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*** implants for corneal regeneration in patients at high risk of rejecting donor transplantation

Annals of Eye Science 2019年第1期 197-197页

作者： May Griffith M.Mirazul Islam Oleksiy Buznyk Fiona Simpson Per Fagerholm Keith Meek Virender Sangwan department of Ophthalmology and Institute of Biomedical Engineering University of Montreal and Maisonneuve-Rosemont Hospital and CHUM Research CentresMontrealQCCanada department of Clinical and Experimental Medicine Linköping UniversityLinköpingSweden Schepens Eye Research Institute and Massachusetts Eye and Ear Infirmary Harvard Medical SchoolBostonMAUSA Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine OdessaUkraine School of Optometry and Vision Sciences College of Biomedical and Life Sciences and Cardiff Institute for Tissue Engineering and Repair(CITER)Cardiff UniversityCardiffUK Tej Kohli Cornea Institute LV Prasad Eye InstituteHyderabadIndia Dr.Schroff Charity Eye Hospital New DehliIndia

Background:Patients with inflammation or severe corneal pathology are often at high risk of rejecting the human donor corneas that they receive during *** goal was to determine whether cell-free implants incorporating phosphorylcholine-based polymer,2-methacryloyloxyethyl phosphorylcholine(MPC),which has inflammation suppressing properties,can support repair and regeneration of ulcerated,high-risk ***:Interpenetrating networks of recombinant human collagen and MPC(RHC-MPC)were fabricated into corneal implants in a certified and monitored *** open-label,first-in-human observational study was conducted following ISO 14971 and 14155:2011,the Declaration of Helsinki and relevant laws of Ukraine and India,after respective ethical approval and trial *** unilaterally blind patients,aged 36 to 76 years old,diagnosed with conditions putting them at high risk of rejecting conventional corneal transplantation,and capable of providing informed written consent were grafted and followed up for an average of two ***,RHC like native collagen is a large macromolecule and difficult to process and is ***,small,customisable analogs to collagen comprising collagen-like peptides(CLP)conjugated to polyethylene glycol(PEG)were *** CLP-PEG analogs like RHC were combined with MPC into implants and tested in mini-pig models with alkali burned corneas,a high-risk ***:One patient had an unrelated infection that necessitated re-grafting and was excluded from the *** RHC-MPC implants in the remaining six patients were stably integrated throughout the entire observational *** was regeneration of the cornea epithelium and *** vision improvement was observed in in patients with damaged corneas due to *** two weeks post-operation,RHC-MPC implanted corneas of patients with active ulcers were free from the symptoms of pain,irritation and *** the

关键词： Cornea inflammation implant clinical trial pigs

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Oral graft vs host disease:An immune system disorder in hematopoietic cell transplantation

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World Journal of Stomatology 2015年第2期4卷 96-102页

作者： Paulo Sérgio da Silva Santos Cassia Maria Fischer Rubira Héliton Spíndola Antunes Fabio Luiz Coracin Cristiane Miranda França Stomatology department Bauru School of DentistryUniversity of São PauloBauru 17012-901São PauloBrazil Instituto Nacional de Câncer(INCA) Rio de Janeiro 20230-130RJBrazil Universidade Nove de Julho São Paulo 01504-001SPBrazil

Graft vs host disease(GVHD) is a complication of patients who are treated by hematopoietic cell *** Institutes of Health in 2005 by Working Group on Diagnosis and Staging Consensus Development Project on Criteria for Clinical Trials in Chronic GVHD(cGVHD) established 2 principal categories of oral GVHD, acute and chronic. The oral mucosa may be the first site of manifestation of the disease. Clinical diagnosis needs to be confirmed by a biopsy of oral mucosa and minor salivary glands. Microscopic results have played a major role in the diagnosis and management of acute and chronic oral GVHD. Development of second malignancies is the greatest risk of oral cGVHD patients, mostly regarding squamous cell carcinoma. The focus of oral GVHD therapy is to improve symptoms and maintain oral function. The aim of this review article is to update the information on the oral GVHD in its clinical, microscopic features and their complications.

关键词： Stem cell transplantation Graft vs host disease Mouth mucosa Diagnosis Oral Salivary glands

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胰岛细胞移植后的免疫排斥:小鼠模型活体内双重对比增强MR成像

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国际医学放射学杂志 2013年第3期 266-266页

作者： P.Wang C.Schuetz A.Ross G.Dai J.F.Markmann A.Moore 刘义涛 Molecular Imaging Laboratory MGH/MIT/HMS Athinoula A.Martinos Center for Biomedical ImagingDepartment of RadiologyMassachusetts General HospitalHarvard Medical School

目的通过应用长循环顺磁性T1对比剂,一个受保护的接枝共聚物(PGC)共价链接到二乙烯三胺五乙酸钆与荧光素异硫氰酸酯(Gd-DTPA-F),检测胰岛细胞移植小鼠模型中的过继转移的免疫攻击。该对比剂积聚在以血管破坏为特征的炎症部位。材料与方... 详细信息

目的通过应用长循环顺磁性T1对比剂,一个受保护的接枝共聚物(PGC)共价链接到二乙烯三胺五乙酸钆与荧光素异硫氰酸酯(Gd-DTPA-F),检测胰岛细胞移植小鼠模型中的过继转移的免疫攻击。该对比剂积聚在以血管破坏为特征的炎症部位。材料与方法所有动物实验的进行均按照制度准则并经研究动物保护委员会批准。6只重症综合性免疫缺陷的非肥胖性糖尿病小鼠接受人胰岛细胞肾包膜下种植,并且从6周的非肥胖性糖尿病小鼠过继转移5×106个脾淋巴细胞。这些老鼠也作为对照组,与过继转移前、后的MR影像结果进行比较。只接受磷酸盐缓冲生理盐水溶液的小鼠被列为非过继转移对照组(n=2)。经静脉注射PGC-Gd-DTPA-F之前和17h之后进行活体内MR成像,随后进行组织学检查。统计学差异的分析采用配对t检验和双因素方差分析。结果 MR成像结果显示由过继转移的脾淋巴细胞免疫攻击引发后的移植区域的PGC-Gd-DTPA-F积聚较同一区域转移之前更为显著[T1分别为:(137.2±39.3)ms和(239.5±17.6)ms;P<0.001]。这些结果在组织学检查中被证实,这表明有相当多的对比剂泄漏到胰岛细胞间隙。结论 PGC-Gd-DTPA-F增强MRI可以对移植物的T细胞挑战引起的血管损伤进行活体内评价。

关键词：活体内 DTPA 过继转移脾淋巴细胞 PGC 继承性转移 MR 小鼠模型胰岛细胞移植

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骨骼肌卫星细胞梗死心肌移植的细胞因子分泌及血管再生作用

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中华实验外科杂志 2001年第2期18卷 161-162,T002页

作者：钟竑朱洪生张臻 ZHONG Hong Zhu Hongsheng ZHANG Zhen 上海第二医科大学附属仁济医院心胸外科现在上海第二医科大学附属新华医院心胸外科上海第二医科大学附属仁济医院心胸外科 department of Cardio-Thoracic Surgery Renj i Hospital Shanghai Second Medical University

目的　研究骨骼肌卫星细胞梗死心肌移植的胰岛素样生长因子 (IGF) 1、碱性纤维母细胞生长因子 (bFGF)分泌及血管再生的作用。方法　骨骼肌卫星细胞经结扎的冠状动脉左前降支远端灌注移植入梗死区 ,2、4、8周后取标本 ,应用免疫组化学... 详细信息

目的　研究骨骼肌卫星细胞梗死心肌移植的胰岛素样生长因子 (IGF) 1、碱性纤维母细胞生长因子 (bFGF)分泌及血管再生的作用。方法　骨骼肌卫星细胞经结扎的冠状动脉左前降支远端灌注移植入梗死区 ,2、4、8周后取标本 ,应用免疫组化学方法检测细胞因子表达及梗死区血管密度。结果　骨骼肌卫星细胞移植 2、4、8周后梗死区IGF 1和bFGF表达分别为 81.68± 3 .3 4、96.87± 7.78、90 .43± 7.3 6及 81.87± 3 .5 8、65 .66± 4.5 7、74.2 0± 6.41,明显高于对照组 (P <0 .0 1) ;同时 ,移植 2、4、8周后梗死区血管密度高于对照组 (P <0 .0 5 )。结论　骨骼肌卫星细胞梗死心肌移植除有心肌再生外。

关键词：骨骼肌卫星细胞心肌梗死碱性纤维母细胞生长因子胰岛素样生长因子-1 血管再生

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