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Perinatal outcomes of frozen-thawed embryo transfer following blastocyst-stage embryo transfer compared to those of cleavage-stage embryo transfer:analysis of 9408 singleton newborns using propensity score analysis

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Reproductive and Developmental Medicine 2024年第2期8卷 67-74页

作者： Hu-Cen Zhong Qi Wan Yu-Ling Hu Tian Li Li-Juan Huang Mao Wang Xin-Yue Hu Meng-Di Wang Zhao-Hui Zhong School of Public Health Joint International Research Laboratory of Reproduction and Development of the Ministry of Education of ChinaChongqing 400016China department of Obstetrics and Gynecology West China Second HospitalSichuan UniversityChengdu 610041China Sichuan Jinxin Xinan Women and Children’s Hospital Chengdu 610041 SichuanChina department of Reproductive Medicine the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China School of Public Health Research Center for Medical and Social DevelopmentChongqing Medical UniversityChongqing 400016China

Objective:Regarding frozen-thawed embryo transfer(FET),there is limited consensus on whether extending embryo culture from the cleavage stage to the blastocyst stage affects perinatal *** study aimed to compare perinatal outcomes of singletons between blastocyst-stage embryo transfer(BT)and cleavage-stage embryo transfer(CT)in ***:A total of 9408 FET cycles that met the inclusion criteria were included in this retrospective cohort study between 2019 and ***-stage embryo transfers were performed in the BT group,and cleavage-stage embryo transfers were performed in the CT *** logistic regression analyses were performed,as well as propensity score matching(PSM)to adjust for ***:After PSM,a higher risk of pre-term birth(PTB;odds ratio[OR]:1.23,95%confidence interval[CI]:1.00-1.50,P=0.048)and being large for gestational age(LGA;OR:1.16,95%CI:1.00-1.35,P=0.050)was observed in the BT group compared to that in the CT *** stratified PSM,in the subgroup under 35 years of age,only an increased risk of LGA was observed in the BT group compared to the CT *** outcomes in the double-embryo transfer subgroup were similar to those in the unstratified ***,in the subgroup beyond 35 years of age and the single embryo transfer subgroup,perinatal outcomes were not statistically different between the BT and CT groups(P>0.05).Conclusions:In FET,prolonged embryo culture to the blastocyst stage increased the risk of PTB and LGA in single ***,stratified analysis based on age and the number of transferred embryos yielded different results,necessitating further mechanistic studies.

关键词： Frozen-thawed embryo transfer Blastocyst Cleavage stage Perinatal outcomes Pre-term birth Large for gestational age Small for gestational age

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Advances in preimplantation genetic diagnosis/screening

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Science China(Life Sciences) 2014年第7期57卷 665-671页

作者： YAN LiYing WEI Yuan HUANG Jin ZHU XiaoHui SHI XiaoDan XIA Xi YAN Jie LU CuiLing LIAN Ying LI Rong LIU Ping QIAO Jie department of Obstetrics and Gynecology Peking University Third Hospital Key Laboratory of Assisted reproduction ministry of education Beijing Key Laboratory of Reproductive Endocrinology and Assisted reproduction

Preimplantation genetic diagnosis(PGD)gives couples who have a high risk of transmitting genetic disorders to their baby the chance to have a healthy offspring through embryo genetic analysis and *** genetic screening(PGS)is an effective method to select euploid embryos that may prevent repeated implantation failure or ***,how and to whom PGS should be provided is a controversial *** first successful case of PGD of a human being was reported in 1990,and there have been tremendous improvements in this technology since *** embryo biopsy and genetic technologies have been improved dramatically,which increase the accuracy and expand the indications of PGD/PGS.

关键词： preimplantation genetic diagnosis preimplantation genetic screening indications biopsy methods array comparative genomic hybridization next-generation sequencing

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Morphological and Hormonal Identifi cation of Porcine Atretic Follicles and Relationship Analysis of Hormone Receptor Levels During Granulosa Cell Apoptosis In vivo

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Journal of Integrative Agriculture 2014年第5期13卷 1058-1064页

作者： YU De-bing YU Min-li LIN Fei JIANG Bao-chun YANG Li-na WANG Si-yu ZHAO Ying WNAG Zheng-chao department of Animal Genetics Breeding and Reproduction College of Animal Science and Technology Nanjing Agricultural University

Recent reports have demonstrated that follicular atresia is initiated or caused by granulosa cell apoptosis followed by theca cell degeneration in mammalian ovaries, but the mechanism of follicular atresia is still to be elucidated. Therefore, our present study was designed to examine our hypothesis that the changes of follicular microenvironment induce the granulosa cell apoptosis during pocrine follicular atresia in vivo. We firstly isolated intact porcine antral follicles and identified them into three groups, healthy follicles （HF）, early atretic follicles （EAF） and progressed atretic follicles （PAF） through morphology and histology. To further confirm their status, we detected hormone levels in follicular fluids and the expression level of apoptosis gene Bax in granulosa cells. The rate of progesterone （P） and estradiol （E2） was increased with the expression of Bax, indicating hormone can be used as a marker of granulosa cell apoptosis or follicular atresia. Finally, we analyzed the expression level of hormone receptor genes in granulosa cells and their relationship with follicular atresia. In PAF, the expression of Progesterone receptor （PGR） was increased significantly while estradiol receptor （ER） had no notable changes, which suggesting the increased-PGR accelerated the effect of P-stimulated granulosa cell apoptosis. The dramatic increasing of androgen receptor （AR） expression in PAF and the obvious increase of tumor necrosis factor-u receptor （TNFR） in EAF indicated that there are different pathways regulating granulosa cell apoptosis during follicular atresia. Together, our results suggested that different pathways of granulosa cell apoptosis was induced by changing the follicular microenvironment during follicular atresia.

关键词： granulosa cell apoptosis follicular atresia progesterone estradiol porcine

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CETP polymorphism confer genetic contribution to centenarians of Hainan,south of China

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Asian Pacific Journal of Tropical Medicine 2016年第9期9卷 851-855页

作者： Yun-Xia Zhang Ya Su Li Tang Ze-Xing Yang Dai-Feng Zhou Yi-Min Qiu Wang-Wei Cai department of Biochemistry and Molecular biology Hainan Medical College Hainan Cadre Sanatorium Geriatric Hospital of Hainan department of reproduction and Genetics the First Affiliated Hospital of Kunming Medical University

Objective:In this paper,we will discuss if the CETP polymorphism contributes to the centenarians in Hainan ***:We tested the Taq IB and I405 V polymorphisms of CETP gene among 276 centenarians and 301 matched healthy individuals by AS-PCR and analyzed the data with SPSS software package(Version 19.0).Results:Our data indicated that allele B1 and V have the significant differences between centenarians and healthy control groups with P<*** analysis implied that genotypes B1B1(P<0.001,OR=0.148,95% CI=0.095-0.230) and VV(P<0.001 and OR=0.353,95% CI=0.237-0.525) were significantly different between centenarians and matched *** combination of B and V,such as B1B1-II(P<0.001,OR=0.128,95% CI=0.049-0.329),B1B1-IV(P<0.001,OR=0.115,95% CI=0.056-0.237),B1B2-VV(P<0.05,OR=0.534,95% CI=0.310-0.920),and B2B2-VV(P<0.001,OR=0.198,95% CI=0.086-0.453) have significant differences between centenarians and matched healthy individuals from ***:Our results implied that allele B1B1 and VV,as well as the combination B1B1-II,B1B1-IV,B1B2-VV and B2B2-VV may contribute to the longevity in centenarians of Hainan,south of China.

关键词： Centenarians Polymorphisms of CETP Genetic contribution

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Sperm Mitochondria in reproduction:Good or Bad and Where Do They Go?

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Journal of Genetics and Genomics 2013年第11期40卷 549-556页

作者： Shi-Ming Luo Heide Schatten Qing-Yuan Sun Key Laboratory of Animal reproduction and Germplasm Enhancement in Universities of Shandong Qingdao Agricultural University department of Veterinary Pathobiology University of MissouriColumbia State Key Laboratory of Reproductive biology Institute of ZoologyChinese Academy of Sciences

The mitochondrion is the major energy provider to power sperm motility. In mammals, aside from the nuclear genome, mitochondrial DNA （mtDNA） also contributes to oxidative phosphorylation to impact production of ATP by coding 13 polypeptides. However, the role of sperm mitochondria in fertilization and its final fate after fertilization are still controversial. The viewpoints that sperm bearing more mtDNA will have a better fertilizing capability and that sperm mtDNA is actively eliminated during early embryogenesis are widely accepted. However, this may be not true for several mammalian species, including mice and humans. Here, we review the sperm mitochondria and their mtDNA in sperm functions, and the mechanisms of maternal mitochondrial inheritance in mammals.

关键词： Mitochondrial DNA Maternal inheritance Paternal inheritance Autophagy Oxidative phosphorylation Ubiquitination

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A mathematical model for a disease outbreak considering waningimmunity class with nonlinear incidence and recovery rates

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Journal of Biosafety and Biosecurity 2024年第3期6卷 170-180页

作者： Nursanti Anggriani Lazarus Kalvein Beay Meksianis Z.Ndii Fatuh Inayaturohmat Sanubari Tansah Tresna department of Mathematics Universitas PadjadjaranSumedangIndonesia department of Mathematics Universitas PattimuraMalukuIndonesia department of Mathematics Universitas Nusa CendanaKupangIndonesia

In the spread of infectious diseases,intervention levels play a crucial role in shaping interactions between healthy and infected individuals,leading to a nonlinear transmission ***,the availability of medical resources limits the recovery rate of infected patients,adding further nonlinear dynamics to the healing *** research introduces novelty by combining nonlinear incidence and recovery rates alongside waning immunity in an epidemic *** present a modified SIRW-type model,examining the epidemic problem with these *** analysis,we explore conditions for non-endemic and co-existing cases based on the basic reproduction *** local stability of equilibria is verified using the Routh-Hurwitz criteria,while global stability is assessed using Lyapunov functions for each ***,we investigate bifurcations around both non-endemic and co-existing ***,we give some simulations to support our analytical findings.

关键词： SIRW-type model Basic reproduction ratio Waning immunity Nonlinear incidence rate Nonlinear recovery rate Lyapunov functions Bifurcation

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Correlation between HPV sperm infection and male infertility

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Asian Journal of Andrology 2013年第4期15卷 529-532,I0010页

作者： Yang Yang Chan-Wei Jia Yan-Min Ma Li-Ying Zhou Shu-Yu Wang department of reproduction Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing 100026 China

Human papillomavirus （HPV） is one of the most common sexually transmitted diseases which comprises a group of small DNA viruses that infect both cutaneous and mucous squamous epithelia. Liquid bead microarray technology （LBMA） were used to evaluate 24 HPV genotypes in confirmed fertile and infertile males of North China so that the effects of HPV infection on semen parameters and relationship with male infertility could be discussed. A total of 1138 subjects were recruited in this study; 142 were HPV-positive （12.48%）. Among 523 confirmed fertile males, only 35 were HPV-positive （6.70%）, and two of them had multiple infections. Among 615 infertile males, 107 were HPV-positive （17.4%）, and 29 of them had multiple infections. Infertile males had a relatively high HPV infection rate compared with confirmed fertile males. Sperm progressive motility （PR） and the normal morphology rate were significantly decreased in HPV-positive subjects. HPV-45, HPV-52, HPV-18, HPV-59 and HPV-16 infections were more frequently in infertile males. Hence, HPV infection is closely related to male infertility which will decrease sperm PR and morphology. HPV-45, HPV-52, HPV-18, HPV-59 and HPV-16 infection seems to be major risk factors.

关键词： HPV genotype human papillomavirus male infertility

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Numerical Analysis of Bacterial Meningitis Stochastic Delayed Epidemic Model through Computational Methods

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 311-329页

作者： Umar Shafique Mohamed Mahyoub Al-Shamiri Ali Raza Emad Fadhal Muhammad Rafiq Nauman Ahmed department of Mathematics National College of Business Administration and EconomicsLahore54660Pakistan department of Mathematics Applied CollegeMahayl AssirKing Khalid UniversityAbha62529Saudi Arabia department of Physical Sciences The University of ChenabGujrat50700Pakistan department of Mathematics&Statistics College of ScienceKing Faisal UniversityP.O.Box 400Al-Ahsa31982Saudi Arabia department of Computer Science and Mathematics Lebanese American UniversityBeirut1102-2801Lebanon department of Mathematics Faculty of Science and TechnologyUniversity of Central PunjabLahore54000Pakistan department of Mathematics and Statistics University of LahoreLahore54000Pakistan

Based on theWorld Health Organization(WHO),Meningitis is a severe infection of the meninges,the membranes covering the brain and spinal *** is a devastating disease and remains a significant public health *** study investigates a bacterial meningitis model through deterministic and stochastic ***-compartment population dynamics explain the concept,particularly the susceptible population,carrier,infected,and *** model predicts the nonnegative equilibrium points and reproduction number,i.e.,the Meningitis-Free Equilibrium(MFE),and Meningitis-Existing Equilibrium(MEE).For the stochastic version of the existing deterministicmodel,the twomethodologies studied are transition probabilities and non-parametric ***,positivity,boundedness,extinction,and disease persistence are studiedrigorouslywiththe helpofwell-known *** and nonstandard techniques such as EulerMaruyama,stochastic Euler,stochastic Runge Kutta,and stochastic nonstandard finite difference in the sense of delay have been presented for computational analysis of the stochastic ***,standard methods fail to restore the biological properties of the model,so the stochastic nonstandard finite difference approximation is offered as an efficient,low-cost,and independent of time step *** addition,the convergence,local,and global stability around the equilibria of the nonstandard computational method is studied by assuming the perturbation effect is *** simulations and comparison of the methods are presented to support the theoretical results and for the best visualization of results.

关键词： Bacterial Meningitis disease stochastic delayed model stability analysis extinction and persistence computational methods

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Comparison of four methods to evaluate sperm DNA integrity between mouse caput and cauda epididymidis

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Asian Journal of Andrology 2012年第2期14卷 335-337页

作者： Serafin Perez-Cerezales： Alberto Miranda Alfonso Gutierrez-Adan department of Animal reproduction National Institute for Agricultural and Food Research and Technology Madrid 28040 Spain

It is well known that transit through the epididymis involves an increase in the compaction of sperm chromatin, which acquires fully condensed status at the caput epididymidis. The purpose of this study was to compare the terminal deoxyribonucleotidyl transferase-mediated dUTP nick end-labelling （TUNEL） assay, the comet assay, the sperm chromatin structure assay （SCSA） and the sperm chromatin dispersion （SCD） test by analysing spermatozoa from the caput and cauda epididymidis in order to demonstrate the ability of each technique to discriminate between different degrees of sperm maturity related to chromatin compaction and DNA fragmentation. Our results suggest that some populations of DNA-fragmented spermatozoa associated with immature sperm can only be identified using the comet assay and the SCSA but not with the SCD test or the TUNEL assay.

关键词： DNA damage mouse epididymis sperm chromatin sperm maturation the comet assay the sperm chromatin dispersion test the sperm chromatin structure assay TUNEL

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New genetic markers for male fertility

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Asian Journal of Andrology 2012年第6期14卷 807-808页

作者： Alberto Ferlin department of Molecular Medicine & Centre for Human reproduction Pathology University of Padova Padova 35121 Italy

Studies in the last years deFmitively demonstrate the high prevalence of gen- etic causes of spermatogenic impairment. A large proportion of infertile males does not receive a dear diagnosis and are reported as idiopathic or unexplained, also because standard semen analysis cannot clearly distinguish fertile from infertile populations.

关键词： MALE-INFERTILITY HUMANS

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