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Chinese Chemical Letters 2015年第7期26卷 899-904页

作者： Bin Chen Lu Sun Yong-Shu Xie Shanghai Key Laboratory of Functional materials Chemistry East China University of Science and Technology department of Theoretical Chemistry and Biology School of Biotechnology KTH Royal Institute of Technology

Porphyrin dyes have received great attention due to their excellent photovoltaic performance in dye- sensitized solar cells （DSSCs）. In this work, dyes XCI-XC3 were synthesized by introducing various numbers of bis（4-methoxyphenyl）amino and p-hexyloxyphenyl groups to porphyrin meso-positions. The XC1 molecule contains two p-hexyloxyphenyl groups, and its DSSCs showed the power conversion efficiency of 4.81%. For XC2 and XC3, the replacement of p-hexyloxyphenyl with diphenylamino groups can effectively enhance the light harvesting around 500 nm. However, the highest occupied molecular orbitals （HOMOs） were elevated too much, which suppressed the dye regeneration processes, leading to low cell efficiencies of 2.51% and 1.27% for XC2, and XC3, respectively. To further improve the cell performance, an anthracene derivative Cl was used as the cosensitizer for XCl, which increased both the Jsc and Voc values, with an improved efficiency of 5.75：g.

关键词： Porphyrins DSSCs Cosensitizer Theoretical calculation

Estimating the combined toxicity of flufenacet and imazaquin to sorghum with pore water herbicide concentration

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Journal of Environmental Sciences 2016年第3期28卷 154-161页

作者： Donghong Wang Qian Zhang Yuan Zheng Dunli Lin Yunlong Yu department of Plant Protection College of Agriculture & BiotechnologyZhejiang University

Combined toxicity of herbicides to non-target crops is usually resulted from their successive *** present study was conducted to assess the combined toxicity of flufenacet（FLU）and imazaquin（IMA）to sorghum with their concentration in soil pore *** concentrations that inhibited growth by 50%（IC50）of FLU and IMA individually and their combination estimated from the herbicide concentrations in soil pore water notably differed from those based on the amended concentrations,due to the decline in bioavailability resulting from adsorption of the herbicides onto *** to the amended concentrations,the combined effect of FLU and IMA in soil on sorghum growth was identified as additive *** on the concentration in soil pore water,however,it was determined to be antagonism,which was identical to that observed in a test using culture *** results revealed that pore water herbicide concentration might be an effective tool to assess the combined toxicity of herbicides in soil to rotational crops.

关键词： Adsorption Bioavailability Combined toxicity Herbicide Pore water

Biosensors: Types, features, and application in biomedicine

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Asian Pacific Journal of Tropical Biomedicine 2022年第9期12卷 367-373页

作者： Elmira Karami Fatemeh Kazemi-Lomedasht biotechnology Research Center Biotechnology DepartmentPasteur Institute of IranTehranIran

Fast and precise diagnostic techniques are required for the treatment of many *** are one of the diagnostic devices that are applicable in biological and medical *** could be utilized to recognize biological molecules with high *** are consisted of different components and have different *** type of biosensor is used in a particular field according to its specific *** are a novel class of antibodies with small size,high affinity,and specificity to their *** unique properties of nanobodies make them appropriate tools for diagnostic *** this paper,we review biosensors,and their features and roles in ***/nanobody-based biosensors are also specifically discussed.

关键词： Biosensor Nanobody-based biosensor Antibodybased biosensor Biomedicine biotechnology

Effects of chebulinic acid on differentiation of human leukemia K562 cells

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Acta Pharmacologica Sinica 2004年第2期25卷 105-112页

作者： Zong-chun YI, Zhao WANG2, Hai-xia LI, Ming-jie LIU, Rong-cong WU, Xiao-hui WANG department of Biological Sciences and biotechnology, Tsinghua University, Beijing 100084, China department of Biological Sciences and biotechnology Tsinghua University 北京 100084

AIM: To study effects of chebulinic acid on erythroid and megakaryocytic differentiation in K562 cells. METHODS: The benzidine staining method was used to evaluate hemoglobin synthesis; the expression of erythroid specific glycophorin A (GPA) protein and megakaryocytic surface marker CD61 was determined by flow cytometry using fluorescence labeled antibodies; erythroid and megakaryocytic mRNA expression was analyzed by RT-PCR. RESULTS: During erythroid differentiation induced by butyric acid (BA) or hemin, chebulinic acid not only inhib- ited the hemoglobin synthesis of BA- and hemin-treated K562 cells in concentration-dependant manner with IC50 of 4 μmol/L and 40 μmol/L respectively, but also inhibited another erythroid differentiation marker acetylcholinesterase at the concentration of 50 μmol/L in the cells either treated or untreated with each erythroid differentiation inducers, whereas chebulinic acid 50 μmol/L did not change GPA protein expression in these cells significantly. When K562 cells were treated with TPA 50 μg/L for 72 h to induce megakaryocytic differentiation, the presence of chebulinic acid 50 μmol/L slightly provoked the decrease of GPA protein expression induced by TPA. Chebulinic acid did not change the TPA-induced CD61 expression at the same concentration. Chebulinic acid also reduced the mRNA levels of erythroid relative genes including γ-globin, PBGD, NF-E2, and GATA-1 genes in K562 cells either treated or untreated with BA, whereas chebulinic acid upregulated the mRNA levels of GATA-2 transcription factor in these cells. CONCLUSION: Chebulinic acid had inhibitory effect on erythroid differentiation likely through changing transcriptional activation of differentiation relative genes, which suggests that chebulinic acid or other tannins might influence the efficiency of some anti-tumor drugs-induced differentiation or the hematopoiesis processes.

关键词： K562cells chebulinic acid butyrates hemin glycophorin CD61 antigen gene expression regulation celldifferentiation

Influence of different nitrogen application on flour properties,gluten properties by HPLC and end-use quality of Korean wheat

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Journal of Integrative Agriculture 2018年第5期17卷 982-993页

作者： Seong-Woo Cho Chon-Sik Kang Taek-Gyu Kang Kwang-Min Cho Chul Soo Park department of Crop Science and biotechnology Chonbuk National University National Institute of Crop Science Rural Development Administration Research Center of Bioactive materials Chonbuk National University

This study was performed to identify how the different levels of nitrogen application affected the variances of gluten properties and end-use qualities and the differences of variances among Korean wheat cultivars. Protein and dry gluten content, SDS sedimentation volume and water absorption of Mixolab increased as nitrogen application increased. This ratio of the increase was higher in Korean wheat cultivars for bread than in Korean wheat cultivars for noodles and cookies. The proportion of（α＋β）-gliadin measured by reversed-phase high-performance liquid chromatography（RP-HPLC） increased, but the proportion of ω-and γ-gliadin decreased as the protein content increased. The Korean wheat cultivars for bread showed a high proportion of（α＋β）-gliadin increase, the Korean cultivars for noodles had a high proportion of γ-gliadin decrease and the Korean wheat cultivars for cookies had a high proportion of ω-gliadin decrease. However, there was no variation of the component in the proportion of glutenin component measured by RP-HPLC, even though the protein content was increased, but all of the protein fractions measured by size exclusion（SE）-HPLC were increased. The soluble monomeric protein showed a high proportion of Korean wheat cultivars for bread by the increase of protein content. Bread loaf volume increased by the increase of protein content but there were no variances in the ratio of increase among Korean wheat cultivars. The cookie diameter decreased with the increase of protein content, and this ratio of decrease was the highest in Korean wheat cultivars for cookies. The hardness of cooked noodles also increased by the increase of protein content but there were no variations in springiness and cohesiveness. The decrease proportion of ω-gliadin affected the increase of bread loaf volume, the hardness of cooked noodles, and the decrease of cookie diameter.

关键词： wheat gluten end-use quality cultivar nitrogen application

A bioinspired high-modulus mineral hydrogel binder for improving the cycling stability of microsized silicon particle-based lithium-ion battery

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Nano Research 2019年第5期12卷 1121-1127页

作者： Meng Tian Xiao Chen Shengtong Sun Dong Yang Peiyi Wu State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceLaboratory for Advanced MaterialsFudan UniversityShanghai 200433China State Key Laboratory for Modification of Chemical Fibers and Polymer materials College of ChemistryChemical Engineering and BiotechnologyCenter for Advanced Low-dimension MaterialsDonghua UniversityShanghai 201620China

Silicon with high specific capacity is deemed an ideal anode material for lithium ion batteries,which,however suffers from low cycling life due to its dramatic volume ***-soluble polymer binders recently gain increasing attention by providing an eco-friendly and low-cost way in improving the cycling stability of Si-based ***,a novel bioinspired supramolecular mineral hydrogel binder consisting of polyacrylic acid (PAA) physically crosslinked with amorphous calcium carbonate (ACC) nanoparticles is designed for high-performance anodes made from low-cost microsized Si *** to its organic-inorganic hydrophilic nature,ACC-PAA hybrid binder exhibits the reported highest modulus (~22 GPa) for polymer binders in electrolyte,even higher than lithiated Si species (Li15Si4,~12 GPa).Together with its excellent adhesion and electrochemical stability,ACC-PAA binder can effectively suppress the pulverization of Si particles and maintain the mechanical integrity of electrodes during ***,even with a low binder content,the anode still shows an initial discharge capacity of 2,973 mAh·g^-1 and Coulombic efficiency of 81.5%,and retains 75% at a current density of 600 mA·g^-1 after 100 *** present organic-inorganic hybrid mineral binder may open a new approach for designing more effective polymer binders for Si-based lithium-ion batteries.

关键词： polymer binder mineral hydrogel microsized silicon particle lithium-ion battery

Facile synthesis of large-area ultrathin two-dimensional supramolecular nanosheets in water

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Nano Research 2020年第3期13卷 868-874页

作者： Bojian Hu Peiyi Wu State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceLaboratory far Advanced MaterialsFudan UniversityShanghai 200433China State Key Laboratory for Modification of Chemical Fibers and Polymer materials College of ChemistryChemical Engineering and BiotechnologyCenter for Advanced Low-Dimension MaterialsDonghua UniversityShanghai 201620China

Synthesizing large-area ultrathin two-dimensional(2D)nanostructures in aqueous media has received considerable increasing attention but remains a big ***,we report a facile method for the synthesis of two unprecedented large-area ultrathin 2D supramolecular nanosheets via ionic self-assembly in *** consideration of electrostatic interaction and repulsive effect,deprotonated tetrakis(4-carboxyphenyl)porphyrin(TCPP)or Fe(III)tetra(4-carboxyphenyl)porphine chloride(TCPP(Fe))as connection vertex and protonated bis(2-dimethylaminoethyl)ether(BDMAEE)unit as bridging edge connect with each other to form few-layer 2D nanosheet with a thickness of^1.8–1.9 nm,while the lateral size can close to one hundred ***,the well-dispersed 2D TCPP(Fe)-BDMAEE with heme-like active center displays intrinsic peroxidase-like catalytic activity,which can be used to detect hydrogen *** present facile strategy highlights new opportunities in constructing large-area ultrathin 2D supramolecular nanomaterials and paves the avenue to expand their potential applications.

关键词： large-area ultrathin two-dimensional supramolecular nanosheets peroxidase-like catalytic activity

Phytochemical Profiling and Bioactivity of A Mangrove Plant,Sonneratia apetala,from Odisha Coast of India

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Chinese Journal of Integrative Medicine 2015年第4期21卷 274-285页

作者： Jayanta Kumar Patra Swagat Kumar Das Hrudayanath Thatoi department of biotechnology College of Engineering and TechnologyBiju Patnaik University of Technology School of biotechnology Yeungnam University

Objective： To test the antioxidant, antidiabetic, anticancer and antibacterial activities along with phytochemicals of Sonneratia apetala Buch.-Ham. Methods： The antibacterial activity was determined by agar well diffusion method. The antioxidant activity was determined by standard assay. The antidiabetic activity was evaluated by α-glucosidase inhibition assay and in vivo anticancer property was determined against Ehrlich ascites carcinoma （EAC） cells in Swiss Albino mice. Further partial characterization of the methanol extracts was carried out by thin layer chromatography, high performance liquid chromatography, 1H nuclear magnetic resonance spectroscopy and Fourier transform-infra red spectrum spectral analysis. Results： Four solvent extracts （acetone, ethanol, methanol and aqueous） of leaf and bark possess strong antioxidant properties. In vivo anticancer activity of methanol extract leaf indicated positive activity showing 34% inhibition against EAC cells in Swiss Albino mice. All extracts exhibited a-glucosidase inhibitory activity in a dose-dependent manner indicating presence of promising antidiabetic properties. The extracts possess strong antibacterial activity against the selected pathogenic bacteria （minimal inhibitory concentration ranging from 1.25-5.00 mg/mL）. The partial characterization of the methanol extracts of leaf and bark revealed the presence of phenolics as the lead compound responsible for studied bioactivities of the plant extracts. Conclusion： Sonneratia apetala extracts have potent antibacterial, antioxidant, antidiabetic and anticancer properties which can be further exploited for its pharmaceutical applications.

关键词： bioactive compounds chromatography Ehrlich ascites carcinoma mangrove Sonneratia apetala

Revisit of advection-dispersion equation model with velocity-dependent dispersion in capturing tracer dynamics in single empty fractures

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Journal of Hydrodynamics 2018年第6期30卷 1055-1063页

作者： Mu Wang Wei-dong Zhao Rhiannon Garrard Yong Zhang Yong Liu Jia-zhong Qian School of Resources and Environmental Engineering Hefei University of Technology department of Geological Sciences University of Alabama College of Mechanics and materials Hohai University School of Food and biotechnology Engineering Hefei University of Technology

An accurate quantification of the contaminant transport through fractured media is critical for dealing with water-quality related scientific and engineering issues, where the dispersion coefficient is an important and elusive parameter for the solute transport modeling. Many previous studies show that the dispersion coefficient(D) in the standard advection-dispersion equation(ADE) model can be approximated by D=avλ(where a is the dispersivity), a formula to be revisited systematically in this study by laboratory experiments and model analysis. First, a series of tracer transport experiments in single empty fractures are conducted in cases of different hydraulic gradients. Second, the tracer breakthrough curves are determined by simulations based on the ADE model, to obtain the dispersion coefficients corresponding to various fracture roughnesses and flow velocities. A varying trend of λ is analyzed under different flow conditions. Results show that although the standard ADE model cannot be used to characterize the late-time tailing of the tracer BTCs, likely due to the solute retention, this simple model can simulate most of the solute mass dynamics moving through fractures and may therefore provide information for estimating the dispersion in parsimonious models appropriate for the non-Fickian transport. The following three conclusions are drawn:(1) the peak of the breakthrough curves comes earlier with increasing the roughness, according to the ADE simulation,(2) the value of λ generally decreases as the relative roughness of the fracture increases,(3) the value of λ is approximately equal to 2.0 when the dispersion is dominated by the molecular diffusion in the smooth fracture.

关键词： Dispersion coefficient molecular diffusion roughness variation trend single fracture

Synergistic anticancer effect of green synthesized nickel nanoparticles and quercetin extracted from Ocimum sanctum leaf extract

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Journal of materials Science & Technology 2018年第3期34卷 508-522页

作者： Palanivel Rameshthangam Jeyaraj Pandian Chitra department of biotechnology Science Campus Alagappa University department of Biochemistry Manonmaniam Sundaranar University

Leaf extract of medicinally important plant Ocimurn sanctum （O. sanctum） has been used for the synthesis of nickel nanoparticles （NiGs） and extraction of quercetin （Qu）. Qu has been conjugated with NiGs for enhanced anticancer effect on human breast cancer MCF-7 cells. Extracted Qu was conjugated with polyethylene glycol （PEG） coated NiGs （Qu-PEG-NiGs） which was used as carriers for breast cancer treatment. Anticancer activity of Qu-PEG-NiGs was evaluated by assessing cell viability, reactive oxygen species （ROS） production, caspase activity, mitochondrial membrane potential （MMP） and changes in nuclear morphology （staining methods）. 0.85 mg of quercetin was extracted from I g of leaves with retention time （Rt） of 2.914 rain. Loading and encapsulation efficiency of quercetin onto PEG-NiGs was 15.04% and 82% respectively and Qu-PEG-NiGs has shown a sustained release of Qu of about 84% after 48 h. Qu and Qu-PEG-NiGs showed dose dependent （1.56-50 μg/mL） anticancer effect against MCF-7 cells with IC50 values of 50 and 6.25 μg/mL respectively which was mediated by oxidative stress due to ROS over-production that induced loss of mitochondrial membrane potential, capsase -9, -7 activities leading to apoptosis. The present study validates that Qu-PEG-NiGs can be used as a potential anticancer agent for cancer therapy.

关键词： Nickel nanoparticles Quercetin Anticancer Apoptosis MCF-7 cells Ocimum sanctum