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Helicobacter pylori:High dose amoxicillin does not improve primary or secondary eradication rates in an Irish cohort

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World Journal of Clinical Cases 2024年第16期12卷 2773-2779页

作者： Conor Costigan Aoife M O'Sullivan Jim O'Connell Shreyashee Sengupta Thomas Butler Stephen Molloy Fintan John O'Hara Barbara Ryan Niall Breslin Sarah O'Donnell Anthony O'Connor Sinead Smith Deirdre McNamara Trinity academic Gastroenterology Group School of Medicine-Trinity College DublinDublin D2Ireland department of Gastroenterology Tallaght University HospitalDublin D24 NR0AIreland

BACKGROUND Helicobacter pylori(***)eradication rates have fallen globally,likely in large part due to increasing antibiotic resistance to traditional *** areas of high clarithromycin and metronidazole resistance such as ours,Maastricht VI guidelines suggest high dose amoxicillin dual therapy(HDADT)can be considered,subject to evidence for local *** this study we assess efficacy of HDADT therapy for *** eradication in an Irish *** To assess the efficacy of HDADT therapy for *** eradication in an Irish cohort as both first line,and subsequent therapy for patients diagnosed with *** All patients testing positive for *** in a tertiary centre were treated prospectively with HDADT(amoxicillin 1 g tid and esomeprazole 40 mg bid×14 d)over a period of 8 *** was confirmed with Urea Breath Test at least 4 wk after cessation of therapy.A delta-over-baseline>4%was considered *** demographics and treatment outcomes were recorded,analysed and controlled for basic demographics and prior *** *** One hundred and ninety-eight patients were identified with *** infection,10 patients were excluded due to penicillin allergy and 38 patients refused follow up *** all 139 were included in the analysis,55%(n=76)were female,mean age was 46.6 ***,93(67%)of patients were treatment-naïve and 46(33%)had received at least one previous course of *** groups were statistically ***-reported compliance with HDADT was 97%,mild side-effects occurred in 7%.There were no serious adverse drug *** the eradication rate for our cohort was 56%(78/139).Eradication rates were worse for those with previous treatment[43%(20/46)vs 62%(58/93),P=0.0458,odds ratio=2.15].Age and Gender had no effect on eradication *** Overall eradication rates with HDADT were *** being a simple and possibly better tolerated regime,these results do not

关键词： Helicobacter pylori eradication Helicobacter pylori High dose amoxicillin High dose amoxicillin dual therapy Triple therapy

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Mediating function of heart failure in the causal relationship between diastolic blood pressure and hypertensive renal disease with renal failure:a mediated Mendelian randomization study

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Frontiers of Nursing 2024年第3期11卷 285-294页

作者： Lei Pang Zi-Jun Ding Hong-Qiang Chai Fei Li Ming Wu Wei-Bing Shuang department of Urology The Fifth Hospital of Shanxi Medical University(Shanxi Provincial People’s Hospital)TaiyuanShanxi 030012China First Clinical Medical College of Shanxi Medical University TaiyuanShanxi 030012China department of neonatology Shanxi Children’s HospitalTaiyuanShanxi 030013China department of Urology The First Hospital of Shanxi Medical UniversityTaiyuanShanxi 030012China

Objective:To study the causality relationship between diastolic blood pressure(DBP)and hypertensive renal disease with renal failure(HRDRF)and the mediating role of hear t failure(HF)in the causality relationship by network Mendelian randomization(MR).Methods:Genome-wide analysis of DBP,HRDRF,and HF was downloaded from the public database(Genome-Wide Analysis Study[GWAS])and was used to analyze the results and to conduct mediated MR ***:Analysis showed that DBP was positively correlated with HRDRF(OR=1.0002,95%CI:1.0001–1.0003,P=1.8076e-05)and DBP was positively correlated with HF(OR=1.0295,95%CI:1.0221–1.0370,P=2.5292e-15).HF and HRDRF had a positive causal effect(OR=1.0001,95%CI:1.0000–1.0001,P=0.0152).Mediation analysis showed that the contribution ratio of HF to the combined effect of DBP and HRDRF was 24.69%.Conclusions:DBP can increase the risk of renal disease with renal failure,and HF may play an impor tant role in mediating this causal relationship.

关键词： atherosclerotic heart disease diastolic blood pressure heart arrhythmia heart failure hypertensive renal disease with renal failure Mendelian randomization

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A Complex Fuzzy LSTM Network for Temporal-Related Forecasting Problems

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Computers, Materials & Continua 2024年第9期80卷 4173-4196页

作者： Nguyen Tho Thong Nguyen Van Quyet Cu Nguyen Giap Nguyen Long Giang Luong Thi Hong Lan Institute of Information Technology Vietnam Academy of Science and TechnologyHoang Quoc VietCau GiayHanoi100000Vietnam academic Affairs department Thai Nguyen University of EducationThai Nguyen250000Vietnam Center of Science and Technology Research and Development Thuongmai UniversityHo Tung MauCau GiayHanoi100000Vietnam Faculty of Information Technology Hanoi University of IndustryBac Tu LiemHanoi100000Vietnam

Time-stamped data is fast and constantly growing and it contains significant information thanks to the quick development ofmanagement platforms and systems based on the Internet and cutting-edge information communication *** the time series data including time series prediction has many practical *** new techniques were developed for use with various types of time series data in the prediction *** those,this work suggests a unique strategy to enhance predicting quality on time-series datasets that the timecycle matters by fusing deep learning methods with fuzzy *** order to increase forecasting accuracy on such type of time-series data,this study proposes integrating deep learning approaches with fuzzy ***,it combines the long short-termmemory network with the complex fuzzy set theory to create an innovative complex fuzzy long short-term memory model(CFLSTM).The proposed model adds a meaningful representation of the time cycle element thanks to a complex fuzzy set to advance the deep learning long short-term memory(LSTM)technique to have greater power for processing time series *** on standard common data sets and real-world data sets published in the UCI Machine Learning Repository demonstrated the proposedmodel’s utility compared to other well-known forecasting *** results of the comparisons supported the applicability of our proposed strategy for forecasting time series data.

关键词： Complex fuzzy set long short-term memory(LSTM) CFLSTM T-CFLSTM

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Pattern of Potential Laboratory Markers for COVID-19 in Eastern Sudan

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Open Journal of Epidemiology 2024年第3期14卷 508-516页

作者： Nazik Sir El Khatim Bakhit Suliman Mohammed Omer Abaker Gibreel Mervat Sir El Khatim Bakhit Suliman department of Clinical Chemistry College of Medical Laboratory Science Eastern Sudan University of Medical Science and Technology Port Sudan Sudan Dean of the Secretariat of academic Affairs Port Sudan Ahlia University Port Sudan Sudan Cardiology department Cath Lab Fujaira Hospital Fujaira UAE

Background: Coronavirus disease 2019 (COVID-19) is a recent global health crisis. One of the major issues of COVID-19 is its unpredictable manifestations and serious outcomes. Many hematological parameters are thought to change dramatically during the course of the disease. These include white blood cells, red blood cells, and platelets. This study aimed at evaluating certain laboratory results;peripheral blood lymphopenia, relative neutrophilia, high neutrophil-lymphocyte ratio, and elevated C-reactive protein as potential laboratory markers of COVID-19 in Eastern Sudanese patients. Methods: We, retrospectively, aimed at the evaluation of peripheral blood leucocytes count, neutrophil-lymphocyte ratio NLR and C-reactive protein (CRP) levels in confirmed COVID-19 eastern Sudanese patients during the course of the disease. Results: The mean total leucocytes count, % neutrophils count, absolute neutrophils count and C-reactive protein (CRP) were significantly higher (P. value = 0.000) in COVID-19 patients than in the control group while the mean % lymphocytes count and % mixed cells count were found to be significantly lower in COVID-19 patients than in the control group (P. value 0.000). Conclusion: Peripheral blood leucocyte alterations (simultaneous presence of lymphopenia, relative neutrophilia and high neutrophil lymphocyte ratio (NLR) along with elevated CRP levels may be valuable biomarkers associated with COVID-19 in Port Sudan city, Red Sea state, Sudan. These markers might be important in prediction, inspection of disease progression and prognosis.

关键词： COVID-19 SARS 2 WBCs CRP NLR Port Sudan

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Simulation of magnetization process and Faraday effect of magnetic bilayer films

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Chinese Physics B 2024年第9期33卷 590-597页

作者： Sheng Gao An Du Lei Zhang Tian-Guang Li Da-Cheng Ma department of Basic and General Studies Shenyang Institute of Science and TechnologyShenyang 110167China College of Science Northeastern UniversityShenyang 110819China National Frontiers Science Center for Industrial Intelligence and Systems Optimization Northeastern UniversityShenyang 110819China Office of academic Research Shenyang Institute of Science and TechnologyShenyang 110167China State Key Laboratory of Robotics Shenyang Institute of AutomationChinese Academy ofSciencesShenyang 110016China Institutes for Robotics and Intelligent Manufacturing Chinese Academy of SciencesShenyang110016China

We described ferromagnetic film and bilayer films composed of two ferromagnetic layers coupled through antiferromagnetic interfacial interaction by classical Heisenberg model and simulated their magnetization state,magnetic permeability,and Faraday effect at zero and finite temperature by using the Landau–Lifshitz–Gilbert(LLG)*** results indicate that in a microwave field with positive circular polarization,the ferromagnetic film has one resonance peak while the bilayer film has two resonance ***,the resonance peak disappears in ferromagnetic film,and only one resonance peak emerges in bilayer film in the negative circularly polarized microwave *** the microwave field’s frequency exceeds the film’s resonance frequency,the Faraday rotation angle of the ferromagnetic film is the greatest,and it decreases when the thickness of the two halves of the bilayer is *** the microwave field’s frequency remains constant,the Faraday rotation angle fluctuates with temperature in the same manner as spontaneous magnetization *** a DC magnetic field is applied in the direction of the anisotropic axis of the film,the Faraday rotation angle varies with the DC magnetic field and shows a similar shape of the hysteresis loop.

关键词： magnetic bilayer films magnetic permeability hysteresis loop Faraday effect Landau–Lifshitz– Gilbert (LLG) equation

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Analysis of the Current Situation and Influencing Factors of Physical Activity Among the Elderly in the Community

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Journal of Clinical and Nursing Research 2024年第6期8卷 345-350页

作者： Wei Dong Jialiang Wang Dongmei Cui Yanling Li Shaohua Li Zheng Li Physical Examination Center Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina department of Neurosurgery Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina department of Nursing Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina department of neonatology Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina department of Nephrology Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina

Objective:To explore the current situation of physical activity among elderly individuals in the community,identify influencing factors,and provide a theoretical basis for improving their physical activity levels in the ***:A questionnaire survey was conducted among 265 elderly community residents using the Physical Activity Scale for the ***:The median(p50)score on the Physical Activity Scale for the Elderly was 220.425,indicating a high level of physical *** was no statistically significant difference in physical activity levels between ***:Elderly individuals should be supported in actively and scientifically participating in physical activities to mitigate physical function decline and achieve successful aging.

关键词： Community Elderly Physical activity

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Multitarget Thiol-Activated Tetrapyridyl Gold(Ⅲ)Complexes for Hypoxic Cancer Therapy

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CCS Chemistry 2024年第3期6卷 783-797页

作者： Xue-Quan Zhou Selda Abyar Imma Carbo-Bague Lan Wang Sebastian Türck Maxime ASiegler Uttara Basu Ingo Ott Rongfang Liu Adriaan PIJzerman Sylvestre Bonnet Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate School(SIGS)Tsinghua UniversityShenzhen 518055 Leiden Institute of Chemistry Leiden University2333 CC Leiden department of Chemistry Simon Fraser UniversityBurnabyBritish Columbia V5A 1S6 Institute of Medicinal and Pharmaceutical Chemistry Technische Universität Braunschweig38106 Braunschweig department of Chemistry Johns Hopkins UniversityBaltimoreMaryland 21218 Division of Drug Discovery&Safety Leiden Academic Centre for Drug ResearchLeiden University2333 CC Leiden

Gold complexes have emerged as promising anticancer metallodrugs due to their efficient thioredoxin reductase(TrxR)inhibition,which disturbs the redox balance of cancer ***,in this model,the role of the ligand(s)coordinated to gold is often *** this work,we present a series of tetrapyridyl Au(Ⅲ)complexes that exhibit thiol-induced release of a Au(Ⅰ)ion and a tetrapyridyl *** formation of a free Au(Ⅰ)center is responsible for the expected TrxR ***,the released ligand,which was visible in cells due to its intense blue fluorescence,showed excellent binding properties to the hERG potassium ***,these ligands ended up in the lysosomes,resulting in significant lysosome ***,the Au(Ⅲ)complexes presented in this work showed broad-spectrum anticancer properties,both in hypoxic 2D monolayers and 3D tumor *** suggest that the interaction of the released Au(Ⅰ)center and the tetrapyridyl ligand with two different protein targets may combine into prodrugs that overcome hypoxia-induced drug deactivation.

关键词： anticancer Au(Ⅲ)complexes enzyme inhibtion potassium channel affinity lysosome damage cell imaging prodrug

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MSA-Lab:模型驱动的微服务集成设计平台

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软件学报 2024年第3期35卷 1280-1306页

作者：熊靖浏任秋蓉 Shmuel TYSZBEROWICZ 刘志明刘波西南大学计算机与信息科学学院软件研究与创新中心重庆400715 Software Engineering department Afeka Academic College of EngineeringTel-Aviv 6998812Israel 西北工业大学软件学院陕西西安710129

从单体系统迁移到微服务系统是当前业界对遗留系统实施再工程化的主流选项之一,基于单体遗留系统的微服务体系架构重构则是实现该迁移的关键步骤.目前学界多集中在微服务识别方法的研究上;业界虽有许多面向微服务架构的遗留系统重构的实... 详细信息

从单体系统迁移到微服务系统是当前业界对遗留系统实施再工程化的主流选项之一,基于单体遗留系统的微服务体系架构重构则是实现该迁移的关键步骤.目前学界多集中在微服务识别方法的研究上;业界虽有许多面向微服务架构的遗留系统重构的实践,但缺乏系统性的方法及高效鲁棒的工具.鉴于此,在微服务识别与模型驱动开发方法前期研究的基础上,研发一种模型驱动的、可用于单体遗留系统微服务化重构的集成设计平台MSA-Lab.它通过分析单体遗留系统运行日志中的方法调用序列,对其中的类和数据表进行类型识别和聚类以构造抽象微服务,同时生成包括微服务图和微服务序列图在内的系统架构设计模型.它包括用于微服务自动识别与设计模型自动生成的核心部件MSA-Generator,以及用于微服务静态结构模型与动态行为模型可视化展现、交互式建模、模型语法约束检验的核心部件MSA-Modeller.在MSA-Lab平台上,通过对4个开源项目实施有效性、鲁棒性、功能转换完备性等实验以及对3个同类型工具实施性能对比实验,结果表明:所提平台拥有很好的有效性、鲁棒性及实现面向日志的功能转换完备性,且性能更加优越.

关键词：微服务架构服务识别设计模型生成交互式建模工具软件设计评估

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Metaheuristic-Driven Two-Stage Ensemble Deep Learning for Lung/Colon Cancer Classification

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Computers, Materials & Continua 2024年第9期80卷 3855-3880页

作者： Pouyan Razmjouei Elaheh Moharamkhani Mohamad Hasanvand Maryam Daneshfar Mohammad Shokouhifar department of Electrical&Computer Engineering Valie-e-Asr University of RafsanjanKerman***Iran International academic Relations Office(IRO) Computer Science DepartmentUniversity of HalabjaHalabja46018Iraq department of Computer Engineering University of Mohaghegh ArdabiliArdabil***Iran department of Biomedical Engineering Islamic Azad University of MashhadMashhad***Iran department of Electrical&Computer Engineering Shahid Beheshti UniversityTehran***Iran

This study investigates the application of deep learning,ensemble learning,metaheuristic optimization,and image processing techniques for detecting lung and colon cancers,aiming to enhance treatment efficacy and improve survival *** introduce a metaheuristic-driven two-stage ensemble deep learning model for efficient lung/colon cancer *** diagnosis of lung and colon cancers is attempted using several unique indicators by different versions of deep Convolutional Neural Networks(CNNs)in feature extraction and model constructions,and utilizing the power of various Machine Learning(ML)algorithms for final ***,we consider different scenarios consisting of two-class colon cancer,three-class lung cancer,and fiveclass combined lung/colon cancer to conduct feature extraction using four *** extracted features are then integrated to create a comprehensive feature *** the next step,the optimization of the feature selection is conducted using a metaheuristic algorithm based on the Electric Eel Foraging Optimization(EEFO).This optimized feature subset is subsequently employed in various ML algorithms to determine the most effective ones through a rigorous evaluation *** top-performing algorithms are refined using the High-Performance Filter(HPF)and integrated into an ensemble learning framework employing weighted *** findings indicate that the proposed ensemble learning model significantly surpasses existing methods in classification accuracy across all datasets,achieving accuracies of 99.85%for the two-class,98.70%for the three-class,and 98.96%for the five-class datasets.

关键词： Lung cancer colon cancer feature selection electric eel foraging optimization deep learning ensemble learning

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Signaling pathways governing the behaviors of leukemia stem cells

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Genes & Diseases 2024年第2期11卷 830-846页

作者： Shirin Azizidoost Ava Nasrolahi Mohadeseh Sheykhi-Sabzehpoush Amir Anbiyaiee Seyed Esmaeil Khoshnam Maryam Farzaneh Shahab Uddin Atherosclerosis Research Center Ahvaz Jundishapur University of Medical SciencesAhvaz ***Iran Infectious Ophthalmologic Research Center Ahvaz Jundishapur University of Medical SciencesAhvaz ***Iran department of Laboratory Imam Khomeini Hospital ComplexTehran University of Medical SciencesTehran ***Iran department of Surgery School of MedicineAhvaz Jundishapur University of Medical SciencesAhvaz ***Iran Persian Gulf Physiology Research Center Medical Basic Sciences Research InstituteAhvaz Jundishapur University of Medical SciencesAhvaz ***Iran Fertility Infertility and Perinatology Research CenterAhvaz Jundishapur University of Medical SciencesAhvaz ***Iran Translational Research Institute and Dermatology Institute Academic Health SystemHamad Medical CorporationDoha 3050Qatar

Leukemia is a malignancy in the blood that develops from the lymphatic system and bone *** various treatment options have been used for different types of leukemia,understanding the molecular pathways involved in the development and progression of leukemia is *** studies showed that leukemia stem cells(LSCs)play essential roles in the pathogenesis of leukemia by targeting several signaling pathways,including Notch,Wnt,Hedgehog,and *** are highly proliferative cells that stimulate tumor initiation,migration,EMT,and drug *** review summarizes cellular pathways that stimulate and prevent LSCs'self-renewal,metastasis,and tumorigenesis.

关键词： Leukemia Leukemia stem cells Pathogenesis Signaling pathways Stem cells

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