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Identifying the Key Nodes of HIV Molecular Transmission Network Among Men Who Have Sex with Men—Guangzhou,Guangdong Province,China,2015–2017

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China CDC weekly 2021年第38期3卷 803-807,I0007,I0008页

作者： Juan Yang Zhigang Han Huifang Xu Hui Xing Peng Xu Weibin Cheng Yuzhou Gu Fan Lyu The National Center for aids/STD control and prevention Chinese Center for Disease Control and PreventionBeijingChina department of HIV/aids control and prevention Center for Disease Control and PreventionGuangzhouGuangdongChina.

Summary What is already known about this topic?Identifying the most influential spreaders in human immunodeficiency virus(HIV)transmission networks is crucial for developing effective prevention *** is added by this report?This study identified key nodes of the HIV molecular transmission network among men who have sex with men(MSM)by utilizing linkages between sequences to reconstruct the transmission network at the molecular level.

关键词： utilizing prevention network

Trends in Incidence of HIV and Syphilis Among Men Who Have Sex with Men—Tianjin Municipality,China,2013-2022

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China CDC weekly 2024年第27期6卷 651-657页

作者： Yan Guo Fangfang Chen Hui Gong Ziming Wu Xinying Zhang Tielin Ning Zhongquan Liu Jianyun Bai Long Li Jie Yang Fangning Zhao Jinyu Hou Maohe Yu Houlin Tang STD&aids control and prevention Section Tianjin Center for Disease Control and PreventionTianjinChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijingChina STD&aids control and prevention department Tianjin Hongqiao District Center for Disease Control and PreventionTianjinChina Tianjin Shenlan Public Health Counseling Service Center TianjinChina Tianjin Key Laboratory of Pathogenic Microbiology of Infectious Disease Tianjin Centers for Disease Control and PreventionTianjinChina

Summary What is already known about this topic?Given the common modes of transmission,outbreaks of both human immunodeficiency virus(HIV)and syphilis are primarily observed in men who have sex with men(MSM).However,minimal research has been conducted to concurrently evaluate the rates and trends of HIV and syphilis incidence within this community in *** is added by this report?

关键词： Incidence primarily immunodeficiency

Impact of acute vivax malaria on the immune system and viral load of HIV-positive subjects

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Chinese Medical Journal 2003年第12期116卷 1810-1820页

作者：陈小平肖斌权施文钧徐慧芳高凯饶纪礼张周斌 department of aids control and prevention

Objective To explore the mechanisms of malariotherapy for human immunodeficiency virus (HIV)-infected patients and to identify which stage(s) of HIV infection is suitable for the treatment of malariotherapy. Methods Therapeutic acute vivax malaria was induced and terminated after 10 fever episodes in 12 HIV-1-infected subjects: Group 1 (G1) had 5 patients with CD4 T-cell counts500/μl at baseline, Group 2 (G2) had 5 patients with CD4 at 499-200/μl and Group 3 had 2 patients with CD4aids patient in this group experienced clinical improvement after malariotherapy. Most of the 12 patients experienced increase of HIV viral load duri

关键词： HIV · malariotherapy · cytokine · immunophenotyping · viral load · vivax malaria

Diagnosis,Treatment,and Associated Factors Among Patients with HCV Infection—Jiangsu Province,China,2004–2020

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China CDC weekly 2024年第1期6卷 1-5,I0001-I0003页

作者： Dandan Yang Jing Lu Zhi Zhang Chuanwu Sun Zhuping Xu Yao Qi XiaoXia Liu Huan Ding Feifei Chai Zhengdong Zhang Baoli Zhu department of Genetic Toxicology The Key Laboratory of Modern Toxicology of Ministry of EducationCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing CityJiangsu ProvinceChina department of Sexually Transmitted Diseases and aids Center for Disease Control and Prevention of Jiangsu ProvinceNanjing CityJiangsu ProvinceChina department of Sexually Transmitted Diseases and aids Center for Disease Control and Prevention of XuzhouXuzhou CityJiangsu ProvinceChina department of Sexually Transmitted Diseases and aids Center for Disease Control and Prevention of WuxiWuxi CityJiangsu ProvinceChina department of Sexually Transmitted Diseases and aids Center for Disease Control and Prevention of YanchengYancheng CityJiangsu ProvinceChina department of Sexually Transmitted Diseases and aids Center for Disease Control and Prevention of ZhenjiangZhenjiang CityJiangsu ProvinceChina.

What is already known on this topic?The global efforts to address the hepatitis C virus(HCV)are progressing,but there are still significant gaps in the diagnosis and treatment of HCV,leading to an increasing number of deaths related to *** is added by this report?An extensive investigation was conducted to assess HCV RNA diagnosis,treatment uptake,and associated factors among individuals infected with HCV within Jiangsu *** study encompassed a large geographical area and utilized a substantial sample *** are the implications for public health practice?Implementing focused interventions to improve the timely diagnosis of HCV RNA and increase the uptake of HCV treatment could effectively reduce the future burden of HCV-related health problems,deaths,and healthcare *** is essential for achieving the global target of eliminating hepatitis C.

关键词： diagnosis utilized Jiangsu

Spatial-temporal Analysis of Tuberculosis at the Community Level in the Baoshan District, Shanghai 2014–2019

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Biomedical and Environmental Sciences 2022年第5期35卷 458-462页

作者： MA Zhi Tao WANG Na HE Fan LIU Xiao Feng SHEN Xin department of Tuberculosis and HIV/aids prevention Baoshan Centers for Disease Control and PreventionBaoshan 201901ShanghaiChina Division of Tuberculosis and HIV/aids prevention Shanghai Municipal Center for Disease Control and PreventionShanghai 200336China Shanghai Institutes of Preventive Medicine Shanghai 200336China

Mycobacterium tuberculosis is the primary bacteria that leads to human tuberculosis(TB),which usually affects the pulmonary *** is one of the top 10 causes of death worldwide;however,China is one of eight countries th... 详细信息

关键词： organs tuberculosis death

An epidemiology study of bronchial asthma in the Li ethnic group in China

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Asian Pacific Journal of Tropical Medicine 2012年第2期5卷 157-161页

作者： Yi-Peng Ding Hong-Xia Yao Xiao-Lan Tang Hai-Wu He Hui-Fang Shi Li Lin Min Li Shan Shan Chen Jing Chen Hai-Jiao Wang Emergency department of Hainan Provincial People's Hospital Research Center for aids in Hainan Medical College department of Respiratory Medicine in Hainan Provincial Nongken Hospital Shanxi Provincial Committee for aids prevention and control Shanxi Provincial Center for Disease control and prevention

Objective:To investigate the prevalence and risk factors of bronchial asthma in the Li ethnic group in Hainan,***:This study employed a stratified random sample design using custom-designed *** with asthma-like symptoms were first identified by two rounds of surveys and then confirmed by respiratory physicians using pulmonary function test,bronchial dilation test and challenge *** data,information on family history of asthma,history of allergies,smoking habits,domestic cooking fuel and other potential risk factors were *** regression was performed to evaluate risk factors for ***: The prevalence of asthma in the Li ethnic group was 3.38%,much higher than the national average level in ***,agriculture industry(the rubber industry in particular),rural residence,family history of asthma,history of allergies,cold air,inhalation of dust and irritant gases,smoking,domestic cooking fuel and living environment were associated with increased risk of ***:The high prevalence of asthma in the Li ethnic group highlights the importance of asthma prevention and treatment in this *** factors indentified in this study warrant special *** public awareness about asthma in local communities will benefit the prevention of the disease.

关键词： Asthma Li ethnic group Prevalence Risk factors

Multidimensional Analysis of Risk Factors Associated with Breast Cancer in Beijing,China:A Case-control Study

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Biomedical and Environmental Sciences 2020年第10期33卷 785-790页

作者： LI Ai Hua YE Yan CHEN Jun SUN Zhi Feng YUN Shui Ying TIAN Xing Kuan HU Zai Fang Sarah Robbins SCOTT YU Gui Xin HU Li WANG Zi Huan SUN Li Geng SHEN Zhuang Institute for Occupational Health Beijing Center for Diseases Prevention and Control&Center of Preventive Medical ResearchBeijing 100013China University of California Los Angeles 90024CaliforniaUSA department of Occupational Health Dongcheng Center for Diseases Prevention and ControlBeijing 100009China department of Occupational Diseases and Environment Health Shijingshan Center for Diseases Prevention and ControlBeijing 100050China department of Integrated Evaluation Mentougou Center for Diseases Prevention and ControlBeijing 102300China department of Occupational Health Shunyi Center for Diseases Prevention and ControlBeijing 101300China The National Center for aids control and prevention Chinese Center for Disease Control and PreventionBeijing 102206China

Breast cancer is the most common cancer among women worldwide[1].In 2018,2.09 million new breast cancer cases were identified globally,accounting for 11.6% of all cancers in that year[2].The breast cancer incidence in... 详细信息

关键词： Breast cancer Cancer

Study on the Technical Parameters for Estimating HIV-1 Incidence by Using a Recombinant Antigen-based Capture Enzyme Immunoassay—China

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China CDC weekly 2024年第48期6卷 1278-1282页

作者： Wenli Liang Jibao Wang Hongxia Yan Xinhui Zhang Dorjiwangmo Dongmin Li Xing Duan Hao Wu Yinyin Wang Li Bai Jian Sun Mengjie Han Yikui Wang Bin Su Min Wang Tashibazong Wenge Xing Cui Zhang Ruijuan Qiao Maofeng Qiu National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijingChina department of aids/STD control and prevention Dehong Center for Disease Control and PreventionMangshi CountyDehong Dai and Jingpo Autonomous PrefectureYunnan ProvinceChina Beijing Key Laboratory for HIV/aids Research Beijing Youan HospitalCapital Medical UniversityBeijingChina Institute of Infectious Diseases prevention and Treatment Guizhou Provincial Center for Disease Control and PreventionGuiyang CityGuizhou ProvinceChina department of aids control and prevention Xizang Autonomous Region Center for Disease Control and PreventionLhasa CityXizang Autonomous RegionChina Experimental Center Guizhou Provincial Center for Disease Control and PreventionGuiyang CityGuizhou ProvinceChina department of aids control and prevention Gansu Provincial Center for Disease Control and PreventionLanzhou CityGansu ProvinceChina Laboratory department Liupanshui Center for Disease Control and PreventionLiupanshui CityGuizhou ProvinceChina

Introduction:A novel recombinant antigen-based capture enzyme immunoassay(RAg-CEIA)was optimized and used to determine technical parameters for estimating human immunodeficiency virus type 1(HIV-1)incidence in ***:We employed orthogonal experimental design to optimize RAg-CEIA by adjusting raw material dilution *** assay was used to measure normalized optical density(ODn)values in 171 longitudinal plasma specimens from 51 HIV-1 seroconverting individuals,plotted against estimated days *** determined the optimal ODn threshold value for differentiating recent from long-term infections and calculated the mean duration of recent infection(MDRI)for incidence *** false recent rate(FRR)was determined using 481 HIV-1 antibody-positive specimens with infection durations exceeding twice the ***:Optimal RAg-CEIA parameters were established with a raw material dilution ratio of 1/12 for calibrator preparation and an enzyme conjugate titer of 1:*** values demonstrated consistent temporal increases across HIV-1 seroconverting individuals,though with notable kinetic heterogeneity in individual *** optimal ODn threshold value of 0.8 for distinguishing recent from long-term infections corresponded to an MDRI of 205 days and an FRR of 4.78%.Conclusions:The optimized RAg-CEIA effectively differentiates recent from long-term HIV-1 infections at the population level,enabling reliable HIV-1 incidence estimation in China.

关键词： Antigen exceeding false

Characterization of Mutations in Genes Related to Rifampicin and Isoniazid Resistance in Multidrug-resistant Mycobacterium tuberculosis Strains from Hangzhou,China

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Biomedical and Environmental Sciences 2023年第9期36卷 869-873页

作者： HUANG Yin Yan XIE Li WU Yi Fei JIA Qing Jun CHENG Qing Lin LI Qing Chun AI Li Yun BAI Xue Xin department of TB control and prevention Hangzhou Center for Disease Control and PreventionHangzhou 310021ZhejiangChina

Tuberculosis(TB),caused by the Mycobacterium tuberculosis complex(MTBC),is the 13^(th)leading cause of death and the second leading cause of infectious killer after COVID-19(above HIV and aids),according to the World Health Organization's 2022 Global TB *** 2021,10.6 million people were diagnosed with a new episode of TB and 1.6 million people died as a result.

关键词： tuberculosis death Mycobacterium