as additional fuels in model thermobaric compositions containing 20%fuel,20%ammonium perchlorate,and 60%RDX(1,3,5-Trinitro-1,3,5-triazacyclohexane)passivated with *** determined calorimetric measurements of the heat of detonation,along with the overpressure histories in an explosion chamber filled with nitrogen,were used to determine the quasi-static pressure(QSP)under anaerobic *** measurements were also performed in a semi-closed bunker,and all blast wave parameters generated after the detonation of 500 g charges of the tested explosives were *** calorimetry results,QSP values,and blast wave parameters(pressure amplitude,specific and total impulses)clearly indicate that Be is much more effective as an additional fuel than either Al or Mg in both anaerobic post-detonation reactions as well as the subsequent aerobic *** heat of detonation of the RDXwax/AP/Be explosive mixture is over 40%and 50%higher than that of the mixture containing aluminum and magnesium instead of beryllium,***,the TNT equivalent of the Be-containing composition due to the overpressure in the nitrogen-filled explosion chamber is 1.66,while the equivalent calculated using an air shock wave-specific impulse at a distance of 2.5 m is equal to *** high values of these parameters confirm the high reactivity of beryllium in both the anaerobic and aerobic stages of the thermobaric explosion.

关键词： Thermobaric explosives Beryllium Heat of detonation Quasi-static overpressure Blast wave parameters

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pressure Distinguishes the Dual Emissions in Pseudohalide 2D Ruddlesden-Popper Perovskite Cs_(2)Pb(SCN)_(2)Br_(2)

引用

CCS Chemistry 2024年第7期6卷 1748-1756页

作者： Songhao Guo Yuhong Mao Congcong Chen Yao Zhang Guoxiang Zhao Kejun Bu Qingyang Hu Haiming Zhu Guifu Zou Wenge Yang Lingling Mao Xujie Lü Center for High Pressure Science and Technology advanced Research(HPSTAR) Shanghai department of Chemistry Southern University of Science and TechnologyShenzhen department of Chemistry Zhejiang UniversityHangzhou College of Energy Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu ProvinceSoochow UniversitySuzhou

Two-dimensional(2D)Ruddlesden-Popper(RP)halide perovskites with diverse structures and properties have drawn increasing attention due to their promising optoelectronic ***,a new all-inorganic Cs_(2)Pb(SCN)_(2)Br_(2) has been reported that opens up new potential for the development of 2D RP ***,recent reports of unusual dual emissions and two-edge absorption in Cs_(2)Pb(SCN)_(2)Br_(2) have generated intense debate about its origin and remains ***,by combining continuous pressure tuning with in situ diagnostics,we have unambiguously revealed the underlying mechanisms that the 2D Cs_(2)Pb(SCN)_(2)Br_(2) exhibits an intrinsic blue emission at 2.66 eV and an absorption edge close to the emission *** the gradually formed CsPbBr_(3) is responsible for the green emission at 2.33 eV with the absorption shoulder at 2.41 ***,by fitting the temperature-dependent intensity of the intrinsic blue emission,we have determined the corrected value of exciton binding energy for 2D Cs_(2)Pb(SCN)_(2)Br_(2) to be 90 ***,an emission enhancement of 2.5 times is achieved in Cs_(2)Pb(SCN)_(2)Br_(2) under a mild pressure within 0.8 GPa,caused by the pressuresuppressed exciton-phonon *** work not only elucidates the origin of the dual emissions and two-edge absorption in Cs_(2)Pb(SCN)_(2)Br_(2),but it also provides a potential means to regulate and optimize the optoelectronic properties of 2D perovskites.

关键词： two-dimensional perovskite dual emissions two-edge absorption high pressure in situ characterization enhanced photoluminescence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Niosome-encapsulated auraptene reduced the mRNA expression of VEGF-A and PDGFs genes in human retinaderived RPE cell line

引用

International Journal of Ophthalmology(English edition) 2024年第6期17卷 1028-1035页

作者： Akram Vahidi Teymoor Khosravi Farzad Dastaviz Mehdi Sheikh Arabi Ayyoob Khosravi Morteza Oladnabi Student Research Committee Golestan University of Medical SciencesGorgan ***Iran department of Medical Nanotechnology Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Stem Cell Research Center Golestan University of Medical SciencesGorgan ***Iran department of Molecular Medicine Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Gorgan Congenital Malformations Research Center Golestan University of Medical SciencesGorgan ***Iran

AIM:To evaluate the effect of auraptene(AUR)treatment in forms of free and encapsulated in niosome nanoparticles by investigating the mRNA expression level of vascular endothelium growth factor(VEGF)-A and platelet-derived growth factors(PDGFs)in human retinal pigment epithelium(RPE)cell ***:Niosome nanocarriers were produced using two surfactants Span 60 and Tween *** cell line was treated with both free AUR and *** dosage of treatments was calculated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)*** of VEGF-A and PDGF-A,PDGF-B,PDGF-C,PDGF-D genes was measured after total RNA extraction and cDNA synthesis,using real-time polymerase chain reaction(RT-PCR).RESULTS:The highest entrapment efficiency(EE)was achieved by Span 60:cholesterol(1:1)with 64.3%.The half maximal inhibitory concentration(IC50)of free and niosome-encapsulated AUR were 38.5 and 27.78µg/mL,*** study revealed that niosomal AUR had more gradual delivery to the ***-PCR results showed reduced expression levels of VEGF-A,PDGF-A,PDGF-B,PDGF-C,and PDGF-D after treatment with both free and niosomal ***:Niosomal formulation of Span 60:cholesterol(1:1)is an effective drug delivery approach to transfer AUR to RPE ***-A,PDGF-A,PDGF-B,PDGF-C,and PDGF-D are four angiogenic factors,inhibiting which by niosomal AUR may be effective in age-related macular degeneration.

关键词： auraptene niosome age-related macular degeneration angiogenesis nanocarrier

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Magnetic-biased chiral molecules enabling highly oriented photovoltaic perovskites

引用

National Science Review 2024年第2期11卷 221-230页

作者： Jing Chen Caner Deger Zhen-Huang Su Kai-Li Wang Guang-Peng Zhu Jun-Jie Wu Bing-Chen He Chun-Hao Chen Tao Wang Xing-Yu Gao Ilhan Yavuz Yan-Hui Lou Zhao-Kui Wang Liang-Sheng Liao Institute of Functional Nano&Soft Materials(FUNSOM) Laboratory of Advanced Negative Carbon TechnologiesSoochow University department of Physics Marmara University Shanghai Synchrotron Radiation Facility(SSRF) Shanghai Advanced Research InstituteChinese Academy of Sciences College of Energy Soochow Institute for Energy and Materials Innovations Soochow University Macao Institute of Materials Science and Engineering Macau University of Science and Technology

The interaction between sites A, B and X with passivation molecules is restricted when the conventional passivation strategy is applied in perovskite（ABX3） photovoltaics. Fortunately, the revolving A-site presents an opportunity to strengthen this interaction by utilizing an external field. Herein, we propose a novel approach to achieving an ordered magnetic dipole moment, which is regulated by a magnetic field via the coupling effect between the chiral passivation molecule and the A-site（formamidine ion） in *** strategy can increase the molecular interaction energy by approximately four times and ensure a well-ordered molecular arrangement. The quality of the deposited perovskite film is significantly optimized with inhibited nonradiative recombination. It manages to reduce the open-circuit voltage loss of photovoltaic devices to 360 mV and increase the power conversion efficiency to 25.22%. This finding provides a new insight into the exploration of A-sites in perovskites and offers a novel route to improving the device performance of perovskite photovoltaics.

关键词： perovskite photovoltaics magnetic moment A-site regulation chiral molecules

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Managing the surge:A comprehensive review of the entire disposal framework for retired lithium-ion batteries from electric vehicles

引用

Journal of Energy Chemistry 2024年第5期92卷 648-680页

作者： Ruohan Guo Feng Wang M.Akbar Rhamdhani Yiming Xu Weixiang Shen department of Engineering technologies School of ScienceComputing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia department of Chemistry and Biotechnology School of ScienceComputing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia department Mechanical and Product Design Engineering School of EngineeringSwinburne University of TechnologyMelbourne VIC 3122Australia

Anticipating the imminent surge of retired lithium-ion batteries(R-LIBs)from electric vehicles,the need for safe,cost-effective and environmentally friendly disposal technologies has *** paper seeks to offer a comprehensive overview of the entire disposal framework for R-LIBs,encompassing a broad spectrum of activities,including screening,repurposing and ***,we delve deeply into a thorough examination of current screening technologies,shifting the focus from a mere enumeration of screening methods to the exploration of the strategies for enhancing screening ***,we outline battery repurposing with associated key factors,summarizing stationary applications and sizing methods for R-LIBs in their second life.A particular light is shed on available reconditioning solutions,demonstrating their great potential in facilitating battery safety and lifetime in repurposing scenarios and identifying their techno-economic *** the realm of battery recycling,we present an extensive survey of pre-treatment options and subsequent material recovery ***,we introduce several global leading recyclers to illustrate their industrial processes and technical ***,relevant challenges and evolving trends are investigated in pursuit of a sustainable end-of-life management and disposal *** hope that this study can serve as a valuable resource for researchers,industry professionals and policymakers in this field,ultimately facilitating the adoption of proper disposal practices.

关键词： Lithium-ion battery Battery reproposing and recycling Miaieiials recovery technologies Techno-economic issues End-of-life management Disposal framework

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Antisense therapy:a potential breakthrough in the treatment of neurodegenerative diseases

引用

Neural Regeneration Research 2024年第5期19卷 1027-1035页

作者： Roberta Romano Cecilia Bucci department of Biological and Environmental Sciences and technologies(DiSTeBA) University of SalentoLecceItaly

Neurodegenerative diseases are a group of disorders characterized by the progressive degeneration of neurons in the central or peripheral nervous ***,there is no cure for neurodegenerative diseases and this means a heavy burden for patients and the health system ***,it is necessary to find new therapeutic approaches,and antisense therapies offer this possibility,having the great advantage of not modifying cellular genome and potentially being *** preclinical and clinical studies aim to test the safety and effectiveness of antisense therapies in the treatment of neurodegenerative *** objective of this review is to summarize the recent advances in the development of these new technologies to treat the most common neurodegenerative diseases,with a focus on those antisense therapies that have already received the approval of the *** and Drug Administration.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis antisense oligonucleotide Huntington’s disease neurodegenerative disorders Parkinson’s disease siRNA

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cryptanalysis of DBST, a lightweight block cipher

引用

Frontiers of Computer Science 2024年第4期18卷 219-221页

作者： Sadegh SADEGHI Nasour BAGHERI department of Mathematics Institute for Advanced Studies in Basic Sciences(IASBS)Zanjan 45137-66731Iran Research Center for Basic Sciences and Modern technologies(RBST) Institute for Advanced Studies in Basic Sciences(IASBS)Zanjan 45137-66731Iran Electrical Engineering department Shahid Rajaee Teacher Training UniversityTehran 16788-15811Iran School of Computer Science(SCS) Institute for Research in Fundamental Sciences(IPM)Tehran 19395-5531Iran

1 Introduction Conventional cryptographic primitives are not suitable for resource-constrained ***,numerous lightweight primitives have been proposed over the past decade,specifically tailored for such ***,such ciphers would not be used in a real-world application unless they were thoroughly tested for security against existing *** this direction,DBST[1]cipher has been recently proposed by Yan et *** balance security,cost,and efficiency,DBST has implemented a novel 4-branch generalized Feistel variant *** this structure,a 2-branch XOR operation has been incorporated in the middle section,establishing interconnections between all *** the other hand,by leveraging the bit-slice technique and subkeys,the algorithm introduces an innovative approach to constructing a dynamic S-box *** designers of DBST cipher have extensively investigated its resistance to known attacks such as linear and differential cryptanalysis,as well as impossible differential cryptanalysis,among *** them,the objective of differential cryptanalysis[2]is to identify high-probability characteristics in the plaintext that are transmitted to the ciphertext,known as distinguishers.

关键词： structure. primitive branch

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dual-symmetry-perturbed all-dielectric resonant metasurfaces for high-Q perfect light absorption

引用

Chinese Optics Letters 2024年第2期22卷 200-206页

作者：葛俊洋高一骁徐雷周宁沈祥 Laboratory of Infrared Materials and Devices Research Institute of Advanced TechnologiesNingbo UniversityNingbo 315211China Key Laboratory of Photoelectric Detection Materials and Devices of Zhejiang Province Ningbo 315211China advanced Optics&Photonics Laboratory Department of EngineeringSchool of Science and TechnologyNottingham Trent UniversityNottingham NG118NSUK School of Physics and Optoelectronic Engineering Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Ningbo Institute of Oceanography Ningbo 315832China

We demonstrate a high-Q perfect light absorber based on all-dielectric doubly-resonant *** bound states in the continuum(BICs)protected by different symmetries,we manage to independently manipulate the Q factors of the two degenerate quasi-BICs through dual-symmetry perturbations,achieving precise matching of the radiative and nonradiative Q factors for degenerate critical *** achieve a narrowband light absorption with a>600 Q factor and a>99%absorptance atλ_(0)=1550 nm on an asymmetric germanium metasurface with a 0.2λ_(0)*** work provides a new strategy for engineering multiresonant metasurfaces for narrowband light absorption and nonlinear applications.

关键词： resonant metasurface perfect light absorption bound states in the continuum

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：