*** implants for corneal regeneration in patients at high risk of rejecting donor transplantation
作者机构：Department of Ophthalmology and Institute of Biomedical EngineeringUniversity of Montreal and Maisonneuve-Rosemont Hospital and CHUM Research CentresMontrealQCCanada Department of Clinical and Experimental MedicineLinköping UniversityLinköpingSweden Schepens Eye Research Institute and Massachusetts Eye and Ear InfirmaryHarvard Medical SchoolBostonMAUSA Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of UkraineOdessaUkraine School of Optometry and Vision Sciences College of Biomedical and Life Sciencesand Cardiff Institute for Tissue Engineering and Repair(CITER)Cardiff UniversityCardiffUK Tej Kohli Cornea InstituteLV Prasad Eye InstituteHyderabadIndia Dr.Schroff Charity Eye HospitalNew DehliIndia
出 版 物：《Annals of Eye Science》 (眼科学年鉴（英文）)
年 卷 期：2019年第1期
页 面：197-197页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Cornea inflammation implant clinical trial pigs
摘 要：Background:Patients with inflammation or severe corneal pathology are often at high risk of rejecting the human donor corneas that they receive during *** goal was to determine whether cell-free implants incorporating phosphorylcholine-based polymer,2-methacryloyloxyethyl phosphorylcholine(MPC),which has inflammation suppressing properties,can support repair and regeneration of ulcerated,high-risk ***:Interpenetrating networks of recombinant human collagen and MPC(RHC-MPC)were fabricated into corneal implants in a certified and monitored *** open-label,first-in-human observational study was conducted following ISO 14971 and 14155:2011,the Declaration of Helsinki and relevant laws of Ukraine and India,after respective ethical approval and trial *** unilaterally blind patients,aged 36 to 76 years old,diagnosed with conditions putting them at high risk of rejecting conventional corneal transplantation,and capable of providing informed written consent were grafted and followed up for an average of two ***,RHC like native collagen is a large macromolecule and difficult to process and is ***,small,customisable analogs to collagen comprising collagen-like peptides(CLP)conjugated to polyethylene glycol(PEG)were *** CLP-PEG analogs like RHC were combined with MPC into implants and tested in mini-pig models with alkali burned corneas,a high-risk ***:One patient had an unrelated infection that necessitated re-grafting and was excluded from the *** RHC-MPC implants in the remaining six patients were stably integrated throughout the entire observational *** was regeneration of the cornea epithelium and *** vision improvement was observed in in patients with damaged corneas due to *** two weeks post-operation,RHC-MPC implanted corneas of patients with active ulcers were free from the symptoms of pain,irritation and *** the
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