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Resolving the developmental mechanisms of cardiac microthrombosis of SARS-CoV-2 based on single-cell transcriptome analysis

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Science China Life sciences 2025年第1期 103-115页

作者： Xizi Luo Nan Zhang Yuntao Liu Beibei Du Xuan Wang Tianxu Zhao Bingqiang Liu Shishun Zhao Jiazhang Qiu Guoqing Wang State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic infectious diseases Key Laboratory for Zoonosis Research of the Ministry of EducationCollege of Basic MedicineJilin University State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic infectious diseases Key Laboratory for Zoonosis Research of the Ministry of EducationCollege of Veterinary MedicineJilin University College of Mathematics Jilin University Bioinformatic Lab School of MathematicsShandong University department of Cardiology China-Japan Union HospitalJilin University

The coronavirus disease 2019（COVID-19） outbreak caused by the severe acute respiratory syndrome coronavirus-2（SARS-CoV-2） developed into a global health emergency. Systemic microthrombus caused by SARS-CoV-2 infection is a common complication in patients with COVID-19. Cardiac microthrombosis as a complication of SARS-CoV-2 infection is the primary cause of cardiac injury and death in patietns with severe COVID-19. In this study, we performed single-cell sequencing analysis of the right ventricular free wall tissue from healthy donors,patients who died during the hypercoagulable period of characteristic coagulation abnormality（CAC）, and patients who died during the fibrinolytic period of CAC. We collected 61,187 cells enriched in 24 immune cell subsets and 13 cardiac-resident cell subsets. We found that in the course of SARS-CoV-2 infected heart microthrombus, MYO1EhighRASGEF1Bhighmonocyte-derived macrophages promoted hyperactivation of the immune system and initiated the extrinsic coagulation pathway by activating chemokines CCL3, CCL5. This series of events is the main cause of cardiac microthrombi following SARS-CoV-2 infection. In a SARS-CoV-2 infected heart microthrombus, excessive immune activation is accompanied by an increase in cellular iron content, which in turn promotes oxidative stress and intensifies intercellular competition. This induces cells to alter their metabolic environment, resulting in increased sugar uptake via the glycosaminoglycan synthesis pathway. In addition, high levels of reactive oxygen species generated by elevated iron levels promote increased endogenous malondialdehyde synthesis in a subpopulation of cardiac endothelial cells. This exacerbates endothelial cell dysfunction and exacerbates the coagulopathy process.

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Neuroprotective potential for mitigating ischemia-reperfusion-induced damage

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Neural Regeneration Research 2025年第8期20卷 2199-2217页

作者： Zi Ye Runqing Liu Hangxing Wang Aizhen Zuo Cen Jin Nan Wang Huiqi Sun Luqian Feng Hua Yang The Clinical Medical College Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of infectious diseases Department of Internal MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Medical Imaging Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Gastroenterology First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina The Second Clinical Medical College Lanzhou UniversityLanzhouGansu ProvinceChina department of Neurosurgery Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou ProvinceChina

Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion *** studies have elucidated the neuroprotective role of the sirtuin protein family(Sirtuins)in modulating cerebral ischemia-reperfusion ***,the potential of utilizing it as a novel intervention target to influence the prognosis of cerebral ischemia-reperfusion injury requires additional *** this review,the origin and research progress of Sirtuins are summarized,suggesting the involvement of Sirtuins in diverse mechanisms that affect cerebral ischemia-reperfusion injury,including inflammation,oxidative stress,blood-brain barrier damage,apoptosis,pyroptosis,and *** therapeutic avenues related to Sirtuins that may improve the prognosis of cerebral ischemia-reperfusion injury were also investigated by modulating Sirtuins expression and affecting representative pathways,such as nuclear factor-kappa B signaling,oxidative stress mediated by adenosine monophosphate-activated protein kinase,and the forkhead box *** review also summarizes the potential of endogenous substances,such as RNA and hormones,drugs,dietary supplements,and emerging therapies that regulate Sirtuins *** review also reveals that regulating Sirtuins mitigates cerebral ischemia-reperfusion injury when combined with other risk *** Sirtuins show promise as a potential target for the treatment of cerebral ischemiareperfusion injury,most recent studies are based on rodent models with circadian rhythms that are distinct from those of humans,potentially influencing the efficacy of Sirtuinstargeting drug ***,this review provides new insights into the role of Sirtuins in the pathology and treatment of cerebral ischemia-reperfusion injury.

关键词： apoptosis autophagy blood-brain barrier dietary supplements drug hormones inflammation neuroprotection oxidative stress prognosis pyroptosis reperfusion injury risk factors RNA therapeutics

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Risk factors for congenital nasolacrimal duct obstruction in children under two years of age

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国际眼科杂志 2025年第1期25卷 17-23页

作者： Rozhin Kasiri Gholamreza Khataminia Ali Kasiri Mohammad Sadegh Mirdehghan Mohammad Armin Kasiri infectious Ophthalmologic Research Center Ahvaz Jundishapur University of Medical SciencesAhvaz ***Iran Islamic Azad University Tehran Medical sciences Tehran ***Iran

·AIM:To identify various risk factors that may play a significant role in the development of congenital nasolacrimal duct obstruction(CNLDO).·METHODS:This observational case-control study included a case group of 122 children less than two years of age with CNLDO who underwent probing and irrigation treatment at the ophthalmology department of Imam Khomeini Hospital in Ahvaz,Iran,from June 2022 to June2024.A control group of 122 age-matched children without CNLDO was also included for *** was collected from the children's medical records.·RESULTS:The study found a significant correlation between the occurrence of CNLDO and several maternal factors,such as preeclampsia,the use of levothyroxine,hypothyroidism,having more than three pregnancies(gravidity>3),natural pregnancy,and gestational diabetes ***,in children,factors,such as oxygen therapy,anemia,reflux,jaundice,and a family history of CNLDO in first-degree relatives were associated with CNLDO,and maternal preeclampsia and hypothyroidism were found to significantly increase the risk of developing CNLDO in children.·CONCLUSION:Given that CNLDO affects both premature and full-term children,the present findings may potentially facilitate the early identification of children and infants at risk of nasolacrimal duct obstruction,thereby preventing the onset of chronic dacryocystitis.

关键词： risk factors congenital nasolacrimal duct obstruction children

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Porcine Coronaviruses: Overview of the State of the Art

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Virologica Sinica 2021年第5期36卷 833-851页

作者： Hanna Turlewicz-Podbielska Małgorzata Pomorska-Mo´l department of preclinical sciences and infectious diseases Faculty of Veterinary Medicine and Animal SciencesPoznan University of Life Sciencesul.Wołyn´ska 3560-637 PoznanPoland

Like RNA viruses in general,coronaviruses(CoV)exhibit high mutation rates which,in combination with their strong tendency to recombine,enable them to overcome the host species barrier and adapt to new *** is currently known that six CoV are able to infect *** of them belong to the genus Alphacoronavirus[transmissible gastroenteritis coronavirus(TEGV),porcine respiratory coronavirus(PRCV),porcine epidemic diarrhea virus(PEDV),swine acute diarrhea syndrome coronavirus(SADS-CoV)],one of them to the genus Betacoronavirus[porcine hemagglutinating encephalomyelitis virus(PHEV)]and the last one to the genus Deltacoronavirus(PDCoV).PHEV was one of the first identified swine CoV and is still widespread,causing subclinical infections in pigs in several ***,a spike deletion mutant of TGEV associated with respiratory tract infection,appeared in the 1980 *** is considered nonpathogenic since its infection course is mild or *** its appearance,pig populations have become immune to both PRCV and TGEV,leading to a significant reduction in the clinical and economic importance of ***,PEDV and PDCoV are enteropathogenic CoV and cause clinically indistinguishable acute gastroenteritis in all age groups of *** and SADS-CoV have emerged in 2014(US)and in 2017(China),*** diagnosis is crucial for controlling CoV infections and preventing them from *** vaccines are available only for some porcine CoV,prevention should focus mainly on a high level of *** view of the diversity of CoV and the potential risk factors associated with zoonotic emergence,updating the knowledge concerning this area is essential.

关键词： Coronavirus Pig Emerging Re-emerging

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一种基于偶氮键一级断裂与C–C键二级断裂释放药物的β-lapachone高分子纳米前药用于肿瘤选择性治疗（英文）

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Science China Materials 2025年

作者：赵唯栋郑梦飞褚虹宇张景宣王昆杨晨光沈娜汤朝晖 Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences School of Applied Chemistry and Engineering University of Science and Technology of China department of Gastrointestinal Colorectal and Anal Surgery China-Japan Union Hospital of Jilin University department of Pathogenbiology State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases College of Basic Medicine Jilin University

lapachone (β-Lap)是一种极具潜力的邻萘醌类抗肿瘤药物,但β-Lap临床应用受限于低水溶性和严重的毒副作用.前药修饰策略可有效增强药物的肿瘤选择性,但β-Lap受限于缺乏可修饰基团.本文设计了一种新型偶氮键一级断裂和碳碳键(C–C)二...

lapachone (β-Lap)是一种极具潜力的邻萘醌类抗肿瘤药物,但β-Lap临床应用受限于低水溶性和严重的毒副作用.前药修饰策略可有效增强药物的肿瘤选择性,但β-Lap受限于缺乏可修饰基团.本文设计了一种新型偶氮键一级断裂和碳碳键(C–C)二级断裂的β-Lap高分子纳米前药(Azo-Lap NP),自消除的对氨基苯基连接子通过偶氮键连接聚谷氨酸,在高表达NQO1和低pH的肿瘤环境下,实现肿瘤响应性β-Lap释放. Azo-Lap NPs对β-Lap的有效共价负载可显著提高β-Lap的给药剂量,并延长药物的肿瘤停留时间.此外, Azo-Lap NPs通过避免溶血和高铁血红蛋白的产生显著降低β-Lap的毒副作用.通过小鼠抑瘤实验验证了Azo-Lap NPs安全性.在4T1模型中, Azo-Lap NPs组的抑瘤率明显高于β-Lap组.本研究为肿瘤选择性递送β-Lap提供了一种更有效且安全的高分子纳米前药.

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Sodium butyrate protects against toxin-induced acute liver failure in rats

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Hepatobiliary & Pancreatic diseases International 2014年第3期13卷 309-315页

作者： Fan Yang Li-Kun Wang Xun Li Lu-Wen Wang Xiao-Qun Han Zuo-Jiong Gong department of infectious diseases Renmin Hospital of Wuhan University department of infectious diseases Linyi People's Hospital

BACKGROUND: Acute liver failure(ALF) is a serious clinical syndrome with high mortality. Sodium butyrate has been shown to alleviate organ injury in a wide variety of preclinical models of critical diseases. The aim of this study was to investigate the protective effect of sodium butyrate on ALF in ***: All rats were randomly divided into control,model and sodium butyrate treatment groups. Except the control group, the rats were induced ALF animal model by subcutaneous injection of human serum albumin+D- galactosamine+lipopolysaccharide. After induction of ALF,the rats in the treatment group received sodium butyrate(500mg/kg) at 12-hour or 24-hour time point. Fourty-eight hours after ALF induction, the animals were sacrificed and samples were harvested. Serum endotoxin, high mobility group box-1(HMGB1), liver function parameters, tumor necrosis factoralpha(TNF-α) and interferon-gamma(IFN-γ) were *** expression of HMGB1 and nuclear factor-kappa B(NF-κB)p65 protein in liver tissue was detected by Western blotting. The histological changes of liver and intestine were examined. The survival duration was also ***: Serum endotoxin, alanine aminotransferase, HMGB1,TNF-α and IFN-γ were significantly increased and the liver histology showed more severe histopathological injury in the model group compared with the control group(P<0.05).Compared to the model group, sodium butyrate treatment significantly improved the histopathological changes in the liver and intestine, reduced serum endotoxin and inflammatory cytokines, suppressed HMGB1 and NF-кB p65 proteins in liver tissue, and prolonged the survival duration regardless of treatment at 12 hours or 24 hours after induction of ALF(P<0.05).CONCLUSIONS: Sodium butyrate protected the liver from toxin-induced ALF in rats. The mechanisms may be due to direct hepatoprotection and decreased intestinal permeability.

关键词： acute liver failure high mobility group box-1 nuclear factor-kappa B p65 animal model sodium butyrate

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Prion protein in myelin maintenance: what does the goat say?

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Neural Regeneration Research 2021年第6期16卷 1216-1217页

作者： Fredrik S.Skedsmo Arild Espenes Michael A.Tranulis department of preclinical sciences and Pathology Norwegian University of Life SciencesOsloNorway

The cellular prion protein PrPC has been extensively studied because it can adopt a pathogenic three-dimensional conformation that causes rare,but invariably fatal,neurodegenerative prion diseases in humans and other *** disease-causing conformer of the protein is called PrPSc,of which oligomeric aggregates constitute prion agents that can bind to,and convert further,PrPC molecules into PrPSc(Prusiner,1998).Thus,in the poorly understood process of prion propagation,there is transfer of biological information encoded solely by protein *** can spread within a tissue secondary to a spontaneous conversion of PrPC to PrPSc or upon transmission of prion agents between individuals.

关键词： Prion convert invar

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Available for millions of years but discovered through the last decade:Insects as a source of nutrients and energy in animal diets

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Animal Nutrition 2022年第4期11卷 60-79页

作者： Bartosz Kieronczyk Mateusz Rawski Zuzanna Mikołajczak Natalia Homska Jan Jankowski Katarzyna Ognik Agata Jozefiak Jan Mazurkiewicz Damian Jozefiak department of Animal Nutrition Poznan University of Life SciencesPoznanPoland Laboratory of Inland Fisheries and Aquaculture Department of ZoologyPoznan University of Life SciencesPoznanPoland department of Poultry Science University of Warmia and MazuryOlsztynPoland department of Biochemistry and Toxicology Faculty of Animal Sciences and BioeconomyUniversity of Life Sciences in LublinLublinPoland department of preclinical sciences and infectious diseases Poznan University of Life SciencesPoznanPoland

The aim of this review is to present and discuss the most recent literature about the processing of insect biomass and its impact on nutritive value,further implementation of meals and fats derived from invertebrates to livestock(poultry and swine),aquaculture(salmonids),and companion animal diets and their impact on growth performance,metabolic response,and gastrointestinal microbiota ***,the most important barriers to obtaining unified products in terms of their nutritive value are considered,i.e.,to define insects'nutrient requirements,including various technological groups and further biomass processing(slaughtering,drying,and storage).Due to the current limitation in the insect production process consisting of the lack of infrastructure,there is stress on the relatively small amount of insect products added to the animal diets as a functional feed ***,only in the case of pet nutrition may insects be considered a full replacement for commonly used environmentally harmful and allergenic ***,the least information has been published on this ***,more scientific data are needed,particularly when the pet food branch and insect-based diets are rapidly growing.

关键词： Insect protein Poultry Pig Fish Pet Nutritive value

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CCR10 and its ligands in regulation of epithelial immunity and diseases

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Protein & Cell 2012年第8期3卷 571-580页

作者： Na Xiong Yaoyao Fu Shaomin Hu Mingcan Xia Jie Yang Center for Molecular Immunology and infectious diseases and department of Veterinary and Biomedical sciences The Pennsylvania State UniversityPA 16802USA

Epithelial tissues covering the external and internal surface of a body are constantly under physical,chemical or biological *** protect the epithelial tissues and maintain their homeostasis,multiple layers of immune defense mechanisms are *** the epithelial tissue-resident immune cells that provide the first line of defense,circulating immune cells are also recruited into the local tissues in response to *** and chemokine receptors regulate tissue-specific migration,maintenance and functions of immune *** them,chemokine receptor CCR10 and its ligands chemokines CCL27 and CCL28 are uniquely involved in the epithelial ***27 is expressed predominantly in the skin by keratinocytes while CCL28 is expressed by epithelial cells of various mucosal ***10 is expressed by various subsets of innate-like T cells that are programmed to localize to the skin during their developmental processes in the *** T cells might be imprinted by skin-associated antigen-presenting cells to express CCR10 for their recruitment to the skin during the local immune *** the other hand,IgA antibody-producing B cells generated in mucosa-associated lymphoid tissues express CCR10 for their migration and maintenance at mucosal *** evidence also found that CCR10/ligands are involved in regulation of other immune cells in epithelial immunity and are frequently exploited by epithelium-localizing or-originated cancer cells for their survival,proliferation and evasion from immune ***,we review current knowledge on roles of CCR10/ligands in regulation of epithelial immunity and diseases and speculate on related important questions worth further investigation.

关键词： CCR10 epithelial immunity epithelial diseases

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Lemierre's syndrome with double heterozygote status in the methylenetetrahydrofolate reductase gene

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World Journal of Pediatrics 2014年第3期10卷 281-283页

作者： Mostafa Behpour-Oskooee Abdollah Karimi Shirin Sayyahfar Pediatric infectious diseases Department of PediatricsNajmieh HospitalBaghyatollah University of Medical SciencesTehranIran Pediatric infectious diseases Pediatric Infectious Research CenterMofi d Children HospitalShahid Beheshti University of Medical SciencesTehranIran Pediatric infectious diseases Department of PediatricsAli Asghar Children HospitalIran University of Medical SciencesTehranIran

Background:There are some risk factors being more vulnerable to Lemierre's syndrome such as a hypercoagulable ***:We report a rare case of Lemierre's syndrome with ethmoid and maxillary sinusitis,bilateral mastoiditis,and sigmoid sinus ***:Genetic study revealed a double heterozygote status in the methylenetetrahydrofolate reductase gene including C677T and ***:It is suggested to screen patients with Lemierre's syndrome for a hypercoagulable state to consider anticoagulant therapy.

关键词： Lemierre's syndrome mastoiditis methylenetetrahydrofolate reductase sigmoid sinus thrombosis

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