CETP polymorphism confer genetic contribution to centenarians of Hainan,south of China

作     者：Yun-Xia Zhang Ya Su Li Tang Ze-Xing Yang Dai-Feng Zhou Yi-Min Qiu Wang-Wei Cai 

作者机构：Department of Biochemistry and Molecular BiologyHainan Medical College Hainan Cadre SanatoriumGeriatric Hospital of Hainan Department of Reproduction and Geneticsthe First Affiliated Hospital of Kunming Medical University 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2016年第9卷第9期

页      面：851-855页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071007[理学-遗传学] 

基　　金：supported by the National Science Foundation of China(No.31501018 and 81260510) social development project of Hainan Province (SF201401) 

主　　题：Centenarians Polymorphisms of CETP Genetic contribution 

摘      要：Objective:In this paper,we will discuss if the CETP polymorphism contributes to the centenarians in Hainan ***:We tested the Taq IB and I405 V polymorphisms of CETP gene among 276 centenarians and 301 matched healthy individuals by AS-PCR and analyzed the data with SPSS software package(Version 19.0).Results:Our data indicated that allele B1 and V have the significant differences between centenarians and healthy control groups with P*** analysis implied that genotypes B1B1(P0.001,OR=0.148,95% CI=0.095-0.230) and VV(P0.001 and OR=0.353,95% CI=0.237-0.525) were significantly different between centenarians and matched *** combination of B and V,such as B1B1-II(P0.001,OR=0.128,95% CI=0.049-0.329),B1B1-IV(P0.001,OR=0.115,95% CI=0.056-0.237),B1B2-VV(P0.05,OR=0.534,95% CI=0.310-0.920),and B2B2-VV(P0.001,OR=0.198,95% CI=0.086-0.453) have significant differences between centenarians and matched healthy individuals from ***:Our results implied that allele B1B1 and VV,as well as the combination B1B1-II,B1B1-IV,B1B2-VV and B2B2-VV may contribute to the longevity in centenarians of Hainan,south of China.